Biomedicine hub最新文献

{"title":"Relationship between Maternal Retinal Microvascular Changes in the Postpartum Period, Tumor Necrosis Factor Receptor 2, and Cotinine.","authors":"Yogavijayan Kandasamy, Rachel Lim, Jean Calleja-Agius, Donna Rudd","doi":"10.1159/000548212","DOIUrl":"10.1159/000548212","url":null,"abstract":"<p><strong>Introduction: </strong>During pregnancy, placental microvasculature undergoes significant adaptations to support the developing fetus. However, studying placental microcirculation in vivo remains challenging. This study examined the potential of using retinal microvasculature measurements as a proxy, along with umbilical cord blood markers of angiogenesis and inflammation together with urine cotinine (a nicotine metabolite), to gain insights into the microvasculature changes in the human placenta.</p><p><strong>Methods: </strong>During the 24-month recruitment period (August 2019 to August 2021), the study was open to all pregnant women receiving antenatal care at Townsville University Hospital in Australia. Immediately after childbirth, the maternal central retinal artery equivalent (CRAE) diameter, the central retinal vein equivalent (CRVE) diameter, and the arteriovenous ratio (AVR) were determined using a handheld non-mydriatic retinal camera. Umbilical cord blood and maternal urine were also collected and analyzed.</p><p><strong>Results: </strong>Data from 80 women were analyzed. Multivariate analyses found a significant negative correlation between CRAE, CRVE, and tumor necrosis factor receptor 2 (TNFR2) and a significant positive correlation between CRVE and urine cotinine, the diagnosis of preeclampsia, and diabetes mellitus in pregnancy.</p><p><strong>Conclusions: </strong>We propose that the changes in the retinal artery and vein may reflect alterations in the placenta's spiral artery and its draining vein, with TNFR2 acting as a common mediator.</p>","PeriodicalId":101351,"journal":{"name":"Biomedicine hub","volume":"10 1","pages":"183-190"},"PeriodicalIF":0.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MedReadr: Development and Evaluation of an In-Browser, Rule-Based Natural Language Processing Algorithm to Estimate the Reliability of Consumer Health Articles.","authors":"Joshua Winograd, Autumn Kim, Nikit Venishetty, Alia Codelia-Anjum, Dean Elterman, Naeem Bhojani, Kevin C Zorn, Adithya Balasubramanian, Andrew Vickers, Bilal Chughtai","doi":"10.1159/000548163","DOIUrl":"10.1159/000548163","url":null,"abstract":"<p><strong>Introduction: </strong>The internet is a major source of medical information for patients, yet the quality of online health content remains highly variable. Existing assessment tools are often labor-intensive, invalidated, or limited in scope. We developed and validated MedReadr, an in-browser, rule-based natural language processing (NLP) algorithm that automatically estimates the reliability of consumer health articles for patients and providers.</p><p><strong>Methods: </strong>Thirty-five consumer medical articles were independently assessed by two reviewers using validated manual scoring systems (QUEST and Sandvik). Interrater reliability was evaluated with Cohen's κ, and metrics with κ > 0.6 were selected for model fitting. MedReadr extracted key features from article text and metadata using predefined NLP rules. A multivariable linear regression model was trained to predict manual reliability scores, with internal validation performed on an independent set of 20 articles.</p><p><strong>Results: </strong>High interrater reliability was achieved across all QUEST and most Sandvik domains (Cohen's κ > 0.6). The MedReadr model demonstrated strong performance, achieving <i>R</i> ² = 0.90 and RMSE = 0.05 on the development set and <i>R</i> ² = 0.83 and RMSE = 0.07 on the validation set. All model coefficients were statistically significant (<i>p</i> < 0.05). Key predictive features included currency and reference scores, sentiment polarity, engagement content, and the frequency of provider contact, intervention endorsement, intervention mechanism, and intervention uncertainty phrases.