中华神经医学杂志最新文献

{"title":"Intracranial primary Ewing's sarcoma/primitive neuroectodermal tumor with EWS-FLI1 fusion: one case report and literature review","authors":"Feng Ye, Yuanhong Ge, Pingfu Deng, Xiaowei Liu, Ronghua Xu","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.014","url":null,"abstract":"","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"75 1","pages":"191-193"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84788898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of biglycan on neural apoptosis in mice with early brain injury after subarachnoid hemorrhage","authors":"Yuke Xie, Kecheng Guo, Jianhua Peng, Jinwei Pang, Jian Zhou, Long Gu, Lifang Zhang, Shigang Yin, Ligang Chen, Yong Jiang","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.006","url":null,"abstract":"Objective \u0000To investigate the effect of biglycan (BGN) on neural apoptosis in mice with early brain injury (EBI) after subarachnoid hemorrhage (SAH). \u0000 \u0000 \u0000Methods \u0000SAH models were induced by endovascular perforation in young male C57BL/6J mice. (1) Totally, 48 mice were randomly divided into sham-operated group, SAH 6 h group, SAH 12 h group, SAH 24 h group, SAH 48 h group, and SAH 72 h group (n=8); the BGN protein and mRNA expressions were detected by Western blotting and real-time quantitative PCR (qRT-PCR). (2) Totally, 16 mice were randomly divided into sham-operated group and SAH 48 h group (n=8); immunofluorescent double staining was conducted to explore the BGN expression in the neurons of brain tissues. (3) Totally, 24 mice were randomly divided into sham-operated group, sham+control lentivirus group, and sham+BGN lentivirus group (n=8); BGN lentiviral vector and control lentivirus were administered intracerebroventricularly 7 d before sham-operation; qRT-PCR was performed to explore the BGN mRNA expression. (4) Totally, 48 mice were randomly divided into sham-operated group, SAH+control lentivirus group, and SAH+BGN lentivirus group (n=16); BGN lentiviral vector and control lentivirus were administered intracerebroventricularly 7 d before SAH; neurological scores were detected by modified Garcia scale and beam balance tests; TUNEL was used to detect the neuronal apoptosis, and Western blotting was performed to explore the expressions of nuclear transcription factor kappa B (NF-κB) and phosphorylated-(p-) NF-κB. \u0000 \u0000 \u0000Results \u0000(1) Mice in the SAH 48 h group had the highest BGN protein and mRNA expressions, which showed statistical differences as compared with the sham-operated group (P<0.05). (2) A majority of BGN expressions were detected in the neurons 48 h after SAH. (3) The sham+BGN lentivirus group had statistically lower BGN mRNA expression than the sham+control lentivirus group (P<0.05). (4) As compared with those in the SAH+control lentivirus group, both scores of modified Garcia scale and beam balance tests were significantly higher in SAH+BGN lentivirus group (6.125±1.246 vs. 13.000±1.309; 1.125±1.126 vs. 2.875±0.835), and neural apoptosis ratio and ratio of p-NF-κB/NF-κB were significantly lower in the SAH+BGN lentivirus group (51.950%±11.166% vs. 31.938%±7.705%; 1.161±0.156 vs. 0.886±0.142, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Inhibition of BGN can effectively reduce neuronal apoptosis in mice with EBI after SAH, and attenuate neurological deficits. \u0000 \u0000 \u0000Key words: \u0000Subarachnoid hemorrhage; Early brain injury; Biglycan; Neuron; Apoptosis","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"22 1","pages":"138-145"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88639475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of endovascular recanalization 6-24 h after onset in patients with acute basilar artery occlusion","authors":"Z. Hou, Z. Shi, Fang Liu, S. Zhang, Shunyuan Guo","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.002","url":null,"abstract":"Objective \u0000To investigate the efficacy and safety of endovascular recanalization 6-24 h after onset in patients with acute basilar artery occlusion, and explore the related factors for their prognoses. \u0000 \u0000 \u0000Methods \u0000Clinical data of 37 patients with acute basilar artery occlusion, received endovascular recanalization in our hospital from January 2016 to July 2019, were retrospectively collected; 23 patients were into group of onset-to-puncture time (OPT)>6 h (6-24 h), and 14 patients were into group of OPT≤6 h (0-6 h). Statistical methods were used to compare the postoperative symptomatic intracranial hemorrhage rate, good prognosis rate (modified Rankin scale [mRS] scores≤3) and mortality 3 months after onset between the two groups; clinical data between the subgroups with good and