Revista Colombiana de Reumatología (English Edition)最新文献

{"title":"Capillaroscopic findings in individuals with Sjögren’s syndrome, systemic sclerosis, and primary Raynaud’s phenomenon at a capillaroscopy referral centre in Medellin, Colombia","authors":"Simón Hoyos-Patiño ,&nbsp;Alejandro Arango-Martínez ,&nbsp;Libia María Rodriguez-Padilla ,&nbsp;Andrés Chavarriaga-Restrepo ,&nbsp;Carlos Jaime Velasquez-Franco","doi":"10.1016/j.rcreue.2026.102165","DOIUrl":"10.1016/j.rcreue.2026.102165","url":null,"abstract":"<div><h3>Introduction</h3><div>Nailfold capillaroscopy is a fundamental technique for studying systemic autoimmune diseases such as Sjögren’s syndrome, particularly in patients with Raynaud’s phenomenon and sclerodermiform features. However, in this condition, studies are scarce and often use instruments less precise than digital videocapillaroscopy, limiting the available evidence.</div></div><div><h3>Objective</h3><div>To compare capillaroscopic findings among individuals with Sjögren's syndrome (SS), primary Raynaud's phenomenon (PRP), and systemic sclerosis (SSc) at a national referral centre for nailfold videocapillaroscopy in Medellin, Colombia, between 2016 and 2022.</div></div><div><h3>Materials and methods</h3><div>An analytical cross-sectional observational study that included individuals over 18 years of age with SS, SSc, and PRP. Clinical and capillaroscopic characteristics information was obtained from capillaroscopy reports at an expert centre. Pearson's chi-square test was used to compare qualitative variables, and the Kruskal-Wallis test for quantitative variables. A <em>P</em>-value &lt;.05 was considered statistically significant.</div></div><div><h3>Results</h3><div>A total of 195 patients were included. Subjects with SS had a lower prevalence of abnormal capillaroscopic variables than patients with SSc (<em>P</em> &lt; .001). All abnormal capillaroscopic variables were more frequent in the SS group compared to PRP. There were statistically significant differences among the three patient groups in the capillaroscopic pattern (<em>P</em> &lt; .001). The main capillaroscopic finding in SS was the presence of dilated capillaries (55.4%; 36/65). In the SS group, an early scleroderma pattern was present in 4.6%, and an active scleroderma pattern in 13.8%, both findings less frequent than in SSc but more common than in PRP.</div></div><div><h3>Conclusions</h3><div>In a population of SS patients with a high prevalence of secondary Raynaud's phenomenon and anticentromere antibodies, a high prevalence of capillaroscopic abnormalities was found. Although less frequent compared to the SSc group, these abnormalities were more common than in the PRP group.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102165"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147453988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The significance of inflammatory markers derived from blood cell counts in predicting rheumatoid arthritis among the elderly","authors":"Nabaa S. Abdul-Sahib ,&nbsp;Majid M. Mahmood ,&nbsp;Ali H. Ad’hiah","doi":"10.1016/j.rcreue.2026.102157","DOIUrl":"10.1016/j.rcreue.2026.102157","url":null,"abstract":"<div><h3>Introduction</h3><div>The systemic immune inflammation index and neutrophil-platelet-to-lymphocyte–hemoglobin ratio are blood-cell-based markers that have recently been described as significant predictors of systemic inflammation in related diseases. However, these markers have not been studied in rheumatoid arthritis and their relationship to aging has not been explored.</div></div><div><h3>Materials and methods</h3><div>In this case–control study, systemic immune inflammation index and neutrophil-platelet-to-lymphocyte–hemoglobin ratio were analyzed in two age groups of rheumatoid arthritis patients: &lt;40 years (young adults; RA_Y) and &gt;60 years (elderly; RA_E). Similar control groups were included (HC_Y and HC_E, respectively). Each group consisted of 50 individuals (total number<!--> <!-->=<!--> <!-->200) with a 1:1 male-to-female ratio.</div></div><div><h3>Results</h3><div>Systemic immune inflammation index and neutrophil-platelet-to-lymphocyte–hemoglobin ratio were significantly elevated in RA_Y and RA_E compared to HC_Y and HC_E, respectively. Neutrophil-platelet-to-lymphocyte–hemoglobin ratio was also significantly elevated in RA_E compared to RA_Y. When systemic immune inflammation index and neutrophil-platelet-to-lymphocyte–hemoglobin ratio were stratified by gender, disease duration, disease activity, or therapy type, no significant differences were found. Disease duration in RA_Y was an exception, and systemic immune inflammation index and neutrophil-platelet-to-lymphocyte–hemoglobin ratio gradually decreased with increasing disease duration. Neutrophil-platelet-to-lymphocyte–hemoglobin ratio showed a very good performance in distinguishing between RA_E and HC_E (area under the curve<!