The Microbe最新文献

{"title":"Optimizing diagnosis of pediatric Streptococcus pyogenes infections: A clinical prediction model","authors":"F.C. Ihenetu ,&nbsp;C.I. Okoro ,&nbsp;M.M. Ozoude ,&nbsp;K.E. Dunga ,&nbsp;C. Nwaoha","doi":"10.1016/j.microb.2024.100168","DOIUrl":"10.1016/j.microb.2024.100168","url":null,"abstract":"<div><div>Group A Streptococcus (GAS) infections, caused by <em>Streptococcus pyogenes</em>, are a major health concern among children under 12 years, leading to conditions such as tonsillitis, rheumatic fever, and post-streptococcal glomerulonephritis. Accurate diagnosis is essential for effective treatment and prevention. This study aimed to develop and validate a Clinical Prediction Rule (CPR) for predicting the presence of <em>S. pyogenes</em> in throat swabs from children under 12. We analyzed clinical and laboratory data from 1015 pediatric patients presenting with symptoms suggestive of GAS infection at Federal University Teaching Hospital, Owerri, Imo State, between January 2019 and December 2022. <em>S. pyogenes</em> was first isolated from throat swabs cultured on blood agar, and 233 positive isolates were further identified using Polymerase Chain Reaction (PCR) targeting the Spy 1258 gene, with DNA extracted via boiling and confirmed through phenotypic methods. Data from these 233 identified cases were used to develop and validate the CPR. Variables examined included gender, age, ward of admission, clinical diagnosis, and antibiotic susceptibility. Logistic regression modeling identified significant predictors of <em>S. pyogenes</em> presence, with potential biases minimized through systematic case review, standardized data extraction and cross-checking by multiple reviewers. Among the 233 cases analyzed, the mean age was 4 ± 0.25 years, with 62.7 % under age 3. Tonsillitis was the predominant diagnosis, with GAS prevalence ranging from 56.7 % to 69.3 %. Antibiotic susceptibility test result varied, with significant predictors including Sepsis/Tonsillitis and ear discharge/tonsillitis (p &lt; 0.001). The CPR model demonstrated a sensitivity of 95.4 % and a specificity of 36.8 %, highlighting its potential to enhance clinical diagnosis and management of GAS infections. This study offers valuable insights into predictors of <em>S. pyogenes</em> infection in pediatric patients and highlights the CPR’s potential for improving clinical diagnosis and management.</div></div>","PeriodicalId":101246,"journal":{"name":"The Microbe","volume":"5 ","pages":"Article 100168"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950194624001353/pdfft?md5=e66a3a406af26f561ff68e01b00b93e2&pid=1-s2.0-S2950194624001353-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation and identification of major cockroaches associated pathogenic bacteria in Bonga town, Ethiopia","authors":"Gebreegziabher Gebreyohans ,&nbsp;Nafyad Ibrahim Batu ,&nbsp;Tegegn Muche ,&nbsp;Nigus Kalayou ,&nbsp;Ketema Bacha ,&nbsp;Soressa Gershe ,&nbsp;Zerihun Ango","doi":"10.1016/j.microb.2024.100158","DOIUrl":"10.1016/j.microb.2024.100158","url":null,"abstract":"<div><p>Cockroaches are a reservoir of various pathogenic microorganisms that pose a significant risk to public health because of unsanitary living spaces, poor waste management, inappropriate food storage, limitations of public health guidelines, and education on hygiene practices. The aim of this study was to isolate and identify major pathogenic bacteria associated with cockroaches in Bonga Town, Kaffa Zone. A total of 300 cockroaches were collected from Restaurants, Houses, and Hospitals, with 100 specimens from each location. The collected cockroaches were then subjected to microbiological analysis in the laboratory to identify potential bacterial pathogens<em>.</em> The cockroaches were killed using cotton-soaked chloroform, surface-sterilized using 70 % ethanol, and dissected aseptically. The cockroaches were added to 2 mL of sterile normal saline and shaken thoroughly for two minutes. The cockroaches were taken out of the tubes, and the remaining liquid was centrifuged at 2000 rpm for 10 minutes. The supernatants were then removed, and the remaining sediments were used for culture. In each tube, a fixed volume of 1 mL of the sediments was cultured on various culture media separately. Different species of bacteria with similar morphological characteristics were identified on the external and internal surfaces of the cockroaches. These results indicate the morphological characteristics of the colonies grown on each agar plate in different settings (Hospital, Restaurants and Households). The specific characteristics of the colonies can help in identifying different bacterial species<em>.