</p><p><strong>Conclusion: </strong>MedReadr demonstrates that structural reliability scoring of online health articles can be automated using a transparent, rule-based NLP approach. Applied to English-language articles from mainstream search results on common medical conditions, the tool showed strong agreement with validated manual scoring systems. However, it has only been validated on a narrow scope of content and is not designed to analyze search results for specific questions or detect misinformation. Future research should assess its performance across a broader range of web content and evaluate whether its integration improves patient comprehension, digital health literacy, and clinician-patient communication.</p>","PeriodicalId":101351,"journal":{"name":"Biomedicine hub","volume":"10 1","pages":"162-170"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Patient Health Literacy on Disease Control in Type 2 Diabetes: An Analytical Cross-Sectional Study.","authors":"Mohamad Alchawa, Rana Alasaad, Jihene Maatoug Maaloul, Mahmoud Zirie, Iheb Bougmiza","doi":"10.1159/000548011","DOIUrl":"10.1159/000548011","url":null,"abstract":"<p><strong>Introduction: </strong>Health literacy (HL) is crucial in the management of type 2 diabetes mellitus (T2DM), affecting patient outcomes and treatment adherence. Despite its importance, the specific impact of HL on glycemic control remains inconclusive, particularly in Qatar, a country with very high T2DM prevalence. This study aimed to investigate the role of HL as a predictor of disease control among T2DM patients in Qatar.</p><p><strong>Methods: </strong>This cross-sectional study recruited a random sample of adults with T2DM from the largest healthcare electronic system in the country. Participants were interviewed using a multicomponent questionnaire that included the European Health Literacy Survey Questionnaire (HLS-EU-Q16) and data on demographic and clinical variables. HbA1c <7% was used to define disease control. In addition to bivariate analyses, hierarchical logistic regression analysis was used to assess the association between sociodemographic, clinical variables, HL, and glycemic control.</p><p><strong>Results: </strong>Among the 450 recruited patients, 55.3% had uncontrolled disease. HL was significantly associated with glycemic control; higher HL scores correlated with lower HbA1c levels with a Spearman's correlation coefficient of -0.624, <i>p</i> < 0.001. Hierarchical logistic regression revealed that HL was a significant predictor of disease control (AOR: 2.192, <i>p</i> < 0.001), after adjusting for sociodemographic and clinical variables.</p><p><strong>Conclusion: </strong>HL is a key predictor of glycemic control in T2DM patients. Routine HL assessment should be part of diabetes care. Tailored interventions targeting low HL warrant investigation to improve outcomes. Further research is needed to address the effects of low HL in this group.</p>","PeriodicalId":101351,"journal":{"name":"Biomedicine hub","volume":"10 1","pages":"171-182"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Adults and Pediatric-Inspired Schemes on Negative Measurable Residual Disease and Overall Survival in Adults with Acute Lymphoblastic Leukemia: A Retrospective Analysis from the Hematology Department at Hospital Regional de Alta Especialidad de Ixtapaluca, Mexico.","authors":"Christian Omar Ramos Peñafiel, Irma Olarte Carrillo, Adán Germán Gallardo Rodríguez, Daniela Pérez Sámano, Álvaro García Cabrera, Carolina Balderas Delgado, Carlos Martínez Murillo, Adolfo Martínez Tovar","doi":"10.1159/000545952","DOIUrl":"10.1159/000545952","url":null,"abstract":"<p><strong>Introduction: </strong>The treatment for acute lymphoblastic leukemia (ALL) is based upon combining chemotherapy, tyrosine kinase inhibitors, and bispecific monoclonal antibodies. Screening throughout the measurable residual disease is the main tool to establish the prognosis and risk of relapse. Induction protocols include a combination of steroids, anthracyclines, vinca alkaloids, and, in the pediatric-inspired schemes, asparaginase.</p><p><strong>Methods: </strong>A retrospective study included clinical records of patients with ALL who received treatment based on Hyper-CVAD (adult scheme) or CALGB10403 (pediatric scheme) between 2018 and 2023.</p><p><strong>Results: </strong>A total of 460 clinical records of patients were collected. 50.2% were male. The average age was 34 years old. 20.7% (<i>n</i> = 95) received the pediatric scheme, while 79.3% (<i>n</i> = 365) received the adult scheme. Pediatric scheme patients presented a higher ratio of complete remissions (67.4%) than adult scheme (57.3%) (<i>p</i> = 0.047). When comparing survival according to groups, pediatric scheme patients presented higher survival rates than adult patients (log rank 0.000).