Revista Colombiana de Reumatología (English Edition)最新文献

{"title":"Cutaneous spectrum of lupus erythematosus: A cohort of patients from a referral-center in Colombia","authors":"Verónica Noguera-Castro ,&nbsp;Claudia-Lorena Cano-Cuadros ,&nbsp;Mariana Botero-Varón ,&nbsp;Daniela Marín-Acevedo ,&nbsp;Omar-Javier Calixto ,&nbsp;Juan-Manuel Bello-Gualtero ,&nbsp;Consuelo Romero-Sánchez","doi":"10.1016/j.rcreue.2025.06.007","DOIUrl":"10.1016/j.rcreue.2025.06.007","url":null,"abstract":"<div><h3>Introduction</h3><div>To date, few epidemiological studies compare the incidence and prevalence of systemic lupus erythematosus (SLE) and isolated cutaneous lupus erythematosus (CLE). The information is even more scarce in Latin America. The aim of this study is to describe the phenotype of CLE in a reference center in Colombia.</div></div><div><h3>Materials and methods</h3><div>A retrospective cross-sectional study was carried out. SLE was confirmed according to EULAR/ACR 2019 classification criteria and patients were simultaneously evaluated in the rheumatology and dermatology clinics. A descriptive and bivariate analysis was carried out. The institutional committee approved the study.</div></div><div><h3>Results</h3><div>Thirty participants were diagnosed with SLE and CLE. Most patients were female (83.3%), with a mean age of 37<!--> <!-->±<!--> <!-->13 years. Chronic CLE was the most prevalent subtype (46.7%), followed by acute (30%) and subacute (16.7%) CLE. There were statistically significant differences when comparing acute CLE and reduced C4 (<em>p</em> <!-->=<!--> <!-->.032); in subacute CLE and interstitial lung disease (<em>p</em> <!-->=<!--> <!-->.010); and in lymphopenia (<em>p</em> <!-->=<!--> <!-->.012) and thrombocytopenia (<em>p</em> <!-->=<!--> <!-->.046). Finally, there was a difference in patients with chronic CLE and the use of topical corticosteroid (<em>p</em> <!-->=<!--> <!-->.026), methotrexate (<em>p</em> <!-->=<!--> <!-->.036), and SLEDAI<!--> <!-->&gt;<!--> <!-->3 points (<em>p</em> <!-->=<!--> <!-->.025).</div></div><div><h3>Conclusion</h3><div>This study provides valuable insights into the phenotypic characteristics and associations of CLE with systemic manifestations in the Colombian population, contributing to the understanding and managing of this complex autoimmune disease.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 3","pages":"Pages 231-235"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of 50 years of the Rheumatology Service of Universidad Nacional de Colombia: The first in Colombia and a pioneer in Latin America","authors":"Yimy F. Medina,&nbsp;Antonio Iglesias Gamarra","doi":"10.1016/j.rcreue.2025.06.009","DOIUrl":"10.1016/j.rcreue.2025.06.009","url":null,"abstract":"<div><h3>Introduction</h3><div>The Rheumatology Unit of the National University of Colombia (UNAL) has a history spanning over half a century, producing many prominent rheumatologists. This article provides a description of its history to understand its trajectory, historical context, challenges, achievements, and contributions.</div></div><div><h3>Reflections</h3><div>In 1960, the Rheumatology Section at UNAL was officially approved, founded by professors Mario Peña, Humberto Lizarazo, and Fernando Chalem. In 1962, Drs. Peña, Chalem, and Lizarazo established the Rheumatology Service at San Juan de Dios Hospital. In 1963, the outpatient clinic for rheumatic patients began operating at the same hospital. Dr. Enrique Clavijo Acero became the first rheumatologist qualified through a Colombian university in 1971. By 1973, various specialty programmes at UNAL, including rheumatology, were officially approved, and the Rheumatology Unit was elevated to the status of a section.</div></div><div><h3>Discussion</h3><div>For more than 50 years, the Rheumatology Unit has trained medical students and specialists, who have played a critical role in the field. It remains a vital part of rheumatology both in Colombia and the region.</div></div><div><h3>Conclusion</h3><div>The Rheumatology Unit at the National University of Colombia, as the first academic institution in this field within the country, celebrates over 60 years of activity and 50 years of official recognition. It has achieved numerous milestones and has been a pioneering force in rheumatology.