Landscape of Aeroallergen Sensitization in Asia.

IF 5.2 2区医学 Q1 ALLERGY

Clinical and Experimental Allergy Pub Date : 2025-08-18 DOI:10.1111/cea.70137

Xiaoling Yin, Xiangling Zhang, Feng Xu, Hao Xiao, Juan Meng, Philip H Li

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Abstract

Allergic diseases caused by aeroallergens are emerging as a critical public health issue across Asia. Diverse climatic and geographic conditions play a significant role in shaping regional variation in aeroallergy sensitisation patterns across Asia. House dust mites (HDMs) remain the predominant indoor allergens, while pollen sensitisation varies substantially based on regional flora. Rapid urbanisation, evolving lifestyles, increasing air pollution, and genetic susceptibility further influence allergen exposure and sensitisation profiles. Although pharmacological and biologic therapies have advanced, allergen-specific immunotherapy (AIT) remains the only disease-modifying therapeutic strategy. This review synthesises current evidence on aeroallergen sensitisation patterns across Asia, elucidates key influencing factors across various Asian regions, and discusses current prevention and treatment strategies, emphasising the role and challenges of AIT. Improved understanding of these regional allergenic profiles and management practices is essential for developing tailored clinical guidelines and public health interventions.

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亚洲空气过敏原致敏的概况。

由空气过敏原引起的过敏性疾病正在成为亚洲一个重要的公共卫生问题。不同的气候和地理条件在塑造亚洲空气过敏致敏模式的区域差异中起着重要作用。室内尘螨（HDMs）仍然是主要的室内过敏原，而花粉致敏性因区域菌群而有很大差异。快速城市化、不断演变的生活方式、日益严重的空气污染和遗传易感性进一步影响了过敏原暴露和致敏情况。虽然药物和生物疗法已经取得进展，但过敏原特异性免疫疗法（AIT）仍然是唯一的疾病修饰治疗策略。本综述综合了亚洲地区空气过敏原致敏模式的现有证据，阐明了亚洲不同地区的关键影响因素，并讨论了当前的预防和治疗策略，强调了AIT的作用和挑战。提高对这些区域过敏原概况和管理做法的了解对于制定有针对性的临床指南和公共卫生干预措施至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Allergy 医学-过敏

CiteScore

10.40

自引率

9.80%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Clinical & Experimental Allergy strikes an excellent balance between clinical and scientific articles and carries regular reviews and editorials written by leading authorities in their field. In response to the increasing number of quality submissions, since 1996 the journals size has increased by over 30%. Clinical & Experimental Allergy is essential reading for allergy practitioners and research scientists with an interest in allergic diseases and mechanisms. Truly international in appeal, Clinical & Experimental Allergy publishes clinical and experimental observations in disease in all fields of medicine in which allergic hypersensitivity plays a part.