Serodiagnosis and Immunotherapy in Infectious Disease最新文献_第9页

Latent infection and reactivation of human cytomegalovirus 人巨细胞病毒的潜伏感染与再激活

Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-06-01 DOI: 10.1016/0888-0786(95)95348-T

K Numazaki, H Asanuma, S Chiba

{"title":"Latent infection and reactivation of human cytomegalovirus","authors":"K Numazaki, H Asanuma, S Chiba","doi":"10.1016/0888-0786(95)95348-T","DOIUrl":"10.1016/0888-0786(95)95348-T","url":null,"abstract":"<div><p>Human cytomegalovirus (HCMV) is the most common cause of congenital and perinatal infections throughout the world. Primary infection with HCMV usually follows a benign course, but the virus remains latent or persistent in the host cell thereafter. Under immunosuppressive conditions, latent or persistent infection can be reactivated to produce a wide variety of clinical manifestations. Understanding the epidemiology of HCMV infection is a key element in development of strategies for prevention of infection. Definition of sites and mechanisms involved in the maintenance of latent or persistent HCMV infection and reactivation is also essential for a thorough understanding of the pathogenesis of HCMV infection. This mini review focuses on recent advances in the study of persistent infection and reactivation of HCMV. Although the actual sites of latency or persistence of HCMV infections are still controversial, peripheral blood mononuclear cells (PBMC) and endothelial cells appear to be the principal site of infection. Persistent infections caused by HCMV could be augmented by a decrease in major histocompatibility complex (MHC) expression as well as by virus-mediated immune dysfunction. It is also likely that specific cellular interactions as well as production of several cytokines are necessary for the reactivation of HCMV.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 2","pages":"Pages 70-74"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)95348-T","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80089421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Specific IgG1 avidity maturation after rubella vaccination: A comparison with avidity maturation after primary infection with wild rubella virus 风疹疫苗接种后特异性IgG1贪婪成熟:与原发感染野生风疹病毒后贪婪成熟的比较

Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-06-01 DOI: 10.1016/0888-0786(95)95349-U

H.I.J Thomas , A Charlett , H.A Cubie

{"title":"Specific IgG1 avidity maturation after rubella vaccination: A comparison with avidity maturation after primary infection with wild rubella virus","authors":"H.I.J Thomas , A Charlett , H.A Cubie","doi":"10.1016/0888-0786(95)95349-U","DOIUrl":"10.1016/0888-0786(95)95349-U","url":null,"abstract":"<div><p>Rubella reinfection, which can affect the developing foetus, is said to occur more frequently among people who have received rubella vaccine than among those whose rubella immunity is the result of a natural infection. We have compared the rate of increase in avidity of rubella-specific antibody in these two groups since differences either in the ability of the immune response to mature or in the rate at which it matures might be attributable to differences in antigen handling during the two modes of infection. Any differences in the type or the rate of maturation might then be responsible, at least in part, for the apparent increased susceptibility of vaccinees to reinfection. Although there was evidence to suggest that there was a slightly slower maturation rate at the later stages of the immune response among the vaccinees, the number of corresponding sera from cases of natural infection, taken several months after onset of symptoms, was insufficient to allow this to be demonstrated statistically. A larger, longitudinal study would be required to establish conclusively whether a true relationship between avidity maturation and an increase in reinfection rate among vaccinees exists.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 2","pages":"Pages 75-80"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)95349-U","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80041270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The immunoassay handbook 免疫测定手册

Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-06-01 DOI: 10.1016/0888-0786(95)90000-4

P.P Mortimer

引用次数: 1

The serological response to keyhole limpet haemocyanin in imported Schistosoma mansoni and Schistosoma haematobium infections 输入性曼氏血吸虫和血球血吸虫感染对锁眼帽贝血青素的血清学反应

Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-03-01 DOI: 10.1016/0888-0786(95)93027-9