</em> The isolated pathogens were then identified using standard microbiological techniques, including gram staining, morphology, microscopic slides, and biochemical tests. The results revealed the presence of bacterial pathogens, including <em>E. coli</em>, <em>Salmonella</em>, <em>Pseudomonas</em>, <em>Staphylococcus spp</em>., <em>Shigella spp.,</em> and <em>Proteus spp</em>. The bacterial species were predominantly found in Households and Hospital areas, while fewer were found in restaurant areas. The presence of these pathogenic bacteria in cockroaches highlights the potential risk of food contamination and subsequent human diseases. Therefore, further analysis and characterization of these pathogenic bacteria should be done at the molecular level, and more clinical evaluation must be undertaken after the final identification and characterization.</p></div>","PeriodicalId":101246,"journal":{"name":"The Microbe","volume":"5 ","pages":"Article 100158"},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950194624001250/pdfft?md5=9c8ae19ba3e9c211c9dc5c50b73c2d5c&pid=1-s2.0-S2950194624001250-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of genetic landscape of carbapenem-resistant Acinetobacter baumannii in India: A computational whole-genome study","authors":"Rhythm Sharma,&nbsp;Dinesh Lakhanpal","doi":"10.1016/j.microb.2024.100166","DOIUrl":"10.1016/j.microb.2024.100166","url":null,"abstract":"<div><div><em>Acinetobacter baumannii</em> is a Gram-negative, aerobic bacterium responsible for multidrug-resistant nosocomial infections, especially in Intensive Care Units. This study investigated the genetic diversity, antimicrobial genes, virulence factors, and mobile genetic elements, resistance genes in clinically relevant strains of <em>A. baumannii</em> circulating in the Indian population, consistent with reports from other Asian countries, including China, Southeast Asia, and Thailand. A comprehensive analysis of carbapenem-resistant <em>A. baumannii</em> strains was conducted using publicly available genomic data. Pan-genome fanalysis revealed an open genome structure, indicating the pathogen's potential for ongoing genetic evolution. The study identified significant resistance genes, including <em>blaOXA-23</em>, AdeIJK and AdeFGH type efflux pumps, and carbapenemases. Virulence factors such as <em>OmpA</em>, phospholipase, and Csu pili were prevalent, contributing to the bacterium's pathogenicity. Mobile genetic elements, including Tn<em>2006</em> and <em>ISAba1</em>/<em>blaOXA-23</em> gene combinations, were also identified, highlighting the mechanisms behind the rapid spread of resistance genes. Subtractive proteomics was employed to identify core proteins essential to the bacterium but non-homologous to humans, highlighting them as potential drug targets. This analysis identified 2165 core proteins, with 550 non-homologous essential proteins located in the cytoplasm. Further evaluation of these proteins based on stability and involvement in essential pathways, we identified 15 druggable proteins as potential targets for antimicrobial agents. The findings underscore the critical need for continuous surveillance, innovative drug development, and targeted therapeutic strategies to mitigate the impact of multidrug-resistant <em>A. baumannii</em> in healthcare settings. Addressing antimicrobial resistance in <em>A. baumannii</em> remains a global health priority, especially in high-burden regions like India, where the prevalence of resistant strains is notably high. This study provides a foundation for future research and development in combating this formidable pathogen.