中华神经医学杂志最新文献

{"title":"Nocardia brain abscess in an immunocompetent host: one case report and literature review","authors":"Shaopeng Peng, Jian Zhang, Jianxiong Liu, Hua Yan, Xue Gong, Qun Wan, Lingke Wu","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.015","url":null,"abstract":"","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"35 1","pages":"76-78"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81150132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swirl sign and black hole sign on CT scanning in predicting early hematoma expansion in intracerebral hemorrhage: a comparative study","authors":"Yeqing Wang, D. Shi, K. Lu, D. Jin, Rui Wang, Liang Xu, G. Fan, Jun-Kang Shen, J. Gong","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.005","url":null,"abstract":"Objective \u0000To compare the predictive values of swirl sign and black hole sign on CT scanning in early hematoma expansion in spontaneous intracerebral hemorrhage (SICH) patients. \u0000 \u0000 \u0000Methods \u0000Two hundred and ten firstly diagnosed SICH patients, admitted to our hospital from January 2012 to December 2018, were enrolled in the study. All patients were divided into hematoma expansion and non-hematoma expansion group according to whether early hematoma expansion appeared; and they were also divided into positive imaging sign group and negative imaging sign group according to whether imaging signs appeared; the clinical and imaging data were compared between these groups, respectively. The accuracies of swirl sign and black hole sign in predicting early hematoma expansion were analyzed using receiver operator characteristic (ROC) curve. Multivariate Logistic regression analysis was performed to determine the independent risk factors for early hematoma expansion. \u0000 \u0000 \u0000Results \u0000(1) In the 57 patients with early hematoma expansion, 21 (36.8%) had swirl sign, and 17 (29.8%) had black hole sign; in the 153 patients without hematoma expansion, 12 (7.8%) had swirl sign and 22 (14.4%) had black hole sign; the differences between the two groups were statistically significant (P 0.05); the hematoma volume in patients with black hole sign (n=39) was significantly increased as compared with that in patients without black hole sign (n=171, P 0.05). (3) The areas under ROC curve of swirl sign, black hole sign, and \"swirl sign combined with black hole sign\" were 0.645, 0.577, and 0.570, respectively. (4) Multivariate Logistic regression analysis showed that admission systolic blood pressure, swirl sign and black hole sign were independent risk factors for early hematoma expansion (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000In comparison to black hole sign and \"swirl sign combined with black hole sign\" , the swirl sign has higher predictive value in early hematoma expansion in ICH patients. \u0000 \u0000 \u0000Key words: \u0000Spontaneous intracerebral hemorrhage; Hematoma expansion; Swirl sign; Black hole sign","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"170 1","pages":"29-35"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77569799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coptisine up-regulates miR-146a-5p expression to attenuate injury of Parkinson's disease cell models induced by 1-methyl-4-phenylpy ridinium via PI3K/AKT pathway","authors":"Hong-li Chen, Hu-Yi Liang, Yan Li","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.001","url":null,"abstract":"Objective \u0000To investigate the effect of coptisine on 1-methyl-4-phenylpy ridinium(MPP+) induced Parkinson's disease (PD) cell injury and its mechanism. \u0000 \u0000 \u0000Methods \u0000SK-N-SH cells were treated with 0.3 mmol/L MPP+ to induce PD cell models (MPP+ group); normal cultured cells were used as blank controls (NCs); pretreatment with coptisine at concentrations of 10, 20, and 40 μmol/L for 4 h was performed after giving 0.3 mmol/L MPP+, different concentration coptisine treatment groups were named. And miR-con and miR-146a-5p were transfected into SK-N-SH cells and treated with 0.3 mmol/L MPP+, and named MPP++miR-con group and MPP++miR-146a-5p group; anti-miR-con and anti-miR-146a-5p were transfected into SK-N-SH cells and pretreated with 20 μmol/L coptisine for 4 h, and then, treated with 0.3 mmol/L MPP+, and named MPP++Cop+anti-miR-con group and MPP++Cop+anti-miR-146a-5p group. Cell viability was determined by MTT assay; Western blotting was used to detect the protein expressions of cleaved cysteine-containing aspartate-specific proteases-3 (caspase-3), CyclinD1, phosphorylated protein kinase B (p-AKT), p-phosphoinositide 3 kinase (p-PI3K); apoptosis was detected by flow cytometry; real-time quantitative PCR (RT-qPCR) was used to detect the miR-146a-5p expression. \u0000 \u0000 \u0000Results \u0000As compared with the NCs, the MPP+ induced SK-N-SH cells had significantly decreased viability and CyclinD1 and miR-146a-5p expressions, and significantly increased cleaved caspase-3 expression and apoptosis rate (P<0.05). After coptisine treatment and miR-146a-5p overexpression, MPP+ induced SK-N-SH cells had significantly increased viability and expressions of CyclinD1 and miR-146a-5p, and significantly decreased cleaved-caspase-3 expression and apoptosis rate (P<0.05). Low expression of miR-146a-5p reversed the effect of coptisine on proliferation promotion and apoptosis inhibition of SK-N-SH cells. The expression levels of p-AKT and p-PI3K in MPP+-induced SK-N-SH cells were significantly increased after coptisine treatment. Low expression of miR-146a-5p reversed the effect of coptisine on expressions of p-AKT and p-PI3K. \u0000 \u0000 \u0000Conclusion \u0000Coptisine can promote cell survival and inhibit MPP+-induced apoptosis, which may be related to miR-146a-5p and PI3K/AKT signaling pathways. \u0000 \u0000 \u0000Key words: \u0000Coptisine; MiR-146a-5p; PI3K/AKT signaling pathway; Parkinson's disease; Cell injury","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"36 1","pages":"2-8"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78744427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for pulmonary infection in severe neurological patients","authors":"Ting Xu, Jianliang Chen","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.009","url":null,"abstract":"Objective \u0000To analyze the influencing factors for pulmonary infection in neurosurgical critical patients, and provide references for prevention and treatment of pulmonary infection. \u0000 \u0000 \u0000Methods \u0000Sixty-five patients with severe neurological diseases complicated with pulmonary infection, admitted to our hospital from May 2017 to May 2018, were chosen in our study. General information, laboratory examination results, chest CT and other imaging results, hospital stay, antibiotic/ventilator use, tracheotomy and other treatments of these patients were collected and compared to identify the independent factors influencing pulmonary infection in patients with severe neurological disease. \u0000 \u0000 \u0000Results \u0000There was a statistically significant difference in incidence of pulmonary infection among patients with different diseases (P<0.05), and the infection rate of patients with cerebral hemorrhage was the highest, reaching to 50.8% (32/63). GCS scores (OR=2.903, 95%CI: 1.069-7.881, P=0.037), serum albumin level (OR=3.690, 95%CI: 1.157-11.768, P=0.027), ventilator use (OR=15.799, 95%CI: 6.305-39.591, P=0.000), tracheotomy or endotracheal intubation (OR=7.036, 95%CI: 2.913-16.993, P=0.000), history of diabetes (OR=2.442, 95%CI: 1.026-5.809, P=0.043), and prophylactic use of antibiotics (OR=6.021, 95CI%: 2.340-15.489, P=0.000) were independent risk factors for pulmonary infection in patients with severe neurological conditions. \u0000 \u0000 \u0000Conclusion \u0000Effective measurements, including recovering consciousness as soon as possible, shortening accommodation, actively avoiding endotracheal intubation and ventilator-associated pneumonia, and rectifying hypoproteinemia and diabetes mellitus can effectively prevent the occurrence of severe pulmonary infection of neurosurgical critical patients. \u0000 \u0000 \u0000Key words: \u0000Severe nervous system; Pulmonary infection; Influencing factor","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"109 1","pages":"54-58"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80877033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse reactions of blepharospasm and hemifacial spasm after botulinum toxin A injection and their corresponding responses","authors":"Y. Wen, R. Wu, Rui Shi, Dongyun Feng, M. Shi","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.010","url":null,"abstract":"Objective \u0000To summarize the adverse reactions of blepharospasm (BSP) and hemifacial spasm (HFS) after botulinum toxin A (BoNT-A) injection and offer corresponding responses. \u0000 \u0000 \u0000Methods \u0000Clinical data of 163 BSP patients and 221 HFS patients, admitted to and subjected to BoNT-A injection in our hospital from September 2017 to October 2019, were analyzed retrospectively. Albert and Cohen evaluation scale was used to evaluate the therapeutic efficacy after injection. All adverse reactions were recorded and corresponding responses were proposed. \u0000 \u0000 \u0000Results \u0000The effective rates of BoNT-A injection for BSP and HFS were 97.5% and 100%, respectively. The most common early-onset adverse reactions were local pain (BSP: 13.5%; HFS: 17.2%) and hematoma (BSP: 3.7%; HFS: 4.5%); the late-onset adverse reactions included dry eyes/epiphora (BSP: 9.8%; HFS: 11.3%), incomplete closure of eyelid (BSP: 20.2%; HFS: 20.4%), facial stiffness (HFS: 39.4%) and asymmetry (HFS: 11.8%), and eyelid edema could be noted in a few patients (BSP: 1.2%; HFS: 1.4%). The main measures on reducing or avoiding adverse reactions after injection included appropriate injection apparatus, accurate injection sites, exact drug doses, and consideration of the individual differences of patients. \u0000 \u0000 \u0000Conclusion \u0000BoNT-A is effective in the treatment of BSP and HFS, but it is necessary to avoid early-onset and late-onset adverse reactions to maximize the benefits of patients. \u0000 \u0000 \u0000Key words: \u0000Botulinum toxin type A; Blepharospasm; Hemifacial spasm; Adverse reaction","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"11 1","pages":"59-62"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88404120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in interaction between acute subdural hematoma and disorder of intracranial superficial venous circulation","authors":"Weiming Xu, Shuwen Mu, Wei Wang, Hengheng Zhai, Shousen Wang","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.020","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.020","url":null,"abstract":"Traumatic acute subdural hematoma (ASDH) is often severe, and bridging vein rupture is one of the case mechanisms of ASDH. After traumatic ASDH, venous reflux disorder, cerebral ischemia, delayed bleeding in other parts of the brain, and intraoperative encephalocele are prone to occur. This article reviews the occurrence and development of ASDH and its relation with intracranial venous circulation. \u0000 \u0000 \u0000Key words: \u0000Acute subdural hematoma; Cortical vein; Bridging