</p><p><strong>Conclusions: </strong>The introduction of bearable and accessible schemes with the choice of outpatient administration is ideal for the health systems of Latin America. Along with the treatment selection, strict screening through a standardized technique remains the main prognosis factor for the treatment of adult ALL.</p>","PeriodicalId":101351,"journal":{"name":"Biomedicine hub","volume":"10 1","pages":"152-161"},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Expression of Micro-RNA in Maternal Blood of Pregnancies Affected with Late-Onset Fetal Growth Restriction.","authors":"José Morales-Roselló, Ana Isabel Martínez-Hernández, Julia Scheel, Gabriela Loscalzo, Eva María García-López, Colin Murdoch","doi":"10.1159/000546518","DOIUrl":"10.1159/000546518","url":null,"abstract":"<p><strong>Introduction: </strong>Micro-RNAs (miRNAs) participate in different biological processes, including fetal hypoxia. In this work, we aimed to evaluate the existence of a miRNA differential expression profile in maternal blood of pregnancies affected with late-onset fetal growth restriction (LO-FGR).</p><p><strong>Methods: </strong>In a prospective study, a group of 35 fetuses were evaluated with Doppler ultrasound after 36 weeks. These included 15 fetuses with LO-FGR defined as fetal birth weight <10th centile plus a cerebroplacental ratio (CPR) <0.6765 MoM and 20 normal fetuses (normal BW plus a normal CPR). Afterward, for every pregnancy, maternal blood plasma was collected at birth, miRNAs were extracted, and full miRNA sequencing was performed using 20 of the indicated samples (12 with LO-FGR and 8 normal), determining the existence of differentially expressed miRNAs. Finally, this differential expression was validated in a wider population of 35 fetuses by means of quantitative reverse transcription polymerase chain reaction.</p><p><strong>Results: </strong>Full mRNA sequencing showed that FGR mothers expressed differential expression of several miRNA. The highest differences were seen for miR-486-5p/3p, miR-516a/b-5p, miR-19a/b-3p, miR-296-5p, miR-10b-5p, miR-205-5p, and Let-7g-5p. However, PCR validation only confirmed significant differences in miR-486-5p/3p.</p><p><strong>Conclusion: </strong>Mothers delivering FGR fetuses express a miRNA profile, which includes differential expression of miR-486-5p/3p. This information might improve our understanding of the pathophysiological processes involved in late-onset FGR. Future validation and feasibility studies will be required to propose maternal blood miRNAs as a valid tool in the diagnosis and management of FGR.</p>","PeriodicalId":101351,"journal":{"name":"Biomedicine hub","volume":"10 1","pages":"134-151"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12410966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145017100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postmortem Inductively Coupled Plasma Mass Spectrometry Analysis Reveals Elevated Heavy Metal Concentrations in Coronary Arteries: A Comparative Autopsy Study Supporting a Toxic Inflammatory Hypothesis for Atherosclerosis.","authors":"Onur Yolay, Emine Esra Kasapbasi, Erdem Tezcan, Ceyhun Kucuk, Hasan Karaoglu, Emir Canturk, Bekir Inan, Dogac Oksen, Ozge Cetinarslan, Fadil Umihanić, Serdar Baki Albayrak, Ayhan Olcay","doi":"10.1159/000546499","DOIUrl":"10.1159/000546499","url":null,"abstract":"<p><strong>Introduction: </strong>A large number of studies have been carried out for the etiology of atherosclerosis and many risk factors have been identified, including environmental factors and heavy metals, which are related to the pathogenesis. This study aimed to determine the effects of heavy metals, which have activation and inhibition effects on various metabolic pathways, on atherosclerosis by examining coronary arteries obtained from autopsy series.</p><p><strong>Methods: </strong>Coronary arteries of 28 autopsy cases were analyzed by inductively coupled plasma mass spectrometry method. Sixteen of the cases had coronary atherosclerotic plaques and 12 of the coronaries were normal. Twenty trace metal concentrations were examined from the samples obtained.