</div></div>","PeriodicalId":101246,"journal":{"name":"The Microbe","volume":"5 ","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S295019462400133X/pdfft?md5=1d413dc1c072a0ea93de3a68b14f861b&pid=1-s2.0-S295019462400133X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of salinity on Streptococcus agalactiae and health parameters of Oreochromis niloticus during streptococcosis outbreaks","authors":"Rajan Preenanka ,&nbsp;Muhammed P. Safeena ,&nbsp;Basura Vidhya ,&nbsp;TG Sumithra","doi":"10.1016/j.microb.2024.100167","DOIUrl":"10.1016/j.microb.2024.100167","url":null,"abstract":"<div><p><em>S. agalactiae</em> infection is one of the most important bacterial diseases imparting mass mortality in the aquaculture sector, worldwide. It is responsible for posing both economic burdens and risks of cross-infectivity and zoonotic transmission. In this aspect, this study examined the virulence gene profiles, molecular serotyping and pathogenicity of <em>S. agalactiae</em> strains isolated from tilapia farms in Kerala, India in 2022. Following sample collection and processing, three <em>S. agalactiae</em> strains (KSA/01, KSA/02, and KSA/03) were isolated and confirmed the bacterial identity using 16S rRNA sequencing. In pathogenicity test, the LD₅₀ of the <em>S. agalactiae</em> was found to be 1 × 10⁶ CFU/ml. An increase in the salinity was found to affect the pathogenicity of <em>S. agalactiae</em> as well as the hematological and serological profile of tilapia. Thus the presence of <em>S. agalactiae</em>, a highly virulent and zoonotic pathogen in tilapia farms, underscores the imperative of continuous monitoring in aquaculture facilities.</p></div>","PeriodicalId":101246,"journal":{"name":"The Microbe","volume":"5 ","pages":"Article 100167"},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950194624001341/pdfft?md5=d3c727e5eb4fc183a71b3fd26757f25a&pid=1-s2.0-S2950194624001341-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing management strategies for mitigating Rhizoctonia damping-off in sugar beet cultivation","authors":"Abdelaaziz Farhaoui ,&nbsp;Abdessalem Tahiri ,&nbsp;Mohammed Khadiri ,&nbsp;Nabila El Alami ,&nbsp;Rachid Lahlali","doi":"10.1016/j.microb.2024.100164","DOIUrl":"10.1016/j.microb.2024.100164","url":null,"abstract":"<div><p><em>Rhizoctonia solani</em> is recognized as one of the most economically significant pathogens that can cause both crown root rot (CRR) and damping-off (DO) in the sugar beet (SB) plant. This report details the first investigative study on <em>R. solani</em> as a fungus causing DO of SB in Morocco. The identification of the fungal pathogen was done both based on morphological features as well as on molecular tools utilizing internal transcribed spacer region of ribosomal DNA (ITS rDNA) and specific primers. In vitro evaluation of the antifungal effect of four commonly used fungicides, tebuconazole, azoxystrobin, trifloxystrobin, and difenoconazole, revealed their effectiveness in inhibiting the growth of pathogenic strains on potato dextrose agar (PDA) medium. <em>Bacillus subtilis</em> Y1336, available in the market, was tested as a potential biocontrol agent (BCA) against <em>R. solani</em>-induced DO. The effectiveness of the BCA was confirmed through double culture tests on PDA, in vitro seed inoculation with both <em>B. subtilis</em> and <em>R. solani</em>, and by employing the antagonist agent as a seed coat in greenhouse settings. This marks the first instance of the effectiveness of <em>B. subtilis</em> Y1336 against <em>R. solani-</em>induced DO in SB. <em>B. subtilis</em> Y1336 should be integrated into SB damping-off control strategies, in conjunction with the fungicides that have been shown to be more effective.</p></div>","PeriodicalId":101246,"journal":{"name":"The Microbe","volume":"5 ","pages":"Article 100164"},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950194624001316/pdfft?md5=ddc2074383f9d4d134e1f7617a1289aa&pid=1-s2.0-S2950194624001316-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic overview of gut microbiota and mucosal pathogens with respect to cardiovascular diseases","authors":"H. Shayista ,&nbsp;M.N. Nagendra Prasad ,&nbsp;S. Niranjan Raj ,&nbsp;H.K. Ranjini ,&nbsp;K. Manju ,&nbsp;Syed Baker","doi":"10.1016/j.microb.2024.100160","DOIUrl":"10.1016/j.microb.2024.100160","url":null,"abstract":"<div><p>The present study provides a mechanistic overview on the correlation between the gut microbiota and mucosal pathogens and their influence on cardiovascular diseases (CVD’s). The study emphasises the crucial role of homeostatic activity of microbiota to suppress the dysbiosis posed due to the inflammatory responses. These responses trigger the endothelial dysfunction which leads to progression of cardiovascular implications with myriad thrombotic events. The study envisions the role of secondary metabolites to mitigate pathologies which can serve as biomarker in early management of cardiovascular diseases. The role of dietary habits and transplantation of fecal microbiota can minimize the heart related illness is also discussed in the present study. Overall, the present study highlights the comprehensive understanding of the gut microbiota and mucosal pathogens with their cardiometabolic activities.