Revista Colombiana de Reumatología (English Edition)最新文献

{"title":"Skin ultrasound in the evaluation of rheumatic diseases: Systemic sclerosis and psoriatic disease","authors":"Alejandro Correa Giraldo,&nbsp;Eybar Diaz,&nbsp;Edwin Castillo","doi":"10.1016/j.rcreue.2026.504937","DOIUrl":"10.1016/j.rcreue.2026.504937","url":null,"abstract":"<div><div>The clinical relevance of skin ultrasound evaluation in systemic sclerosis (SSc) and psoriasis (PsO) is significant, as it provides a non-invasive, objective, and reproducible method for assessing skin involvement, which is crucial for diagnosis, monitoring disease progression, and evaluating treatment efficacy. High-frequency ultrasound (HFUS) and shear wave elastography (SWE) are particularly useful in quantifying skin thickness and stiffness, parameters that correlate with disease activity and severity. This approach offers a more sensitive alternative to traditional methods such as the modified Rodnan skin score (mRSS), which can be subjective and variable. This article details the specific clinical applications and benefits of skin ultrasound (US) in SSc and PsO. Although the reviewed studies primarily focus on SSc, the principles of using US for skin evaluation can be extended to PsO. In PsO, US can help assess the extent of skin involvement, monitor treatment response, and potentially differentiate between active and inactive lesions, although specific studies on PsO were not detailed in the analyzed contexts. In contrast to advancements in SSc, the application of skin US in PsO requires further exploration to establish standardized protocols and validate its clinical utility. The potential of US to provide detailed insights into PsO-related skin pathology remains promising, warranting further research to fully understand its benefits. This document presents different US techniques, imaging windows, and technical aspects of performing skin US in SSc and PsO with skin involvement, covering the advantages and limitations of each method in both diseases.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 3","pages":"Article 504937"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytomegalovirus as a profibrotic modulator in systemic sclerosis: experimental evidence","authors":"Victoria E. Butrón-Verástegui,&nbsp;José M. Vela-Ruiz,&nbsp;Sacha Barrios Healey","doi":"10.1016/j.rcreue.2026.504913","DOIUrl":"10.1016/j.rcreue.2026.504913","url":null,"abstract":"","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 3","pages":"Article 504913"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of musculoskeletal ultrasound (MSK-US) in the diagnosis of COVID-19 related arthritis","authors":"Amarilis J. Pérez De Jesús,&nbsp;Andrea C. Vincenti Pérez","doi":"10.1016/j.rcreue.2026.504910","DOIUrl":"10.1016/j.rcreue.2026.504910","url":null,"abstract":"<div><div>Since the emergence of COVID-19 in December 2019, a wide array of musculoskeletal and rheumatic manifestations has been observed in affected patients, with inflammatory arthritis emerging as a notable complication. This article explores the radiographic and musculoskeletal ultrasound (MSK-US) findings in COVID-19-related arthritis, which often resembles seronegative rheumatoid arthritis. A literature review was conducted to identify studies on post-viral inflammatory arthritis, particularly COVID-19-related cases and their distinction from seronegative RA. The role of imaging, particularly musculoskeletal ultrasound, is emphasized as an effective diagnostic tool for assessing inflammation, joint effusions, and enthesopathy in COVID-19-related arthritis. Studies have shown that musculoskeletal ultrasound can help distinguish COVID-19-related arthritis from rheumatoid arthritis by detecting synovitis and the absence of erosions. Further research is needed to refine diagnostic criteria and improve treatment approaches for patients with persistent arthritis following SARS-CoV-2 infection.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 3","pages":"Article 504910"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound in vasculitis and other vessel pathologies","authors":"Juan Molina-Collada,&nbsp;Edward-Camilo Vera-Parra,&nbsp;Luis Javier Cajas,&nbsp;Josué Guillermo López-Velandia","doi":"10.1016/j.rcreue.2026.504929","DOIUrl":"10.1016/j.rcreue.2026.504929","url":null,"abstract":"<div><div>Ultrasound as a tool in rheumatology has an increasingly wide range of applications. Its harmless nature, low cost, and the possibility of use in the consultation itself have made it gain increasing strength in its indications. With training, it is possible to identify findings that can contribute to diagnosis, monitoring, and risk stratification in inflammatory and non-inflammatory vascular diseases. We propose a review of the literature on the different vascular pathologies in which rheumatologists can receive support with this imaging technique, which is also considered a semiological prolongation.