中华神经医学杂志最新文献

{"title":"Myeloperoxidase anti-neutrophil cytoplasmic antibody positive hypertrophic cranial pachymeningitis with elevated serum immunoglobulin 4: one case report","authors":"Weina Guo, Na Li, Wei Jin, Junshu Gao, Hezheng Zhang","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.11.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.11.014","url":null,"abstract":"","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"76 1","pages":"1155-1158"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91148108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial Rosai-Dorfman disease misdiagnosed as meningioma: one case report and literature review","authors":"Delin Wang, Z. Qiu, Sheng Chen","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.11.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.11.015","url":null,"abstract":"","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"81 1","pages":"1159-1160"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84323665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in cerebral organoids","authors":"Jing Lu, Dongmei Zhang, Qingxia Huang, Tianye Lan, Peng Xu, Jian Wang","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.10.022","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.10.022","url":null,"abstract":"The 3D human brain organ is an in vitro cultured organ that can be implemented by a researcher in recent years in a standard tissue culture chamber. Its growth and development is very similar to the endogenous developmental program of the human brain. The 3D human brain organs can promote people's understanding of human brain characteristics, and thus, conduct more in-depth research on human brain neuropsychiatric diseases. This is a review of the development, application, obstacles and prospects of 3D human brain organs. \u0000 \u0000 \u0000Key words: \u00003D in vitro culture; Cerebral organoid; Alzheimer's disease","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"81 1","pages":"1076-1078"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78639606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal cord stimulation and pulsed radiofrequency in treatment of herpes zoster neuralgia in the elderly","authors":"Zhongyi Zhang, L. Sima, Bo-tao Liu, B. Fan","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.10.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.10.010","url":null,"abstract":"Objective \u0000To investigate the efficacies and differences of spinal cord stimulation (SCS) and pulsed radiofrequency (PRF) in the treatment of herpes zoster neuralgia in the elderly. \u0000 \u0000 \u0000Methods \u0000Sixty-three patients with herpes zoster neuralgia over 50 years old, admitted to our hospital from January 2018 to January 2019, were divided into SCS group (n=31) and PRF group (n=32) by prospective, randomized and controlled study. The stimulating electrodes were placed in epidural spinal ganglion segment for two weeks after percutaneous puncture in SCS group. In the PRF group, the radiofrequency needles were percutaneously punctured to the dorsal root ganglion under the guidance of X-ray. After the location of contrast medium was confirmed, each target was treated by pulsed radiofrequency for 360 seconds, followed by anti-inflammatory compound liquid injection. Numeric Rating Scale (NRS) scores, effective rate (percentage of patients having pain relief>50%) and complete relief rate (percentage of patients having NRS scores≤3) before, and one, 4, 12 and 24 weeks after operation of the patients from the two groups were recorded. Use of analgesics and calcium channel antagonists of the patients from the two groups were compared. \u0000 \u0000 \u0000Results \u0000NRS scores of patients from the two groups after operation were significantly lower than those before operation (P 0.05). The effective rates of pain treatment of patients from the two group reached to 56.67%-81.25%, and there was no significant difference between the two groups at each time point (P>0.05). The complete pain relief rate reached to 37%-71% in the two groups, and there was no significant difference between the two groups at each time point (P>0.05). Number of patients used analgesics and calcium channel antagonists before and after operation in the two groups showed significant differences (χ2=20.917, P=0.000; χ2=18.273, P=0.000), and number of patients used analgesics and calcium channel antagonists 4, 12 and 24 weeks after operation in the two groups was significantly smaller than that before operation (P 0.05). \u0000 \u0000 \u0000Conclusion \u0000SCS and PFR can effectively treat herpes zoster neuralgia and reduce the incidence of sequelae, without no significant difference in the clinical efficacy. \u0000 \u0000 \u0000Key words: \u0000Herpes zoster neuralgia; Spinal cord stimulation; Pulsed radiofrequency","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"1 1","pages":"1025-1030"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90749886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in triggering receptor expressed in myeloid 2 and its role in Alzheimer's disease","authors":"Jinhuan Ning, Zhao-ji Liu, Jingzhou Li, D. Can","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.10.