中华神经医学杂志最新文献

{"title":"Comparison of clinical characteristics of anti-N-methyl-D-aspartate receptor encephalitis with positive and negative anti-thyroid antibodies","authors":"Shuang Zhang, Lulu Yan, Xiaoxue Huang, Yao-Mao Tang","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.009","url":null,"abstract":"Objective \u0000To summarize and compare the clinical characteristics of anti N-methyl-D-aspartate (NMDA) receptor encephalitis with positive and negative anti-thyroid antibodies (ATAbs), and explore the clinical characteristics and possible mechanism of anti-NMDA receptor encephalitis with positive ATAbs. \u0000 \u0000 \u0000Methods \u0000The clinical data of 53 patients with definitely diagnosed anti-NMDA receptor encephalitis, admitted to our hospital from January 2016 to April 2019, were collected. The patients were divided into two groups according to positive and negative ATAbs, and the clinical characteristics, experimental results and prognoses of the two groups were compared. \u0000 \u0000 \u0000Results \u0000Among the 53 patients, 16 were combined with positive ATAbs, of which 11 were female (68.8%); 37 were combined with negative ATAbs, of which 11 were female (29.7%); number of female patients in the positive ATAbs group was significantly larger than that in the negative ATAbs group (P 0.05). There were no significant differences in prodromal manifestations, first symptoms (abnormal mental behavior or cognitive impairment, and epilepsy), main clinical manifestations, and incidence of complications between the two groups (P>0.05). As compared with the negative ATAbs group, positive ATAbs group had significantly higher maximum modified Rankin scale scores (4[4, 5] vs. 3[2, 5]), abnormal rate of rheumatic immunity antibodies (50.0% vs. 13.6%), and rate of adopting two or more immunotherapy measures (93.7% vs. 51.4%; P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The clinical manifestations of anti-NMDA receptor encephalitis in the positive ATAbs patients are similar to those in the negative ATAbs patients, but the illness is more serious; moreover, the positive ATAbs patients are mostly combined with multiple antibody abnormalities, which may require more active immunotherapy. \u0000 \u0000 \u0000Key words: \u0000Encephalitis; Anti-thyroid antibody; Hashimoto's encephalopathy; Autoantibody","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"110 1","pages":"164-169"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85783810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stent sticking during mechanical thrombectomy with retrievable stent for acute vertebrobasilar artery occlusion: one case report","authors":"Xudong Su, Dongjing Yao, Zengpin Liu, Cunhe Zhou","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.017","url":null,"abstract":"","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"3 1","pages":"200-201"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90375021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in treatment of persistent posture-perceived dizziness","authors":"Xiyu Zhao, Wei-zhen Yue","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.021","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.021","url":null,"abstract":"Persistent posture-perceived dizziness is a chronic functional vestibular disorder, which is characterized with persistent non-vertigo dizziness and unsteady for more than 3 months. Its possible pathogeneses include overlapping mechanism of vestibular pathways and anxiety-related neural networks, classical and operant conditioning, failure of re-adaptation, changes in brain activity areas, and molecular pathological mechanisms. Current treatments include psychotherapy, medication, vestibular and balance rehabilitation therapy, cognitive behavioral therapy, and non-invasive vagus nerve stimulation for refractory persistent posture-perceived dizziness. This paper mainly focuses on the above contents and summarizes as follows. \u0000 \u0000 \u0000Key words: \u0000Dizziness; Vestibular balance rehabilitation; Non-invasive vagus nerve stimulation","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"1 1","pages":"214-216"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88156960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo study of resveratrol regulating Wnt signaling pathway to enhance temozolomide against gliomas","authors":"Sen Hu, Jun‐yi Wang, Nianxuan Li, X. Bu, Zhao-yue Yan, Bang‐qing Wang, Yu-Shuai Gao","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.007","url":null,"abstract":"Objective \u0000To investigate the effect of resveratrol (Res) on temozolomide (TEM) against gliomas in vivo. \u0000 \u0000 \u0000Methods \u0000Human glioma cell line T98G was transplanted into BALB/C-nu female nude mice to establish orthotopic human glioma cell transplanted models. Five d after modeling, the 48 successfully modeled nude mice were randomly divided into solvent control group, Res group, TEM group, combination drug group, Wnt