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 3","pages":"Article 504929"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex hormones in psoriasis and psoriatic arthritis: unraveling a complex immunoendocrine dialogue","authors":"Daniela B. Tovar-Bastidas,&nbsp;Enrique R. Soriano","doi":"10.1016/j.rcreue.2026.504964","DOIUrl":"10.1016/j.rcreue.2026.504964","url":null,"abstract":"","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 3","pages":"Article 504964"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of fibrinogen, fibrinogen to albumin ratio, and blood cell-derived inflammatory indices in patients with systemic sclerosis: A case–control study","authors":"Fatma M. Helbawi,&nbsp;Maha S.I. Abdelrahman,&nbsp;Aml A. Rayan","doi":"10.1016/j.rcreue.2026.102177","DOIUrl":"10.1016/j.rcreue.2026.102177","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Systemic sclerosis (SSc) is a rare autoimmune systemic disorder characterized by inflammation and fibrosis. Fibrinogen and C-reactive protein (CRP) are raised during inflammation. Blood cell-derived inflammatory indices are helpful for monitoring disease activity in several autoimmune diseases. In this study, we aimed to evaluate the levels of fibrinogen, fibrinogen to albumin ratio (FAR), CRP, CRP to albumin ratio (CAR), and blood cell-derived inflammatory indices in SSc patients.</div></div><div><h3>Patients and methods</h3><div>This observational case–control study included 31 SSc patients and 20 age- and sex-matched healthy participants. Clinical assessment was performed for SSc patients. Complete blood count, CRP, fibrinogen, and albumin were done for all study subjects with calculation of the following: CAR, FAR, lymphocyte to CRP ratio, neutrophil to lymphocyte ratio (NLR), systemic inflammation response index (SIRI), systemic immune inflammation index (SII), and prognostic nutritional index (PNI).</div></div><div><h3>Results</h3><div>We detected significant differences between SSc patients and healthy subjects regarding all studied variables except for albumin and PNI. Both fibrinogen and FAR were positively correlated with disease activity (<em>P</em>-value = .006 and .009, respectively), while NLR, SIRI, and SII were positively correlated with the modified Rodnan Skin Score (<em>P</em>-value = .04, .034, and .005, respectively). ROC curve analysis for active disease cutoff point detection revealed that fibrinogen had an area under the curve of 0.75 (<em>P</em>-value = .04) at a criterion of 3.2 with 70% sensitivity and 62% specificity.</div></div><div><h3>Conclusions</h3><div>Fibrinogen and FAR are reliable indicators of inflammation and disease activity in SSc patients.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 3","pages":"Article 102177"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of response to the high dose intravenous cyclophosphamide in Egyptian lupus nephritis patients: a retrospective cohort study","authors":"Doaa Attia,&nbsp;Nessma Abdel-Malik,&nbsp;Dina Effat","doi":"10.1016/j.rcreue.2026.102170","DOIUrl":"10.1016/j.rcreue.2026.102170","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;To identify the predictors of response to the high dose intravenous cyclophosphamide (IV CYC) in Egyptian patients with lupus nephritis using the commonly used laboratory tests.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;div&gt;Data were collected retrospectively at baseline (T&lt;sub&gt;0&lt;/sub&gt;), and after 3 (T&lt;sub&gt;1&lt;/sub&gt;), and 6 (T&lt;sub&gt;2&lt;/sub&gt;) cycles of CYC. The percentages of laboratory values at T&lt;sub&gt;1&lt;/sub&gt; relative to T&lt;sub&gt;0&lt;/sub&gt; [(T&lt;sub&gt;1&lt;/sub&gt;/T&lt;sub&gt;0&lt;/sub&gt;)&lt;!--&gt; &lt;!--&gt;×&lt;!--&gt; &lt;!--&gt;100] were calculated to detect the potential predictors of response. ROC curves and Youden index were used to determine the cut-off values that best predict complete, partial, and global responses [CR, PR, GR (CR&lt;!--&gt; &lt;!--&gt;+&lt;!--&gt; &lt;!--&gt;PR), respectively].&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;One hundred eighteen patients were included. At T&lt;sub&gt;2&lt;/sub&gt;, 40 (33.9%) patients had achieved CR, 28 (23.7%) patients had PR, and 50 (42.4%) patients were resistant to treatment. The percent changes of platelet count, complement 3 (C3) level, and 24-h proteinuria were significantly different between the three groups (&lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.042, 0.029, &lt;0.001, respectively). Concerning CR, the AUC for proteinuria was the greatest (AUC&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.763, &lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;&lt;0.001). Accordingly, the cut-off value of the percent change of proteinuria for CR prediction was 72.3% with 87.5% sensitivity and 55.1% specificity. Concerning GR, the AUC for C3 (AUC&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.788, &lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.011) and proteinuria (AUC&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.810, &lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;&lt;0.001) were the highest. Accordingly, the cut-off value of the percent change of C3 for GR prediction was 145.11% with 76.9% sensitivity and 85.7% specificity, while that of proteinuria was 78.34% with 86.8% sensitivity and 66% specificity.