中华神经医学杂志最新文献

{"title":"Effect of functional electrical stimulation on limb motor function and extra cellular signal-regulated kinase expression in adult rats with spinal cord injury","authors":"Wang Wei, Guo Yue, W. Wenjuan, Cai Hongmei","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.006","url":null,"abstract":"Objective \u0000To investigate the protective effect of functional electrical stimulation on limb motor function and its mechanism in rats with spinal cord injury. \u0000 \u0000 \u0000Methods \u0000One hundred and twenty healthy adult SD rats were randomly divided into sham-operated group, model group, and functional electrical stimulation (FES) group (n=40). The rats in the latter two groups were replicated as spinal cord injury models on T9 using NYU method; and only laminectomy without spinal cord injury was performed in rats of the sham-operated group; FES was performed in rats of the functional electrical stimulation group 8 h after model making. One d, and one, two, and four weeks after model making, 10 rats in each group were chosen for experiment, respectively; BBB scale was used to evaluate the motor function of the rats; immunohistochemical staining was used to detect the extra cellular signal-regulated kinase (ERK) expression in the injured spinal cords; ERK mRNA expression in the injured spinal cords was detected by real-time PCR. \u0000 \u0000 \u0000Results \u0000As compared with rats in the control group, rats in the model group and FES group had significantly decreased BBB scale scores and statistically increased ERK protein and mRNA expressions at each time point after injury (P<0.05). One, two, and four weeks after model making, rats in the FES group had significantly higher BBB scale scores and statistically lower ERK protein and mRNA expressions than rats in the model group (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000FES can protect the spinal cords by inhibiting the ERK expression in the injured areas, thereby improving the limb motor function of rats with spinal cord injury. \u0000 \u0000 \u0000Key words: \u0000Functional electrical stimulation; Spinal cord injury; Extra cellular signal-regulated kinase; BBB scale","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"32 1","pages":"1224-1228"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77721424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of hematoma puncture and drainage on blood-brain barrier permeability and neuronal apoptosis in rats with cerebral hemorrhage","authors":"Jidong Sun, Yan Liu, Jia Wang, Xiao-liang Liu, Chen Zhang, Jun Liu","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.11.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.11.002","url":null,"abstract":"Objective \u0000To explore the mechanism of hematoma puncture and drainage in the treatment of cerebral hemorrhage at molecular level. \u0000 \u0000 \u0000Methods \u0000Twenty-four healthy male SD rats were induced cerebral hemorrhage models by autologous blood basal ganglia injection, and randomly divided into control group and puncture and drainage group (n=12). The rats in the control group did not receive intervention, while rats in the puncture and drainage group received puncture and drainage for hematoma. Modified neurological severity scale (mNSS) was performed on rats from the two groups before and after operation; 6 rats were taken from each group for HE staining and TUNEL to detect the number of apoptotic nerve cells in the brain tissues around the hematoma; 6 rats were taken from each group to detect the infiltration amount of brain Evans blue (EB). \u0000 \u0000 \u0000Results \u0000The mNSS scores of the puncture and drainage group after surgery (11.01±1.63) were significantly higher than those before surgery (9.62±2.05, P<0.05), and significantly higher than those in the control group (10.13±0.82, P< 0.05). The number of apoptotic nerve cells in the peripheral brain tissues of hematoma in the puncture and drainage group ([136.56±13.35] cells/mm2) was significantly smaller as compared with that in the control group ([297.19±51.90] cells/mm2), and the amount of EB infiltration ([289.67±122.43] μg/g brain tissue) in the puncture and drainage group was significantly decreased as compared with that in the control group ([325.48±51.43] μg/g brain tissue, P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Puncture and drainage for hematoma can improve the microenvironment of brain tissues around hematoma, alleviate the damage of blood-brain barrier, and inhibit the apoptosis of nerve cells. Although