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.10.017","url":null,"abstract":"Mutations in the triggering receptor expressed in myeloid 2 (TREM2) gene have recently been found to be closely related to the development of Alzheimer's disease (AD) and other neurodegenerative diseases. However, the detailed mechanism underlying TREM2’s participation in the pathogenesis of AD and other diseases has yet to be fully elucidated. In this review, we discuss current understanding on the structure and function of TREM2, the relevance between TREM2 and AD, and the possible causes of AD by TREM2 mutations. \u0000 \u0000 \u0000Key words: \u0000Alzheimer's disease; Triggering receptor expressed in myeloid 2; DAP12","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"10 1","pages":"1049-1053"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90783039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of moderate to severe leukoaraiosis in prognoses of acute ischemic stroke patients after endovascular treatment","authors":"Chao-chao Jiang, Yaxing Lyu, Beilei Chen, Jian Jing, Jun Li","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.10.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.10.002","url":null,"abstract":"Objective \u0000To investigate the influence of moderate to severe leukoaraiosis (LA) in prognoses of acute ischemic stroke patients after endovascular treatment. \u0000 \u0000 \u0000Methods \u0000From January 2017 to December 2018, 60 patients with acute ischemic stroke due to anterior circulation large vessel occlusion underwent endovascular treatment and obtained complete vessel recanalization in our hospital were evaluated for degrees of LA severity according to head CT scan and van Swieten scale (2-4 scores were defined as moderate-severe LA). According to modified Rankin scale (mRS) scores 90 d after treatment, the patients were divided into poor prognosis group and good prognosis group. Univariate analysis was used to compare the differences of influencing factors of the two groups. Multivariate Logistic regression analysis was further used to explore the influence of moderate to moderate-severe LA in poor prognosis of patients after endovascular treatment. \u0000 \u0000 \u0000Results \u0000Of the 60 patients, 18 did not have LA, 19 had mild LA, and 23 had moderate-severe LA; 32 had poor prognosis and 28 had good prognosis. Univariate analysis showed that the patients from the poor prognosis group had significantly higher proportion of moderate-severe LA (59. 4% [19/32] vs. 14.3% [4/28]), significantly higher baseline National Institutes of Health Stroke Scale (NIHSS) scores ([23.4±10.1] vs. [14.7±7.0]), significantly higher baseline diastolic blood pressure ([87.5±18.9] mmHg vs. [78.3±15.1] mmHg), significantly higher proportion of patients with hypertension history (68.8% [22/32] vs. 42.9% [12/28]), and statistically older age ([70.6±9.4] years vs. [61.3±12.5] years) than the patients from the good prognosis group (P<0.05). On multivariable Logistic regression analysis, the presence of moderate-severe LA (OR=5.032, 95%CI: 1.026-24.679, P=0.046) and baseline NIHSS scores were independent risk factors for poor prognosis of patients after endovascular treatment. \u0000 \u0000 \u0000Conclusion \u0000Patients with acute ischemic stroke accompanied with moderate-severe LA are more likely to have poor prognosis after endovascular treatment. \u0000 \u0000 \u0000Key words: \u0000Leukoaraiosis; Ischemic stroke; Endovascular treatment; Prognosis","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"20 1","pages":"980-984"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88316054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of degrees of leukoaraiosis severity with prognoses of patients with acute anterior circulation large-artery occlusive stroke after mechanical thrombectomy","authors":"Z. Shi, Sujie Zheng, Tianming Shi, Jie Pan, Y. Geng","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.10.