中华神经医学杂志最新文献

{"title":"Recent advance in common complications and management after revascularization of moyamoya disease","authors":"Changwen Li, Nan Zhang, C. Xia","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.10.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.10.019","url":null,"abstract":"Moyamoya disease (MMD) is a kind of chronic, occlusive cerebrovascular disease of unknown etiology, characterized by bilateral steno-occlusive changes at the terminal portion of the internal carotid artery and with the development of collateral vessels (Moyamoya vessels) at the base of the brain. Surgical revascularization is an efficient way to treat MMD. But there is rare systemic analysis about complications after revascularization and perioperative management of MMD in the domestic and foreign articles at present. In order to improve the surgical treatment outcomes, and decrease the incidence of complications after revascularization, we review the latest articles about common complications after revascularization of MMD. \u0000 \u0000 \u0000Key words: \u0000Moyamoya disease; Revascularization; Complication","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"47 1","pages":"1060-1064"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82847454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy observation and reconsideration of spontaneous hypertension pontine hemorrhage via microsurgery","authors":"Shangming Zhang, Ming-chao Shang, Lin Zhao, Liangfeng Wei, Bangqing Yuan","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.10.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.10.005","url":null,"abstract":"Objective \u0000To explore the efficacy and experience of surgical approaches of puncture drainage and urokinase thrombolysis for spontaneous hypertensive pontine hemorrhage. \u0000 \u0000 \u0000Methods \u0000The clinical data of 42 patients with spontaneous pontine hemorrhage, admitted to our hospital from January 2014 to December 2018, were retrospectively analyzed. Craniotomy evacuation of hematoma was performed in 18 patients (control group), and puncture drainage and urokinase thrombolysis assisted by neuronavigation was performed in 24 patients (observation group). The clinical efficacies of the two groups were observed and analyzed. \u0000 \u0000 \u0000Results \u0000There were 24 patients having hematoma clearance rate≥50%, including 7 from control group and 17 from observation group. The hematoma clearance rate≥50% in the observation group (70.83%) was significantly higher than that in the control group (38.89%, P 0.05). \u0000 \u0000 \u0000Conclusion \u0000The surgical approach of puncture drainage and urokinase thrombolysis can effectively improve hematoma clearance rate for spontaneous hypertensive pontine hemorrhage, but clinical prognoses are not improved due to influence of multiple factors. \u0000 \u0000 \u0000Key words: \u0000Spontaneous pontine hemorrhage; Puncture drainage and urokinase thrombolysis; Craniotomy evacuation of hematoma","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"14 1","pages":"996-1000"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84860450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior two-thirds or complete corpus callosotomy for treatment of medically drug-resistant epilepsy","authors":"Hong-yu Zhou, Junfeng Ma, Xiao-Lai Ye, Qiangqiang Liu, Changquan Wang","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.10.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.10.008","url":null,"abstract":"Objective \u0000To investigate the extents of corpus callosotomy (CC) resulting in optimal seizure control and compare the efficacies and complications of two CC approaches. \u0000 \u0000 \u0000Methods \u0000Clinical data of 25 patients underwent CC in our hospital from January 2013 to December 2018 were retrospectively analyzed. All 25 patients were diagnosed as having medically refractory epilepsy, and 27 CC procedures were performed. The patients underwent either anterior two thirds CC (n=13) or single-stage complete CC (n=12). Two patients had a second-stage posterior CC in 61 and 36 months after anterior CC, respectively. The efficacies were studied by using two evaluation indexes, the effective rate (worthwhile improvements) and the markedly effective rate (favorable outcomes). \u0000 \u0000 \u0000Results \u0000The average postoperative follow-up time was 2.6 years. In comparison, the markedly effective rate (>75% reduction in seizure frequency or severity) was 71.4% after complete CC and 15.4% after anterior two thirds CC with a statistical significant difference between the two groups (P 50% reduction in seizure frequency or severity) of complete CC (78.6%) was