Tetrahedron Green Chem最新文献

{"title":"A review on synthesis of β-amino carbonyl compounds using nanocatalyst","authors":"Satyaranjan Behera","doi":"10.1016/j.tgchem.2025.100065","DOIUrl":"10.1016/j.tgchem.2025.100065","url":null,"abstract":"<div><div>Nanomaterials have piqued researchers' interest in various fields due to their extraordinary advantages, which include a large surface area. The use of nanomaterials in catalysis is a hot issue for researchers. Catalysis plays a vital role in the synthesis of medicinal as well as pharmaceutical compounds. Pharmaceutical chemicals, including β-amino carbonyl compounds and their derivatives, are commonly used as synthetic intermediates in manufacturing natural products, pharmaceuticals, physiologically active molecules, and medicines. Synthesis of β-amino carbonyl compounds involves many processes, including Mannich and aza-Michael reactions. The synthesis of β-amino carbonyl compounds remains challenging for chemists due to their severe side products. Researchers have now used nanocatalysts to achieve clean and smooth reactions, high purity of products, and reusability. Due to high surface area, nanocatalysts have tremendous catalytic activity. Nowadays many modified nanocatalyst have been developed to produce high yields of the products. The present review described the synthesis of β-amino carbonyl compounds by using different nanocatalysts reported to date.</div></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"5 ","pages":"Article 100065"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced approach to O-alkyl/aryl salicylaldehyde derivatives: Synthesis, characterization, and free-radical homopolymerization for improved thermal stability","authors":"Aashna Perwin,&nbsp;Nasreen Mazumdar","doi":"10.1016/j.tgchem.2025.100072","DOIUrl":"10.1016/j.tgchem.2025.100072","url":null,"abstract":"<div><div>In the development of bioactive materials centered around salicylaldehyde, we synthesized O-alkyl/aryl derivatives through the etherification of the phenolic group. Salicylaldehyde underwent a copper-catalyzed reaction with various halides under basic conditions, yielding 2-(3-chloropyrazin-2-yl)oxy benzaldehyde, 2-(6-chloropyrimidin-4-yl)oxy benzaldehyde, and 3-(2-formylphenoxy)-2-hydroxypropyl methacrylate. Meanwhile, 2-(2-formylphenoxy)ethyl methacrylate was synthesized via a sonication-assisted Mitsunobu reaction, affording high yields of ether derivatives. Structural elucidation was achieved using standard analytical techniques, such as ¹H NMR, ¹³C NMR, FT-IR and LC-MS. The free radical homopolymerization of 3-(2-formylphenoxy)-2-hydroxypropyl methacrylate using benzoyl peroxide as an initiator was successfully achieved. The resulting polymer exhibited enhanced thermal stability, as confirmed by solid-state ¹³C NMR, FT-IR, TGA, DSC, and SEM analyses, with a higher glass transition temperature than the reported poly(glycidyl methacrylate). This increase in <em>T</em>_<em>g</em> is attributed to the enhanced rigidity introduced by the aromatic ring in the homopolymer. This study highlights the successful synthesis of various O-alkyl/aryl salicylaldehyde derivatives using different techniques and functionalities, followed by the effective polymerization of one of the monomers, 3-(2-formylphenoxy)-2-hydroxypropyl methacrylate.</div></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"5 ","pages":"Article 100072"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of homogeneous catalytic reactions of hexafluoroisopropanol (HFIP)","authors":"Huiying Xu,&nbsp;Huidan Luo,&nbsp;Yi Wang,&nbsp;Hui Gao","doi":"10.1016/j.tgchem.2025.100071","DOIUrl":"10.1016/j.tgchem.2025.100071","url":null,"abstract":"<div><div>1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) is a solvent with unique properties. In recent years, it has received widespread attention due to its ability to stabilize ionic species, transfer protons, and participate in a range of intermolecular interactions, demonstrating excellent benefits in facilitating a variety of challenging chemical reactions. In this review, after a brief introduction to the physical and chemical properties of HFIP in hand, we present examples from the literature representing theoretical studies using HFIP as a solvent in transition metal-, Lewis/Brønsted acid-catalyzed reactions, and homogeneous catalytic reactions (with HFIP itself acting as a catalyst. These examples emphasize the multifunctional role played by HFIP. This indicates that in-depth understanding of its reaction mechanism and performance characteristics is helpful to optimize its application conditions in organic synthesis and improve the efficiency and yield of the reaction. The deep theoretical studies of HFIP in chemical reactions is expected to provide more possibilities and selectivity for the synthesis and application of new compounds.