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.10.001","url":null,"abstract":"Objective \u0000To assess whether degrees of leukoaraiosis (LA) severity is associated with prognoses of patients with acute anterior circulation large-artery occlusive stroke after mechanical thrombectomy. \u0000 \u0000 \u0000Methods \u0000Clinical data of patients with acute anterior circulation large-artery occlusive stroke who underwent mechanical thrombectomy in our hospital from January 2016 to August 2017 were collected. The subjects were divided into non-to-moderate LA group and severe LA group according to preoperative degrees of LA severity; the baseline data, successful reperfusion rate, and symptomatic intracranial hemorrhage rate within 24 h of surgery, good prognosis rate 90 d after surgery(modified Rankin scale [mRS] scores≤2) and mortality 90 d after surgery were analyzed. According to the prognoses, the patients were divided into good prognosis group and poor prognosis group; univariate regression analysis and multivariate Logistic regression analysis were used to evaluate the relations of degrees of LA severity with prognoses 90 d after surgery. \u0000 \u0000 \u0000Results \u0000In these 146 patients, 100 patients were into the non-to-moderate LA group and 46 patients were into the severe LA group. As compared with patients in the non-to-moderate LA group, patients in the severe LA group had significantly older age (70.50 [59.75, 79.75] years vs. 79 [73, 82] years), significantly higher baseline NIHSS scores (20[16, 25]) vs. 22 [18, 28]), significantly higher rate of symptomatic intracranial hemorrhage 24 h after surgery (11.0% [11/100]) vs. 26.1% [12/46]), statistically higher mortality rate 90 d after surgery (14.0%[14/100]) vs. 14.0% [14/46]), significantly lower successful reperfusion rate (97.0% [97/100] vs. 84.8% [39/46]), and statistically lower good prognosis rate (54.0% [54/100] vs. 21.7% [10/46], P<0.05). Among the 146 patients, 64 had good prognosis and 82 had poor prognosis; univariate analysis showed that as compared with than those from the good prognosis group, patients from the poor prognosis group had significantly older age (70.50 [59.75, 79.75] years old vs. 79 [73, 82] years old) and statistically higher baseline NIHSS scores (20 [16, 25] vs. 22 [18, 28]), and significantly higher proportion of central source embolism by TOAST etiology classification (68.8% [44/64] vs. 76.8%[63/82]) and proportion of severe LA (15.6% [10/64] vs. 43.9% [36/82], P<0.05); multivariate Logistic regression analysis showed that severe LA (OR=3.109, 95%CI: 1.241-7.788, P=0.015), age, baseline NIHSS scores, and TOAST etiology classification were all independent risk factors for poor prognosis 90 d after surgery (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Severe LA may be associated with poor prognosis of patients with acute anterior circulation large-artery occlusive stroke after mechanical thrombectomy. \u0000 \u0000 \u0000Key words: \u0000Ischemic stroke; Thrombectomy; Leukoaraiosis; Prognosis","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"105 1","pages":"973-979"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72972180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in association between ring finger protein 213 gene p.R4810K and moyamoya disease","authors":"X. Ni, Wen-jun Xu","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.10.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.10.018","url":null,"abstract":"Moyamoya disease (MMD) is a chronic progressive steno-occlusive vasculopathy that involves terminal portions of the bilateral internal carotid arteries and/or the initial segment of the middle cerebral arteries and/or the initial segment of the anterior cerebral arteries. Ring finger protein 213 gene (RNF213) is considered as the major susceptibility gene of MMD. RNF213 p.R4810K is mainly distributed in East Asians and is the founder variant of Asian patients with MMD. RNF213 p.R4810K is associated with the incidence, prevalence, severity of illness and clinical manifestations of MMD. The biochemical mechanisms of RNF213 p.R4810K are still unclear and may affect angiogenesis of endothelial cells through both cell cycle-dependent and cell cycle-independent mechanisms. This paper reviews the research progress of RNF213 p.R4810K and the related mechanisms in MMD. \u0000 \u0000 \u0000Key words: \u0000Moyamoya disease; Ring finger protein 213 gene p.R4810K; Genetics","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"23 1","pages":"1054-1059"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90977183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of post-stroke depression with tryptophan hydroxylase 2 rs4641528 polymorphism and risk factors of post-stroke depression","authors":"Jia Hu, Zhiming Zhou, Qian Yang, Wanli Dong, Junfeng Xu","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.10.