R.P. Bendall, K. Lalloo, P.L. Chiodini

引用次数: 1

Diagnosis of Chlamydia trachomatis urethritis in men by three different methods 三种不同方法诊断男性沙眼衣原体尿道炎

Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-03-01 DOI: 10.1016/0888-0786(95)93031-6

A. Aǧaçfidan PhD , M. Genç MD , T. Alp MD , H. Ander MD , M. Onel BS , S. Badur PhD

引用次数: 0

Antibody pattern to hepatitis C virus antigens in patients with acute and chronic liver diseases 急慢性肝病患者对丙型肝炎病毒抗原的抗体模式

Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-03-01 DOI: 10.1016/0888-0786(95)93026-8

G.J. Padron , E. Arus , L. Rivera , Z. Rodriguez , A. Fernandez , B. Gra , L. Blitz-Dorfman

引用次数: 2

ELISA-IgM applied to cerebrospinal fluid in human leptospirosis ELISA-IgM在人钩端螺旋体病脑脊液中的应用

Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-03-01 DOI: 10.1016/0888-0786(95)93025-7

E.D. Camargo , M.V. Silva , A.J. Va , L. Batista , A.P. Brandão , A.W. Ferreira , E.C. Romero , P.R.S. Barbosa

引用次数: 4

Dye-immunoassay for the diagnosis of schistosomiasis mansoni 曼氏血吸虫病的染料免疫诊断

Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-03-01 DOI: 10.1016/0888-0786(95)93022-4

A.L.T. Rabello, M.M.A. Garcia, P.F. Gomes, M.N. Amorim, N. Katz

{"title":"Dye-immunoassay for the diagnosis of schistosomiasis mansoni","authors":"A.L.T. Rabello, M.M.A. Garcia, P.F. Gomes, M.N. Amorim, N. Katz","doi":"10.1016/0888-0786(95)93022-4","DOIUrl":"https://doi.org/10.1016/0888-0786(95)93022-4","url":null,"abstract":"<div><p>A novel serological method dot-dye immunoassay (DIA) is described and the system is tested for the diagnosis of schistosomiasis mansoni. Sera of 32 chronic <em>Schistosoma mansoni</em>-infected patients and 12 non-infected individuals were simultaneously tested for the presence of IgG antibodies against soluble egg antigen (SEA) by DIA and enzyme-linked immunosorbent assay (ELISA). Optical density (OD) readings using 2,2′azino-bis 3-ethylbenzthiazoline-6-sulphonic acid (ARTS) substrate in ELISA (ODABTS) and dye conjugate in DIA (ODDYE) showed the coefficient of correlation of Pearson to be 0.91 (<em>P</em> < 0.0001). The DIA method has one step less than the ELISA technique, thus shortening the time of the test. The advantages of textile dyes as reaction indicators in the DIA method also include the absence of contact with potentially hazardous substrates, mostly employed in ELISA. Furthermore, colloidal dyes are less expensive than enzyme conjugates and substrates. The DIA method is a reliable and simple alternative for the serological diagnosis of <em>Schistosoma mansoni</em> infection.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 1","pages":"Pages 3-6"},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)93022-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137004759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of antibody responses to infection with Salmonella 检测沙门氏菌感染的抗体反应

Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-03-01 DOI: 10.1016/0888-0786(95)93029-B

H. Chart

引用次数: 2

Evaluation of an enzyme immunoassay (IgM cap dot EIA) using a peroxidase-labelled Toxoplasma gondii antigen (Alk-Toxo) for the diagnosis of acute toxoplasmosis 使用过氧化物酶标记的刚地弓形虫抗原(Alk-Toxo)进行酶免疫测定(IgM cap dot EIA)诊断急性弓形虫病的评价

Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-03-01 DOI: 10.1016/0888-0786(95)93030-F

O.S. Nakahara , S. Hoshino-Shimizu , Y.I. Yamamoto , M.E. Camargo

引用次数: 1