poor prognoses in patients of group of OPT>6 h were compared. \u0000 \u0000 \u0000Results \u0000The postoperative symptomatic intracranial hemorrhage rate, and good prognosis rate and mortality of patients from group of OPT>6 h were 30.4%, 47.8% and 43.5%, respectively; and there were no statistically significant differences as compared with those in patients from group of OPT≤6 h (35.7%, 35.7%, and 42.9%, P>0.05). Scores of scales based on preoperative CTA images(posterior circulation-Alberta stroke program early CT scale [pc-ASPECTS], scale of posterior circulation on CTA [pc-CTA], and scale of basilar artery on CTA [BATMAN]) showed significant differences between the good prognosis subgroup and poor prognosis subgroup in patients from group of OPT>6 h (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Endovascular recanalization 6-24 h after onset is effective in patients with acute basilar artery occlusion, and the safety does not obviously decrease; scores of pc-ASPECTS, pc-CTA and BATMAN may be related to the clinical prognoses. \u0000 \u0000 \u0000Key words: \u0000Basilar artery occlusion; Time-window; Endovascular therapy; Curative effect; Safety","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"40 4 1","pages":"113-119"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89152631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of mechanical thrombectomy with Solitaire stent in acute basilar artery occlusion: an analysis of 5 cases","authors":"B. Ren, Haibo Tong","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.003","url":null,"abstract":"Objective \u0000To explore the efficacy and safety of mechanical thrombectomy with Solitaire device in patients with acute basilar artery occlusion (ABAO). \u0000 \u0000 \u0000Methods \u0000The clinical data of 5 patients with ABAO, underwent mechanical thrombectomy with Solitaire stent in our hospital from May 2016 to November 2018, were analyzed retrospectively. The clinical treatment efficacy and safety were recorded. \u0000 \u0000 \u0000Results \u0000All these 5 patients accepted endovascular mechanical thrombectomy successfully; successful recanalization (modified Thrombolysis in Cerebral Infarction [mTICI] grading 2b or 3) was achieved in 4 patients; the embolus was detached to the distal arteriole in one patient. There was no symptomatic intracranial hemorrhage; one patient accepted decompressive craniectomy resulting from massive infarction of cerebellum. Follow up results 90 d after treatment indicated that 4 patients enjoyed good prognosis (modified Rankin Scale scores: 0-3). \u0000 \u0000 \u0000Conclusion \u0000Mechanical thrombectomy with Solitaire device is suggested to be safe and efficient in ABAO patients complying with appropriate operative indications. \u0000 \u0000 \u0000Key words: \u0000Acute basilar artery occlusion; Mechanical thrombectomy; Solitaire stent","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"115 1","pages":"120-124"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89849373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in relation between chronic subdural hematoma and intracranial vein circulation","authors":"Haibing Liu, Jing-fang Hong","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.019","url":null,"abstract":"Chronic subdural hematoma often has occult onset and acute aggravation of neurological deficits, which has complex pathophysiological processes and complex causality relation with intracranial venous system. This paper reviews the researches on the relation between chronic subdural hematoma and intracranial vein circulation in recent years. \u0000 \u0000 \u0000Key words: \u0000Chronic subdural hematoma; Intracranial vein system; Cerebral circulation time; Digital subtraction angiography","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"21 1","pages":"208-210"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74448886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in statins in post-stroke epilepsy","authors":"Y. Li, Zhengli Di, Xurong Zhu","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.020","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.020","url":null,"abstract":"Post-stroke epilepsy (PSE), as one of the common complications after stroke, often seriously affect the quality of life of the survivors. In recent years, more and more studies have found that statins can protect the integrity of blood-brain barrier, alleviate excitotoxic damage of neurotransmitters, reduce neuronal apoptosis, and reduce neuroinflammation, which play a role in brain protection, thereby reducing the risk of PSE. This article reviews the treatment of PSE and application of statins in PSE. \u0000 \u0000 \u0000Key words: \u0000Stroke; Epilepsy; Statins","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"28 1","pages":"211-213"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81025539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute mitochondrial myopathy with respiratory failure and remarkably elevated creatine kinase as predominant manifestations: one case report and literature review","authors":"Q. Tong, Liujun Xue, Lijun Wang, J. Zhen, Zhou Ou, Ming Wei","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.016","url":null,"abstract":"","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"41 1","pages":"197-199"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80566002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult H3 K27M mutant diffuse midline glioma: one case report and literature review","authors":"Kai Wang, P. Zou, Ao Li","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.015","url":null,"abstract":"","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"44 1","pages":"194-196"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83707082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes of functional brain networks and their relations with cognitive function in patients with end-stage renal disease","authors":"Baolin Wu, Zheng Yue, Xuekun Li, Lei Li, Meng Zhang, J. Ren, Wenling Liu, D. Han","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.012","url":null,"abstract":"Objective \u0000To investigate the change patterns of functional brain networks and their relations with cognitive function in patients with end-stage renal disease (ESRD). \u0000 \u0000 \u0000Methods \u0000Sixty-two patients with ESRD (ESRD group), admitted to our hospital from July 2018 to June 2019, and 36 age-, gender-, and education level-matched healthy controls (HC group) were enrolled. Mini-mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Trail Making Test A (TMT-A), TMT-B and Symbol Digit Modalities Test (SDMT) were used to evaluate the cognitive function for all subjects. Resting-state functional magnetic resonance imaging data were acquired; after data preprocessing, the brain functional networks were constructed and the topological parameters were calculated. Statistical methods were used to compare the differences of cognitive function scores and topological parameters between the two groups, and to analyze the correlations between these topological parameters and cognitive function scores in the ESRD group. \u0000 \u0000 \u0000Results \u0000The MMSE, MoCA and SDMT scores of the ESRD group were significantly lower than those of the HC group (P<0.05), and the ESRD group took significantly longer time to complete TMT-A and TMT-B than the HC group (P<0.05). The ESRD group had significantly lower normalized clustering coefficient (γ), small-worldness (σ) and local efficiency (Elocal) values than the HC group (P<0.05). Patients in the ESRD group exhibited significantly decreased nodal efficiency in the paralimbic-limbic network (including the bilateral insula, median cingulate and paracingulate gyri, hippocampus, parahippocampal gyrus, amygdala, temporal pole: superior temporal gyrus, and temporal pole: middle temporal gyrus), right heschl gyrus and left superior temporal gyrus, and exhibited significantly increased nodal efficiency in the visual network (including the right distal-shaped gyrus, bilateral wedge, and left superior and middle occipital gyrus) as compared with the HC group (P< 0.05). In the ESRD group, the area under the curve (AUC) of γ and σwas positively correlated with MoCA scores (r=0.698, P=0.000; r=0.661, P=0.000), and the AUC of Elocal showed positive correlation with MMSE scores (r=0.407, P=0.003). \u0000 \u0000 \u0000Conclusion \u0000Abnormal topological organization of the functional brain networks is revealed in patients with ESRD, which affects the cognitive function of these patients. \u0000 \u0000 \u0000Key words: \u0000End-stage renal disease; Cognitive impairment; Functional brain network; Resting-state functional magnetic resonance imaging; Graph theory","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"28 1","pages":"181-187"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77287580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretation of Guidelines for Treatment of Adults with Metastatic Brain Tumors (2019) by American Association of Neurological Surgeons/Congress of Neurological Surgeons","authors":"W. Du, Yake Xue, Xinting Wei, Guangyi Jiang","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.001","url":null,"abstract":"","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"1 1","pages":"109-112"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77471194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}