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.10.003","url":null,"abstract":"Objective \u0000To investigate the association of post-stroke depression (PSD) with tryptophan hydroxylase 2 (TPH2) gene polymorphism and related clinical risk factors of PSD. \u0000 \u0000 \u0000Methods \u0000Three hundred and seventy-six patients diagnosed as having acute ischemic stroke for the first time, admitted to our hospital from March 2015 to September 2017, were chosen in our study. According to Hamilton depression scale scores and Diagnostic and statisistical Manual of Mental Disorders, fourth edition (DSM-IV), these patients were divided into PSD group and non-PSD group. High-resolution melt analysis was used to complete the genotyping of TPH2 gene rs4641528 and rs1386494 in the enrolled patients. The correlations of single nucleotide polymorphisms and PSD were analyzed. Logistic regression analysis was performed on items with statistically significant differences in univariate analysis to identify independent factors affecting PSD. \u0000 \u0000 \u0000Results \u0000There were 104 patients into the PSD group and 272 patients into the non-PSD group; there were statistically significant differences between the two groups in years of education and NIHSS scores (P 0.05); there were significant differences in rs4641528 genotype and allele frequency between the two groups (P> 0.05). The C allele in the chromosomes of PSD patients accounted for 54.3%, while the C allele in the chromosomes of non-PSD patients accounted for 43.4%; the presence of allele (C) increased the risk of PSD (OR=1.552, 95%CI: 1.126-2.141, P=0.007). The results of multivariate Logistic regression analysis showed that baseline NIHSS scores and genotypes of rs4641528 (C/C+C/T) were independent influencing factors of PSD. \u0000 \u0000 \u0000Conclusion \u0000TPH2 rs4641528 gene polymorphism and baseline NIHSS scores are found to be associated with depression 3 months after stroke in south Anhui province. \u0000 \u0000 \u0000Key words: \u0000Stroke; Post-stroke depression; Tryptophan kinase 2; Gene polymorphism","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"2 1","pages":"985-990"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74336348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and evaluation of malnutrition risk prediction and scoring system in Parkinson's disease patients","authors":"Xue-qi Wang, Li-xiang Zhang, Chi Xiong, Hong-xia Zhuang, Peng Chen","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.10.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.10.006","url":null,"abstract":"Objective To understand the clinical nutritional status and malnutrition risk factors of Parkinson's disease (PD) patients and construct their risk scoring system. Methods A total of 221 patients with PD admitted to our hospital from January 2015 to January 2019 were enrolled. The nutritional status of the patients was assessed by Mini Nutrition Assessment (MNA), and according to the MNA scores, these patients were divided into well-nourished groups (n=176) and malnourished group (including patients having malnutrition and malnutrition risk, n=45). Single factor analysis and Logistic regression analysis were used to analyze the risk factors; their scoring systems were constructed and Hosmer-Lemeshow goodness of fit test was used. Accuracy and discrimination of evaluation scoring systems were evaluated by area under receiver operating characteristic (ROC) curve. Results A total of 45 patients (20.36%) had malnutrition or risk of malnutrition. Multivariate regression analysis suggested that the course of disease≥9 years, motor symptoms (unified PD rating scale III scores≥54), Hoehn-Yahr (H-Y) staging≥4, daily levodopa equivalent dose≥600 mg, scores of non-motor symptom scale (NMSS) scores≥101, and quality of life (39-item PD questionnaire scores≥81) were independent risk factors for malnutrition in PD patients (P<0.05). The constructed risk scoring system scored from 0 to 30, and Hosmer-Lemeshow goodness of fit test were: χ2=6.259, P=0.618; the area under ROC curve was 0.830 (95%CI: 0.801-0.860); when the predicted score was 14, Yoden index was the largest (0.517), and the sensitivity and specificity were 75.70% and 76.00%, respectively. Conclusions PD patients have a high risk of malnutrition or malnutrition. The risk scoring system based on risk factors has high predictive ability and discriminating ability, and can be used as an important tool for malnutrition risk assessment in PD patients. Key words: Parkinson's disease; Malnutrition; Risk factor; Prediction scoring system","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"2 1","pages":"1001-1005"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72937656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}