中华神经医学杂志最新文献

{"title":"Relative factors for \"incongruent phenomenon\" of brain electrical activity and cerebral blood flow during brain death determination for potential organ donors","authors":"Guixing Xu, Yuan Liao, Ping Yu, Ping Xu, Dong-hua Zheng","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.006","url":null,"abstract":"Objective \u0000To identify the relative factors for \"incongruent phenomenon\" of brain electrical activity and cerebral blood flow during brain death determination for potential organ donors, and intensify the understanding and cognition of this phenomenon. \u0000 \u0000 \u0000Methods \u0000The clinical data of 127 potential donors accepted donation after brain death (DBD), admitted to our hospital from June 2018 to May 2019, were collected prospectively. All patients preferred brain electrical activity and cerebral blood flow assessments as the confirmatory tests of brain death determination. For patients with \"incongruent phenomenon\", further test of median nerve short latency evoked potential or brain electrical activity and cerebral blood flow assessments after waiting for 24 h were performed to confirm brain death determination again. Fifteen parameters, such as gender, age, time of spontaneous respiration arrest, blood pressure, operative types, neurological examination, neuroimaging index, and serum Na+ level, were selected; univariate and multivariate Logistic regression analyses were used to identify these risk factors related to \"incongruent phenomenon\". \u0000 \u0000 \u0000Results \u0000Among the 127 patients, 22 patients (17.3%) appeared \"incongruent phenomenon\"; 17 (77.2%) had electrical silence earlier than cerebral blood flow arrest, and 5 (22.7%) had cerebral blood flow arrest earlier than electrical silence. Multivariate Logistic analysis showed that age≤14 years (OR=6.250, 95CI: 1.201-32.220, P=0.028), systolic blood pressure≥140 mmHg(OR=7.430, 95CI: 1.621-33.992, P=0.010), primary brain-stem injury (OR=15.890, 95CI: 3.042-82.930, P=0.006), spontaneous respiratory arrest time≤72 h (OR=11.964, 95CI: 3.045-82.932, P=0.006), and unilateral/bilateral decompressive craniectomy (OR=16.281, 95CI: 1.590-89.785, P=0.001) were independent risk factors for \"incongruent phenomenon\". \u0000 \u0000 \u0000Conclusion \u0000\"Incongruent phenomenon\" is common in confirmatory test of brain death determination in China; patients with age≤14 years, systolic blood pressure≥140 mmHg, primary brain-stem injury, spontaneous respiratory arrest time≤72 h, and decompressive craniectomy (unilateral/bilateral) are more likely to have \"incongruent phenomenon\". \u0000 \u0000 \u0000Key words: \u0000Organ donation; Brain death; Electroencephalogram; Cerebral blood flow; Incongruent phenomenon","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"136 1","pages":"36-40"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80273688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular recanalization in non-acute symptomatic occlusion of the ophthalmic segment of internal carotid artery","authors":"Jin-long Zhang, J. Gu, Guang Feng, Yongfeng Wang, Jinchao Xia, Hui Gao, Gaoqi Zhang, Yucheng Li, Zi-liang Wang, Tian-Xiao Li","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.01.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.01.004","url":null,"abstract":"Objective \u0000To investigate the safety, efficacy and feasibility of endovascular recanalization in non-acute symptomatic occlusion of the ophthalmic segment of internal carotid artery, and analyze the factors affecting its success. \u0000 \u0000 \u0000Methods \u0000Fifty-four patients with non-acute symptomatic occlusion of the ophthalmic segment of internal carotid artery, underwent endovascular recanalization in our hospital from January 2013 to December 2017, were enrolled. Modified Rankin scale (mRS) and National institutes of health stroke scale (NIHSS) scores were compared before and after treatment; the prognosis results were analyzed after 2 years of follow-up. Independent factors influencing the prognoses were identified by Logistic regression analysis. \u0000 \u0000 \u0000Results \u0000Recanalization was achieved in 52 patients and failure was noted in two patients. The mRS scores and NIHSS scores before treatment (2.25±0.13, 18.43±1.36) were significantly higher than those after treatment (1.44±0.05, 11.81±0.71, P<0.05). After 2 years of follow-up, good prognosis was noted in 42 patients, poor prognosis in 8 patients, and loss of follow-up in 2 patients. Multivariate Logistic analysis showed that history of hypertension and history of diabetes were independent risk factors for the prognoses of patients with non-acute symptomatic occlusion of the ophthalmic segment of internal carotid artery after endovascular recanalization (OR=1.429, 95CI: 1.146-1.783, P=0.005; OR=2.597, 95CI: 2.364-2.854, P=0.005). \u0000 \u0000 \u0000Conclusion \u0000The curative effect of interventional therapy for non-acute occlusion of symptomatic internal carotid artery is reliable, and histories of hypertension and diabetes can affect the prognoses of patients. \u0000 \u0000 \u0000Key words: \u0000Interventional recanalization; Internal carotid artery occlusion; Prognosis; Clinic","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"42 