it can lead to aggravation of temporary neurological function damage, it is still an effective treatment method for cerebral hemorrhage. \u0000 \u0000 \u0000Key words: \u0000Hematoma puncture and drainage; Intracerebral hemorrhage; Cell apoptosis; Blood-brain barrier","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"21 1","pages":"1087-1090"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73565166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Related factors affecting postoperative pneumonia in patients with cavernous cerebrovascular malformation","authors":"Fang-yu Wang, Chenyu Ding, W. Fan, Yuan-xiang Lin, Zhang-ya Lin","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.11.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.11.012","url":null,"abstract":"Objective \u0000To explore the related factors affecting postoperative pneumonia in patients with cavernous cerebrovascular malformation (CCM). \u0000 \u0000 \u0000Methods \u0000Clinical data of 151 CCM patients admitted to our hospital from January 2010 to January 2017 were retrospectively collected. Patients were divided into postoperative pneumonia group (n=11) and postoperative non-pneumonia group (n=140) according to the occurrence of postoperative pneumonia. Univariate Logistic regression analysis, multivariate Logistic regression analysis and receiver operating characteristic (ROC) curve were used to screen the relevant factors influencing the occurrence of postoperative pneumonia in CCM patients and evaluate the predictive value of relevant factors in postoperative pneumonia. \u0000 \u0000 \u0000Results \u0000As compared with patients from postoperative non-pneumonia group, patients from postoperative pneumonia group had significantly increased modified Rankin scale (mRS) scores and significantly higher percentage of CCM combined with hemorrhage, and significantly decreased Glasgow coma scale (GCS) scores (P<0.05). Multivariate Logistic regression analysis showed that preoperative GCS scores (OR=4.75, 95%CI: 1.14-19.80, P=0.032) and mRS scores (OR=15.61, 95%CI: 3.22-75.58, P=0.001) were independent factors influencing the occurrence of postoperative pneumonia. ROC curve showed that the sensitivity and specificity of mRS scores≥4 to predict postoperative pneumonia were 45.5% and 95.7%, respectively, and the sensitivity and specificity of GCS scores≤13 to predict postoperative pneumonia were 54.5% and 85.7%, respectively. \u0000 \u0000 \u0000Conclusion \u0000For CCM patients with preoperative GCS scores≤13 or mRS scores≥4, more attention should be paid to perioperative lung management and occurrence of postoperative pneumonia should be vigilant. \u0000 \u0000 \u0000Key words: \u0000Cerebral cavernous malformation; Postoperative pneumonia; Modified Rankin scale; Glasgow coma scale","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"66 1","pages":"1146-1150"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74956892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in application of imaging techniques in treatment of Parkinson's disease with deep brain stimulation","authors":"Feng Zhang, F. Meng","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.11.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.11.019","url":null,"abstract":"Deep brain stimulation (DBS) is the main treatment methods of Parkinson's disease (PD), and subthalamic nucleus (STN) is a commonly used surgical target. Accurate localization of electrodes in STN using imaging technology is an important factor for successful surgery. This paper summarizes the advantages and disadvantages of different MR imaging sequences in STN development as follows. \u0000 \u0000 \u0000Key words: \u0000Parkinson's disease; Subthalamic nucleus; Deep brain stimulation","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"278 1","pages":"1173-1176"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76564532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in relation between collateral circulation and prognoses of ischemic stroke based on multimodal imaging evaluation","authors":"Liang'e Xu, S. Zhang, Binze Jiang, Yuan-yue Zhang, Z. Shi, Bin Xu","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.11.