vein; Cerebral ischemia; Acute encephalocele","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"16 2 1","pages":"98-101"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90148741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in functions of zona incerta","authors":"Jingxin He, Jie Gao, Zhi-Cheng Xiao","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.017","url":null,"abstract":"Zona incerta (ZI) belongs to the structure of the subthalamus which contains cells of various sizes and types, and has a wide range of nerve fiber projections underlie complex functions. In recent years, a series of research evidences have demonstrated that ZI is involved in regulation mechanisms of predation, feeding, sleep/arousal, pain, locomotion and emotion. In this paper, the research progresses on the structure and functions of ZI in recent years are reviewed, which is expected to provide references for the future studies on ZI functions. \u0000 \u0000 \u0000Key words: \u0000Zona incerta; Sensation; Motion; Sleep arousal; Emotion","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"16 1","pages":"84-88"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78574034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and risk factors of delayed intracranial hemorrhage after ventriculoperitoneal shunt in traffic hydrocephalus","authors":"X. Qi, Folin Lan, Zhiqin Lin, D. Guo, Junlong Huang, Tianqin Liu","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.008","url":null,"abstract":"Objective \u0000To analyze the clinical features and risk factors of delayed intracranial hemorrhage (DICH) after ventriculoperitoneal shunt (VPS) in patients with communicating hydrocephalus. \u0000 \u0000 \u0000Methods \u0000One hundred and seventy-six patients with ventriculoperitoneal shunt due to communicating hydrocephalus secondary to craniocerebral trauma, hypertensive intracerebral hemorrhage, brain tumor or intracranial aneurysm rupture hemorrhage, admitted to our hospital from January 2012 to August 2018, were selected in our study; these patients were divided into DICH group and non-DICH group according to whether or not DICH occurred. The clinical features, including incidence, time and location of DICH, were analyzed. The differences of age, gender, length of stay, concomitant diseases, previous operation history, incidences of subdural effusion and puncture canal edema after ventriculoperitoneal shunt, and history of down-regulating shunt valve within 2 weeks between the two groups were compared by univariate analysis. The independent risk factors for DICH were further assessed using multivariable Logistic regression. \u0000 \u0000 \u0000Results \u0000Among 176 patients, 23 (13.07%) had DICH; 2-11 d after surgery, DICH appeared, manifesting as subdural, ventriculoventricular end canal and/or hemorrhage in one or more areas of the ventricle. There were significant differences in incidence of subdural effusion and history of down-regulating shunt valve within 2 weeks between the two groups (P<0.05). Multivariate Logistic regression analysis showed that subdural effusion after surgery and down-regulation of shunt valve pressure within 2 weeks after ventriculoperitoneal shunt were independent risk factors for DICH (OR=4.516, 95%CI: 1.555-13.110, P=0.006; OR=5.352, 95%CI: 1.987-14.414, P=0.001). \u0000 \u0000 \u0000Conclusion \u0000High incidence of DICH mighty be noted within two weeks of ventriculoperitoneal shunt; subdural effusion and pressure reduction of shunt valve within 2 weeks are independent risk factors for DICH, which needs close monitoring and clinical intervention. \u0000 \u0000 \u0000Key words: \u0000Delayed intracranial hemorrhage; Communicating hydrocephalus; Ventriculoperitoneal shunt; Risk factor","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"6 1","pages":"48-53"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73308353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-NMDAR encephalitis and anti-GABABR encephalitis in a child after herpes simplex encephalitis","authors":"Hongming Zhu, Dan Sun, Jia-sheng Hu, Ke-Hu Wu, Xiaoqing Luo","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.014","url":null,"abstract":"","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"1 1","pages":"73-75"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85176914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of spasticity in patients with chronic disorders of consciousness","authors":"Yi Yang, Jianghong He, Ji-zong Zhao","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.018","url":null,"abstract":"Spasticity is a kind of dyskinesia that often occurs after central nervous system injury. The reason for its occurrence is caused by lack of control and recombination of pyramidal system and extrapyramidal nerve fibers, and often leads to increased tension and hyperreflexia of affected muscle groups. For patients with chronic disorders of consciousness (DoC) after brain injury, the occurrence of such symptoms is very common, but effective treatment is rarely reported. The current treatment mainly includes intrathecal injection of baclofen and soft splint to solve joint contracture. Other therapeutic schemes still need further research, including acupuncture, botulinum toxin injection, and deep brain electrical stimulation. This article is summarized as follows. \u0000 \u0000 \u0000Key words: \u0000Disorders of consciousness; Spasticity; Pain; Prevalence rate; Treatment","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"68 1","pages":"89-92"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75434973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}