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Serodiagnosis and Immunotherapy in Infectious Disease最新文献

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Immunogenic potential of solar-inactivated typhoid antigens 太阳灭活伤寒抗原的免疫原性
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-09-01 DOI: 10.1016/0888-0786(95)97897-E
B.A. Ngwu , J.A.C. Agboz , C.E. Anyiwo
{"title":"Immunogenic potential of solar-inactivated typhoid antigens","authors":"B.A. Ngwu ,&nbsp;J.A.C. Agboz ,&nbsp;C.E. Anyiwo","doi":"10.1016/0888-0786(95)97897-E","DOIUrl":"https://doi.org/10.1016/0888-0786(95)97897-E","url":null,"abstract":"<div><p>The purpose of this study was to explore the antigenic potential of solar-inactivated typhoid antigens and compare them with those produced by acetone treatment. The agglutination titre levels of 1 :512, 1 :256 and 1 :256 were observed with antigens produced by 8 h, 8.5 h and 9 h exposure to the sun, respectively. This was compared with the agglutination titre levels of 1 : 128, 1 : 256 and 1 : 512 produced by 5 : 1 vol/vol, 3 : 1 vol/vol and 2 : 1 vol/vol acetone inactivation respectively. This result showed that high immunogenic, cost effective typhoid antigens can be produced with solar energy. This information can be exploited in future formulation of typhoid vaccine and for serodiagnosis.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 3","pages":"Pages 133-134"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)97897-E","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91726351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applications of polymerase chain reaction to diagnose lyme borreliosis 聚合酶链反应在莱姆病诊断中的应用
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-09-01 DOI: 10.1016/0888-0786(95)97893-A
J. Gutiérrez , M.A. Rodriguez , M.C. Maroto
{"title":"Applications of polymerase chain reaction to diagnose lyme borreliosis","authors":"J. Gutiérrez ,&nbsp;M.A. Rodriguez ,&nbsp;M.C. Maroto","doi":"10.1016/0888-0786(95)97893-A","DOIUrl":"10.1016/0888-0786(95)97893-A","url":null,"abstract":"<div><p>Molecular diagnosis of Lyme disease is hindered by genetic variability and, in genes that have a certain degree of stability, by the presence of identical regions in other genera in both related and unrelated species. There are therefore certain limitations in genetic diagnostic techniques and as yet no definitive laboratory diagnostic technique has been discovered.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 3","pages":"Pages 109-113"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)97893-A","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87422475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Clinical determinants and time course of serum antibody response against listeriolysin O in experimental listeriosis 实验性李斯特菌病抗李斯特菌素O血清抗体反应的临床决定因素及时间进程
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-09-01 DOI: 10.1016/0888-0786(95)97892-9
J. Aittoniemi , J. Husu , O. Jaakkolat, T. Solakivit, A. Miettinen
{"title":"Clinical determinants and time course of serum antibody response against listeriolysin O in experimental listeriosis","authors":"J. Aittoniemi ,&nbsp;J. Husu ,&nbsp;O. Jaakkolat,&nbsp;T. Solakivit,&nbsp;A. Miettinen","doi":"10.1016/0888-0786(95)97892-9","DOIUrl":"10.1016/0888-0786(95)97892-9","url":null,"abstract":"<div><p>The serum antibody response against listeriolysin O (LLO) was studied in goats experimentally infected with <em>Listeria monocytogenes</em>, using two sequential oral inoculations at 8 months interval. The serum IgG antibody response against LLO correlated closely with that against the whole bacterium, supporting the role of LLO as the major antigenic determinant of the humoral response against <em>L. monocytogenes</em>. However, only severe listeric infections were accompanied by a distinct anti-LLO antibody response, whereas milder, albeit bacteraemic infections remained only weakly responsive or totally non-responsive. Elevated anti-LLO IgG antibody levels persisted for several months after past infection and even high levels of anti-LLO IgG antibodies without evidence of past or ongoing listeriosis were found. Therefore, in the serodiagnosis of listeriosis, the determination of antiLLO antibody response may be applicable only in severe listeric infections and should always be based on IgG seroconversion.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 3","pages":"Pages 105-108"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)97892-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73998851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Monoclonal antibodies and peptide therapy in autoimmune diseases 自身免疫性疾病的单克隆抗体和肽治疗
