Immunogenic potential of solar-inactivated typhoid antigens

Abstract

The purpose of this study was to explore the antigenic potential of solar-inactivated typhoid antigens and compare them with those produced by acetone treatment. The agglutination titre levels of 1 :512, 1 :256 and 1 :256 were observed with antigens produced by 8 h, 8.5 h and 9 h exposure to the sun, respectively. This was compared with the agglutination titre levels of 1 : 128, 1 : 256 and 1 : 512 produced by 5 : 1 vol/vol, 3 : 1 vol/vol and 2 : 1 vol/vol acetone inactivation respectively. This result showed that high immunogenic, cost effective typhoid antigens can be produced with solar energy. This information can be exploited in future formulation of typhoid vaccine and for serodiagnosis.