Recent advance in cytokine influencing oncolytic virus therapy through brain tumor microenvironment

Q4 Medicine

中华神经医学杂志 Pub Date : 2019-12-15 DOI:10.3760/CMA.J.ISSN.1671-8925.2019.12.015

H. Tian, X. Lun, Bin Jiang, Wenqiang Guo, Zhigang Wang

{"title":"Recent advance in cytokine influencing oncolytic virus therapy through brain tumor microenvironment","authors":"H. Tian, X. Lun, Bin Jiang, Wenqiang Guo, Zhigang Wang","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.12.015","DOIUrl":null,"url":null,"abstract":"Glioma, especially glioblastoma, is one of the most common malignancies in the central nervous system. Traditional surgery combined with radiotherapy and chemotherapy did not significantly change the survival time of gliomas. Invasive growth, high heterogeneity and existence of glioma stem cell are the main causes of tumor recurrence. In addition, various immune cells and cytokines secreted by them in tumor microenvironment, as well as their activation status, are the key factors affecting tumor progress and effecacy of various immunotherapy. Interleukin (IL)-33 is a member of IL-1 gene family, and in recent years, it has been confirmed that IL-33 is highly expressed in some brain tumors, and IL-33 is the main coordinator of microenvironment regulation in brain tumors. In this paper, we will introduce the immunosuppressive state of brain tumors and their microenvironment and the limitation of tumor growth and immunotherapy, and recent advance that cytokine regulate and intervene the microenvironment of glioma to adapt tumor-lytic virus-immunotherapy. \n \n \nKey words: \nGlioma; Interleukin-33; Glioma microenvironment; Oncolytic virus-immunotherapy","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"8 1","pages":"1274-1278"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华神经医学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.12.015","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Glioma, especially glioblastoma, is one of the most common malignancies in the central nervous system. Traditional surgery combined with radiotherapy and chemotherapy did not significantly change the survival time of gliomas. Invasive growth, high heterogeneity and existence of glioma stem cell are the main causes of tumor recurrence. In addition, various immune cells and cytokines secreted by them in tumor microenvironment, as well as their activation status, are the key factors affecting tumor progress and effecacy of various immunotherapy. Interleukin (IL)-33 is a member of IL-1 gene family, and in recent years, it has been confirmed that IL-33 is highly expressed in some brain tumors, and IL-33 is the main coordinator of microenvironment regulation in brain tumors. In this paper, we will introduce the immunosuppressive state of brain tumors and their microenvironment and the limitation of tumor growth and immunotherapy, and recent advance that cytokine regulate and intervene the microenvironment of glioma to adapt tumor-lytic virus-immunotherapy. Key words: Glioma; Interleukin-33; Glioma microenvironment; Oncolytic virus-immunotherapy

查看原文本刊更多论文

细胞因子通过脑肿瘤微环境影响溶瘤病毒治疗的研究进展

胶质瘤，尤其是胶质母细胞瘤，是中枢神经系统最常见的恶性肿瘤之一。传统手术联合放化疗对胶质瘤的生存时间无明显影响。胶质瘤干细胞的侵袭性生长、高异质性和存在是肿瘤复发的主要原因。此外，肿瘤微环境中各种免疫细胞及其分泌的细胞因子及其激活状态是影响肿瘤进展和各种免疫治疗效果的关键因素。白细胞介素(Interleukin, IL)-33是IL-1基因家族的成员，近年来证实IL-33在一些脑肿瘤中高表达，IL-33是脑肿瘤微环境调控的主要协调者。本文将介绍脑肿瘤及其微环境的免疫抑制状态、肿瘤生长和免疫治疗的局限性，以及细胞因子调节和干预胶质瘤微环境以适应溶瘤病毒免疫治疗的最新进展。关键词:胶质瘤;Interleukin-33;神经胶质瘤微环境;溶瘤细胞的virus-immunotherapy

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