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.11.018","url":null,"abstract":"Cerebral collateral circulation can improve cerebral blood flow and protect neurons in ischemic stroke, which provides valuable time for reperfusion therapy and is closely related to the prognoses of patients with acute ischemic stroke. With the continuous emergence and development of new techniques for vascular reperfusion therapy in acute phase, it is urgent to establish a scheme for individualized evaluation of collateral circulation to guide clinical decision-making. Collateral circulation based on multi-mode imaging evaluation can provide guidance for clinical individualized diagnoses and accurate treatments more quickly and effectively to improve the clinical prognoses of patients. In order to provide guidance for the reperfusion treatment of acute ischemic stroke and effectively evaluate the clinical prognoses of patients, the authors summarize the research progress on correlation between collateral circulation and prognoses of ischemic stroke based on multi-mode imaging evaluation in recent years. \u0000 \u0000 \u0000Key words: \u0000Ischemic stroke; Collateral circulation; Multimode imaging; Prognosis","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"26 1","pages":"1168-1172"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83233522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of resveratrol in alleviating neuroinflammation after cerebral ischemia reperfusion by inhibiting Toll like receptor 4 signaling pathway","authors":"S. Ma, Zhongjun Yan, Junchao Li, L. Fan","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.11.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.11.001","url":null,"abstract":"Objective \u0000To explore the mechanism of resveratrol in alleviating neuroinflammation after cerebral ischemia-reperfusion injury by inhibiting Toll like receptor 4 (TLR4) signaling pathway. \u0000 \u0000 \u0000Methods \u0000Sixty adult male SD rats were randomly divided into sham-operated group, cerebral ischemia-reperfusion injury group, and resveratrol treatment group (n=20). Rat models of transient middle cerebral artery occlusion (MCAO) in the latter two groups were prepared by modified thread embolization method; reperfusion was performed after 2 h of occlusion, and 20 mg/kg normal saline or resveratrol via tail vein injection was given 15 min before model preparation and one min before reperfusion, respectively. At 72 h after MACO, neurological severity scale (NSS) was applied to evaluate the neurological functions of rats. Enzyme linked immunosorbent assay was performed to detect the expressions of pro-inflammatory cytokines interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α and anti-inflammatory cytokines IL-4, IL-10, and transforming growth factor (TGF)-β. Reverse transcription-polymerase chain reaction was performed to detect the mRNA expressions of M1 signature markers IL-1β and CD32 and M2 signature markers CD206 and Arginase-1. Western blotting was used to detect the expressions of TLR4 signaling molecules TLR4, myeloid differentiation protein 88 (MyD88), tumor necrosis factor receptor-associated factor 6 (TRAF6), IL-1 receptor associated kinase 1 (IRAK1) and nuclear factor (NF)-κB. \u0000 \u0000 \u0000Results \u0000As compared with those in the sham-operated group, rats in the cerebral ischemia-reperfusion injury group had significantly decreased NSS scores, significantly elevated levels of IL-1β, IL-6, TNF-α, IL-4, IL-10, and TGF-β in the damaged brain tissues, significantly elevated mRNA expression levels of IL-1β, CD32, CD206, and Arginase-1, and significantly elevated protein expression levels of TLR4, MyD88, TRAF6, IRAK1 and NF-κB (P<0.05). As compared with rats in the cerebral ischemia-reperfusion injury group, rats in the resveratrol treatment group had significantly decreased NSS scores, significantly decreased levels of IL-1β, IL-6, and TNF-α, significantly elevated levels of IL-4, IL-10, and TGF-β in the damaged brain tissues, significantly deceased mRNA expression levels of IL-1β and CD32, significantly elevated mRNA expression levels of CD206 and Arginase-1, and significantly decreased protein expression levels of TLR4, MyD88, TRAF6, IRAK1 and NF-κB (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Resveratrol inhibits microglia M1-type polarization and promotes M2-type polarization after cerebral ischemia reperfusion by inhibiting TLR4 signaling pathway, which further reduces neuroinflammation and neurological deficits. \u0000 \u0000 \u0000Key words: \u0000Resveratrol; Cerebral ischemia reperfusion; Toll like receptor 4; Microglia; Neuroinflammation","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"58 1","pages":"1081-1086"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90885491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance in treatment of carotid-ophthalmic segment