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 3","pages":"Pages 276-285"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nailfold capillaroscopy in mixed connective tissue disease, systemic sclerosis, and primary Raynaud phenomenon in a capillaroscopy service from Medellin, Colombia 2015–2020","authors":"Adriana Margarita Trejos Tenorio ,&nbsp;Carlos Jaime Velásquez Franco ,&nbsp;Libia María Rodríguez Padilla ,&nbsp;Miguel Antonio Mesa Navas","doi":"10.1016/j.rcreue.2025.03.004","DOIUrl":"10.1016/j.rcreue.2025.03.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Nailfold capillaroscopy is a useful tool to evaluate microcirculation. In mixed connective tissue disease (MCTD), microvascular changes are not clearly defined. This study aims to compare the angiographic findings between patients with mixed connective tissue disease, systemic sclerosis, and primary Raynaud phenomenon (pRP) in a capillaroscopy reference centre.</div></div><div><h3>Methods</h3><div>A retrospective descriptive study with an exploratory analytical component was designed. Clinical and capillaroscopic characteristic information was obtained from medical records and capillaroscopic reports from an expert capillaroscopy service using an Optilia 200x videocapillaroscope. To compare qualitative variables, the Pearson or Fisher exact chi-square test was used in case of expected frequencies lower than five.</div></div><div><h3>Results</h3><div>One hundred and twenty capillaroscopy charts were reviewed. In the MCTD group, 42.5% of patients showed a normal pattern, 37.5% had a non-scleroderma pattern, and 20% exhibited a scleroderma pattern. Among pRP patients, 62.5% had a normal and 37.5% had a non-specific pattern; both groups preserved capillary density. In MCTS, compared to SS, there were fewer avascular areas (10% vs. 62.5% p &lt; .001), megacapillaries (20% vs 100%, p &lt; .001), and haemorrhages (37.5 vs. 92.5% p &lt; .001). Bushy capillaries predominated in the MCTD (10%) compared to SS (5%) and pRP (0%) groups without significance difference (p = .122).</div></div><div><h3>Conclusions</h3><div>Compared to systemic sclerosis, mixed connective tissue disease presents greater capillary density and a greater frequency of arborescent capillaries.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 3","pages":"Pages 209-215"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Videocapillaroscopy findings in a Colombian population of healthy volunteers with standardization criteria","authors":"Yimy F. Medina ,&nbsp;Henry F. Cárdenas-Sánchez ,&nbsp;Carlos Jaime Velásquez-Franco","doi":"10.1016/j.rcreue.2025.06.006","DOIUrl":"10.1016/j.rcreue.2025.06.006","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Videocapillaroscopy is a diagnostic procedure that allows an assessment of the microcirculation in the nailfold of patients with Raynaud's phenomenon. There are few reports of videocapillaroscopic findings in healthy subjects, none in Colombia. It is important to know the findings that exist in the Colombian healthy population to have a reference and define abnormalities in people with diseases.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;Our aim was to describe the standardized qualitative, quantitative videocapillaroscopic findings and the sociodemographic characteristics in healthy volunteers from a Colombian population.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;div&gt;A cross-sectional descriptive study was conducted at the Simon Bolívar and Hospital Universitario Nacional de Colombia in Bogota, Colombia. Healthy adult volunteers over 18 years of age were included in the study. Two images were taken per finger from the second to fifth of each hand. A pilot test was conducted to refine the procedure and establish the agreement between the evaluators of the test, in which a kappa concordance index was estimated for the findings of capillary density, presence of dilated capillaries, megacapillaries, abnormal morphologies and avascular areas. Subsequently, measurements of the venous loop, arterial loop, apical portion, intercapillary distance, capillary density, presence of dilated capillaries, megacapillaries, avascular zones, and description of capillary morphology were performed. Finally, a capillaroscopic diagnosis was issued by Fast-track flowchart.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;One hundred one videocapillaroscopy studies were performed. The age range of the participants was 20–62 years (average 31 years). 