中华神经医学杂志最新文献

{"title":"Effect of combined therapy of radiosurgery and temozolomide on U87-epidermal growth factor receptor and variant III cells and their xenograft","authors":"Yiguang Lin, Dong Liu, Xiaomin Liu, De-sheng Xu","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.005","url":null,"abstract":"Objective \u0000To explore the effect of radiosurgery in combination of temozolomide therapy in vitro and in vivo on invasion and endocrine function of human glioma cell line U87-epidermal growth factor receptor and variant III (EGFRvIII) and their xenograft. \u0000 \u0000 \u0000Methods \u0000(1) Human glioma U87-EGFRvIII cells were routinely cultured; CCK-8 was used to detect the effect of temozolomide at different concentrations on proliferation of U87-EGFRvIII cells, and the semi-inhibitory concentration (IC50) of temozolomide was calculated; the U87-EGFRvIII cells were divided into control group, 6 Gy radiotherapy group and 12 Gy radiotherapy group, and the expressions of invasion-related proteins and gene repair proteins in the three groups were detected by Western blotting after 0, 6 and 12 Gy edge-dose irradiation, respectively; the U87-EGFRvIII cells were divided into control group, 6 Gy radiotherapy group and 6 Gy radiation combined with temozolomide treatment group (5 mmol/L temozolomide was added after 6 Gy irradiation), and 24 h after each treatment, Western blotting was used to detect the expressions of invasion related proteins and gene repair related proteins in the three groups. (2) Nude mouse transplantation intracranial glioma models were established with cell suspension of the control group, 6 Gy radiotherapy group and 6 Gy radiation combined with temozolomide treatment group; 7, 14, 21 d after transplantation, bioluminescence imaging (BLI) was employed to detect luciferase expression in nude mice in vivo and measurement of transplanted tumors was performed; survival curve and body mass curve were drew in nude mice; immunohistochemical staining was used to detect the expressions of EGFRvIII, epidermal growth factor receptor (EGFR), matrix metalloproteinase (MMP)-9, vascular endothelial growth factor (VEGF) and Ki67 in intracranial transplanted gliomas. \u0000 \u0000 \u0000Results \u0000(1) The IC50 of temozolomide on U87-EGFRvIII cells was 5 mmol/L; as compared with those in the control group, the expressions of EGFRvIII, EGFR, MMP-2, MMP-9, VEGF, MGMT, AKT-1, β-catenin and Ku70 significantly increased in the cells of the 6 Gy radiotherapy group, while the expressions of EGFRvIII, EGFR, MMP-2, MMP-9, VEGF, MGMT, AKT-1, β-catenin and Ku70 significantly decreased in the cells of the 12 Gy radiotherapy group as compared with those in the 6 Gy radiotherapy group (P<0.05); as compared with those in the 6 Gy radiotherapy group, the expressions of EGFRvIII, EGFR, MMP-2, MMP-9, VEGF, MGMT, AKT-1, β-catenin and Ku70 in cells of the 6 Gy radiotherapy combined with temozolomide group were statistically decreased (P<0.05). (2) As compared with mice in the control group and 6 Gy radiotherapy group, mice in the 6 Gy radiotherapy combined with temozolomide group had significantly lower cell tumorigenicity, significantly higher survival rate and body mass 21 d after transplantation, and significantly smaller volume of xenograft tumors (P<0.05); the expressions of EGFRvIII, EGFR, MMP-9, V","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"27 1","pages":"1215-1223"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87045206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of a nomogram model for risk of pulmonary infection after craniocerebral injury and preliminary assessment of its effectiveness","authors":"Wang Yuchan, Changqing Shi, Wenyong Li, Liu Shuyun, Liu Zhihui, Xuehong Yu","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.004","url":null,"abstract":"Objective \u0000To explore the risk factors of postoperative pulmonary infection in patients with craniocerebral injury and establish a nomogram model to predict the risk of postoperative pulmonary infection after craniocerebral injury. \u0000 \u0000 \u0000Methods \u0000The clinical data of 169 patients with craniocerebral injury, admitted to and underwent craniotomy in our hospital from January 2013 to December 2018, were retrospectively analyzed. The clinical data of patients with postoperative pulmonary infection and without postoperative pulmonary infection were compared. The risk factors of postoperative pulmonary infection were analyzed by multivariate Logistic regression. R language was used to establish a nomogram model to predict the risk of postoperative pulmonary infection after craniocerebral injury. Receiver operating characteristic (ROC) curve was used to explore the prediction efficiency of the nomogram model for pulmonary infection after craniocerebral injury. \u0000 \u0000 \u0000Results \u0000Among the 169 patients, 74 (43.8%) were complicated with pulmonary infection and 95 (56.2%) were not complicated with pulmonary infection. As compared with non-pulmonary infection group, pulmonary infection group had significantly higher percentages of patients with open craniocerebral injury and Glasgow coma scale (GCS) scores<7, significantly higher American Society of Anesthesiologists (ASA) grading, lower albumin level one week after surgery, statistically longer operation time, and significantly higher percentages of patients with