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-09-01 DOI: 10.1016/0888-0786(95)90005-5
M.H.V. Van Regenmortel
{"title":"Monoclonal antibodies and peptide therapy in autoimmune diseases","authors":"M.H.V. Van Regenmortel","doi":"10.1016/0888-0786(95)90005-5","DOIUrl":"https://doi.org/10.1016/0888-0786(95)90005-5","url":null,"abstract":"","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 3","pages":"Page 143"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)90005-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136556113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alterations in the immune response of golden hamsters during the course of Leishmania donovani infection and after treatment with sodium stibogluconate 多诺瓦利什曼原虫感染过程中及用顽固性葡萄糖酸钠治疗后金仓鼠免疫反应的变化
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-09-01 DOI: 10.1016/0888-0786(95)97894-B
A. Pal, S. Gupta, J.C. Katiyar, A. Puri, R. Sahai, R.P. Saxena
{"title":"Alterations in the immune response of golden hamsters during the course of Leishmania donovani infection and after treatment with sodium stibogluconate","authors":"A. Pal,&nbsp;S. Gupta,&nbsp;J.C. Katiyar,&nbsp;A. Puri,&nbsp;R. Sahai,&nbsp;R.P. Saxena","doi":"10.1016/0888-0786(95)97894-B","DOIUrl":"https://doi.org/10.1016/0888-0786(95)97894-B","url":null,"abstract":"<div><p>The immune response of golden hamsters was monitored following experimental infection with <em>Leishmania donovani</em> and subsequent treatment with sodium stibogluconate (Stibanate Sb<sup>v</sup>) taking macrophage migration index (MMI), phagocytic activity of peritoneal macrophages, blastogenic response of splenocytes in presence of phytohaemagglutinin (PHA) and specific antibodies to <em>Leishmania</em> antigen, as parameters. MMI, a correlate of macrophage activation and cellular immune response (CMI) decreased to a value of 0.46 ± 0.09 (in infected hamsters) from the normal control value of 1.0 on day 21 post infection (p.i.). The value remained suppressed during the course of observation up to day 54 p.i. in untreated animals. Following stibanate treatment from day 21 p.i. the MMI started rising and was restored to slightly above the normal value (1.20 ± 0.12) on day 54 p.i. The phagocytic activity of peritoneal macrophages using <sup>14</sup>4c leucine labelled <em>Escherichia coli</em> and blastogenic response of splenocytes to PHA did not alter during the infection or after stibanate treatment. The specific humoral response to promastigote antigen as assessed by enzyme-linked immunosorbent assay (ELISA) revealed the appearance of antileishmanial antibodies on day 14 p.i., which gradually reached a peak titre of 1 :3200 on day 34 p.i. On stibanate treatment the antileishmanial antibodies started declining after day 7 post treatment (p.t.) and reached almost normal level on day 28 p.t. These observations strengthen the claim that hamsters can be used as a useful model for the study of the immune response in human visceral leishmaniasis.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 3","pages":"Pages 115-120"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)97894-B","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91726350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Immunogenic potential of solar-inactivated typhoid antigens 太阳灭活伤寒抗原的免疫原性
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-09-01 DOI: 10.1016/0888-0786(95)97897-E
B. Ngwu, J.A.C. Agboz, C. Anyiwo
{"title":"Immunogenic potential of solar-inactivated typhoid antigens","authors":"B. Ngwu, J.A.C. Agboz, C. Anyiwo","doi":"10.1016/0888-0786(95)97897-E","DOIUrl":"https://doi.org/10.1016/0888-0786(95)97897-E","url":null,"abstract":"","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"30 1","pages":"133-134"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75765904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of Legionella species by polymerase chain reaction 聚合酶链反应检测军团菌菌种