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;The magnitude of change in proteinuria and C3 levels during the early course of IV CYC could predict the final response to the drug.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objetivos&lt;/h3&gt;&lt;div&gt;Identificar predictores de respuesta a la dosis alta de ciclofosfamida intravenosa (IV CYC) en pacientes con nefritis lúpica, mediante las pruebas de laboratorio comúnmente utilizadas.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Material y métodos&lt;/h3&gt;&lt;div&gt;Se evaluaron de forma retrospectiva 118 pacientes al inicio del estudio (T&lt;sub&gt;0&lt;/sub&gt;), y después de 3 (T&lt;sub&gt;1&lt;/sub&gt;) y 6 (T&lt;sub&gt;2&lt;/sub&gt;) ciclos de CYC. Se calcularon los porcentajes de los valores de laboratorio en T&lt;sub&gt;1&lt;/sub&gt; respecto a T&lt;sub&gt;0&lt;/sub&gt; [(T&lt;sub&gt;1&lt;/sub&gt; &lt;!--&gt;/&lt;!--&gt; &lt;!--&gt;T&lt;sub&gt;0&lt;/sub&gt;)&lt;!--&gt; &lt;!--&gt;×&lt;!--&gt; &lt;!--&gt;100] para detectar los posibles predictores de respuesta. Se utilizaron las curvas ROC y el índice de Youden para determinar los valores de corte que mejor predicen las respuestas completas, parciales y globales [RC, RP, RG (RC&lt;!--&gt; &lt;!--&gt;+&lt;!--&gt; &lt;!--&gt;RP), respectivamente].&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Resultados&lt;/h3&gt;&lt;div&gt;En T&lt;sub&gt;2&lt;/sub&gt;,","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 3","pages":"Article 102170"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological significance of sex hormones (testosterone and estrogen) associated with pro-inflammatory cytokines (IL-12, IL-17A, and IL-23) in patients with psoriasis and psoriatic arthritis","authors":"Randa R. Ghamyes,&nbsp;Abdul Kareem A. Alkazaz","doi":"10.1016/j.rcreue.2026.102167","DOIUrl":"10.1016/j.rcreue.2026.102167","url":null,"abstract":"<div><h3>Introduction</h3><div>Psoriasis (PsO) and psoriatic arthritis (PsA) are immune-mediated inflammatory disorders, in which pro-inflammatory cytokines play a pathogenic role. In addition, sex hormones have been shown to influence the systemic inflammation associated with psoriatic disease.</div></div><div><h3>Objective</h3><div>Therefore, combined assessment of pro-inflammatory cytokines and sex hormones may shed more light on the pathological inflammatory response associated with PsO and PsA.</div></div><div><h3>Materials and methods</h3><div>In this case–control study, serum concentrations of three pro-inflammatory interleukins (IL-12, IL-17A, and IL-23) and two sex hormones (testosterone and estrogen) were explored in 88 patients with psoriatic disease (44 PsO and 44 PsA) and 88 controls using enzyme-linked immunosorbent assay kits.</div></div><div><h3>Results</h3><div>IL-12, IL-17A, and IL-23 concentrations were significantly greater in PsO and PsA patients than in controls. In addition, IL-12 was significantly higher in PsO than in PsA, while IL-17A was significantly elevated in PsA compared to PsO. IL-23 showed no significant difference between PsO and PsA. Testosterone concentrations were significantly elevated in PsA patients compared to PsO patients or controls, whereas there was no significant difference between PsO patients and controls. Estrogen concentrations were significantly lower in PsO and PsA patients compared to controls. Correlation analysis revealed that IL-12 was positively correlated with IL-17A in PsO, while in PsA it was positively correlated with IL-23. IL-17A and IL-23 were positively correlated with testosterone in PsO, while in PsA, IL-17A and IL-23 were negatively correlated with estrogen and testosterone, respectively.</div></div><div><h3>Conclusions</h3><div>IL-12, IL-17A, and IL-23 were up-regulated in the serum of PsO and PsA patients. However, IL-12 was more bound to PsO, IL-17A was more bound to PsA, while IL-23 levels were similar in PsO and PsA. Up-regulated testosterone levels were only linked to PsA and not PsO. PsO and PsA shared down-regulated levels of estrogen. Testosterone and estrogen were differentially associated with IL-12, IL-17A, and IL-23 in PsO and PsA.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 3","pages":"Article 102167"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal and cardiopulmonary manifestations in patients with juvenile systemic lupus erythematosus: Clinical experience in Cali, Colombia","authors":"María Paula Rengifo Mosquera,&nbsp;Robinson Pacheco,&nbsp;María del Pilar Gómez Mora","doi":"10.1016/j.rcreue.2026.504909","DOIUrl":"10.1016/j.rcreue.2026.504909","url":null,"abstract":"<div><h3>Introduction</h3><div>Juvenile systemic lupus erythematosus (jSLE) is a chronic, multisystemic autoimmune disease with a variable course and prognosis. The pediatric population accounts for 20% of total SLE cases. Renal and cardiopulmonary manifestations contribute significantly to morbidity and mortality.