Autoimmune haemolytic anaemia due to cold agglutinins associated with systemic lupus erythematosus. Case presentation and literature review

Revista Colombiana de Reumatología (English Edition) Pub Date : 2025-04-01 DOI:10.1016/j.rcreue.2024.12.004

Jaime Alberto Coral Enríquez , Victoria Eugenia Cajas Bravo

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Abstract

Introduction

Cold agglutinin autoimmune haemolytic anaemia (AIHA) secondary to systemic lupus erythematosus (SLE) is a rare manifestation. There are no cohorts or case series that allow us to evaluate the characteristics of this group of patients.

Objective

To describe the clinical and serological characteristics of patients with systemic lupus erythematosus (SLE) and cold agglutinin hemolytic anemia.

Materials and methods

We present two cases with SLE that debuted with cold agglutinin AHAI, their clinical and immunological profile and response to immunosuppressive treatment.

Results

Eleven cases reported in the literature from 1950 to 2023 are described.

Conclusion

Cold agglutinin AIHA secondary to SLE is rare, with unclear clinical features compared to idiopathic forms and usually not associated with manifestations or serious organic involvement.

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与系统性红斑狼疮相关的冷凝集素引起的自身免疫性溶血性贫血个案报告及文献回顾

继发于系统性红斑狼疮（SLE）的冷凝集素自身免疫性溶血性贫血（AIHA）是一种罕见的表现。没有队列或病例系列允许我们评估这组患者的特征。目的探讨系统性红斑狼疮（SLE）合并感冒型凝集素溶血性贫血的临床及血清学特点。材料和方法我们报告了两例以冷凝集素AHAI首发的SLE患者，他们的临床和免疫学特征以及对免疫抑制治疗的反应。结果对1950 ~ 2023年文献报道的16例病例进行了分析。结论继发于SLE的冷凝集素AIHA是罕见的，与特发性形式相比，其临床特征不明确，通常不伴有表现或严重的器质性受累。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Colombiana de Reumatología (English Edition)

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