Serodiagnosis and Immunotherapy in Infectious Disease最新文献

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Alterations in the immune response of golden hamsters during the course of Leishmania donovani infection and after treatment with sodium stibogluconate 多诺瓦利什曼原虫感染过程中及用顽固性葡萄糖酸钠治疗后金仓鼠免疫反应的变化
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-09-01 DOI: 10.1016/0888-0786(95)97894-B
A. Pal, S. Gupta, J. C. Katiyar, A. Puri, R. Sahai, R. Saxena
{"title":"Alterations in the immune response of golden hamsters during the course of Leishmania donovani infection and after treatment with sodium stibogluconate","authors":"A. Pal, S. Gupta, J. C. Katiyar, A. Puri, R. Sahai, R. Saxena","doi":"10.1016/0888-0786(95)97894-B","DOIUrl":"https://doi.org/10.1016/0888-0786(95)97894-B","url":null,"abstract":"","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"107 1","pages":"115-120"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83726836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
IgG, IgM and IgA antibody responses against immediate-early, early and late human cytomegalovirus proteins in patients with HCMV infections HCMV感染患者IgG、IgM和IgA抗体对人巨细胞病毒蛋白的早期、早期和晚期反应
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-09-01 DOI: 10.1016/0888-0786(95)97895-C
M. Segondy , S.L Salhi
{"title":"IgG, IgM and IgA antibody responses against immediate-early, early and late human cytomegalovirus proteins in patients with HCMV infections","authors":"M. Segondy ,&nbsp;S.L Salhi","doi":"10.1016/0888-0786(95)97895-C","DOIUrl":"https://doi.org/10.1016/0888-0786(95)97895-C","url":null,"abstract":"<div><p>The IgG, IgM and IgA antibody responses against the immediate-early, early and late proteins of human cytomegalovirus (HCMV) strain AD169 in sera from HCMV-seropositive subjects and from patients with primary and secondary HCMV infections were studied by immunoblotting. Antibodies against 16 HCMV proteins with molecular masses of 150, 145, 140, 130, 100, 92, 85, 72, 65, 62, 55, 52, 45, 39, 32 and 28 kDa were identified. The antibodies significantly associated with HCMV infection were directed against the 92 and 72 kDa immediate-early gene products, the 130, 62 and 45 kDa early gene products and the 150, 65, 52, 39 and 32 kDa late gene products. Our results also showed that the detection of IgA antibodies against HCMV proteins was as sensitive but less specific than the detection of IgM for the diagnosis of HCMV infections.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 3","pages":"Pages 121-128"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)97895-C","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91726352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoclonal antibodies and peptide therapy in autoimmune diseases 自身免疫性疾病的单克隆抗体和肽治疗
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-06-01 DOI: 10.1016/0888-0786(95)90001-2
M.H.V Van Regenmortel
{"title":"Monoclonal antibodies and peptide therapy in autoimmune diseases","authors":"M.H.V Van Regenmortel","doi":"10.1016/0888-0786(95)90001-2","DOIUrl":"10.1016/0888-0786(95)90001-2","url":null,"abstract":"","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 2","pages":"Page 91"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)90001-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83100758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic meningoencephalitis due to Histoplasma capsulatum. Usefulness of serodiagnostic procedures in diagnosis 由荚膜组织浆体引起的慢性脑膜脑炎。血清诊断程序在诊断中的作用
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-06-01 DOI: 10.1016/0888-0786(95)95351-P
R Negroni , A.M Robles , A.I Arechavala , C Iovannitti , S Helou , L Kaufman
{"title":"Chronic meningoencephalitis due to Histoplasma capsulatum. Usefulness of serodiagnostic procedures in diagnosis","authors":"R Negroni ,&nbsp;A.M Robles ,&nbsp;A.I Arechavala ,&nbsp;C Iovannitti ,&nbsp;S Helou ,&nbsp;L Kaufman","doi":"10.1016/0888-0786(95)95351-P","DOIUrl":"10.1016/0888-0786(95)95351-P","url":null,"abstract":"<div><p>This study presents details of four male patients with meningoencephalitis of chronic evolution, probably due to <em>Histoplasma capsulatum</em>. The diagnoses were mainly made by immunodiffusion test (ID), counterimmunoelectrophoresis test (CIF) and complement fixation test (CFT) with specific antigens. In case 1, the diagnosis of histoplasmosis was established through the isolation of <em>H. capsulatum</em> from a cutaneous biopsy and in the other three patients, through the results of serological tests. The neurological changes were those typical of chronic meningitis of basal predominance, with non-purulent cerebrospinal fluid (CSF) and signs of hydrocephaly in three patients. Two patients had other organ involvement which was clinically consistent with histoplasmosis (nose, oral mucosa, lungs, adrenal glands). The four patients were treated with amphotericin B and received fluconazole, itraconazole, cotrimoxazole (TMS) and ketoconazole, in most cases as secondary prophylaxis. Three of the patients presented episodes of valvular obstruction which complicated their clinical courses.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 2","pages":"Pages 84-89"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)95351-P","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88165293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