signaling pathway agonist group, and Wnt signaling pathway inhibitor group(n=8); and dimethyl sulfoxide (10 mg/kg), Res (10 mg/kg), TEM (25 mg/kg), Res (10 mg/kg+TEM (25 mg/kg), Res (10 mg/kg)+TEM (25 mg/kg)+lithium chloride (2 mg/kg), and Res (10 mg/kg)+TEM (25 mg/kg)+IWR-1 (5 mg/kg) were given, respectively, once/d for 30 d. During the administration, the survival status of nude mice in each group was continuously observed, tumor volume was measured by MR imaging every 5 d. Thirty d after administration, TUNEL was used to detect the apoptosis of tumor cells, and immunofluorescence was used to detect the immunofluorescent intensity of O6-methylguanine-DNA methyltransferase (MGMT) and β-catenin in the tumor tissues. Western blotting was used to detect the protein expression levels of Wnt signaling pathway-related proteins (Wnt2, and β-catenin), MGMT, and glycogen synthase kinase 3β (GSK3β). \u0000 \u0000 \u0000Results \u0000As compared with the TEM group, the combination drug group and Wnt signaling pathway inhibitor group had significantly decreased tumor volumes 20, 25, 30, and 35 d after modeling (P<0.05); as compared with the combination drug group, the Wnt signaling pathway inhibitor group had significantly decreased tumor volumes while Wnt signaling pathway agonist group had significantly increased tumor volumes 20, 25, 30, and 35 d after modeling (P<0.05). TUNEL showed that the apoptosis rate of tumor cells in the combination drug group and Wnt signaling pathway inhibitor group was significantly increased as compared with that in the temozolomide group (P<0.05); as compared with that in the TEM group, the apoptosis rate of tumor cells in the Wnt signaling pathway inhibitor group was significantly increased while that in the Wnt signaling pathway agonist group was statistically decreased (P<0.05). Western blotting results showed that as compared with those in the combination drug group, the protein expression levels of Wnt2, β-catenin, and MGMT in the Wnt signaling pathway inhibitor group were significantly reduced, and GSK-3β protein expression level was significantly increased; while the protein expression levels of Wnt2, β-catenin, and MGMT in the Wnt signaling pathway agonist group were significantly increased, and GSK-3β protein expression level was significantly decreased (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Res inhibits Wnt signaling pathway by reducing expressions of Wnt2 and β-catenin, leading to decrease in MGMT expression, thereby enhancing the anti-glioma effect of TEM. \u0000 \u0000 \u0000Key words: \u0000Resveratrol; Temozolomide; Wnt signaling pathway; Glioma","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"52 1","pages":"146-153"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90945543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of direct mechanical thrombectomy and bridging therapy for acute anterior circulation large-artery occlusive stroke","authors":"Haibing Ren, Hui-qin Liu, Si-Yang Wang, Jianying Zhang, Wenjin Yang, Xiaohui Zhao, Ke Qing, G. Xiao, Yongjun Cao","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.005","url":null,"abstract":"Objective \u0000To comparatively analyze the safety and efficacy of direct mechanical thrombectomy and bridging therapy for patients with acute anterior circulation large-artery occlusive stroke. \u0000 \u0000 \u0000Methods \u0000A total of 116 patients with acute anterior circulation large-artery occlusive stroke, admitted to our hospitals from October 2015 to March 2018, were chosen in our study; their clinical data were analyzed retrospectively. Among them, 63 patients accepted direct mechanical thrombectomy and 53 accepted bridging therapy. The preoperative baseline data and the diagnoses and treatments of the two groups were analyzed; the degrees of modified thrombolysis in cerebral infarction (mTICI), incidences of hemorrhage transformation and symptomatic intracranial hemorrhage, and modified Rankin scale (mRS) scores and mortality rate 90 d after operation were compared between the two groups. \u0000 \u0000 \u0000Results \u0000The preoperative Alberta stroke program early CT scale (ASPECTS) and Glasgow Coma Scale (GCS) scores of the direct mechanical thrombectomy group were significantly lower than those of the bridge therapy group (P 0.05). \u0000 \u0000 \u0000Conclusion \u0000The clinical efficacy and safety of direct mechanical thrombectomy and bridging therapy for patients with acute anterior circulation large-artery occlusive stroke are similar. \u0000 \u0000 \u0000Key words: \u0000Ischemic stroke; Anterior circulation; Mechanical thrombectomy; Intravenous thrombolysis; Bridging therapy","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"9 1","pages":"131-137"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76134360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microsurgical treatment of hypertensive basal ganglia hemorrhage with moderate blood loss","authors":"Pei-lin Lu, Xu-tao Jiang, Tao