59 women and 42 men. A total of 1611 photographs at 200× were analyzed. Agreement between the two observers was excellent for capillary density, dilated capillaries, microhemorrhages and abnormal shapes. The average of each the findings was as follows: capillary density of 8.2&lt;!--&gt; &lt;!--&gt;capillaries/mm, apical diameter 14.1&lt;!--&gt; &lt;!--&gt;μm, arterial loop 10.8&lt;!--&gt; &lt;!--&gt;μm, venous loop 13.7&lt;!--&gt; &lt;!--&gt;μm, and intercapillary distance 147&lt;!--&gt; &lt;!--&gt;μm. Morphology was evaluated in 10,855 capillaries. The predominant morphology was hairpin with 58.8%, followed by crossed 30.2% tortuous 10.4%, and abnormal forms corresponded to 0.48% of the sample. No avascular or megacapillary zones were documented. In 53 individuals, there were some dilated capillaries (182), corresponding to 1.7% of the capillaries analyzed (median of apical diameter: 23.3&lt;!--&gt; &lt;!--&gt;μm). Microhemorrhages was found in 16 volunteers, most of them hemosiderin content. The capillaroscopic diagnosis using the Fast-Track algorithm and standardization criteria were category I (a non-scleroderma pattern) in the entire sample, non-specific abnormal findings were observed in 67 (66.3%) of the 101 videocapillaroscopy analyzes.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 3","pages":"Pages 222-230"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behçet’s disease in pediatrics, a diagnostic challenge: Qualitative systematic review of the literature","authors":"Nathalie Yepes Madrid ,&nbsp;María del Pilar Gómez Mora ,&nbsp;José Fernando Gómez Urrego","doi":"10.1016/j.rcreue.2025.04.006","DOIUrl":"10.1016/j.rcreue.2025.04.006","url":null,"abstract":"<div><div>Behçet’s disease (BD) is a systemic inflammatory disease that mainly affects the oral and genital mucosa, skin and eyes. A qualitative systematic review of the literature is carried out in search of finding the epidemiology, etiopathogenesis, spectrum of clinical manifestations, diagnosis, treatment approach and current Clinical Trials of Behçet's disease in the pediatric population. A bibliographic search was performed in PubMed without language or publication date restrictions. References of included articles were examined for additional relevant literature. The initial search yielded a total of 570 studies from PubMed, 1 from a website, 4 from the Colombian Ministry of Health and 4 from a review of bibliographic citations, of which 32 articles were included used for the present review, finding that the prevalence At a global level it is estimated around 10.3 per 100,000 inhabitants. BD is a vasculitis that affects vessels of all sizes including veins. It was recently reclassified as variable type vasculitis. Other frequent clinical manifestations are joint, skin and digestive manifestations. Although its etiopathogenesis is not clear, in recent years it has been considered a multicausal autoinflammatory entity. Its diagnosis is mainly clinical. Management should be individualized based on the manifestations of the disease given the clinical variability. Multicenter, placebo-controlled, standardized studies that involve large series of patients, use clinical scores, and have long-term follow-up are needed to better understand the nature of this disease.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 3","pages":"Pages 267-275"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of glyceryl trinitrate patch use in secondary Raynaud's phenomenon","authors":"Silvia Méndez-Flores ,&nbsp;Dulce María Carrillo-Córdova ,&nbsp;Rafael López-Loya ,&nbsp;Bruno Estañol-Vidal","doi":"10.1016/j.rcreue.2024.12.005","DOIUrl":"10.1016/j.rcreue.2024.12.005","url":null,"abstract":"<div><h3>Introduction/objective</h3><div>Secondary Raynaud's phenomenon is one of the primary cutaneous manifestations of various rheumatological diseases, which can significantly impact quality of life and whose systemic treatment can lead to several adverse effects. Therefore, this study was conducted to assess the effectiveness of glyceryl trinitrate (in transdermal patch form) in patients with secondary Raynaud's phenomenon (SRP), evaluated through vascular flow photoplethysmography.