1","pages":"23-28"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76722608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relation between trend of temperature changes and intracranial infection after ventriculoperitoneal shunt","authors":"Huan Zhang, Xiaozheng He, Y. Ye","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.008","url":null,"abstract":"Objective \u0000To observe the trend of temperature changes after ventriculoperitoneal shunt and its relation with postoperative infection. \u0000 \u0000 \u0000Methods \u0000A retrospective cohort study was conducted on 272 patients underwent ventriculoperitoneal shunt in our hospital from January 2015 to December 2018. Patients were divided into infected group and non-infected group according to whether intracranial infection occurred after surgery. According to the occurring time of postoperative intracranial infection, patients were divided into early infection group and delayed infection group. Temperature levels of all patients were monitored on the surgery day, and on the first, 3rd, 5th and 7th d of surgery, and the temperature changes and fever rate of the two groups were compared. \u0000 \u0000 \u0000Results \u0000Among 272 patients, intracranial infection occurred in 25 (9.19%), including 21 with early infection and 4 with delayed infection, and un-infection in 247 (90.81%). As compared with those in the non-infected group, the fever rate and body temperature of the infected group were significantly higher on the 3rd, 5th and 7th d after surgery (P 0.05). \u0000 \u0000 \u0000Conclusions \u0000The fever rate is higher and the body temperature decreases faster after ventriculoperitoneal shunt. The fever since the third d of surgery is closely related to postoperative intracranial infection, which has a certain predictive significance for postoperative infection, so we should consider anti-infection treatment in time. \u0000 \u0000 \u0000Key words: \u0000Postoperative body temperature; Ventriculoperitoneal shunt; Intracranial infection","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"40 1","pages":"1236-1240"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78815990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulse index continuous cardiac output combined with intracranial pressure monitoring in patients with severe craniocerebral injury","authors":"Jian-Guo Yang, X. Zhong, Yi-Qi Wang, Zhaohui Zhao, Yong Cai, Z. Fei, Lei Zhang, H. Gu, T. Yang, Zhenzhen Xu, Kankai Tang","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.003","url":null,"abstract":"Objective \u0000To explore the value of pulse index continuous cardiac output (PICCO) combined with intracranial pressure monitoring in patients with severe craniocerebral injury. \u0000 \u0000 \u0000Methods \u0000One hundred and thirty-eight patients with severe craniocerebral injury accepted controlling decompression surgical treatment in our hospital from February 2015 to February 2019 were prospectively chosen. According to patients' families will, postoperative application of PICCO combined with intracranial pressure monitoring for fluid management was performed in 72 patients (treatment group) and application of central venous pressure combined with intracranial pressure monitoring for fluid management was performed in 66 patients (control group). All patients were adjusted according to the monitoring results. The intracranial pressure and cerebral perfusion pressure one week after surgery, incidences of new traumatic cerebral infarction, neurogenic pulmonary edema, pulmonary infection, scalp exudation, and intracranial infection, average hospitalization days, total hospitalization costs, intensity of antimicrobial use, and Glasgow coma scale scores two weeks after operation were compared and analyzed between the two groups. Glasgow outcome scale was used to evaluate the prognoses of the patients 6 months after injury. \u0000 \u0000 \u0000Results \u0000There were 7 patients (3 from the control group and 4 from the treatment group) dropped out of the study due to various reasons and 131 patients (63 from the control group and 68 from the treatment group) included in the final statistical analysis; there was no significant difference in drop-out rate of the two groups (P>0.05). The intracranial pressure in the treatment group ([14.28±2.98] mmHg) was significantly lower than that in the control group ([18.99±2.78] mmHg) and cerebral perfusion pressure ([66.72±2.25] mmHg) was significantly higher than that in the control group ([52.96±3.12] mmHg) one week after operation (P<0.05). During hospitalization, the incidences of new traumatic cerebral infarction, neurogenic pulmonary edema, pulmonary infection, scalp exudation and intracranial infection in the treatment group (8.8%, 13.2%, 11.8%, 7.4%, and 2.9%) were significantly lower than those in the control group (22.2%, 27.0%, 25.4%, 19.0%, and 12.7%, P<0.05). The average hospitalization days, total hospitalization expenses and intensity of antimicrobial use in the treatment group were significantly shorter/lower than those in the control group (P<0.05). Glasgow coma scale scores (11.88±1.78) and good recovery rate (76.5%) in the treatment group were significantly higher than those in the control group (8.06±1.12, 54.0%) two weeks after operation (P<0.05). Good recovery rate (76.5%) in the treatment group was significantly higher