</p></div>","PeriodicalId":101246,"journal":{"name":"The Microbe","volume":"5 ","pages":"Article 100160"},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950194624001274/pdfft?md5=8a62f4d7786cb85bd218c8a65ed9adc6&pid=1-s2.0-S2950194624001274-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of cold plasma treatment technology in biosynthesized silver nanoparticles encapsulated with chitosan by Aliinostoc persicum SA14 against HepG-2","authors":"Naeema Hadi Ali ,&nbsp;Amir Hossein Sari ,&nbsp;Bahareh Nowruzi ,&nbsp;Samaneh Jafari Porzani","doi":"10.1016/j.microb.2024.100148","DOIUrl":"10.1016/j.microb.2024.100148","url":null,"abstract":"<div><p>Hepatocellular carcinoma (HCC) is the commonest cancer and the third most common cause of cancer-related mortality. The combination of cold atmospheric plasma (CAP) and nanoparticles is a promising treatment for hepatocellular carcinoma cancers. In the present study, activated water was prepared using the cold atmospheric plasma technique (JET and PAW), and then the biosynthesis ability of silver nanoparticles by the cyanobacterium <em>Aliinostoc persicum</em> SA14 was measured after cultivation in the culture medium containing activated water at 5, 15, and 20 min. After the encapsulation of nanoparticles with chitosan and UV–visible spectroscopy analysis, the characterization of AgNPs, including FTIR analysis. X-ray diffraction, particle size and zeta potential, SEM, TEM, as well as cytotoxicity assays against HepG-2 cell lines, were performed. The comparison of the absorption spectra of silver oxide nanoparticles prepared by the boiling-dender method at concentrations and different times showed that the production of silver nanoparticles was confirmed for all three samples based on the amount of absorption obtained. The outcomes of field emission scanning electron microscopy at all magnifications exhibited that spherical nanoparticles are scattered on the surface of the polymer matrix. Furthermore, the FT-IR spectrum and XRD crystallography confirmed the success of chitosan's production of microcoated silver nanoparticles. The results of the cytotoxicity test against HepG-2 cell lines showed that with increasing concentrations of silver nanoparticles, the survival frequency of cancer cells declined significantly. In conclusion, the tests confirmed that the silver nanoparticles produced by cyanobacteria act as both a stabilizing and reducing agent. The results indicated that CAP decreases nanoparticle size, decreases surface charge distribution of AgNP, and induces uptake, aggregation, and enhanced cytotoxicity against HepG-2 in vitro. The chitosan-AgNPs with cold plasma could have potential applications in the food, agricultural, and pharmaceutical industries.</p></div>","PeriodicalId":101246,"journal":{"name":"The Microbe","volume":"4 ","pages":"Article 100148"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950194624001158/pdfft?md5=1a6d29d81addb2920cd1ee864cccae55&pid=1-s2.0-S2950194624001158-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142097954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computer-aided molecular modeling and design studies of some N-(4-(dimethyl amino) phenyl)-4-methoxy-3-propionamidobenzamide derivatives as NS5B polymerase inhibitors","authors":"Abubakar Sadiq Bello ,&nbsp;A. Uzairu ,&nbsp;G.A. Shallangwa ,&nbsp;A. Ibrahim ,&nbsp;Muhammad Tukur Ibrahim","doi":"10.1016/j.microb.2024.100154","DOIUrl":"10.1016/j.microb.2024.100154","url":null,"abstract":"<div><p>Hepatitis C Virus (HCV) is a stealthy ailment, and most people are unaware they have it in the early stages. Insilco modeling was used to develop a model with high predictive power for N-(4-(dimethyl amino) phenyl)-4-methoxy-3-propionamidobenzamide inhibitors. The inhibitors were optimized using Density Functional Theory (DFT) based on a notion of B3LYP/6–31 G* levels. The genetic function algorithm (GFA) was utilized to create the QSAR models. The best model was chosen based on its statistical fitness using the subsequent measurement parameters: R²trng = 0.828181, R²adj = 0.800468, Q²cv = 0.734795, R²test = 0.7028, and LOF = 0.613985, led to its