higher than that of anterior two thirds CC (53.8%), but without significant difference (P>0.05). Overall, 66.7% of patients benefited from anterior or complete CC. There were no such complications as intracranial hemorrhage, hydrocephalus, cerebrospinal fluid leakage or postoperative infection. \u0000 \u0000 \u0000Conclusion \u0000Complete CC is more effective for seizure control than anterior two thirds CC; no permanent neurological deficits are observed postoperatively. \u0000 \u0000 \u0000Key words: \u0000Drug-resistant epilepsy; Anterior callosotomy; One-stage total callosotomy","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"55 1","pages":"1014-1018"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81410083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of toll-like receptors in multiple sclerosis and inhibiting effect of cinnamaldehyde on them","authors":"Xin He, Lujun Zhang, Jingyuan Tian","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.10.020","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.10.020","url":null,"abstract":"Toll-like receptors (TLRs) are a kind of transmememal protein receptors, which can aggravate the progress of multiple sclerosis (MS) by mediating inflammatory response, activating microglia cells and inducing their transformation into M1 type, promoting CD4+T cells to differentiate into Th1 and Th17 cells, and inducing the overexpression of nitric oxide synthase (iNOS). Cinnamaldehyde (CA) is the main component of cinnamon, which can inhibit the activity of TLRs and has a significant anti-inflammatory effect, and may play an active role in the treatment of MS. This paper will focus on the relations between TLRs and MS and how CA inhibits TLRs. \u0000 \u0000 \u0000Key words: \u0000Multiple sclerosis; Cinnamaldehyde; Toll-like receptor","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"138 1","pages":"1065-1069"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78515655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in correlation between imaging evaluation before endovascular treatment of acute basilar artery occlusion and clinical prognoses","authors":"Z. Hou, S. Zhang, Z. Shi, Yihan An, Y. Geng","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.10.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.10.004","url":null,"abstract":"Acute basilar artery occlusion (ABAO) has a high rate of disability and mortality, and the key to its treatment is to start reperfusion therapy as early as possible. A number of retrospective studies have found that the good prognosis rate of endovascular treatment of ABAO is related to number of infarction locus, extent of ABAO, vascular occlusion and collateral circulation. Screening patients through imaging evaluation before endovascular treatment may further improve the rate of favorable outcome. This article reviews research progress on the correlation between imaging evaluation before endovascular treatment of ABAO and clinical prognoses. \u0000 \u0000 \u0000Key words: \u0000Basilar artery occlusion; Endovascular treatment; Imaging evaluation; Prognoses","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"42 1","pages":"991-995"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81286649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in clinical application of deep brain stimulation","authors":"Xufeng Pan, Guofeng Yu","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.09.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.09.016","url":null,"abstract":"Deep brain stimulation is widely used for treatment of neuropsychiatric diseases, showing its unique advantages in the treatment of central nervous diseases, such as epilepsy, Parkinson's disease, essential tremor, drug-refractory psychiatric diseases, drug-refractory pain, improvement of arousal and cognitive functions, and addiction diseases. After more than 30 years of clinical research, animal experiments and material research, the scopes and modes of DBS use have been fully developed, and important progress has been made in seeking better stimulation targets and modes. The complexity and individuality of the disease lead to differences in the response of each patient to DBS treatment, so it is necessary to further clarify its mechanism of action and explore better therapeutic targets and parameters to meet higher clinical requirements. This paper reviews the clinical application of DBS as follows. \u0000 \u0000 \u0000Key words: \u0000Deep brain Stimulation; Nervous system disease; Psychiatric disease; Disorder of consciousness; Pain","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"60 1","pages":"957-961"},"PeriodicalIF":0.0,"publicationDate":"2019-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77230270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in role of macrophage migration inhibitory factor in the central nervous system","authors":"Jing Yang, Yueqian Zhu, Hong-ting Zhao","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.09.