--> <!-->=<!--> <!-->.831). Neutrophil-platelet-to-lymphocyte–hemoglobin ratio was also a significant marker in increasing the risk of rheumatoid arthritis (1.20-fold), particularly in the elderly (1.33-fold). The two blood-cell-based markers showed strong positive pairwise correlations in RA_Y and RA_E.</div></div><div><h3>Conclusion</h3><div>The study indicates for the first time that the blood-cell-based inflammatory markers, systemic immune inflammation and neutrophil-platelet-to-lymphocyte–hemoglobin ratio, are cost-effective predictors of rheumatoid arthritis and are associated with the risk of developing the disease, especially in the elderly.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102157"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147454081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TREX1 c.590C>T variant as a cause of monogenic systemic lupus erythematosus in a 10-year-old girl: case report","authors":"Leosirlay Rojas-Gómez ,&nbsp;Adriana Díaz-Maldonado ,&nbsp;María Fernanda Reina-Ávila","doi":"10.1016/j.rcreue.2025.102161","DOIUrl":"10.1016/j.rcreue.2025.102161","url":null,"abstract":"<div><div>Juvenile systemic lupus erythematosus is a chronic, autoimmune, and multisystemic disease that affects individuals under 18 years of age. Its early onset suggests a strong genetic relationship, with identified genetic variants causing monogenic systemic lupus erythematosus. The case of a 10-year-old patient with juvenile systemic lupus erythematosus is reported, presenting atypically, severely, and with failure to respond to standard treatment, in whom a variant in the TREX1 gene c.590C&gt;T, p.Ala197Val was identified. TREX1 variants represent up to 2% of systemic lupus erythematosus cases and should be considered in children with early onset, atypical, and severe presentation.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102161"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147453993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schnitzler syndrome: A deep insight into a rare medical disorder","authors":"Luisa Fernanda Jiménez Arcia ,&nbsp;Gloria Vásquez Duque","doi":"10.1016/j.rcreue.2026.102164","DOIUrl":"10.1016/j.rcreue.2026.102164","url":null,"abstract":"<div><div>Schnitzler syndrome is a rare autoinflammatory syndrome, in most cases, its characteristic features are chronic urticaria and monoclonal gammopathy. Over 300 cases have been reported worldwide since its discovery, more frequently in Europe than other regions such as North America, Japan, and Latin America. No predisposing conditions or inheritance pattern associated with this disease have been identified to date. However, it seems that disruption of interleukin 1 (IL-1) homeostasis plays an important role as the main pathophysiological mechanism. The main complications described associated with this disease are malignant lymphoproliferative disorders or the development of amyloidosis. Treatment consists primarily of IL-1 blockade and this has shown significant control of clinical symptoms. In this review we aim to take an in-depth look at the possible pathophysiological mechanisms of this rare entity.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102164"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147454073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of implementing a pharmaceutical service in consultations with patients with rheumatoid arthritis","authors":"Sebastián Ospina Pérez ,&nbsp;Evanny S. Valencia Patiño ,&nbsp;Daniel Efrén Rodríguez Ariza ,&nbsp;Juan C. Díaz Coronado ,&nbsp;Carolina Pérez Ríos","doi":"10.1016/j.rcreue.2025.102185","DOIUrl":"10.1016/j.rcreue.2025.102185","url":null,"abstract":"<div><h3>Introduction</h3><div>Rheumatoid arthritis (RA) is an autoimmune, chronic disease with significant morbidity, often hindered by access barriers to therapy.</div></div><div><h3>Objective</h3><div>To assess the effect of a pharmaceutical service in an outpatient rheumatology unit that dispensed medications at the end of the consultation.</div></div><div><h3>Material and methods</h3><div>An observational-analytical, retrospective study tracking a cohort of RA patients (before and after the introduction of the pharmacy service). Bivariate analysis was conducted using the Chi-square test, and multivariate analysis using a regression model with the variables disease remission (DAS28 (ESR) &lt; 2.6) and moderate-to-high RA activity (DAS28 (ESR) &gt; 3.2).</div></div><div><h3>Results</h3><div>A total of 544 patients were included, of which 435 (80.0%) were female. Remission was observed in 266 (48.9%) patients before and 384 (70.6%) after implementation of the pharmaceutical service. Factors associated with RA remission included biological therapy (HR .37 95% CI .25–.56), corticosteroid therapy (HR .31 95% CI .21–.44), leflunomide (HR .55 95% CI .42–.72), sulfasalazine (HR .60 95% CI .42–.86), and having access to the pharmaceutical service (HR 2.93 95% CI 2.23–3.85).