than that in the control group (54.0%, P<0.05). The mortality rate (5.9%) was significantly lower than that in the control group (17.5%, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000PICCO combined with intracranial pressure monitori","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"16 1","pages":"1201-1208"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89049832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Related risk factors for progressive occlusion of intracranial aneurysms treated with low-profile visualized intraluminal support device stent in mid-term follow up","authors":"Linchun Huan, Yunshuai Sun, Hao Zhang, Jianjun Yu, Feng Guo, Jing Cai, Yu-Hui Liu, Shi-Lian Wang","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.007","url":null,"abstract":"Objective \u0000To analyze the angiographic results of intracranial aneurysms without complete embolization immediately after low-profile visualized intraluminal support device (LVIS) stent at mid-term follow up, and explore the risk factors for healing of partial occluded aneurysms. \u0000 \u0000 \u0000Methods \u0000One hundred and sixty-one patients with intracranial aneurysms treated by LVIS stent embolization in our hospital from December 2014 to December 2018 were selected; 193 aneurysms in total, including 93 un-ruptured aneurysms and 100 ruptured aneurysms, were noted. DSA was performed immediately after operation to evaluate the degrees of aneurysm embolization according to Raymond grading criteria. The embolization degrees of aneurysms were compared at 8 months after surgery and immediately after surgery, and the healing of aneurysms (Raymond grading 1) was calculated. Univariate Logistic regression analysis and multivariate Logistic regression analysis (forward maximum likelihood ratio method) were used to screen the risk factors for healing of incomplete aneurysm embolization. \u0000 \u0000 \u0000Results \u0000The embolization degrees immediately after surgery were as follows: 78 were with Raymond grading 1, 54 with Raymond grading 2, and 61 with Raymond grading 3; complete aneurysm embolization were noted in 78 aneurysms (40.41%) and incomplete aneurysm embolization were noted in 115 (59.59%). Follow up (8 months after surgery) results indicated that, of the 193 aneurysms, 171 were with Raymond grading 1, 10 with Raymond grading 2, and 12 with Raymond grading 3; there were 171 aneurysms (88.60%) having complete aneurysm embolization and 22 (11.40%) having incomplete aneurysm embolization. In the aneurysms having incomplete aneurysm embolization immediately after surgery, the healing rate was 81.74% (94/115). Univariate Logistic regression analysis showed that hypertension, diabetes mellitus, posterior circulation aneurysm, dissecting aneurysm, body-neck ratio and embolization degrees immediately after surgery were risk factors for healing of aneurysms (P<0.05). Multivariate Logistic regression analysis revealed that posterior circulation aneurysm and diabetes mellitus were independent risk factors for healing of aneurysms (P<0.05). The area under the curve of receiver operating characteristic curve of the regression model was 0.755, indicating that the prediction efficiency of the regression model was moderate. \u0000 \u0000 \u0000Conclusion \u0000Treatment of intracranial aneurysms with LVIS stent is effective, and the complete occlusion rate is high, even in the aneurysms with incomplete embolization immediately after surgery; aneurysms located in the posterior circulation and associated with diabetes can affect the treatment of aneurysms. \u0000 \u0000 \u0000Key words: \u0000Intracranial aneurysm; Endovascular treatment; LVIS stent; Embolization","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"48 1","pages":"1229-1235"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84444149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in disease-modifying drugs for multiple sclerosis","authors":"Yang Liu","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.016","url":null,"abstract":"Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, mainly characterized by demyelination of white matter. It has been relapsed and remitted repeatedly during the course of the disease. In the remission period, it is treated with disease-modifying therapies. The goal is to reduce the risk of recurrence and disability progression. Until now, many disease-modifying drugs have been approved for MS, including subcutaneous injection of interferon β and glatiramer acetate, oral small molecule preparations (teriflunomide, dimethyl fumarate, fingolimod, cladribine, and siponimod), intravenous injection of monoclonal antibodies (ocrelizumab, alemtuzumab, and natalizumab) and chemotherapy drug (mitoxantrone). This article will review the recent advance in disease-modifying drugs for MS. \u0000 \u0000 \u0000Key words: \u0000Multiple sclerosis; Disease-modifying drug; Disease-modifying therapy","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"6 1","pages":"1279-1283"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87443864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep brain stimulation of subthalamic nucleus combined with drugs in two patients with Parkinson's disease related neuroleptic malignant syndrome","authors":"Zhihao Zou, Zhenmin Lei, Xiaojun Wang, Shiwei Zhao, Jun