A comparative, prospective study of serological, virus isolation and PCR amplification techniques for the laboratory diagnosis of dengue infection 血清学、病毒分离和PCR扩增技术对登革热感染实验室诊断的前瞻性比较研究
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-06-01 DOI: 10.1016/0888-0786(95)95345-Q
C.L.K Seah , V.T.K Chow , Y.C Chan , S Doraisingham
{"title":"A comparative, prospective study of serological, virus isolation and PCR amplification techniques for the laboratory diagnosis of dengue infection","authors":"C.L.K Seah ,&nbsp;V.T.K Chow ,&nbsp;Y.C Chan ,&nbsp;S Doraisingham","doi":"10.1016/0888-0786(95)95345-Q","DOIUrl":"10.1016/0888-0786(95)95345-Q","url":null,"abstract":"<div><p>Serum specimens from 58 hospitalized patients with clinical suspicion of dengue fever were obtained in a prospective study. All 58 acute serum samples were tested by IgM capture enzyme-linked immunosorbent assay (ELISA) and commercial Dengue Blot serological assays, virus isolation in C6/36 mosquito cells, and polymerase chain reaction (PCR) by single-step and semi-nested approaches using NS3 gene primers. Of the 22 acute sera positive by any one of the five methods, 17 (77.3%) were positive by IgM capture ELISA, 12 (54.5%) by Dengue Blot, none (0%) by virus isolation, two (9.1%) by single-step PCR and three (13.6%) by the more sensitive semi-nested PCR approach. Dengue virus type 2 was detected by both PCR assays. Convalescent sera were also collected from 13 of the 58 patients and haemagglutination inhibition (HI) tests performed on paired serum samples. HI confirmed five positive sera, while the other eight sera were negative or inconclusive. In our study cohort, although PCR was more sensitive than virus isolation for detecting the presence of dengue virus in sera, serological techniques were able to identify more dengue infections than both PCR and virus isolation. These results may be attributed to the collection of serum samples after the period of viraemia which is appropriate for serological assays, in contrast to early or highly viraemic sera which are more suitable for PCR and virus isolation methods.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 2","pages":"Pages 55-58"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)95345-Q","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90725093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Serodiagnosis & Immunotherapy in Infectious Disease calendar 传染病日历中的血清诊断与免疫治疗
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-06-01 DOI: 10.1016/0888-0786(95)90002-0
{"title":"Serodiagnosis & Immunotherapy in Infectious Disease calendar","authors":"","doi":"10.1016/0888-0786(95)90002-0","DOIUrl":"https://doi.org/10.1016/0888-0786(95)90002-0","url":null,"abstract":"","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 2","pages":"Page 93"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)90002-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136840317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interpretation of hepatitis B virus serology results by medical scientists 医学科学家对乙型肝炎病毒血清学结果的解释
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-06-01 DOI: 10.1016/0888-0786(95)95347-S
S.C Thompson , C.G Ryan , R.J Warren
{"title":"Interpretation of hepatitis B virus serology results by medical scientists","authors":"S.C Thompson ,&nbsp;C.G Ryan ,&nbsp;R.J Warren","doi":"10.1016/0888-0786(95)95347-S","DOIUrl":"10.1016/0888-0786(95)95347-S","url":null,"abstract":"<div><p>Medical laboratory scientists who had agreed to participate in an evaluation which required them to measure the level of anti-HBs in a panel of sera, were given a brief clinical scenario for seven of the results and asked to comment on the person's immune status. The interpretations of immune status were assessed against the matters considered by the authors to reflect the current state of knowledge about immunity to hepatitis B and recommendations from authorities. There were a number of common but not universal misconceptions in the interpretation of results and current guidelines, particularly regarding appropriate use of hepatitis B immune globulin (HBIG), equating the absence of anti-HBs in a previous seroconverter with no immunity or the need to institute a new course of vaccination, and inappropriate recommendations for further testing or retesting. Given that the cost of serology for anti-HBs now exceeds the cost of three doses of vaccine, more effective and rational testing of immune status to hepatitis B is required.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 2","pages":"Pages 64-69"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)95347-S","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85846204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A dichromatic latex agglutination test for semiquantitative detection of antibodies to Toxoplasma gondii 刚地弓形虫抗体半定量检测的二色乳胶凝集试验