</div></div><div><h3>Conclusions</h3><div>Implementing a pharmaceutical service that dispenses medications for rheumatoid arthritis immediately after consultation was associated with disease remission.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102185"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147454076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Narrative review: Mesenchymal stem cells derived from the umbilical cord and osteoarthritis","authors":"Sofía Arias-Correal ,&nbsp;Ana María Santos ,&nbsp;María Helena Pedraza ,&nbsp;John Londoño ,&nbsp;Igor Rueda-Cárdenas ,&nbsp;Keisy Orduz-Uribe ,&nbsp;Laura Manuela Olarte-Bermúdez ,&nbsp;Luz Mabel Ávila-Portillo","doi":"10.1016/j.rcreue.2026.504859","DOIUrl":"10.1016/j.rcreue.2026.504859","url":null,"abstract":"<div><div>Osteoarthritis (OA) is the leading cause of articular pain in adult patients, with a high worldwide prevalence and a trend towards increasing. By 2050, 642 million people are expected to suffer from knee OA. Current treatment focuses on measures to prevent progressive joint wear and control symptoms such as pain. Research in regenerative medicine, including the infiltration of platelet-rich plasma, has not yet provided solid evidence for its efficacy. With the advent of cellular therapy, the isolation and expansion of mesenchymal stem cells (MSCs) from various origins have shown promise in reducing inflammation and creating a suitable environment for the regeneration of articular cartilage. This narrative review focuses on umbilical cord-derived mesenchymal stem cells (UC-MSCs), which have certain advantages over other types of MSCs. It summarizes the various clinical trials conducted in recent years, based on a search of multiple databases.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 504859"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147453991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic diarrhea as initial manifestation of polyarteritis nodosa: A case-based review","authors":"Paul J. Tejada-Llacsa ,&nbsp;Julia Sumire Umes ,&nbsp;Manuel Francisco Ugarte-Gil ,&nbsp;Graciela S. Alarcón ,&nbsp;Víctor Román Pimentel-Quiroz","doi":"10.1016/j.rcreue.2026.102174","DOIUrl":"10.1016/j.rcreue.2026.102174","url":null,"abstract":"<div><h3>Introduction</h3><div>Polyarteritis nodosa is a rare form of vasculitis which affects medium and small arteries. Gastrointestinal involvement occurs in 14–65% of patients, the most common symptom being abdominal pain; in a few cases, intestinal perforation may occur. Chronic diarrhea at disease onset is, however, very uncommon.</div></div><div><h3>Objective</h3><div>To present the case of an elderly man with chronic diarrhea as the main manifestation of polyarteritis nodosa that progressed to intestinal perforation.</div></div><div><h3>Material and methods</h3><div>The diagnosis of polyarteritis nodosa was made by intestinal biopsy; cyclophosphamide was administered as induction treatment with progressive clinical improvement. Furthermore, a PubMed literature review was conducted.</div></div><div><h3>Results</h3><div>Three communications on which diarrhea was reported as a manifestation of polyarteritis nodosa; in one of these patients, a 13-year-old girl, chronic diarrhea was the main manifestation.</div></div><div><h3>Conclusion</h3><div>This case illustrates the diagnostic complexity of polyarteritis nodosa due to non-specific symptoms and atypical presentation such as diarrhea, underscoring the importance for early recognition and intervention.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102174"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147453994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silicone breast implant-related illness or breast implant-related “ASIA” syndrome: Expert consensus","authors":"Andrés A. Hormaza-Jaramillo ,&nbsp;Damaris Romero Chamorro ,&nbsp;Yeison Santamaría Alza ,&nbsp;Alejandro Duque Restrepo ,&nbsp;David Enrique Guarín Sastre ,&nbsp;Jaime Eduardo Pachón Suárez ,&nbsp;María Isabel Cadena Ríos ,&nbsp;Diana Rocío Gil Calderón ,&nbsp;Daniel G. Fernández-Ávila ,&nbsp;Felipe Mesa Betancur ,&nbsp;Gloria María Vásquez D. ,&nbsp;Héctor Ernesto Barbosa Landínez ,&nbsp;Adriana Rojas-Villarraga","doi":"10.1016/j.rcreue.2026.102186","DOIUrl":"10.1016/j.rcreue.2026.102186","url":null,"abstract":"<div><h3>Introduction</h3><div>Breast augmentation surgeries are very common, but in recent years there has been a growing interest in their possible relationship with the appearance of nonspecific symptoms and signs, as well as the development of autoimmune disorders. The lack of a consensus about the syndrome is a controversial issue for the scientific community and generates uncertainty among women with breast implants in Colombia.