Variants of the MRGPRX2 Gene Found in Patients With Hypersensitivity to Quinolones and Vancomycin Show Amplified and Drug-Specific Activation Responses In Vitro.

IF 6.3 2区医学 Q1 ALLERGY

Clinical and Experimental Allergy Pub Date : 2025-05-01 DOI:10.1111/cea.70068

Paola Leonor Quan, Laia Ollé, Marina Sabaté-Bresco, Elizabeth Guruceaga, José Julio Laguna, Inmaculada Doña, Rosa Muñoz-Cano, José Luis Perez-Gracia, Margarita Martín, Gabriel Gastaminza

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在喹诺酮类药物和万古霉素过敏患者中发现的MRGPRX2基因变异在体外表现出扩增和药物特异性激活反应。

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来源期刊

Clinical and Experimental Allergy 医学-过敏

CiteScore

10.40

自引率

9.80%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Clinical & Experimental Allergy strikes an excellent balance between clinical and scientific articles and carries regular reviews and editorials written by leading authorities in their field. In response to the increasing number of quality submissions, since 1996 the journals size has increased by over 30%. Clinical & Experimental Allergy is essential reading for allergy practitioners and research scientists with an interest in allergic diseases and mechanisms. Truly international in appeal, Clinical & Experimental Allergy publishes clinical and experimental observations in disease in all fields of medicine in which allergic hypersensitivity plays a part.