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-09-01 DOI: 10.1016/0888-0786(95)97891-8
M. Iwamoto, H. Koga, S. Kohno, M. Kaku, K. Hara
{"title":"Detection of Legionella species by polymerase chain reaction","authors":"M. Iwamoto,&nbsp;H. Koga,&nbsp;S. Kohno,&nbsp;M. Kaku,&nbsp;K. Hara","doi":"10.1016/0888-0786(95)97891-8","DOIUrl":"10.1016/0888-0786(95)97891-8","url":null,"abstract":"<div><p>The nested polymerase chain reaction (PCR) was clinically investigated to detect the <em>mip</em> gene of <em>Legionella</em> species. PCR detected 20 clinically important <em>Legionella species</em>, such as <em>L. pneumophila, L. micdadei</em>, and <em>L. bozemanii</em>. Eight species of Gram-positive and -negative bacteria other than <em>Legionella</em> species were negative for PCR. The sensitivity of PCR determined by the detection limit of DNA quantity was 1.0 pg for the first PCR, but the sensitivity increased approximately 100-fold to 10 fg following the second PCR. The nested PCR was applied to detect <em>L. pneumophila</em> in the sputum and pleural effusion fluid obtained from a patient with <em>Legionnaires'</em> disease. Both fluids were PCR positive, but culture was negative for <em>L. pneumophila</em>. Our results indicated that the nested PCR may be a useful tool for the rapid detection of <em>L. pneumophila</em> and the clinical diagnosis of Legionnaires' disease.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 3","pages":"Pages 99-103"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)97891-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89984561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
IgG, IgM and IgA antibody responses against immediate-early, early and late human cytomegalovirus proteins in patients with HCMV infections HCMV感染患者IgG、IgM和IgA抗体对人巨细胞病毒蛋白的早期、早期和晚期反应
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-09-01 DOI: 10.1016/0888-0786(95)97895-C
M. Segondy, S. Salhi
{"title":"IgG, IgM and IgA antibody responses against immediate-early, early and late human cytomegalovirus proteins in patients with HCMV infections","authors":"M. Segondy, S. Salhi","doi":"10.1016/0888-0786(95)97895-C","DOIUrl":"https://doi.org/10.1016/0888-0786(95)97895-C","url":null,"abstract":"","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"2 1","pages":"121-128"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87796177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The evaluation of a combined ‘dry’ latex agglutination test for detecting rotaviruses and adenoviruses in faeces 一种用于检测粪便中轮状病毒和腺病毒的联合“干”乳胶凝集试验的评价
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-09-01 DOI: 10.1016/0888-0786(95)97896-D
A. Bryden
{"title":"The evaluation of a combined ‘dry’ latex agglutination test for detecting rotaviruses and adenoviruses in faeces","authors":"A. Bryden","doi":"10.1016/0888-0786(95)97896-D","DOIUrl":"https://doi.org/10.1016/0888-0786(95)97896-D","url":null,"abstract":"","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"70 1","pages":"129-131"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82865963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Contribution of latex agglutination test for the diagnosis of pretreated meningitis 胶乳凝集试验对预处理脑膜炎诊断的贡献
Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-09-01 DOI: 10.1016/0888-0786(95)97899-G
Maria das Graças Adelino Alkmin , Carmo Elias Andrade Melles , Ilka Maria Landgraf
{"title":"Contribution of latex agglutination test for the diagnosis of pretreated meningitis","authors":"Maria das Graças Adelino Alkmin ,&nbsp;Carmo Elias Andrade Melles ,&nbsp;Ilka Maria Landgraf","doi":"10.1016/0888-0786(95)97899-G","DOIUrl":"10.1016/0888-0786(95)97899-G","url":null,"abstract":"","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 3","pages":"Pages 141-142"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)97899-G","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89355686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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