selection and publication. The model underwent additional assessments, including the Y-scrambling test, and applicability domain, and was considered to have statistical significance. The docking results demonstrate that compound 17 has the greatest inhibitory effect on NS5B-polymerase of any drug in the dataset. Using this compound as a template, novel anti-hepatitis C compounds were developed by including a few beneficial substituents. The docking results of the proposed compounds yielded a high MolDock score (−152.12), indicating effective binding to the target's active sites. Two comparable compounds (SBD4 and SBD3) were shown to be superior to the food drug administration (FDA) approved medication, revibirin/pegylated interferon. The chemicals were determined to be orally accessible after passing Lipinski's criteria, a drug similarity test. Furthermore, the synthesized compounds were found to have favorable pharmacokinetic (absorption, distribution, metabolism, excretion, and toxicity) properties. In conclusion, using the QSAR model, a model with excellent prediction power for certain Biaryl amide inhibitors was constructed. The model was validated and determined to have good internal and external assessment criteria. According to the docking results, compound 17 inhibits NS5B-polymerase the most out of the compounds in the dataset. Furthermore, the compounds' oral bioavailability met drug-like standards. The ultimate goal of this research is to contribute to the development of new therapeutic agents for the treatment of HCV infections, addressing the pressing need for effective antiviral medications.</p></div>","PeriodicalId":101246,"journal":{"name":"The Microbe","volume":"4 ","pages":"Article 100154"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950194624001213/pdfft?md5=c01796cf7bbecc5bfe7782e00f8c5235&pid=1-s2.0-S2950194624001213-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142097957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Emphysematous spontaneous bacterial peritonitis and renal azotemia due to Escherichia coli infection in a Saint Bernard dog” [Microbe 3 (2024) 100056]","authors":"Salini Varghese ,&nbsp;Arun George ,&nbsp;Y. Ajith ,&nbsp;A. Javed Jameel ,&nbsp;Binu K. Mani","doi":"10.1016/j.microb.2024.100122","DOIUrl":"10.1016/j.microb.2024.100122","url":null,"abstract":"","PeriodicalId":101246,"journal":{"name":"The Microbe","volume":"4 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S295019462400089X/pdfft?md5=b1d268bc1b267fdcc9b61c4b9684971e&pid=1-s2.0-S295019462400089X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141705708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on latent role of stress proteins in antibiotic resistance","authors":"Nagarjuna Prakash Dalbanjan,&nbsp;Arihant Jayawant Kadapure,&nbsp;Praveen Kumar S.K","doi":"10.1016/j.microb.2024.100151","DOIUrl":"10.1016/j.microb.2024.100151","url":null,"abstract":"<div><p>The growing worldwide epidemic of antibiotic resistance demands a better understanding of the primary molecular pathways, with stress response systems emerging as critical players. Understanding the mechanisms of antibiotic resistance reveals the complex strategies bacteria employ to withstand the effects of antibiotics. Analyzing the intricate relationships between stress proteins and antibiotic resistance links the relationship of how these proteins serve as architects of bacterial resilience. The current review addresses the complex relationship between stress proteins and antibiotic resistance by emphasizing bacteria’s adaptive mechanisms in response to antimicrobial attacks. It summarizes the key stress response proteins involved in bacterial survival and antibiotic resistance, highlighting their critical roles. The review also explores the significance of stress-induced mutations in the evolution of antibiotic resistance and considers potential measures to combat this global health catastrophe, including targeting stress response systems as a therapeutic strategy. These findings establish a framework for future studies, offering promise for a new era in the fight against antibiotic resistance.</p></div>","PeriodicalId":101246,"journal":{"name":"The Microbe","volume":"4 ","pages":"Article 100151"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950194624001183/pdfft?md5=8feb55833e4934aeaa0bc226cb046064&pid=1-s2.0-S2950194624001183-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}