Ma, Hongyan Yan, Youcai Shi","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.013","url":null,"abstract":"Objective \u0000To explore the role of deep brain stimulation of subthalamic nucleus (STN-DBS) in treatment of Parkinson's disease (PD) related neuroleptic malignant syndrome (NMS). \u0000 \u0000 \u0000Methods \u0000The medical history, clinical features, STN-DBS programmed treatment process and treatment results of two patients admitted to our hospital in December 2014 and November 2018 were retrospectively analyzed. \u0000 \u0000 \u0000Results \u0000Two patients with post-operative STN-DBS were evoked by dose-reduced treatment of anti-parkinsonian drugs, and presented with high fever, disorder of consciousness, aggravation of the original parkinsonism, and increase of creatine phosphokinase, which were not correlated with outcomes of infection. After admission, anti-parkinsonian drugs and other supportive therapies were supplemented; STN-DBS modulation were given to improve the symptoms; the final parameters of patient one were the left (C+, 2-, 1-), pulse width 110 μs, frequency 200 Hz, and strength 3.8 V; the right side (C+, 6-, 5-), pulse width 110 μs, frequency 200 Hz, strength 4.4 V; and those of patient two were the left (C+, 3-), pulse width 60 μs, frequency 130 Hz, strength 2.0 V; right side (C+, 6-), pulse width 80 μs, frequency 160 Hz, and strength 2.8 V. Both patients were cured, but their motor function and self-care ability were severely impaired. \u0000 \u0000 \u0000Conclusion \u0000STN-DBS may play an important role in the treatment of PD related NMS. \u0000 \u0000 \u0000Key words: \u0000Parkinson's disease; neuroleptic malignant syndrome; Drug withdrawal; Deep brain stimulation of subthalamic nucleus","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"91 1","pages":"1268-1270"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89510551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perihematomal edema in basal ganglia intracerebral hemorrhage by using radiomics approach of CT images","authors":"Guangwei Yang, Hua Xiao, Yuzhou Liu, Shan Hu","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.010","url":null,"abstract":"Objective \u0000To explore the value of CT images in distinguishing perihematomal edema in basal ganglia intracerebral hemorrhage with normal brain tissue, and its significance in assessing patients' conditions and prognoses. \u0000 \u0000 \u0000Methods \u0000CT images and clinical data of 120 patients with basal ganglia intracerebral hemorrhage admitted to our hospital from January 2017 to September 2018 were collected, and these 120 patients were randomly assigned to group of training data set (n=90) and group of test data set (n=30) at a ratio of 3:1. The texture analysis software Mazda was used to preprocess the CT images and manually sketch the regions of interest (ROIs) to extract the texture parameters in patients from the group of training data set; Mazda software provides texture feature selection methods including mutual information (MI), Fisher coefficients (Fisher), classification error probability combined with average correlation coefficients (POE+ACC), and texture feature analysis including raw data analysis (RDA), principal component analysis (PCA), linear classification analysis (LDA) and nonlinear classification analysis (NDA); texture feature selection methods and texture feature analysis were grouped by pairs to establish different image omics labels; the error rate was used to evaluate the performance of different labels. Random forest model, support vector machine model and neural network model were built for texture parameters in patients from the group of test data set, and texture parameters extracted from patients from group of training data set were imported into these models; receiver operating characteristics curve was used to assess the performance of models. According to the maximum diameter of the hematomas, Glasgow coma scale (GCS) scores at admission, median of National Institute of Health Stroke Scale (NIHSS) scores 3 months after follow up, all patients were divided into two groups; Mazda software was used repeatedly for dimension reduction and establishment of different images omics labels; the sum of error rates from the two groups was taken as total error rate to evaluate the significance of different labels in predicting patients' conditions and prognoses. \u0000 \u0000 \u0000Results \u0000A total of 295 texture parameters were extracted from the ROIs of the best CT images of 90 patients from group of training data set, and 10 characteristic texture parameters were obtained by each of the three dimensionality reduction methods. Among all texture post-processing methods, the lowest error rate was 2.22% for POE+ACC/NDA; AUCs were 0.87 (95% CI: 0.76-0.97), 0.81 (95% CI: 0.72-0.93) and 0.76 (95%CI: 0.67-0.89) for random forest model, support vector machine model and neural network model in the test dataset, respectively, which indicated that random forest model had the best forecast performance. The imaging omics labels established based on POE+ACC/NDA had the lowest total error rate for analysis of maximum diameter of hematoma and GCS scores at admission","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"70 