</div></div><div><h3>Objective</h3><div>To clinically and demographically characterize the renal and cardiopulmonary manifestations of jSLE in the study population.</div></div><div><h3>Materials and methods</h3><div>A cross-sectional observational study was conducted in patients with jSLE (EULAR/ACR-2019 criteria) at a Pediatric Rheumatology clinic in Cali, Colombia, between 2012 and 2024. Data were collected from medical records and analyzed using the IBM SPSS v29 statistical program.</div></div><div><h3>Results</h3><div>Among 98 patients with JSLE, 30.6% had renal involvement, 10.2% had cardiopulmonary involvement, and 6.1% had both. Regarding renal involvement, 83.3% were female, with a mean age of 11.4 years; 76.6% presented at disease onset, while 13.3% developed renal involvement more than two years after diagnosis. Most patients presented with proteinuria, hypertension, and nephrotic syndrome. Renal biopsy was performed in 73.3% of cases, revealing nephritis types 2, 3, and 4 (ISN/RPS classification) in 13.3%, 10%, and 50% of patients, respectively. The mean activity index was 9/24, and the chronicity index was 2/12. Regarding cardiopulmonary involvement, 90% of patients were female, with a mean age of 12.5 years; 90% presented at diagnosis. The most common clinical manifestations were chest pain, pleuritis, and pericarditis. Laboratory findings in renal involvement included anemia, elevated erythrocyte sedimentation rate (ESR), decreased complement levels (C3 and C4), and positive Anti-DNA and Anti-SM antibodies. In cardiopulmonary involvement, findings included elevated C-reactive protein and ESR, decreased C3 and C4 levels, and positive Anti-DNA, Anti-SM, and Anti-RNP antibodies. Additionally, 40% of patients with renal involvement and 60% of those with cardiopulmonary involvement had other autoimmune diseases. Mortality occurred in one patient with mixed involvement.</div></div><div><h3>Conclusion</h3><div>In jSLE, renal involvement is a common presentation at disease onset, while cardiopulmonary involvement is less prevalent. Despite the severity of these manifestations, mortality was low. However, the high inflammatory activity and significant percentage of autoimmune comorbidities highlight the complexity of this condition and underscore the importance of early identification and treatment to improve the quality of life of this population.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 3","pages":"Article 504909"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The landscape of reactive arthritis in Colombia (2017–2022): A national registry-based study","authors":"Liz Beltrán-Medina,&nbsp;Julián Barahona-Correa,&nbsp;Karen Gualdrón-Chaparro,&nbsp;Santiago Bernal-Macías,&nbsp;Daniel Fernández-Ávila","doi":"10.1016/j.rcreue.2026.504904","DOIUrl":"10.1016/j.rcreue.2026.504904","url":null,"abstract":"<div><div>Introduction/Objectives Registries allow for ascertaining the epidemiology of chronic diseases such as reactive arthritis (ReA). The Colombian Ministry of Health has implemented a National Health Registry (SISPRO, Sistema Integrado de Información de la Protección Social, by its in Spanish acronym) that collects data from each medical contact in the system, which provides close to universal coverage (around 98%). We aimed to estimate the 6-year prevalence of ReA in Colombia and to describe its demographics, using data from January 1st, 2017 to December 31st, 2022.</div><div>Material and methods We performed an observational, cross-sectional study using the International Classification of Diseases terms associated with ReA based on RIPS (Registros Individuales de Prestación de Servicios de Salud) database on SISPRO and calculated the period prevalence per 100,000 inhabitants.</div><div>Results We found 19,081 patients with a primary diagnosis of ReA, with an estimated 6-year prevalence of 40 cases per 100,000 inhabitants (0.04%). We observed a higher prevalence in women (male-to- female ratio 0.5:1). We found the highest prevalence of cases in the 75–79 years group. Most cases were reported in Atlántico, Quindío, Bolivar, Sucre, and Magdalena. The absolute number of cases was higher in pre-COVID-19 pandemic years (2017: 3630, 2018: 3843, 2019: 4711) when contrasted with COVID-19 pandemic (2020: 2715, 2021: 3021) and post-COVID-19 pandemic (2022: 2451) years.</div><div>Conclusion This is the first study to describe the demographic characteristics of ReA in Colombia. The Caribbean region presents the highest prevalence and elderly patients were most commonly affected, possibly due to misclassification with similar conditions like inflammatory ostearthritis or pseudogout.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 3","pages":"Article 504904"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149096965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}