</div></div><div><h3>Materials and methods</h3><div>A comparative, analytical, open-label, non-randomized study was conducted to evaluate the efficacy of 4.5 mg of glyceryl trinitrate in a transdermal patch placed on the proximal region of one hand in patients diagnosed with SRP compared to the untreated contralateral hand. To determine the primary outcome, vascular flow photoplethysmography assessment was performed 30 days after daily patch use. Secondary results were obtained using an infrared thermometer to measure local temperature in both hands before patch application, 30 min after patch use, and at the end of the follow-up period. Additionally, various questionnaires, including the Visual Analogue Scale for pain, Raynaud's Condition Score (RCS), and Dermatology Quality of Life Index (DLQI), were administered on the first and last days of the study.</div></div><div><h3>Results</h3><div>Sixteen patients, all female, with a median age of 54 years, were included. Regarding the rheumatological diseases associated with secondary Raynaud's phenomenon, twelve patients (75% of the sample) were associated with systemic sclerosis, three patients (19%) with lupus erythematosus, and one (6%) with mixed connective tissue disease (MCTD). There was a significant increase in peripheral blood flow after 30 days of treatment with 4.5 mg of glyceryl trinitrate every 24 h, along with improvement in clinical symptom and quality of life questionnaires.</div></div><div><h3>Conclusions</h3><div>This study supports the use of low-dose glyceryl trinitrate via transdermal patches to improve vascular flows, translating into short-term clinical symptom improvement associated with SRP.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 2","pages":"Pages 130-136"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk predictors for adverse COVID-19 outcomes in Latin American patients with autoimmune rheumatic diseases: A multicentre study in Ecuador and Mexico","authors":"Santiago Guzmán-García ,&nbsp;Goethe Sacoto-Flores ,&nbsp;Johanna Román-Bermeo ,&nbsp;Fabiana Samaniego-Burneo ,&nbsp;María Ochoa ,&nbsp;Franklin Uguña-Sari ,&nbsp;Gladis Molina-Alvarado ,&nbsp;Luis M. Amezcua-Guerra","doi":"10.1016/j.rcreue.2025.04.004","DOIUrl":"10.1016/j.rcreue.2025.04.004","url":null,"abstract":"<div><h3>Introduction/objectives</h3><div>The understanding of COVID-19 progression among patients with autoimmune rheumatic diseases (SARDs) in Latin America remains limited. This study aimed to identify risk predictors associated with poor outcomes of COVID-19 in patients with SARDs.</div></div><div><h3>Materials and methods</h3><div>An observational multicentre study including patients with SARDs from Ecuador and Mexico.</div></div><div><h3>Results</h3><div>A total of 103 patients (78% women), aged 52.5<!--> <!-->±<!--> <!-->17.7 years, were enrolled. The most prevalent SARDs were rheumatoid arthritis (59%) and systemic lupus erythematosus (SLE; 24%). Severe COVID-19 was observed in 28% of patients at admission, 43% experienced complications during follow-up, and 8% ultimately died. Mortality rates were highest in patients with antiphospholipid syndrome (27%) or SLE (20%). Poor prognostic factors included acute respiratory distress syndrome (odds ratio [OR]<!--> <!-->=<!--> <!-->17.07), severe COVID-19 at admission (OR<!--> <!-->=<!--> <!-->11.45), and presence of SLE (OR<!--> <!-->=<!--> <!-->4.62). In multivariate analysis, SLE emerged as the sole predictor of mortality (OR<!--> <!-->=<!--> <!-->15.61).</div></div><div><h3>Conclusions</h3><div>Patients with SARDs in Latin America face significant risks of adverse COVID-19 outcomes, with SLE being a major risk factor for mortality.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 2","pages":"Pages 152-158"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential biomarkers present in the urine of patients with systemic lupus erythematosus: An exploratory study in Colombian patients","authors":"Yeimy Paola Trujillo ,&nbsp;Alfonso Kerguelen ,&nbsp;Sandra Amado ,&nbsp;Santiago Bernal-Macías ,&nbsp;Daniel Gerardo Fernández-Ávila ,&nbsp;Alfonso Barreto-Prieto ,&nbsp;Luz-Stella Rodríguez","doi":"10.1016/j.rcreue.2024.12.006","DOIUrl":"10.1016/j.rcreue.2024.12.006","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the urinary levels of molecules related to removing apoptotic cells and triggering inflammation, as well as cytokines involved in Colombian patients with systemic lupus erythematosus without and with lupus nephritis compared to healthy controls.