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.09.015","url":null,"abstract":"Macrophage migration inhibitory factor (MIF) is involved in a variety of physiological and pathological processes. Pathological increase of MIF is sufficient to promote inflammation, aggravate metabolic dysfunction, and increase oxidative stress. MIF inhibition, through either gene knockout or pharmacological inhibitors, is clinically beneficial for treatment. Ironically, both detrimental and beneficial effects of MIF have been reported in ischemic stroke, neurodegenerative diseases, and spinal cord injury; thus, the roles of MIF appear to be bidirectional in the central nervous system. In the current review, we focus on the roles of MIF in the central nervous system, as well as its regulating mechanisms. \u0000 \u0000 \u0000Key words: \u0000Macrophage migration inhibitory factor; Central nervous system; Ischemic stroke; Spinal cord injury","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"30 1","pages":"952-956"},"PeriodicalIF":0.0,"publicationDate":"2019-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80859640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic roles of telomerase reverse transcriptase promoter mutation and 1p/19q co-deletion in newly-diagnosed O6-methylguanine-DNA methyltransferase promoter un-methylated/isocitrate dehydrogenase wild-type glioblastoma multiform","authors":"Q. Lu, Xiwei Zhang, Yang Wang, Xiaofang Sheng, Xueyong Wu, Xiaobai Wei, Hongyuan Gao, Xiaofeng Yin, F. Xie, Yueming Zhu, Z. Jin, Zhenghua Zhang, Haimin Wei, Dan Li, R. Huang, Xiang-Yu Wang, F. Xiao","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.09.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.09.004","url":null,"abstract":"Objective \u0000To explore the prognostic values of telomerase reverse transcriptase promoter (TERTp) mutation and 1p/19q co-deletion in newly-diagnosed O6-methylguanine-DNA methyltransferase (MGMT) promoter un-methylated/isocitrate dehydrogenase (IDH) wild-type glioblastoma multiform (GBM). \u0000 \u0000 \u0000Methods \u0000A total of 82 patients pathologically newly-diagnosed MGMT promoter un-methylated/IDH wild-type GBM, admitted to our hospitals from March 2016 to November 2018, were included in this study. TERTp mutations (TERTp wild-type and TERTp mutation [C228 mutation and C250 mutation]) in GBM specimens were detected by PCR sequencing, 1p/19q co-deletion in GBM specimens was detected by fluorescence in situ hybridization (FISH), and clinical data, adverse reactions and prognoses of patients with different molecular typing were compared. \u0000 \u0000 \u0000Results \u0000There were 33 patients in the TERTp wild type group with mean age of 48 years, and 49 patients in the TERTp mutation group with mean age of 59 years; the difference of age was significant (P 0.05). There were 8 patients with 1p/19q co-deletion and 74 patients without 1p/19q co-deletion; no significant differences in above clinical parameters were noted between the two groups. There were no statistically significant differences in the incidences of bone marrow suppression, digestive tract response and fatigue, disease progression rate, or survival rate between patients from TERTp wild type group and TERTp mutation group, and between patients with 1p/19q co-deletion and patients without 1p/19q co-deletion (P>0.05). No significant differences in above clinical parameters, disease progression rate, and survival rate were noted between patients with C228 mutation and C250 mutation (P>0.05). \u0000 \u0000 \u0000Conclusion \u0000TERTp typing and 1p/19q co-deletion status do not have prognostic value in newly-diagnosed MGMT un-methylated/IDH wild-type GBM patients; patients with TERTp mutations have older age than wild-type patients; patients with C250 mutation trend to have higher survival rate than those with C228 mutation. \u0000 \u0000 \u0000Key words: \u0000Glioblastoma; O6-methylguanine-DNA methyltransferase; Isocitrate dehydrogenase; Telomerase reverse transcriptase promoter mutation and lp/19q co-deletion","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"77 1","pages":"896-903"},"PeriodicalIF":0.0,"publicationDate":"2019-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75053627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in factors related to efficacy and complications of gamma knife in treating trigeminal neuralgia","authors":"Dongli Liu","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.09.