中华神经医学杂志最新文献

{"title":"Risk analysis of vaccination in children with genetic epilepsy combined with febrile seizures plus","authors":"Xiaoli Shao, Jiani Hu, Ying-shui Yao, D. Yu, Zhefeng Yuan","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.011","url":null,"abstract":"Objective \u0000To assess the risk of vaccination in children with genetic epilepsy combined with febrile seizures plus (GEFS+). \u0000 \u0000 \u0000Methods \u0000Sixty-seven children with GEFS+, admitted to our hospital from May 2016 to May 2019, were enrolled in our study; using targeted second-generation sequencing technology, these patients were divided into positive SCN1A gene mutation group (SCN1A+ group, n=11) and negative SCN1A gene mutation group (SCN1A- group, n=51) after kicking out 5 patients with other gene mutations. The frequencies of convulsion and changes of body temperature after vaccination were analyzed retrospectively in the two groups from birth to age of 7 years. The levels of interleukin (IL)-2, IL-6, IL-10 and tumor necrosis factor (TNF)-α in peripheral blood were measured by flow cytometry in both groups after seizures. \u0000 \u0000 \u0000Results \u0000Children from SCN1A+ group were vaccinated for 34 times, with incidence of post-vaccine convulsion reaching 47% (16/34); children from SCN1A- group were vaccinated for 186 times, with incidence of post-vaccine convulsions reaching 6.45% (12/186); incidence of post-vaccine convulsion was statistically significant between the two groups (P<0.05). The mean body temperature in children from the SCN1A+ group ([38.06±0.57] ℃) during convulsion was significantly lower than that in SCN1A- group ([39.49±0.49] ℃, P<0.05). Expressions of IL-6 and IL-10 in peripheral blood after convulsion in children from SCN1A+ group (96.80±25.05 and 74.90±18.28) were significantly higher than those in SCN1A- group(72.97±4.81 and 43.99±10.63, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000GEFS+ children in the SCN1A+ group are more prone to convulsion after vaccination than those in the SCN1A- group; cytokines may be involved in the development of convulsion. \u0000 \u0000 \u0000Key words: \u0000SCN1A gene; Epilepsy; Convulsion; Vaccine; Heat-sensitivity","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"41 11 1","pages":"176-180"},"PeriodicalIF":0.0,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82849556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in clinical manifestations and differential diagnoses of Kikuchi-Fujimoto disease involving nervous system","authors":"Jialei Yang, Lei Wang, Hua-Ling Chen, Fang Xu, Shimin Yin","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.016","url":null,"abstract":"Histiocytic necrotic lymphadenitis is known as Kikuchi-Fujimoto disease (KFD). KFD is a systemic disease, which is characterized by fever, necrotizing lymphadenopathy and leukopenia. However, involvement of the central and peripheral nervous system is rare. It can present as aseptic meningitis, encephalomyelitis, peripheral neuropathy, cerebellar ataxia and tremor, which makes it difficult to be differentiated with other nervous system diseases. Our review summarizes the clinical manifestations and differential diagnoses of KFD involving nervous system in order to reduce misdiagnoses and mistreatments. \u0000 \u0000 \u0000Key words: \u0000Histiocytic necrotic lymphadenitis; Kikuchi-Fujimoto disease; Nervous system; Clinical manifestation; Differential diagnosis","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"34 1","pages":"79-83"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73721869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative assessment of white matter damage caused by delayed neuropsychiatric sequelae after carbon monoxide poisoning with diffusion kurtosis imaging","authors":"Tianhong Wang, Yanli Zhang, You-Quan Gu, J. Lei, Shun-lin Guo","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.007","url":null,"abstract":"Objective \u0000To investigate the value of quantitative evaluation in white matter damage caused by delayed neuropsychiatric sequelae (DNS) after carbon monoxide poisoning (CO) with diffuse kurtosis imaging (DKI). \u0000 \u0000 \u0000Methods \u0000A prospective study was conducted from November 2016 to February 2019 in 28 patients diagnosed as having DNS after CO poisoning and 30 healthy controls in our hospital. DKI scans were performed within 7 d of onset and DKI-derived parameters (9 regions of interest), including mean kurtosis (MK), axial kurtosis (AK), and radial kurtosis (RK), were obtained. Mini Mental State Examination Scale (MMSE), Barthel Index, Verbal Fluency Test (VFT), and Digital Breadth Test (DST) were performed on both subjects to conduct neurocognitive assessment; multivariate regression analysis was performed to determine the statistical relations of scores of above neurocognitive scales with AK values of ROIs. \u0000 \u0000 \u0000Results \u0000As compared with those in the control group,the MK, AK and RK values in all ROIs showed an increased trend in DNS group; among which, the anterior semioval center, posterior semioval center and frontal lobe enjoyed the most obvious increase, with significant differences (P<0.05). In the genu of corpus callosum, body of corpus callosum and parietal lobe, the AK value of DNS group was significantly higher than that in the controls (P<0.05). Except for temporal lobe and occipital lobe, area under the curve (AUC) of AK value of other ROIs in diagnosing DNS was larger