</p><p><strong>Results: </strong>Twenty-eight coronary artery samples (16 with atherosclerosis, 12 normal) were analyzed using ICP-MS. Levels of Mg, K, Ca, P, Fe, Zn, Al, S, As, Pt, Sb, Hg were significantly higher in atherosclerotic arteries (e.g., Ca: 51,384 vs. 1,723 ppm, <i>p</i> = 0.005; P: 30,791 vs. 3,443 ppm, <i>p</i> = 0.003; Hg: 3.2 vs. 0 ppm, <i>p</i> < 0.001). Elements such as lead, cobalt, and cadmium remained below detection limits in both groups.</p><p><strong>Conclusion: </strong>Heavy metals through inflammation, oxidative stress, and disrupted antioxidant pathways are independent risk factors that increase the risk of atherosclerosis. These findings provide tissue-level evidence that heavy metal accumulation may contribute to atherosclerosis through oxidative stress, inflammation, and disruption of antioxidant defenses.</p>","PeriodicalId":101351,"journal":{"name":"Biomedicine hub","volume":"10 1","pages":"124-133"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Cutaneous Reactions to Monoclonal Antibodies: Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis, Erythema Multiforme, and Fixed Drug Eruption - A Systematic Review.","authors":"Kenan Kherallah, Imran Ahmad, Anishka Bandara, Jacob Kattoula, Ivan Rodriguez, Scott Worswick","doi":"10.1159/000545623","DOIUrl":"10.1159/000545623","url":null,"abstract":"<p><strong>Introduction: </strong>The therapeutic use of monoclonal antibodies (mAbs) has significantly increased since the first mAb was introduced. Despite their therapeutic benefits, mAbs have been accompanied by a rise in adverse effects, affecting various organ systems including the skin. This systematic review consolidates the current literature on the incidence, characteristics, and management of adverse dermatological events (ADEs) post-mAb treatment, focusing on Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), erythema multiforme (EM), and fixed drug eruption (FDE).</p><p><strong>Methods: </strong>A comprehensive PubMed search from 1980 to January 2024 included studies on mAbs causing SJS, TEN, EM, or FDE in humans. Screening was conducted using Covidence, and data were extracted on demographics, mAb details, rash characteristics, and treatment.</p><p><strong>Results: </strong>Of the initial 2002 articles, 29 met the inclusion criteria, highlighting 31 cases of ADEs. The onset of these rashes was delayed, often occurring significantly after starting mAb therapy, with a mean onset time considerably longer than that associated with traditional drugs. Additionally, neither patient sex nor concurrent medication use affected the likelihood of developing these reactions.</p><p><strong>Conclusion: </strong>This review underscores the prolonged timeline for the onset of ADEs from mAbs, distinct from reactions induced by traditional drugs, aligning with the characteristics of progressive immunotherapy-related mucocutaneous eruption. The lack of correlation with patient sex or concurrent medications reaffirms the inherent risk of mAbs. These findings highlight the need for clinicians to monitor and educate patients about the potential for delayed dermatological reactions from mAb treatment to ensure timely management and better outcomes.</p>","PeriodicalId":101351,"journal":{"name":"Biomedicine hub","volume":"10 1","pages":"105-115"},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Routine Use of Analgesia for Venipuncture in a Tertiary Level Neonatal Intensive Care Setting: A Quality Improvement Study.","authors":"Sonam Shah, Dwayne Mascarenhas, Medha Goyal, Santoshi Subadarshini, Ruchi Nimish Nanavati, Anitha Ananthan","doi":"10.1159/000545874","DOIUrl":"10.1159/000545874","url":null,"abstract":"<p><strong>Introduction: </strong>Neonatal exposure to pain can lead to altered pain perception in later years of life. Despite the availability of measures to alleviate pain, routine use is lacking. We decided to conduct a quality improvement (QI) study to increase the use of analgesia during venipuncture, a common procedure in neonatal intensive care units, from a baseline of 0% to 50% over 8 weeks.</p><p><strong>Methods: </strong>Fishbone analysis was used to identify the potential barriers, which were targeted to bring improvement through Plan-Do-Study-Action (PDSA) cycles. In the first cycle, education and training of healthcare providers were conducted for 3 weeks, followed by the second cycle, wherein the mother's own milk was made available bedside for analgesia use. In the third cycle, a small amount of pasteurized donor human milk was kept separately for analgesia, and 25% dextrose was made available in the fourth cycle as a last resort. The 2nd-4th PDSA cycles were performed for a period of 2 weeks each.