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.09.019","url":null,"abstract":"Gamma knife has the characteristics of high effectiveness, high safety and less complications in the treatment of primary trigeminal neuralgia. It can be used as the first treatment and repeated treatment. The treatment parameters such as irradiation dose, irradiation position, and irradiation length of the gamma knife can affect the efficacy and complications. In addition, the optimal treatment time, related treatment history and other clinically relevant factors of the patients need further research. This article reviews the factors related to the efficacy and complications of gamma knife treatment. \u0000 \u0000 \u0000Key words: \u0000Gamma knife; Trigeminal neuralgia; Curative effect; Complication; Related factor","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"53 1","pages":"969-972"},"PeriodicalIF":0.0,"publicationDate":"2019-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86764327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of cerebral microbleeds with intracranial aneurysm rupture and hemorrhage","authors":"Xi-feng Li, C. Duan, Xin Zhang, Wenchao Liu, Shenquan Guo","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.09.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.09.007","url":null,"abstract":"Objective \u0000To evaluate the effect of cerebral microbleeds (CMBs) on intracranial aneurysm rupture and hemorrhage. \u0000 \u0000 \u0000Methods \u0000A total of 2023 patients with intracranial single aneurysms (944 un-ruptured aneurysms and 1029 ruptured aneurysms) were enrolled in our study. The 3D-DSA was applied to all patients to evaluate the aneurysm sizes, locations, and morphous features, and to confirm the presence of A1 dominance and variations of Circle of Willis; moreover, aspect ratio (AR), size ratio (SR) and aneurismal inclination angle were measured. The presence of CMBs identified by T2-weighted gradient-recalled-echo sequence on magnetic resonance imaging (MRI) was evaluated; the clinical data of combined with/without CMBs patients were compared. Ninety-two untreated intracranial aneurysms patients combined with CMBs were followed up to evaluate the incubation periods of CMBs-related intracranial aneurysm rupture and hemorrhage; the clinical data of patients with un-ruptured aneurysms and ruptured aneurysms were compared; the risk factors of intracranial aneurysm rupture and hemorrhage were analyzed by univariate and multivariate Logistic regression analyses. \u0000 \u0000 \u0000Results \u0000CMBs confirmed by MR imaging were presented in 158 patients, with 7.81% incidence rate (158/2023). Age, proportion of smokers, aneurysm inclination Angle, SR, narrow neck, irregular aneurysm shape, proportion of rupture and hemorrhage, aneurysm sites, and hypertension showed significant differences between patients without CMBs and patients with CMBs (P<0.05). In the untreated intracranial aneurysms patients combined with CMBs, 27 had intracranial aneurysm rupture and 65 did not appear intracranial aneurysm rupture; the rupture time was 3-46 months, with an average of (15.07±10.76) months. As compared with the un-ruptured group, the ruptured group had a statistically higher proportion of patients with irregular aneurysm morphology (P<0.05). Univariate analysis showed that CMBs, female, age, aneurysm size, aneurysm morphology, ICA and ACA aneurysms, AR, variations of Circle of Willis, hypertension grading II and III, diabetes mellitus with fasting blood glucose≤6.0 mmol/L, hyperlipidemia, coronary heart disease, and drinking alcohol were important factors affecting intracranial aneurysm rupture, and the differences were statistically significant (P<0.05). Multivariate Logistic regression analysis showed that CMB was an independent risk factor for intracranial aneurysm rupture and hemorrhage; as compared with patients without CMBs, patients with CMBs had a 1.75 fold increased risk of aneurysm rupture. \u0000 \u0000 \u0000Conclusions \u0000Patients with intracranial aneurysms with older age, smaller aneurysm inclination Angle and larger SR are more likely to be associated with CMBs. Intracranial aneurysms with CMBs patients with irregular morphology are prone to have rupture and hemorrhage. CMBs is an independent risk factor for intracranial aneurysm rupture and hemorrhage. \u0000 \u0000 \u0000Key words: \u0000Intracranial a","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"45 1","pages":"914-921"},"PeriodicalIF":0.0,"publicationDate":"2019-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88164251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}