</div></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"5 ","pages":"Article 100071"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An efficient photo-degradation of methylene blue by poly-3-thenoic acid sensitized Co/TiO2 under visible light and inactivation of pathogens","authors":"Neha Kumari ,&nbsp;Sudhakar Chintakula ,&nbsp;Immandhi Sai Sonali Anantha ,&nbsp;Pilla Pushpavati ,&nbsp;Suresh Maddila","doi":"10.1016/j.tgchem.2024.100058","DOIUrl":"10.1016/j.tgchem.2024.100058","url":null,"abstract":"<div><div>Methylene blue dye is used extensively in industries, including paper, temporary hair coloring, coating for paper stock wool, and cotton dying. When the amount of methylene blue dye is more significant than 2 mg/kg, it can lead to serious health issues in people, including cyanosis, tissue necrosis, elevated heart rate, vomiting, shock, and Heinz body formation. The present chapter discusses the sol-gel-assisted synthesis of P3TA-supported Cobalt-doped TiO₂ nanohybrid. This study investigated the characteristics of both prepared bare TiO₂ and metal (Co) doped nano-hybrid using a variety of analytical tools, including XRD, SEM-EDX, BET, FTIR, XPS, and UV–visible DRS. The photo-catalytic performance of prepared samples was executed towards the degradation of methylene blue (MB) dye under visible light irradiations. Additionally, tests for antibiotic resistance were performed on the pathogens <em>E. coli</em> and <em>S. aureus</em>. Significant antibacterial activities against <em>E. coli</em> and <em>S. aureus</em> were demonstrated by the chemical under investigation (P3TA/Co-TiO₂) at a higher dosage of 800 μg/mL, with inhibition zones of 2.0 mm and 2.1 mm, respectively. The antibacterial activity against <em>E. coli</em> and <em>S. aureus</em> at 400 μg/mL was negligible, with inhibition zones of 1.0 mm and 1.2 mm, respectively. Because these materials are affordable and adaptable, they further the field of nano photo-catalysts.</div></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"5 ","pages":"Article 100058"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrosynthesis of benzimidazole-fused quinazolinones via a cascade addition-desulfurization-cyclization process","authors":"Khuyen Thu Nguyen ,&nbsp;Mongkol Sukwattanasinitt ,&nbsp;Sumrit Wacharasindhu","doi":"10.1016/j.tgchem.2025.100068","DOIUrl":"10.1016/j.tgchem.2025.100068","url":null,"abstract":"<div><div>The electrosynthesis of benzimidazole-fused quinazolinones from <em>N</em>-substituted <em>o</em>-phenylenediamines and isothiocyanates <em>via</em> a cascade addition-desulfurization-cyclization process was introduced. This electrochemical approach utilizes the mild and efficient non-metal oxidizing agent, NaI in sub-stoichiometric amounts as an electrolyte/mediator under open-flask conditions. A variety of benzimidazole-fused quinazolinones were prepared in moderate to excellent yields (30–98 %, 10 examples). Additionally, the optimal conditions were successfully applied to the synthesis of benzoxazoloquinazolinones and benzothiazolquinazolinones (30–72 %, 6 examples). This electrochemical process is scalable, while maintaining reaction efficiency even at the gram scale.</div></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"5 ","pages":"Article 100068"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143386522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the photocatalytic activity of suspended and floating Ag-decorated TiO2 for dye removal","authors":"Nila Davari ,&nbsp;Ermelinda Falletta ,&nbsp;Claudia L. Bianchi ,&nbsp;Viviane Yargeau ,&nbsp;Cristina Rodriguez-Seco ,&nbsp;Daria C. Boffito","doi":"10.1016/j.tgchem.2024.100059","DOIUrl":"10.1016/j.tgchem.2024.100059","url":null,"abstract":"<div><div>We proposed a two-step synthesis process to fabricate floating TiO₂ and Ag-decorated TiO₂ (Ag/TiO₂) photocatalysts. In the first step, an ultrasound-assisted sol-gel method followed by spray drying was adopted to synthesize powder photocatalysts. Next, the powder samples were immobilized onto a floating polyurethane foam (PUF) support with an ultrasound-assisted impregnation method. The photocatalytic activity of TiO₂ and Ag/TiO₂ was evaluated to remove methyl orange (MO) as a dye pollutant in two suspended and floating photocatalytic systems. Ag decoration on TiO₂ improved the optical and textural properties by narrowing the bandgap energy to 2.9 eV and increasing the surface area from 10 m²/g to 30 m²/g. Ag/TiO₂ exhibited higher photocatalytic activity compared to TiO₂ for MO removal, which was 98 % for suspended and 95 % for floating catalysts under simulated sunlight irradiation. In addition, floating photocatalysts exhibited higher photocatalytic activity over five cycles of reuse. Floating Ag/TiO₂@PUF maintained 89 % of its initial photoactivity, while suspended Ag/TiO₂ lost 50 % after the five cycles. Moreover, we investigated the effect of operating conditions on the photocatalytic performance of floating Ag/TiO₂@PUF. Optimal conditions for the complete removal of MO below detection limits were obtained as follows: Ag/TiO₂@PUF loading = 0.4:200 g/mL, initial MO concentration = 5 mg/L, time = 90 min, and pH = 4 under simulated sunlight irradiation. This study highlights the potential of floating photocatalyst systems as a sustainable, reusable, and scalable approach for wastewater treatment, addressing challenges in catalyst recovery and efficiency under real-world conditions.