than that of RK and MK values of other ROIs; AK value of anterior semioval center (AUC=0.802, P=0.000), posterior semioval center (AUC=0.785, P=0.000), frontal lobe (AUC=0.749, P=0.001), genu of corpus callosum, (AUC=0.730, P=0.003), parietal lobe (AUC=0.699, P=0.009) and body of corpus callosum (AUC=0.654, P=0.045) had better performance than RK and MK in diagnosing DNS, with statistically significant differences (P<0.05). Multivariate regression analysis results show that the DST value (reverse) is the independent influencing factors of AK values of anterior semioval center, genu of corpus callosum, and frontal lobe; VET (vegetable) is the independent influencing factors of AK values of body of corpus callosum, age is the independent influencing factors of AK values of posterior semioval center, splenium of corpus callosum, and frontal, temporal and occipital lobes; and education is the independent influencing factors of AK values of temporal lobe. \u0000 \u0000 \u0000Conclusion \u0000DKI can quantitatively evaluate the microstructural damage of white matter caused by DNS, and the increase of AK is related to the decrease of neurological function in patients with DNS. \u0000 \u0000 \u0000Key words: \u0000Delayed neuropsychiatric sequelae; White matter; Diffusion kurtosis imaging; Magnetic resonance imaging","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"17 1","pages":"41-47"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89400805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One case of acute medullary infarction with myasthenia gravis crisis","authors":"Guan Pei, Xue Zhang, Xinlei Wang, S. Zhao, Chen Chen","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.013","url":null,"abstract":"","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"24 1","pages":"70-72"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81945857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in glutamate receptor in levodopa-induced dyskinesia","authors":"Huidan Weng, Haiqiang Zou","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.021","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.021","url":null,"abstract":"In Parkinson's disease (PD), long-term use of levodopa-induced dyskinesia (LID) significantly affects the therapeutic efficacy of levodopa and quality of life of patients. Current existing therapies are not ideal, which is related to that mechanism of LID has not been fully clarified. Recently, more and more studies have confirmed that the glutamatergic system is closely related to the dopaminergic system, and the role of glutamate receptors in LID is increasingly prominent, especially, metabolic glutamate receptor (mGluR)4, mGluR 5 and partial ionotropic glutamate receptors are current research hotspots in the mechanism and clinical observation of drugs of LID. Therefore, this review summarizes the changes and roles of various glutamate receptors in LID and related clinical studies, hoping to provide new ideas for the diagnosis and treatment of LID in PD patients. \u0000 \u0000 \u0000Key words: \u0000Glutamate receptor; Levodopa; Dyskinesia; Parkinson's disease","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"92 1","pages":"102-106"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83768548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrophysiological characteristics of 5 patients with cingulate gyrus epilepsy and their different applications in treatment","authors":"Y. Zhong, Haitao Xie, Youliang Wu, Chun‐Tse Chen, L. Cheng, Lisen Sui","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.011","url":null,"abstract":"","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"17 1","pages":"63-66"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78907571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lateralizing and localizing values of Griffiths developmental assessment scale in preoperative evaluation of intractable epilepsy: one case report and literature review","authors":"Si-Min Li, Y. Chen, Chen Yao, Yang Sun, Xiaodong Cai","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.012","url":null,"abstract":"","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"21 1","pages":"67-69"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72645488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in epoxyeicosatrienoic acids in intracerebral hemorrhage","authors":"H. Wei, Jixu Yu, Zhenchuan Liu, Yushuang Wang, Huimin Zhu","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.019","url":null,"abstract":"Epoxyeicosatrienoic acids (EETs) are mainly from intracellular arachidonic acids catalyzed by cytochrome P450 cyctooxygenase and degraded to lower active dihydroxyeicosapentaenoic acids by soluble epoxide hydrolase. In recent years, EETs have been found to be a new target for prevention and treatment of various nervous system diseases, such as anti-inflammatory reaction, anti-atherosclerosis, anti-cell apoptosis and angiogenesis. Intracerebral hemorrhage is a kind of serious acute cerebrovascular disease. Cerebral hemorrhage is a kind of acute cerebrovascular disease; secondary injury is one of the important mechanisms of cerebral hemorrhage; the present studies have confirmed that EETs have protective role in brain tissues after cerebral hemorrhage, thus, become new hotspot in the research of cerebral hemorrhage. This review focuses on the role and mechanism of EETs in intracerebral hemorrhage, hoping to provide some references for exploration of new research directions