Xin","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.013","url":null,"abstract":"","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"11 1","pages":"188-190"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81822087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in mesenchymal stem cell-derived exosomes in treatment of central nervous system diseases","authors":"Yesheng Sun, Zhi-qian Yang","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.018","url":null,"abstract":"The treatment of central nervous system diseases has always been a hot topic, owning to its complexity and existence of blood-brain barrier. In recent years, studies on mesenchymal stem cells-derived exosomes (MSCs-EVS) showed that MSCs-EVS are not only potential therapeutic drugs for central nervous system diseases, but also natural carriers of therapeutic drugs due to their good biocompatibility and ability to cross the blood-brain barrier. This paper reviews the application and underling mechanism of MSCs-EVS in treatment of central nervous system diseases, and looks forward to its applications in central nervous system disease. \u0000 \u0000 \u0000Key words: \u0000Mesenchymal stem cell; Exosome; Central nervous system disease","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"65 1","pages":"202-207"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79434573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative risk factors associated with prognoses of patients with acute ischemic stroke accepted mechanical thrombectomy","authors":"Xiao-Dong Wang, Ya Peng, Li-Min Zhang, Bao-xu Zhang, Lili Yu, Panpan Song, Xu-Peng Wang, Chunxiao Gui, Yongchang Liu, Jia Zhen","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.004","url":null,"abstract":"Objective \u0000To investigate the perioperative risk factors associated with prognoses of patients with acute ischemic stroke accepted mechanical thrombectomy under general anesthesia. \u0000 \u0000 \u0000Methods \u0000The clinical data of 108 patients with acute ischemic stroke, admitted to and accepted mechanical thrombectomy under general anesthesia in our hospital from January 1, 2016 to October 31, 2018, were collected. According to modified Rankin scale (mRS) scores 90 d after surgery, patients were divided into good prognosis group (mRS scores≤2) and poor prognosis group (mRS scores ≥3). Univariate analysis was used to compare the general data (age, gender, body mass index, and underlying diseases) and perioperative conditions (immediate heart rate, systolic and diastolic blood pressures immediately after admission, operative time, and anesthesia time) between the two groups of patients. Multivariate Logistic regression analysis was used to identify the perioperative risk factors influencing the prognoses of patients with acute ischemic stroke accepted mechanical thrombectomy. \u0000 \u0000 \u0000Results \u0000Among the 108 patients, 65 had good prognosis and 43 had poor prognosis. Univariate analysis showed that there was no significant difference in general data between the two groups (P>0.05), but there were significant differences in heart rate immediately after admission, National Institutes of Health Stroke Scale (NIHSS) scores immediately after admission and 3 d after operation, maximum hemoglobin and blood glucose values from immediately after admission to 3rd d of operation, and thrombolysis in myocardial infarction (TIMI) blood flow classification (P<0.05). Multivariate Logistic regression analysis showed that heart rate immediately after admission (OR=1.035, 95%CI: 1.002-1.067, P=0.037) and NIHSS scores 3 d after operation (OR=1.153, 95%CI: 1.016-1.272, P=0.030) were the perioperative risk factors influencing the prognoses of patients with acute ischemic stroke accepted mechanical thrombectomy. \u0000 \u0000 \u0000Conclusion \u0000For patients with acute ischemic stroke who have rapid heart rate immediately after admission and high NIHSS scores 3 d after mechanical thrombectomy, possibility of poor prognosis should be noticed. \u0000 \u0000 \u0000Key words: \u0000Acute ischemic stroke; Mechanical thrombectomy; General anesthesia; Prognosis; Perioperative period; Risk factor","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"46 1","pages":"125-130"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73723986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative ultrasound in microsurgical resection of supratentorial cavernous malformations","authors":"Jin-Zhao Mao, Xiaopeng Li, Gang Li, Anyu Tao, F. Mao, Yibo Ou, Bao-feng Wang, Yue He, Dongsheng Guo","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.010","url":null,"abstract":"Objective \u0000To analyze the application value and clinical experience of intraoperative ultrasound in microsurgical resection of supratentorial cavernous malformations. \u0000 \u0000 \u0000Methods \u0000From March 2018 to March 2019, 31 patients with supratentorial cavernous malformations were operated with assistance of intraoperative