Correlations of high mobility group protein box-1 level with severity and prognoses of acute cerebral infarction

Abstract

Objective To investigate the correlations of high mobility group protein box-1 (HMGB1) level with severity and prognoses of acute cerebral infarction. Methods Between April 2018 and October 2018, 300 patients with acute cerebral infarction and 122 healthy control subjects were enrolled. According to National Institute of Health stroke scale (NIHSS) scores, patients with acute cerebral infarction were divided into group A (NIHSS scores 2) after 3 months of follow up. The serum levels of HMGB1, low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) in different groups were detected and compared. Pearson correlation analysis and receiver operating characteristic curve were used to analyze the correlations of serum HMGB1 level with other indicators and evaluate their predictive values in poor prognosis. Results The serum HMGB1 level in the acute cerebral infarction patients was significantly higher than that in the controls ([7.98±3.99] μg/L vs. [4.61±1.02] μg/L, P<0.05); the serum HMGB1 level in the group C was significantly higher than that in group B ([12.86±1.91] μg/L vs. [7.30±1.07] μg/L, P<0.05), and that in group B was statistically higher than that in group A ([7.30±1.07] μg/L vs. [3.78±0.95] μg/L, P<0.05). Serum HMGB1 level was positively correlated with LDL-C level and NIHSS scores (r=0.521, P=0.000; r=0.931, P=0.000), and negatively correlated with HDL-C level (r=-0.114, P=0.001). The serum HMGB1 level in good prognosis group was significantly lower than that in poor prognosis group ([6.52±3.29] μg/L vs. [9.88±4.03] μg/L, P<0.05), and the serum HMGB1 level was positively correlated with mRS scores (r=0.160, P=0.000). The area under the curve of HMGB1 predicting poor prognosis of acute cerebral infarction (0.736[95%CI: 0.677-0.795]) was larger than that under the curve of LDL-C predicting poor prognosis of acute cerebral infarction (0.634[95%CI: 0.570-0.698]). Conclusion Serum HMGB1 level in patients with acute cerebral infarction is significantly increased, which is related to severity of disease, and has certain predictive value in prognoses of acute cerebral infarction. Key words: High mobility group protein box-1; Acute cerebral infarction; Disease severity; Prognosis