conscious disorder, patients accepted intraoperative blood transfusion, patients used breathing machine, and patients stayed in bed for 4 weeks or more (P<0.05). Multivariate Logistic regression analysis showed that GCS scores (OR=0.243, 95%CI: 0.122-0.497, P=0.000), ASA grading (OR=3.349, 95%CI: 2.233-5.021, P=0.000), disturbance of consciousness (OR=3.185, 95%CI: 1.217-8.334, P=0.018), and use of ventilator (OR=3.376, 95%CI: 1.590-7.167, P=0.002) were independent risk factors for postoperative pulmonary infection in patients with craniocerebral injury. The scores of the nomogram model were 13.7, 100.0, 38.0 and 27.5 in GCS scores, ASA grading, disturbance of consciousness and use of ventilator, respectively. The consistency index of the nomogram model for predicting postoperative pulmonary infection in patients with craniocerebral injury was 0.835. ROC curve showed that the area under the curve predicted by nomogram model for postoperative pulmonary infection in patients with craniocranial injury was 0.840 (95%CI: 0.778-0.901). \u0000 \u0000 \u0000Conclusion \u0000Based on the risk factors for pulmonary infection after craniocerebral injury, a nomogram model for predicting the risk of pulmonary infection is established, which has a good differentiation degree and prediction effect, and can provide a reference for medical staff to identify high-risk patients at an early stage, so as to take more targeted intervention measures. \u0000 \u0000 \u0000Key words: \u0000Craniocerebral injury; Pulmon","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"66 1","pages":"1209-1214"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89870642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One case report of right temporal lobe injury with bilateral sudden deafness as its main manifestation","authors":"Zhaoxi Ma, Yu-qiu Yue, Yan Luo, Wanhua Wang","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.014","url":null,"abstract":"","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"81 1","pages":"1271-1273"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81002131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencing factors of secondary brain injury adjacent to acute epidural hematoma after surgical evacuation","authors":"Shi-long Fu, Bangqing Yuan, Bi-song Liu, Liangfeng Wei, Shangming Zhang, Jun Li, Haibing Liu, Shousen Wang","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.001","url":null,"abstract":"Objective \u0000To explore the risk factors, mechanism and treatment strategies of secondary brain injury (cerebral hemorrhage or cerebral infarction/encephaledema) adjacent to acute epidural hematoma after surgical evacuation. \u0000 \u0000 \u0000Methods \u0000Forty-four patients with acute epidural hematoma underwent craniotomy in our hospital from March 2013 to December 2018 were chosen in this study. According to postoperative CT or MR imaging examination results, patients were divided into group of secondary brain injury (n=11) and group of non-secondary brain injury (n=33). The clinical data of the two groups were compared, and the significance of epidural hematoma thickness in assessing secondary brain injury was analyzed by receiver operating characteristic (ROC) curve. Binary Logistic regression analysis was used to analyze the independent risk factors affecting secondary brain injury. \u0000 \u0000 \u0000Results \u0000After surgery, 11 showed secondary brain injury: 3 occurred cerebral hemorrhage, one of whom was diagnosed as having cerebral venous hemorrhage in the cortical vein drainage area caused by traumatic cerebral venous circulation disorder; 6 had cerebral infarction/encephaledema, and 2 occurred hemorrhagic cerebral infarction/encephaledema; two underwent secondary craniotomy and both achieved satisfactory effect. As compared with patients from the non-secondary brain injury group, patients from secondary brain injury group had significantly higher percentage of patients with epidural hematoma thickness≥33.5 mm (P<0.05). ROC curve analysis showed that the thickness of epidural hematoma had predictive value in secondary brain injury after surgery (P<0.05), and area under the curve was 0.722 and diagnostic threshold was 33.5 mm. Binary Logistic regression analysis revealed that epidural hematoma thickness≥33.5 mm was an independent risk factor for secondary brain injury adjacent to epidural hematoma after surgery (odds ratio=7.367, P=0.024, 95%CI=1.298-41.797). \u0000 \u0000 \u0000Conclusions \u0000Acute epidural hematoma thickness≥33.5 mm is a high-risk factor associated with secondary brain injury adjacent to epidural hematoma after surgery. Intracranial venous circulatory disorders have non-negligible effect on occurrence of secondary brain injury. \u0000 \u0000 \u0000Key words: \u0000Acute epidural hematoma; Cerebral venous hemorrhage; Cerebral infarction; Encephaledema; Risk factor","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"8 1","pages":"1189-1195"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87879137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of low density lipoprotein receptor related protein 1 regulating β-amyloid metabolism and its implications for prevention and treatment of Alzheimer's disease in the future","authors":"Junchen Zhang, Wu-hua Xu","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.018","url":null,"abstract":"Almost all active immunotherapy