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-06-01 DOI: 10.1016/0888-0786(95)95350-Y
E.H Frost
{"title":"A dichromatic latex agglutination test for semiquantitative detection of antibodies to Toxoplasma gondii","authors":"E.H Frost","doi":"10.1016/0888-0786(95)95350-Y","DOIUrl":"10.1016/0888-0786(95)95350-Y","url":null,"abstract":"<div><p>A dichromatic latex agglutination test was employed to measure antibodies to <em>Toxoplasma gondii</em> in 160 sera. Reactions were deemed negative, weak positive, positive or strong positive on the basis of rapidity of agglutination and/or colour change. This semiquantitative determination agreed well with antibody titres measured by immunofluorescence.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 2","pages":"Pages 81-83"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)95350-Y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90273722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of different second- and third-generation assays for detection of hepatitis C virus antibodies in plasma and sera also tested by polymerase chain reaction 采用聚合酶链反应对不同的第二代和第三代丙型肝炎病毒抗体检测方法在血浆和血清中的有效性进行了测试
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-06-01 DOI: 10.1016/0888-0786(95)95344-P
F.H Pujol , L Blitz-Dorfman , G León , F Monsalve , J.M Echevarría , F Liprandi
{"title":"Efficacy of different second- and third-generation assays for detection of hepatitis C virus antibodies in plasma and sera also tested by polymerase chain reaction","authors":"F.H Pujol ,&nbsp;L Blitz-Dorfman ,&nbsp;G León ,&nbsp;F Monsalve ,&nbsp;J.M Echevarría ,&nbsp;F Liprandi","doi":"10.1016/0888-0786(95)95344-P","DOIUrl":"10.1016/0888-0786(95)95344-P","url":null,"abstract":"<div><p>Sera or plasma from 52 blood donors, initially reactive by Ortho HCV EIA 2.0 were tested by other immunoassays (Abbott HCV EIA, UBI HCV EIA and Innotest HCV EIA). Positivity was confirmed by confirmatory assays (RIBA 2.0 or RIBA 3.0 and Inno-LIA or Inno-LIA III); hepatitis C virus (HCV) RNA was detected by reverse transcription nested polymerase chain reaction (RT-nested PCR). Forty-four (84.6%) were repeatedly positive by Ortho, 41 (78.8%) by Abbot, 37 (71.2%) by Innotest and 36 (69.2%) by UBI. When tested for RIBA 2.0, 35 (67.3%) were positive. Only 26 sera (50%) were positive for HCV RNA. None of the Innotest or UBI negative sera were positive for HCV RNA nor for confirmatory tests. UBI and Innotest seem more reliable for detection of antibodies against HCV, and combined application of anti-HCV immunoblot assay and HCV RNA detection by PCR is required for confirmation of HCV infection.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 2","pages":"Pages 51-54"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)95344-P","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90666777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Lipoarabinomannan antigen and anti-lipoarabinomannan antibody profile in the serum of patients with mycobacterial infections and their significance in disease process 分枝杆菌感染患者血清中脂阿拉比甘露聚糖抗原和抗脂阿拉比甘露聚糖抗体谱及其在疾病过程中的意义
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-06-01 DOI: 10.1016/0888-0786(95)95346-R
S.A Patil, G Ramu, M Patil
{"title":"Lipoarabinomannan antigen and anti-lipoarabinomannan antibody profile in the serum of patients with mycobacterial infections and their significance in disease process","authors":"S.A Patil,&nbsp;G Ramu,&nbsp;M Patil","doi":"10.1016/0888-0786(95)95346-R","DOIUrl":"10.1016/0888-0786(95)95346-R","url":null,"abstract":"<div><p>A sandwich antigen capture assay using a double monoclonal antibody system revealed the presence of lipoarabinomannan (LAM) antigen in about 25% of the serum samples in subjects with pulmonary tuberculosis and tuberculoid leprosy. Lepromatous leprosy sera showed about 40% antigen positivity. Anti-LAM antibodies could be detected in about 90% of subjects with pulmonary tuberculosis and lepromatous leprosy. However in tuberculoid leprosy sera anti-LAM antibodies were positive in only 22% of the patients. Antigen and antibody levels in pulmonary tuberculosis and lepromatous leprosy declined steadily during anti-mycobacterial therapy, whereas in the tuberculoid type leprosy a distinct increase in antibody positivity was noticed. The high percentage of anti-LAM antibodies in pulmonary tuberculosis subjects may be of diagnostic significance.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 2","pages":"Pages 59-63"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)95346-R","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87323140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
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