1","pages":"1248-1254"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75947349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of TAGLN2 gene in low-grade glioma and its correlation with prognoses of the patients by bioinformatic analysis","authors":"Yusheng Chen, Yang Guo, Han-Bin Shen, Peng Zhang","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.012","url":null,"abstract":"Objective \u0000To investigate the expression and signaling pathway of TAGLN2 gene in low-grade glioma (LGG), and the relation of its expression with prognoses of patients. \u0000 \u0000 \u0000Methods \u0000The expression of TAGLN2 gene in Oncomine and TCGA databases was analyzed by bioinformatics analysis. The TAGLN2-related protein-protein interaction network was mapped using STRING database, and the interacting protein coding genes involved in the network were enriched. According to the expression level of TAGLN2 gene in glioma, the patients were divided into high expression group and low expression group; the differences of overall survival (OS) and disease free survival (DFS) were compared between the two groups. \u0000 \u0000 \u0000Results \u0000The expression level of TAGLN2 gene was up-regulated in most of the tumors. The expression level of TAGLN2 gene in the tumors of LGG patients was obviously higher than that in the corresponding normal brain tissues. The missense mutation of TAGLN2 gene was analyzed in TCGA database, and 1.5% of TAGLN2 gene missense mutation occurred in glioma tissues. There were 51 nodes in TAGLN2-related protein-protein interaction network and 254 interaction relations, and the regional clustering index was 0.69. The network protein enrichment was obvious (P=1.0E-16). The proteins encoding and interacting with TAGLN2 gene were mainly concentrated in vesicles, extracellular matrix and cell membrane. Their molecular functions were mainly protein binding, iron binding and accounting binding; their biological processes were mainly concentrated in the regulation of biological functions, cell development and multicellular tissue processes. OS and DFS of TAGLN2 high expression group were significantly lower than those of low expression group (HR=2.7, HR=1.8, P 0.05). \u0000 \u0000 \u0000Conclusion \u0000TAGLN2 is highly expressed in LGG tissues and is associated with poor prognosis. \u0000 \u0000 \u0000Key words: \u0000TAGLN2 gene; Glioma; Bioinformatics analysis","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"47 1","pages":"1262-1267"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86040430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prognostic scoring system for contralateral hematoma progression of bilateral chronic subdural hematomas after initial unilateral evacuation and preliminary assessment of its effectiveness","authors":"Jun Shen, Lili Yuan, Xuefei Shao, Qifu Wang, Xiaochun Jiang","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.011","url":null,"abstract":"Objective \u0000To investigate the risk factors for contralateral hematoma progression of bilateral chronic subdural hematomas (bCSDHs) after initial unilateral evacuation, and finally develop a prognostic scoring system. \u0000 \u0000 \u0000Methods \u0000Sixty-one patients with bCSDHs underwent initial unilateral evacuation in our hospital from October 2012 to March 2019 were chosen in our study. During follow up, CT examination was used to determine whether the patients had developed contralateral hematoma. The clinical data of patients from the progressive group and non-progressive group were retrospectively analyzed and compared. Multivariate Logistic regression was used to analyze the independent risk factors for postoperative contralateral hematoma progression. Receiver operating characteristic (ROC) curve was established to predict the progression of contralateral hematoma for each risk factor. A prognostic grading system was developed on the basis of independent risk factors and cut-off value. All patients were scored according to the scoring system and the progression rate of different scores were re-analyzed. \u0000 \u0000 \u0000Results \u0000As compared with the non-progressive group, the progressive group had higher proportions of patients with extensive contralateral hematoma distribution or low density of contralateral hematoma, higher amount of preoperative contralateral hematoma and postoperative hematoma, with statistically significant differences (P 40 cm3 was set as one score, and that≤40 cm3 was set as 0 score. All patients were scored, and the scoring system was ranged from 0 to 2 scores; the contralateral hematoma progression rate of 0, 1, and 2 were 0%, 23.81%, and 57.69%, respectively, with significant differences (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Extensive contralateral hematoma distribution and hematoma volume after contralateral hematoma surgery are independent risk factors for contralateral hematoma progression of bCSDHs after initial unilateral evacuation; the prognostic scoring system is simple and practical, which can serve as part of clinical references. \u0000 \u0000 \u0000Key words: \u0000Chronic subdural hematoma; Unilateral drainage; Hematoma progression; Scoring system","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"30 1","pages":"1255-1261"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80544482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}