attempts which targeted at clearing or reducing β-amyloid (Aβ) plaques in brains of patients with Alzheimer' disease (AD) were fallen into unprecedented difficulties, because of unsatisfactory curative effects. Recently, more and more evidences support that low density lipoprotein receptor related protein 1 (LRP1) is involved in Aβ production and clearance through multiple non-immune pathways, which has showed the potential as a whole-new interference target different with classical Aβ immunotherapies. So, we try to summarize the research developments of roles of LRP1 in Aβ metabolic process in physiological and AD conditions, and look forward to its possible applications in the prevention and treatment of AD. \u0000 \u0000 \u0000Key words: \u0000Alzheimer's disease; Low density lipoprotein receptor related protein 1; Beta-amyloid metabolism","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"16 1","pages":"1289-1293"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90147623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of cerebrospinal fluid lactic acid in bacterial meningitis after craniotomy for cerebral hemorrhage in adults","authors":"Long He, Wenhua Fang, Chenyu Ding, Xiaorong Yan, Peng Lin","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.009","url":null,"abstract":"Objective \u0000To explore the diagnostic value of cerebrospinal fluid (CSF) lactic acid (LA) level in bacterial meningitis after craniotomy for cerebral hemorrhage in adults. \u0000 \u0000 \u0000Methods \u0000The clinical data of 162 patients with cerebral hemorrhage, admitted to and accepted craniotomy in our hospital from April 2013 to April 2018, were retrospectively collected; patients were divided into infected group (n=75) and non-infected group (n=87) according to whether postoperative bacterial meningitis occurred; univariate analysis was used to compare the differences of CSF-LA concentration and other indicators of CSF between patients of the two groups; multivariate Logistic regression analysis was used to screen the independent factors affecting the occurrence of postoperative bacterial meningitis; receiver operating characteristic (ROC) curve was used to analyze the predictive values of CSF-LA and other indicators in postoperative bacterial meningitis. Furthermore, 17 patients with positive bacterial CSF were divided into Gram-positive (G+) bacteria group (n=9) and Gram-negative (G-) bacteria group (n=8); the predictive values of CSF-LA and other indicators for postoperative meningitis of G- bacteria patients were analyzed in the same way. \u0000 \u0000 \u0000Results \u0000(1) The CSF-LA concentration in infected group([6.3±2.8] mmol/L) was significantly increased as compared with that in non-infected group ([3.3±1.6] mmol/L, P<0.05); the results of multivariate Logistic regression analysis showed that CSF-LA was an independent influencing factor for postoperative bacterial meningitis (odd ratio=1.547, 95% confidence interval: 1.029-2.326, P=0.036); ROC curve results revealed that the area under the curve of CSF-LA concentration in the diagnosis of bacterial meningitis after craniotomy was 0.854 (95% confidence interval: 0.790-0.904), and the optimal cut-off value was 4.61 mmol/L, with sensitivity of 69.3%, specificity of 92.0%, positive predictive value of 88.1% and negative predictive value of 77.7%. (2) The CSF-LA concentration in G- bacteria group ([9.9±2.9] mmol/L) was significantly increased as compared with that in G+ bacteria group ([5.2±3.1] mmol/L, P< 0.05); ROC curve results revealed that, in patients with positive bacterial CSF, the area under the curve of CSF-LA concentration in diagnosis of meningitis with G- bacteria after craniotomy was 0.861 (95% confidence interval: 0.610-0.978), and the optimal cut-off value was 7.20 mmol/L with sensitivity of 87.5%, specificity of 88.9%, positive predictive value of 87.5%, and negative predictive value of 88.9%. \u0000 \u0000 \u0000Conclusion \u0000Detection for concentration of CSF-LA can help predicting bacterial meningitis after craniotomy for cerebral hemorrhage and identify G+ and G- bacteria meningitis. \u0000 \u0000 \u0000Key words: \u0000Bacterial meningitis; Cerebral hemorrhage; Cerebrospinal fluid; Lactic acid; Craniotomy","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"26 1","pages":"1241-1247"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78298726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in Horner syndrome","authors":"Xueling Chen, X. Zhong, Jie Zhong, Cheng Zhang","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.019","url":null,"abstract":"Horner syndrome results from an interruption of the oculosympathetic pathway. Typical clinical manifestations include ptosis, dilated pupils and less sweat on the affected side. The clinical symptoms caused by damage at different sites are not identical. An in-depth understanding of Horner syndrome may help us identify the causes of Horner syndrome early and estimate the severity of the disease. This article reviews the neuroanatomy and common etiology, clinical manifestations, diagnosis and treatment of Horner syndrome to provide reference for clinical work. \u0000 \u0000 \u0000Key words: \u0000Horner's syndrome; Oculosympathetic pathway; Miosis","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"56 1","pages":"1294-1296"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83969196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of