</div></div><div><h3>Objective</h3><div>To provide guidelines for the evaluation, approach, and follow-up of silicone breast implant-related disease, or ASIA syndrome, based on evidence and clinical expert opinion.</div></div><div><h3>Methods</h3><div>Experts from the Colombian Society of Rheumatology and the Colombian Society of Plastic Surgery and an independent methodological team developed a systematic literature review and consensus using a modified Delphi method.</div></div><div><h3>Results</h3><div>The evidence for an association between silicone breast implants and the development of symptoms, autoimmune or rheumatic diseases is limited, and a definitive causal relationship has not been demonstrated. The low certainty of the evidence is due to bias, study heterogeneity, and non-specific, self-reported symptoms. On this basis, 22 consensus statements were formulated, highlighting the importance of an individualized medical approach, comprehensive evaluation, and effective communication with patients about risks and expectations before implantation and explantation procedures.</div></div><div><h3>Conclusions</h3><div>Evaluation and therapeutic decisions in women with suspected silicone implant-associated disease should be based on available scientific evidence. Future research should explore the causality of the syndrome and improve disease characterization.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102186"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147453989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can cardiovascular risk factors affect the result of nailfold videocapillaroscopy? A retrospective multicentre study","authors":"Eva Álvarez Andrés ,&nbsp;Eugenio de Miguel ,&nbsp;Laura Nuño Nuño ,&nbsp;Paloma García de la Peña Lefebvre ,&nbsp;Itsaso Losantos ,&nbsp;Alejandro Balsa ,&nbsp;Paloma Turiel ,&nbsp;Nuria Garvin ,&nbsp;Manuel Beladiez ,&nbsp;Camila Tapia ,&nbsp;Cristina Zamora ,&nbsp;Ana Belén Rodriguez ,&nbsp;Clara Sangüesa ,&nbsp;Patricia López ,&nbsp;Rocío Mustienes ,&nbsp;Ana Cruz","doi":"10.1016/j.rcreue.2026.102171","DOIUrl":"10.1016/j.rcreue.2026.102171","url":null,"abstract":"<div><h3>Objectives</h3><div>Nailfold capillaroscopy (NC) is used in the study of Raynaud’s phenomenon (RPh). Many people have cardiovascular risk factors (CVRF): tobacco (TOB), diabetes (DM), alcohol (ALC), dyslipidaemia (DL), arterial hypertension (HT), and obesity (OBE). The objective of the work was to investigate whether CVRF produce capillaroscopic alterations, which could influence their final interpretation.</div></div><div><h3>Methods</h3><div>Multicentre descriptive retrospective study of patients referred to CP consultation for RPh or suspected connective tissue disease in two Madrid hospitals between 2015 and 2018. 200x videocapillaroscopy (Dinolite®) was used. Analytical, clinical, therapeutic variables, CVRF, and capillaroscopic alterations (tortuosities, ramifications, dilations, giant capillaries, decreased density, and haemorrhages) were collected. For the statistical study, parametric and non-parametric tests were used (statistical significance at p &lt; .05).</div></div><div><h3>Results</h3><div>340 medical records were reviewed, 286 (84.1%), mean age of 52.36±16.97 years; 270 had RPh (79.4%) and 212 (62.4%) CVRF: 108 TOB (31.8%), 108 DL (31.8%), 62 H T (18.2%), 20 DM (5.8%), 8 ALC (2.4%). Three groups were formed: 155 primary RPh (45.6%), 123 with connective tissue disease (36.2%) and 62 with other osteoarticular diseases (18.2%). The statistical study showed an association between all capillaroscopic alterations and CVRF (p &lt; .001), as well as between: decreased density with HT (p = 0.006); tortuosities with HT (p &lt; .001) and hypercholesterolaemia (p = .006); Dilations, ramifications, haemorrhages with HT (p &lt; .001, p = .019, and p = .008) and TOB (p &lt; .001, p = .019, and p = .002); giant capillaries with TOB (p = .034).</div></div><div><h3>Conclusions</h3><div>This work shows the association between capillaroscopic alterations and CVRF, which should be considered for correct CP interpretation.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102171"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147454083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relapses in idiopathic inflammatory myopathies: a perspective from the Colombian clinical experience","authors":"Andrés Hormaza-Jaramillo","doi":"10.1016/j.rcreue.2026.504881","DOIUrl":"10.1016/j.rcreue.2026.504881","url":null,"abstract":"","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 504881"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147454075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}