</div></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"5 ","pages":"Article 100059"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling of bio-inspired synthesis, characterization, DFT calculations, molecular modeling of silver (Ag/Ag2O) nanocomposite: A promising sustainable material against human breast cancer","authors":"R. Kavitha ,&nbsp;M. Srinivas ,&nbsp;Prashantha Karunakar ,&nbsp;G.R. Rekhashree ,&nbsp;R. Priyanka ,&nbsp;K.G. Shilpashree ,&nbsp;M.S. Kavya ,&nbsp;S.M. Basavarajaiah","doi":"10.1016/j.tgchem.2025.100078","DOIUrl":"10.1016/j.tgchem.2025.100078","url":null,"abstract":"<div><div>The extensive use of nanocomposites in the field of medicine and pharmaceuticals stems from their physicochemical properties and due to their potential therapeutic application. Further, nanopharmaceutics take a significant role in designing smart drug-release and controlled drug delivery, where the drug is efficiently reached towards the target sites within a predictable and limited timescale. The scope of present research work is to synthesis an ecofriendly silver nanocomposite (Ag/Ag₂O) by using alcoholic fruit extract of <em>Pheonix slyvestris</em> and its efficiency was evaluated for anticancer activity. PXRD results and HRTEM images confirmed that Ag/Ag₂O was crystalline in nature with diverse morphology and possessed an average particle size of 23–50 nm. Surface plasmon resonance of Ag/Ag₂O was observed at 465–500 nm in UV-DRS. The PL spectrum of Ag/Ag₂O NPs shows two asymmetric peaks confirming the formation of Ag/Ag₂O heterocomposite. The cytotoxicity study Ag/Ag₂Osynthesized via green chemistry was performed using the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide) assay against breast cancer cell line (MCF7) with an IC₅₀21.61 μg/mL. The results of the cytotoxicity tests showed a concentration dependent outcome against tumor cells and a correlation between dosage and effectiveness against tested cancer cell line. DFT studies revealed the sensing response of Ag/Ag₂O composite towards doxorubicin drug confirmed by relative work function changes. Molecular docking and dynamics simulation resulted that the Ag/Ag₂O illustrates to be an excellent lead molecule. In conclusion, the present research work demonstrated that Ag/Ag₂O synthesized from alcoholic fruit extract of <em>Pheonix slyvestris</em> may be an impending remedial drug for breast cancer management.</div></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"5 ","pages":"Article 100078"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of biodiesel and prepared its blend: An ecofriendly, clean, alternative, and sustainable energy source","authors":"Madhuri A. Balpande ,&nbsp;Manish M. Katiya ,&nbsp;Madhukar G. Dhonde ,&nbsp;Jayant M. Gajbhiye","doi":"10.1016/j.tgchem.2025.100074","DOIUrl":"10.1016/j.tgchem.2025.100074","url":null,"abstract":"<div><div>A base catalyzed the transesterification reaction, resulting in a 98 % yield during biodiesel (fatty acid methyl ester - FAME) synthesis. The optimization reaction protocol requires maximum agitation of 600 rpm at room temperature for 20min with a 10mol% KOH as a base catalyst and 1:8 ratios of sunflower oil and methanol to complete the reaction. This study examines the viability of using vegetable oil through transesterification to produce biodiesel on a commercial scale, with the goal of serving as a fuel substitute for diesel engines. We explored well-established spectroscopic techniques, including Infra-Red, ¹H, ¹³C Nuclear Magnetic Resonance, Gas Chromatography Mass Spectra, and High-Resolution Mass Spectra, to investigate the synthesized FAME in accordance with the ASTM specification. The novelty of the current study outlines the significance of synthesizing FAME through catalytic transesterification, examines its physicochemical parameters, and green chemistry matrices have shown that biodiesel is a beneficial fuel, which led to less reaction waste, better environmental compatibility, and long-term use of the current protocol. In addition to exploring biodiesel's fuel applications; we are also looking into its possible uses as a biodetergent for other purposes and a biolubricant for diesel engines. The study highlights the simple, efficient development of current biodiesel, with its sustainability, and its potential contribution to renewable energy goals. It also explores the environmental impact of transitioning to biobased alternatives and its potential applications in industries like cosmetics and automobiles. Therefore, this investigation aims to explore and combine the unique advantages associated with varying ratios of additives in FAME, with the goal of replacing as much diesel as possible. We created and experimented with blends including 10, 20, and 30 % ethanol or iso-octane in FAME; nevertheless, the blend containing 30 % ethanol works better as a diesel substitute.