aneurysm","authors":"Xinyu Lu, Xin Zhang","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.11.022","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.11.022","url":null,"abstract":"In recent years, with the development of imaging technology and materials science, the interventional treatment of aneurysms has progressed rapidly. However, the carotid-ophthalmic segment aneurysm is still one of the difficult points of treatment. This article reviews the current status and progress of treatment indications, surgical clipping and endovascular treatment of the carotid-ophthalmic segment aneurysm. \u0000 \u0000 \u0000Key words: \u0000Intracranial aneurysm; Carotid-ophthalmic segment; Endovascular embolization; Microsurgery","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"89 4 1","pages":"1184-1187"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83634559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations of high mobility group protein box-1 level with severity and prognoses of acute cerebral infarction","authors":"Liping Shen, Jiang-Yan Yang, Dongbai Liu","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.11.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.11.009","url":null,"abstract":"Objective \u0000To investigate the correlations of high mobility group protein box-1 (HMGB1) level with severity and prognoses of acute cerebral infarction. \u0000 \u0000 \u0000Methods \u0000Between April 2018 and October 2018, 300 patients with acute cerebral infarction and 122 healthy control subjects were enrolled. According to National Institute of Health stroke scale (NIHSS) scores, patients with acute cerebral infarction were divided into group A (NIHSS scores 2) after 3 months of follow up. The serum levels of HMGB1, low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) in different groups were detected and compared. Pearson correlation analysis and receiver operating characteristic curve were used to analyze the correlations of serum HMGB1 level with other indicators and evaluate their predictive values in poor prognosis. \u0000 \u0000 \u0000Results \u0000The serum HMGB1 level in the acute cerebral infarction patients was significantly higher than that in the controls ([7.98±3.99] μg/L vs. [4.61±1.02] μg/L, P<0.05); the serum HMGB1 level in the group C was significantly higher than that in group B ([12.86±1.91] μg/L vs. [7.30±1.07] μg/L, P<0.05), and that in group B was statistically higher than that in group A ([7.30±1.07] μg/L vs. [3.78±0.95] μg/L, P<0.05). Serum HMGB1 level was positively correlated with LDL-C level and NIHSS scores (r=0.521, P=0.000; r=0.931, P=0.000), and negatively correlated with HDL-C level (r=-0.114, P=0.001). The serum HMGB1 level in good prognosis group was significantly lower than that in poor prognosis group ([6.52±3.29] μg/L vs. [9.88±4.03] μg/L, P<0.05), and the serum HMGB1 level was positively correlated with mRS scores (r=0.160, P=0.000). The area under the curve of HMGB1 predicting poor prognosis of acute cerebral infarction (0.736[95%CI: 0.677-0.795]) was larger than that under the curve of LDL-C predicting poor prognosis of acute cerebral infarction (0.634[95%CI: 0.570-0.698]). \u0000 \u0000 \u0000Conclusion \u0000Serum HMGB1 level in patients with acute cerebral infarction is significantly increased, which is related to severity of disease, and has certain predictive value in prognoses of acute cerebral infarction. \u0000 \u0000 \u0000Key words: \u0000High mobility group protein box-1; Acute cerebral infarction; Disease severity; Prognosis","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"102 1","pages":"1131-1135"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75850833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations of expressions of peripheral blood regulatory T cells and related inflammatory factors with TOAST subtypes and infection risk in patients with acute cerebral infarction","authors":"Xue-Zhi Gao, Chuan-qing Yu, Mei Zhang, M. Xue, Lei Zhu, Zhiding Shao","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.11.