Preschool Oral Immunotherapy Is Associated With Improved Parental Food Allergy-Specific Anxiety and Quality of Life: A Real-World Observational Study.

IF 5.2 2区医学 Q1 ALLERGY

Clinical and Experimental Allergy Pub Date : 2025-07-04 DOI:10.1111/cea.70111

Ally Baaske, Michael A Golding, Jennifer L P Protudjer, Rishma Chooniedass, Scott B Cameron, Victoria E Cook, Sandeep Kapur, Gregory Rex, Mary McHenry, Tiffany Wong, Raymond Mak, Stephanie C Erdle, Timothy K Vander Leek, Jennifer Y Tong, Edmond S Chan, Lianne Soller

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引用次数: 0

Abstract

Introduction: Preschool oral immunotherapy (OIT) is safe and effective for food allergy, and may improve parental food allergy-specific anxiety (FAA) and food allergy quality of life (FAQL); however, data on these important outcomes are limited, particularly for preschoolers. Herein, we explored the relationship between OIT and parental FAA, including the subdomains: food allergy-related worries, anxiety impact, behavioural avoidance, and coping; and OIT and FAQL in parents of preschool-aged children.

Methods: Parents of preschool-aged children (< 72 months) receiving OIT in Canadian allergy clinics were eligible for this observational study. The Impairment Measure for Parental Food Allergy-Associated Anxiety and Coping Tool (IMPAACT) and the Food Allergy Quality of Life-Parental Burden (FAQL-PB) questionnaire were administered to parents at four timepoints from the start of OIT to 12 months post-build-up. The relationships between OIT and total FAA, each IMPAACT subscale, and FAQL were investigated using a series of linear mixed effect models. Each model included variables related to child age, whether child was receiving OIT to some (partial OIT) or all of (complete OIT) their allergens, time to complete build-up, and two binary variables indexing whether the child experienced a reaction during build-up or maintenance.

Results: Between 2021 and 2025, 788 children participated. Total IMPAACT scores decreased during OIT build-up, indicating improvement (baseline: 70.69; end of build-up: 57.36; marginal mean change: -13.33; b = -18.13; 95% CI = -27.63, -8.62, p < 0.001). IMPAACT scores significantly decreased across three subscales: Worries; anxiety impact, and behavioural avoidance. FAQL-PB scores decreased during OIT build-up (baseline: 27.35; end of build-up: 22.16; marginal mean change: -5.19; b = -7.17; 95% CI = -12.65, -1.69, p = 0.01). Child's age, partial versus complete OIT, time to complete build-up, and reactions during maintenance moderated the relationship between time and some of the outcome variables.

Conclusion: Preschool OIT is associated with significant improvements in parent food allergy-specific anxiety and food allergy quality of life.

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学龄前儿童口服免疫治疗与改善父母食物过敏特异性焦虑和生活质量有关：一项真实世界的观察性研究。

学龄前儿童口服免疫疗法（OIT）治疗食物过敏安全有效，可改善父母食物过敏特异性焦虑（FAA）和食物过敏生活质量（FAQL）；然而，关于这些重要结果的数据是有限的，特别是对于学龄前儿童。在此，我们探讨了OIT与父母FAA之间的关系，包括子领域：食物过敏相关担忧、焦虑影响、行为回避和应对；以及学龄前儿童家长的OIT和FAQL。方法：学龄前儿童家长(结果：2021 - 2025年，788名儿童参与。在OIT积累过程中，总IMPAACT得分下降，表明改善(基线：70.69；累积结束：57.36；边际平均变化：-13.33；b = -18.13；95% CI = -27.63, -8.62， p结论：学龄前OIT与父母食物过敏特异性焦虑和食物过敏生活质量显著改善相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Allergy 医学-过敏

CiteScore

10.40

自引率

9.80%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Clinical & Experimental Allergy strikes an excellent balance between clinical and scientific articles and carries regular reviews and editorials written by leading authorities in their field. In response to the increasing number of quality submissions, since 1996 the journals size has increased by over 30%. Clinical & Experimental Allergy is essential reading for allergy practitioners and research scientists with an interest in allergic diseases and mechanisms. Truly international in appeal, Clinical & Experimental Allergy publishes clinical and experimental observations in disease in all fields of medicine in which allergic hypersensitivity plays a part.