</div></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"5 ","pages":"Article 100074"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green and traditional one-pot synthesis techniques for bioactive quinoline derivatives: A review","authors":"Manav C. Parmar,&nbsp;Bonny Y. Patel","doi":"10.1016/j.tgchem.2025.100062","DOIUrl":"10.1016/j.tgchem.2025.100062","url":null,"abstract":"<div><div>The review examines one-pot strategies and their mechanistic approaches for synthesizing the quinoline nucleus from 2009 to 2024, with a focus on their therapeutic potential. The paradigm shifts from conventional synthetic protocols to advanced green methodologies has revolutionized the synthesis of quinoline derivatives. Strategies that adhere to sustainable chemistry principles by minimizing waste, solvent consumption, and energy input. Various green catalysts, including <em>p</em>-toluenesulfonic acid (<em>p</em>-TSA), <em>para</em>-sulfonic acid calix[4]arene (CX4SO₃H), cerium nitrate, ammonium acetate, potassium carbonate (K₂CO₃), and catalyst-free techniques, have proven effective in synthesizing quinoline analogs. The use of greener solvents such as ethanol and water further supports the eco-friendly synthesis of these compounds. The review also highlights a broad spectrum of pharmacological activities of quinoline derivatives, including antibacterial, antiviral, antidiabetic, anticancer properties and so on. SAR studies show that adding EDGs (-CH₃, –OCH₃, –OH) and EWGs (-Cl, –F, –NO₂, –CF₃) can enhance electronic properties, lipophilicity, and receptor-binding affinities. Moreover, hybridization with heterocyclic scaffolds such as furan, pyrazole, indole, and thiadiazole significantly improves bioactivity, demonstrating the intricate relationship between structural modifications and biological efficacy. By merging sustainable chemistry with targeted pharmacological strategies, quinoline-based compounds emerge as innovative candidates for diverse clinical applications.</div></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"5 ","pages":"Article 100062"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in photodegradation of organic pollutants using polymer supported Fenton catalysts","authors":"Shajahan Rubina ,&nbsp;Kareem A. Feby ,&nbsp;Saithalavi Anas","doi":"10.1016/j.tgchem.2025.100073","DOIUrl":"10.1016/j.tgchem.2025.100073","url":null,"abstract":"<div><div>Photodegradation of organic pollutants in wastewater is an ideal process for reducing environmental pollution, as it harnesses light energy to break down harmful compounds into safer byproducts. Supported catalysts play a crucial role in this process as they increase the stability and reusability of the photocatalysts, enhance light absorption, and improve degradation efficiency by providing a larger surface area for the reaction. This certainly improves the sustainability and effectiveness of the contaminated water treatment. This review article provides a comprehensive overview of various polymer-supported Fenton catalysts for the photodegradation of organic compounds in wastewater treatment. The discussion is structured based on the type of polymer such as polystyrene, polyacrylonitrile, resins, Nafion and other miscellaneous polymers employed as suitable solid support for Fenton catalysts. Key aspects of each category of these supported catalysts are explored, including their preparation methods, structural characteristics, and catalytic performance in degrading pollutants under different conditions. The review also focuses on the recent challenges and gaps in this area of research in terms of catalyst stability, reusability, and efficiency under varying environmental conditions. By consolidating the existing knowledge on the title topic, this article serves as a valuable resource for researchers and practitioners, offering insights into the potential of polymer-supported Fenton catalysts and directing toward more effective and sustainable photocatalytic systems for wastewater treatment.</div></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"5 ","pages":"Article 100073"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}