ultrasound in our hospital. Intraoperative ultrasound could clearly show the locations and sizes of the lesions, and relations of lesions with surrounding structures to choose appropriate surgical routes. The degrees of resection were judged and complications were recorded. The patients were followed up for 3-6 months, and modified Rankin scale (mRS) was used to evaluate the prognoses. \u0000 \u0000 \u0000Results \u0000In these 31 patients, 35 cavernous hemangiomas were diagnosed by MR imaging before surgery; 33 lesions were removed surgically, and the other two lesions located in the contralateral side of the operative field were not removed. The accuracy of intraoperative ultrasound guiding the lesions was up to 100%. There were no postoperative infections or deaths. During follow-up, mRS score of 28 patients was 0; the other 3 patients with postoperative neurological impairment recovered partially during follow-up. \u0000 \u0000 \u0000Conclusion \u0000With the help of real-time monitoring of intraoperative ultrasound and location technique of small pieces of hemostatic yarn, patients with supratentorial cavernous malformations could acquire satisfactory prognosis through meticulous microsurgery. \u0000 \u0000 \u0000Key words: \u0000Cavernous malformation; Intraoperative ultrasound; Microsurgery","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"37 1","pages":"170-175"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75208567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain derived neurotrophic factor alleviates neuronal injury induced by ropivacaine through threonine protein kinase signaling pathway","authors":"Yulin Zhu, Jingying Liu, Xiangyong Liu","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.008","url":null,"abstract":"Objective \u0000To investigate the protective effect of brain-derived neurotrophic factor(BDNF) on neuronal injury induced by ropivacaine (Rop) and its mechanism. \u0000 \u0000 \u0000Methods \u0000(1) Experiment one: 0, 1, 2, 3, 4 and 5 mmol/L Rop was used to stimulate SH-SY5Y cells for 48 h to induce neuronal injury; the morphological changes of the cells were observed under microscope; MTT assay was used to detect the cell activity; flow cytometry was used to detect the cell apoptosis, and immunohistochemistry was used to detect the expressions of protein kinase B (Akt) and proliferating cell nuclear antigen (PCNA). (2) Experiment two: SH-SY5Y cells were treated with 0, 1, 3, 5, 7 mmol/L Rop, respectively; the cell activity was measured 48 h after Rop treatment; the semi inhibitory concentration (IC50) of Rop was calculated by MTT assay; the SH-SY5Y cells were divided into control group (PBS for 48 h), Rop group (Rop at IC50 for 48 h), BDNF+Rop group (20 μg/L BDNF for 2 h, and Rop at IC50 for 48 h), Akt pathway activator SC79+Rop group (5 mg/L SC79 for 2 h, and Rop at IC50 for 48 h), and BDNF+Akt pathway inhibitor API-2+Rop group (20 μg/L BDNF+10 μmol/L API-2 for 2 h, Rop at IC50 for 48 h); the morphological changes of the cells were observed under microscope; MTT assay was used to detect the cell activity; flow cytometry was used to detect the cell apoptosis, and immunohistochemistry was used to detect the expressions of Akt and PCNA; the expressions of B lymphoma-2 (Bcl-2), Bcl-2-associated X (Bax) and cysteine protease-3 (Caspase-3) were detected by reverse transcription (RT)-PCR and Western blotting. Western blotting was used to detect the expressions of Akt and phosphatidylinositol 3-kinase (PI3K). \u0000 \u0000 \u0000Results \u0000(1) As compared with the 0 mmol/L Rop group, the 1, 2, 3, 4, and 5 mmol/L Rop group had significantly decreased cell activity, significantly increased apoptosis rate, and statistically smaller number of Akt and PCNA positive cells (P<0.05). (2) As compared with the control group, the Rop group had significantly decreased cell activity, statistically increased apoptosis rate, significantly smaller number of Akt and PCNA positive cells, significantly decreased Bcl-2 mRNA and protein expressions, significantly increased Bax and caspase-3 mRNA and protein expressions, and significantly decreased phosphorylated- (p-) Akt and p-PI3K protein expressions; as compared with the Rop group, the BDNF+Rop group and SC79+Rop group had significantly higher cell activity, significantly decreased apoptosis rate, significantly larger number of Akt and PCNA positive cells, significantly increased Bcl-2 mRNA and protein expressions, statistically decreased mRNA and protein expressions of Bax and Caspase-3, and significantly increased p-Akt and p-PI3K protein expressions (P<0.05); as compared with the BDNF+Rop group and SC79+Rop group, the BDNF+API-2+Rop group had significantly lower cell activity, significantly increased apoptosis rate, significantly smaller number of Akt and ","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"56 1","pages":"154-163"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87267857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}