</div></div><div><h3>Materials and methods</h3><div>Urine samples were taken from three groups of patients: healthy controls (n = 7), patients with systemic lupus erythematosus without lupus nephritis (n = 7), and patients with lupus and lupus nephritis (n = 4). The urine sample was collected and concentrated by ultrafiltration. A western blot evaluated HMGB1, HISTONE H3, CALRETICULIN (CRT), ANNEXIN A1 and CD46, CX3CL1 by ELISA and cytokines such as IL-8, IL-6, IL-12p70, TNF-α, and IL-1β by flow cytometry.</div></div><div><h3>Results</h3><div>Histone H3 was detected in two patients, one with systemic lupus erythematosus without lupus nephritis and one with systemic lupus erythematosus and lupus nephritis. The detected band suggests a post-translational modification. There were no differences between the levels of HMGB1 and CX3CL1 in the study groups. CD46, ANNEXIN A1, and CRT were not detected in our samples. When evaluating cytokines in urine, an increase in IL-8 was observed in the group of patients with systemic lupus erythematosus without nephritis compared to controls. For IL-6, an increase was found among patients without lupus nephritis when compared with patients with lupus nephritis. No differences were found between the urinary levels of the other cytokines evaluated (IL-12p70, TNF-α, IL-1β, and IL-10).</div></div><div><h3>Conclusion</h3><div>Urinary histone H3 and IL-8 levels may be interesting molecules to be evaluated in more patients with systemic lupus erythematosus, while HMGB1 and CX3CL1 are not useful. Further evaluation of patients is required to confirm these findings.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 2","pages":"Pages 159-167"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common variable immune deficiency complicating proliferative lupus nephropathy: A diagnostic and therapeutic challenge","authors":"Lamia Bengherbia,&nbsp;Said Taharboucht,&nbsp;Oussama Souas,&nbsp;Hassina Chicha,&nbsp;Ahcene Chibane","doi":"10.1016/j.rcreue.2025.04.005","DOIUrl":"10.1016/j.rcreue.2025.04.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Common variable immunodeficiency (CVID) is a rare condition characterized by a constitutional humoral immune deficiency. Its association with systemic lupus is extremely rare.</div></div><div><h3>Case presentation</h3><div>In this case report, we present a 21-year-old woman with a history of Hashimoto's thyroiditis, who, following the onset of nephrotic syndrome revealing her lupus disease, subsequently developed clinical and laboratory features consistent with CVID, alongside recurrent lupus flares. Her initial therapeutic management was intricate, ultimately resulting in stable remission achieved through monthly immunoglobulin infusions.</div></div><div><h3>Conclusion</h3><div>This case illustrates the diagnostic and therapeutic difficulty of lupus disease and a common variable immune deficiency.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 2","pages":"Pages 168-172"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimmune haemolytic anaemia due to cold agglutinins associated with systemic lupus erythematosus. Case presentation and literature review","authors":"Jaime Alberto Coral Enríquez ,&nbsp;Victoria Eugenia Cajas Bravo","doi":"10.1016/j.rcreue.2024.12.004","DOIUrl":"10.1016/j.rcreue.2024.12.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Cold agglutinin autoimmune haemolytic anaemia (AIHA) secondary to systemic lupus erythematosus (SLE) is a rare manifestation. There are no cohorts or case series that allow us to evaluate the characteristics of this group of patients.</div></div><div><h3>Objective</h3><div>To describe the clinical and serological characteristics of patients with systemic lupus erythematosus (SLE) and cold agglutinin hemolytic anemia.</div></div><div><h3>Materials and methods</h3><div>We present two cases with SLE that debuted with cold agglutinin AHAI, their clinical and immunological profile and response to immunosuppressive treatment.</div></div><div><h3>Results</h3><div>Eleven cases reported in the literature from 1950 to 2023 are described.</div></div><div><h3>Conclusion</h3><div>Cold agglutinin AIHA secondary to SLE is rare, with unclear clinical features compared to idiopathic forms and usually not associated with manifestations or serious organic involvement.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 2","pages":"Pages 173-179"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}