</p><p><strong>Results: </strong>The use of analgesia improved to 26% from baseline after the first cycle and subsequently to 46%, 50%, and 53% after the second, third, and fourth cycles, respectively. During the sustenance phase, in the initial 2 months, there was a decrease in analgesia use, but with prompt interventions and timely remediation, it increased up to 60%, which was sustained for the subsequent 3 months.</p><p><strong>Conclusion: </strong>Using the QI model, we were able to identify lacunae in current care and drive a culture change, leading to an increase in the use of analgesia during venipuncture.</p>","PeriodicalId":101351,"journal":{"name":"Biomedicine hub","volume":"10 1","pages":"116-123"},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Replacing Intradialytic Parenteral Nutrition by Oral Nutritional Supplements and Polyester-Polyarylate Membrane on Nutritional Status in Maintenance Hemodialysis Patients with End-Stage Kidney Disease.","authors":"Maxime Hoffmann, Amaury Ben Henda, Omar Mazouz, Rachid Amaria","doi":"10.1159/000545460","DOIUrl":"https://doi.org/10.1159/000545460","url":null,"abstract":"<p><strong>Introduction: </strong>In patients receiving hemodialysis, protein-energy wasting may be frequent and is associated with nutritional and metabolic alterations. This study aimed to describe the effects of a new therapeutic strategy, i.e., oral nutritional supplements (ONS) associated with a polyester-polyarylate (PEPA) membrane, on nutritional markers in high-risk patients with intradialytic parenteral nutrition (IDPN) history.</p><p><strong>Methods: </strong>Patients, who received individually IDPN (M-6 to M0) then ONS (M0 to M6), were followed over a 12-month period.</p><p><strong>Results: </strong>There was no change in serum albumin over time. The BMI increased between M-6 and M6. Food intake showed increase between M0 and M3. Quality-of-life score was stable between M0 and M6. None of the adverse events was judged related to ONS, PEPA, or research procedure.</p><p><strong>Conclusion: </strong>This study focusing on a new therapeutic strategy composed of ONS and PEPA membrane replacing IDPN to maintain nutritional markers in high-risk patients receiving hemodialysis might warrant further research with robust methodology.</p>","PeriodicalId":101351,"journal":{"name":"Biomedicine hub","volume":"10 1","pages":"98-104"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pleuroperitoneal Leak: A Rare Complication of Peritoneal Dialysis.","authors":"Maria Lafrid, Narjiss Labioui, Mohammed Massine El Hammoumi, Mohammed Hallak, Hajar Laasli, Abdelali Bahadi, El Hassane Kabiri, Driss Elkabbaj","doi":"10.1159/000545281","DOIUrl":"https://doi.org/10.1159/000545281","url":null,"abstract":"<p><strong>Introduction: </strong>Pleuroperitoneal leakage is a rare but dramatical cause of pleural effusion; it can lead to the cessation of peritoneal dialysis. It typically manifests as respiratory distress and reduced drainage volumes.</p><p><strong>Case presentation: </strong>In this article, we report a case of pleuroperitoneal leak in a patient undergoing continuous ambulatory peritoneal dialysis who presented to the emergency with shortness of breath, lower limb edema, and weight gain. The diagnosis was established through pleural puncture, revealing that the pleural fluid is transudative with elevated glucose level which is pathognomonic for this condition, \"sweet hydrothorax.\" Furthermore, the composition of this fluid was almost identical to the peritoneal dialysis effluent. The management of this case involved temporarily discontinuing peritoneal dialysis and performing pleurodesis. The evolution was favorable, and peritoneal dialysis was resumed 2 weeks later.</p><p><strong>Conclusion: </strong>Patients on peritoneal dialysis who present with significant pleural effusion, especially if it is unilateral, should prompt clinicians to consider the possibility of a pleuroperitoneal leak.</p>","PeriodicalId":101351,"journal":{"name":"Biomedicine hub","volume":"10 1","pages":"93-97"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}