Recent advance in epoxyeicosatrienoic acids in intracerebral hemorrhage

Q4 Medicine

中华神经医学杂志 Pub Date : 2020-01-15 DOI:10.3760/CMA.J.ISSN.1671-8925.2020.01.019

H. Wei, Jixu Yu, Zhenchuan Liu, Yushuang Wang, Huimin Zhu

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Abstract

Epoxyeicosatrienoic acids (EETs) are mainly from intracellular arachidonic acids catalyzed by cytochrome P450 cyctooxygenase and degraded to lower active dihydroxyeicosapentaenoic acids by soluble epoxide hydrolase. In recent years, EETs have been found to be a new target for prevention and treatment of various nervous system diseases, such as anti-inflammatory reaction, anti-atherosclerosis, anti-cell apoptosis and angiogenesis. Intracerebral hemorrhage is a kind of serious acute cerebrovascular disease. Cerebral hemorrhage is a kind of acute cerebrovascular disease; secondary injury is one of the important mechanisms of cerebral hemorrhage; the present studies have confirmed that EETs have protective role in brain tissues after cerebral hemorrhage, thus, become new hotspot in the research of cerebral hemorrhage. This review focuses on the role and mechanism of EETs in intracerebral hemorrhage, hoping to provide some references for exploration of new research directions and therapeutic targets in the treatment of intracerebral hemorrhage. Key words: Epoxyeicosatrienoic acid; Intracerebral hemorrhage; Soluble epoxide hydrolase; Arachidonic acid

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环氧二碳三烯酸在脑出血中的研究进展

环氧二碳三烯酸(EETs)主要来源于细胞内花生四烯酸，经细胞色素P450环氧化酶催化，经可溶性环氧水解酶降解为活性较低的二羟基二十碳五烯酸。近年来，eet被发现是预防和治疗多种神经系统疾病的新靶点，如抗炎反应、抗动脉粥样硬化、抗细胞凋亡和血管生成。脑出血是一种严重的急性脑血管疾病。脑出血是一种急性脑血管疾病;继发性损伤是脑出血发生的重要机制之一;目前的研究证实了eet对脑出血后脑组织具有保护作用，因此成为脑出血研究的新热点。本文就脑出血中eet的作用及机制进行综述，希望为脑出血治疗探索新的研究方向和治疗靶点提供一些参考。关键词:环氧二碳三烯酸;脑出血;可溶性环氧化物水解酶;花生四烯酸

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