and therapeutic targets in the treatment of intracerebral hemorrhage. \u0000 \u0000 \u0000Key words: \u0000Epoxyeicosatrienoic acid; Intracerebral hemorrhage; Soluble epoxide hydrolase; Arachidonic acid","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"13 1","pages":"93-97"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73243691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of tail vein transplantation of human amniotic mesenchymal stem cells with different transforming growth factor-β expressions on sciatic nerve function in xenografted mice","authors":"Mubin Chen, Qingqing Li, Huihui Chai, Kuntai Xiao, Xiaoguang Huang, Yuting Xu, Shan Xue, Haitao Sun, Yan-wu Guo","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.002","url":null,"abstract":"Objective \u0000To investigate the effect of tail vein transplantation of human amniotic mesenchymal stem cells (hAMSCs) with different transforming growth factor (TGF)-β expressions on recovery of sciatic nerve function in peripheral nerve xenotransplantation mice. \u0000 \u0000 \u0000Methods \u0000The hAMSCs were isolated from amnion membranes by healthy mother donors and identified by fluorescence activated cell sorter. The up-regulated and down-regulated TGF-β lentiviral plasmids were constructed and transfected into the purified hAMSCs; hAMSCs with stable up-regulated or down-regulated TGF-β expression were constructed. The sciatic nerves of C57BL/6 mice were isolated and cut out, and sciatic nerves of SD rats were isolated and transplanted into the sciatic nerve defected C57BL/6 mice to construct peripheral nerve xeno-transplanted mice models; these mice models were divided into 4 groups (n=10) according to random number table: control group, hAMSCs treatment group, high-expressed TGF-β hAMSCs treatment group, and low-expressed TGF-β hAMSCs treatment group; one d before modeling, phosphate buffer saline (PBS) or hAMSCs re-suspension were drawn with a syringe and slowly pushed into the tail veins of mice for transplantation treatment; 14 d after treatment, DigGait analysis system was used to evaluate the recovery of sciatic nerve function in each group of mice. \u0000 \u0000 \u0000Result \u0000Fourteen d after treatment, the sciatic nerve function index (SFI) of the high-expressed TGF-β hAMSCs treatment group (-25.820±0.286) was significantly higher than that of the low-expressed TGF-β hAMSCs treatment group (-33.413±0.920) and hAMSCs treatment group (-30.755±0.421, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The tail vein transplantation of hAMSCs with TGF-β high expression can effectively improve the sciatic nerve function in peripheral nerve xenotransplantation mice, which may be a new breakthrough in the treatment of peripheral nerve defects. \u0000 \u0000 \u0000Key words: \u0000Human amniotic mesenchymal stem cell; Transforming growth factor-β; Stem cell therapy; Peripheral nerve defect","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"33 1","pages":"9-16"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81305968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of brain-derived microvesicles on cytoskeleton of human umbilical vein endothelial cells","authors":"Ji-wei Wang, Yingang Wu, Qi-feng Li, Yalong Gao, Yuan Zhou, Guili Yang, Jian-ning Zhang","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.003","url":null,"abstract":"Objective To observe the effect of brain-derived microvesicles (BDMVs) on cytoskeleton in human umbilical vein endothelial cells (HUVECs). Methods BDMVs were prepared in vitro and identified by transmission electron microscopy and particle size identification. HUVECs were co-cultured with PKH26-labeled BDMVs for 0.5, 1, and 2 h; flow cytometry was used to detect the phagocytosis of HUVECs for BDMVs at different time points. HUVECs cultured in vitro were divided into control group, BDMVs treatment group and nimodipine treatment group; cells in the BDMVs treatment group were given 1.5×107/mL BDMVs; cells in the nimodipine treatment group were pretreated with 2 μg nimodipine (0.2 mg/mL) for 10 min, and then, given 1.5×107/mL BDMVs. After being stained with rhodamine-labeled phalloidin, the fluorescence intensity and number of stress fibers of fibroactin in HUVECs were observed by laser confocal microscopy. Results BDMVs had complete membrane structure with a diameter of 100-1000 nm under transmission electron microscopy.The proportion of cells phagocytizing BDMVs increased significantly with prolonged incubation time, enjoying significant differences (0.5 h: 22.7%±1.2%; 1 h: 52.3%±1.3%; 2 h: 71.6%±1.9%, P<0.05). Laser confocal microscopy showed that, as compared with the control group, the fluorescence intensity of cytoskeletal protein was obviously increased and the number of stress fibers increased was obviously larger in the BDMVs treatment group. As compared with those in the BDMVs treatment group, the fluorescence intensity of cytoskeletal protein was decreased and the number of stress fibers was obviously smaller in the nimodipine group. Conclusion The role of BDMVs in phagocytosis of HUVECs becomes stronger as time being prolonged, and BDMVs phagocytosis leads to cytoskeletal remodeling, which can be partially blocked by nimodipine. Key words: Brain-derived microvesicle; Human umbilical vein endothelial cell; Cytoskeleton","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"87 1","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73620399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}