Lipoarabinomannan antigen and anti-lipoarabinomannan antibody profile in the serum of patients with mycobacterial infections and their significance in disease process
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引用次数: 7
Abstract
A sandwich antigen capture assay using a double monoclonal antibody system revealed the presence of lipoarabinomannan (LAM) antigen in about 25% of the serum samples in subjects with pulmonary tuberculosis and tuberculoid leprosy. Lepromatous leprosy sera showed about 40% antigen positivity. Anti-LAM antibodies could be detected in about 90% of subjects with pulmonary tuberculosis and lepromatous leprosy. However in tuberculoid leprosy sera anti-LAM antibodies were positive in only 22% of the patients. Antigen and antibody levels in pulmonary tuberculosis and lepromatous leprosy declined steadily during anti-mycobacterial therapy, whereas in the tuberculoid type leprosy a distinct increase in antibody positivity was noticed. The high percentage of anti-LAM antibodies in pulmonary tuberculosis subjects may be of diagnostic significance.
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