{"title":"输入性曼氏血吸虫和血球血吸虫感染对锁眼帽贝血青素的血清学反应","authors":"R.P. Bendall, K. Lalloo, P.L. Chiodini","doi":"10.1016/0888-0786(95)93027-9","DOIUrl":null,"url":null,"abstract":"<div><p>Sera from patients with schistosomiasis contain antibodies which react with keyhole limpet haemocyanin (KLH). This is due to carbohydrate epitopes shared by KLH and surface antigens of various <em>Schistosoma</em> species. Previous studies have used this cross-reactivity in enzyme-linked immunosorbent assay (ELISA) tests to distinguish between sera from acute and chronic cases in endemic areas. We describe a modification of the ELISA technique which distinguishes serologically between active schistosomiasis and normal sera. It has a sensitivity (88%) and specificity (94%) comparable with existing tests. If developed for routine clinical use, this test would be more useful in non-endemic areas than one which only detects acute cases.</p></div>","PeriodicalId":101161,"journal":{"name":"Serodiagnosis and Immunotherapy in Infectious Disease","volume":"7 1","pages":"Pages 27-29"},"PeriodicalIF":0.0000,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0888-0786(95)93027-9","citationCount":"1","resultStr":"{\"title\":\"The serological response to keyhole limpet haemocyanin in imported Schistosoma mansoni and Schistosoma haematobium infections\",\"authors\":\"R.P. Bendall, K. Lalloo, P.L. Chiodini\",\"doi\":\"10.1016/0888-0786(95)93027-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Sera from patients with schistosomiasis contain antibodies which react with keyhole limpet haemocyanin (KLH). This is due to carbohydrate epitopes shared by KLH and surface antigens of various <em>Schistosoma</em> species. Previous studies have used this cross-reactivity in enzyme-linked immunosorbent assay (ELISA) tests to distinguish between sera from acute and chronic cases in endemic areas. We describe a modification of the ELISA technique which distinguishes serologically between active schistosomiasis and normal sera. It has a sensitivity (88%) and specificity (94%) comparable with existing tests. If developed for routine clinical use, this test would be more useful in non-endemic areas than one which only detects acute cases.</p></div>\",\"PeriodicalId\":101161,\"journal\":{\"name\":\"Serodiagnosis and Immunotherapy in Infectious Disease\",\"volume\":\"7 1\",\"pages\":\"Pages 27-29\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0888-0786(95)93027-9\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Serodiagnosis and Immunotherapy in Infectious Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0888078695930279\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Serodiagnosis and Immunotherapy in Infectious Disease","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0888078695930279","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The serological response to keyhole limpet haemocyanin in imported Schistosoma mansoni and Schistosoma haematobium infections
Sera from patients with schistosomiasis contain antibodies which react with keyhole limpet haemocyanin (KLH). This is due to carbohydrate epitopes shared by KLH and surface antigens of various Schistosoma species. Previous studies have used this cross-reactivity in enzyme-linked immunosorbent assay (ELISA) tests to distinguish between sera from acute and chronic cases in endemic areas. We describe a modification of the ELISA technique which distinguishes serologically between active schistosomiasis and normal sera. It has a sensitivity (88%) and specificity (94%) comparable with existing tests. If developed for routine clinical use, this test would be more useful in non-endemic areas than one which only detects acute cases.
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