hypertonic saline combined with magnesium sulfate on severe craniocerebral injury","authors":"Genghuan Wang, Wen-Chang Chu, Zhengmin Chu, Jianguo Shen, Yifei Wang, Haihang Zhou, Jianguo Shen, Litao Zhang, Kuncan Zhu, Heping Shen","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.002","url":null,"abstract":"Objective \u0000To explore the effect of hypertonic saline combined with magnesium sulfate on severe craniocerebral injury. \u0000 \u0000 \u0000Methods \u0000Patients with severe craniocerebral injury admitted to our hospital from September 2017 to February 2019 were selected prospectively. With the informed consent of the patients' families, the patients were divided into control group and experimental group according to the random number table. Patients in the two groups accepted intracranial pressure monitoring; patients in the experimental group additionally accepted magnesium sulfate combined with hypertonic saline for a continuous use of 7 d. Incidences of high intracranial pressure, epilepsy, low intracranial perfusion, cerebral vasospasm, cerebral infarction, and intracranial pressure rebound, total mannitol dosages one week after injury, serum neuron specific enolase (NSE) level, and Glasgow outcome scale (GOS) scores and mortality rate 3 months after injury were analyzed and compared between the two groups. \u0000 \u0000 \u0000Results \u0000A total of 93 patients were enrolled; 47 were into the control group and 46 into the experimental group. There were no significant differences in age, gender, Glasgow coma scale (GCS) scores and NSE levels at admission, and percentages of patients accepted craniotomy evacuation of hematoma or bone flap decompression between the two groups (P>0.05). As compared with those in the control group, the total mannitol dosage one week after injury and serum NSE concentration were significantly lower, and GOS scores 3 months after injury in the experimental group were significantly higher(P<0.05). Patients in the experimental group had significantly lower incidences of high intracranial pressure, cerebral vasospasm and intracranial pressure rebound as compared with patients in the control group (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Hypertonic saline combined with magnesium sulfate can improve the prognoses of severe craniocerebral injury; it has few side effects and is cheap; it might be an effective cerebral protective agent. \u0000 \u0000 \u0000Key words: \u0000Severe craniocerebral injury; Hypertonic saline; Magnesium sulfate; Intracranial pressure; Cerebral vasospasm; Prognosis","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"44 1","pages":"1196-1200"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89558982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in cytokine influencing oncolytic virus therapy through brain tumor microenvironment","authors":"H. Tian, X. Lun, Bin Jiang, Wenqiang Guo, Zhigang Wang","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.015","url":null,"abstract":"Glioma, especially glioblastoma, is one of the most common malignancies in the central nervous system. Traditional surgery combined with radiotherapy and chemotherapy did not significantly change the survival time of gliomas. Invasive growth, high heterogeneity and existence of glioma stem cell are the main causes of tumor recurrence. In addition, various immune cells and cytokines secreted by them in tumor microenvironment, as well as their activation status, are the key factors affecting tumor progress and effecacy of various immunotherapy. Interleukin (IL)-33 is a member of IL-1 gene family, and in recent years, it has been confirmed that IL-33 is highly expressed in some brain tumors, and IL-33 is the main coordinator of microenvironment regulation in brain tumors. In this paper, we will introduce the immunosuppressive state of brain tumors and their microenvironment and the limitation of tumor growth and immunotherapy, and recent advance that cytokine regulate and intervene the microenvironment of glioma to adapt tumor-lytic virus-immunotherapy. \u0000 \u0000 \u0000Key words: \u0000Glioma; Interleukin-33; Glioma microenvironment; Oncolytic virus-immunotherapy","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"8 1","pages":"1274-1278"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91080294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in MR imaging features and related diseases of pediatric pituitaries","authors":"Zhiyu Xi","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.017","url":null,"abstract":"The function and related diseases of pituitary in children are very different from those in adults. In the past, understanding of the normal physiology of children's pituitary was neglected. The diagnoses and treatments of these diseases were mostly based on experience from adults, lacking awareness of their specialties. This review focuses on the current research on children's normal pituitary and related diseases from an imaging perspective and explains their differences with adults. \u0000 \u0000 \u0000Key words: \u0000Children; Pituitary; Pituitary disease; Magnetic resonance imaging","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"37 1","pages":"1284-1288"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75094218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}