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.11.007","url":null,"abstract":"Objective \u0000To explore the differences of degrees of immune inflammatory response in patients with different TOAST subtypes of acute cerebral infarction and their relations with infection risk after cerebral infarction. \u0000 \u0000 \u0000Methods \u0000One hundred and fifty-four patients with acute cerebral infarction who were free of detectable infection on admission, admitted to our hospital from October 2017 to June 2018, were recruited as patient group; according to TOAST subtypes, these patients were divided into large-artery atherosclerosis group (LAA, n=72), cardioembolic group (CE, n=38), and small-artery occlusion group (SAO, n=44); 45 healthy subjects enrolled at the same period were selected as control group. Fasting blood samples were taken on the next day of admission or during physical examination. Treg% (percentage of CD4+CD25+CD127[low] regulatory T cells [Treg] in CD4+ lymphocytes) was measured by flow cytometry. Interleukin (IL)-6, IL-10, and hypersensitive C-reactive protein (hsCRP) levels were measured by ELISA or Turbidimetric inhibition immuno assay. Spearman correlation analysis was performed to investigate the relations of Treg% and related inflammatory factors with TOAST subtypes of acute cerebral infarction and post-stroke infection risk. Receiver operating characteristic (ROC) curve was used to analyze the predictive values of Treg% and inflammatory factors in post-stroke infection. Univariate Logistic regression analysis and multivariate Logistic regression analysis were used to screen the risk factors of infection after cerebral infarction. \u0000 \u0000 \u0000Results \u0000(1) Treg% in LAA group was significantly lower than that in control group (P<0.05), and Treg% in CE group was statistically higher than that in control group (P<0.05); patients in the LAA and CE groups had significantly higher IL-6 and hsCRP levels as compared with those in the control group (P<0.05); patients in the LAA, CE and SAO groups had significantly lower IL-10 level than those in the control group (P<0.05); patients in the LAA and SAO groups had significantly decreased IL-6 and IL-10 levels as compared with those in the CE group (P<0.05); patients in the SAO group had significantly lower hsCRP level as compared with those in the CE group (P<0.05). Spearman correlation analysis showed that Treg% was negatively correlated with LAA (rs=-0.488, P=0.000) and positively correlated with CE and SAO (rs=0.355, P=0.000; rs=0.200, P= 0.013); the levels of IL-6, IL-10 and hsCRP were positively correlated with CE (rs=0.578, P=0.000; rs= 0.508, P=0.000; rs=0.299, P=0.015), and negatively correlated with SAO (rs=-0.404, P=0.001; rs=0.394, P=0.001; rs=0.308, P=0.012). (2) There were 36 patients who developed infection associated with cerebral infarction in the patient group; as compared with those in the non-infection group, Treg%, IL-6, IL-10 and hsCRP levels in the infection group were significantly increased (P<0.05); Spearman correlation analysis showed that Treg% and hsCRP were positively ","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"17 1","pages":"1116-1123"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75277660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expressions of regulatory B cells in peripheral blood of patients with Guillain-Barre syndrome","authors":"Yan Wang, Chenguang Hao, Yanfang Li, Yugang Zheng, Jian-Xia Ma","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.11.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.11.013","url":null,"abstract":"Objective \u0000To investigate the expressions of regulatory B cells and related cytokines in patients with Guillain-Barre syndrome (GBS). \u0000 \u0000 \u0000Methods \u0000Forty-four patients with GBS admitted to our hospital from October 2018 to June 2019 were enrolled as GBS group; 44 healthy subjects accepted physical examination in our hospital at the same period were selected as control group. Flow cytometry was used to determine the proportions of CD19+CD24hiCD38hi regulatory B cells and CD19+CD24hiCD27+ regulatory B cells in CD19+ lymphocytes in peripheral blood mononuclear cells of the two groups. ELISA was employed to detect the serum contents of interleukin (IL)-10, IL-35 and transforming growth factor (TGF)-β1 of the two groups. \u0000 \u0000 \u0000Results \u0000As compared with those in the control group, the proportions of CD19+CD24hiCD38hi regulatory B cells and CD19+CD24hiCD27+ regulatory B cells in CD19+B lymphocytes of the GBS group were significantly decreased (P 0.05). \u0000 \u0000 \u0000Conclusion \u0000Regulatory B cells play a role in the pathogenesis of GBS through IL-10 and IL-35 cytokine pathways. \u0000 \u0000 \u0000Key words: \u0000Regulatory B cell; Guillain-Barre syndrome; Cytokine; Interleukin","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"13 1","pages":"1151-1154"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81931684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}