间充质干细胞衍生外泌体治疗中枢神经系统疾病的研究进展

Q4 Medicine

中华神经医学杂志 Pub Date : 2020-02-15 DOI:10.3760/CMA.J.ISSN.1671-8925.2020.02.018

Yesheng Sun, Zhi-qian Yang

{"title":"间充质干细胞衍生外泌体治疗中枢神经系统疾病的研究进展","authors":"Yesheng Sun, Zhi-qian Yang","doi":"10.3760/CMA.J.ISSN.1671-8925.2020.02.018","DOIUrl":null,"url":null,"abstract":"The treatment of central nervous system diseases has always been a hot topic, owning to its complexity and existence of blood-brain barrier. In recent years, studies on mesenchymal stem cells-derived exosomes (MSCs-EVS) showed that MSCs-EVS are not only potential therapeutic drugs for central nervous system diseases, but also natural carriers of therapeutic drugs due to their good biocompatibility and ability to cross the blood-brain barrier. This paper reviews the application and underling mechanism of MSCs-EVS in treatment of central nervous system diseases, and looks forward to its applications in central nervous system disease. \n \n \nKey words: \nMesenchymal stem cell; Exosome; Central nervous system disease","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"65 1","pages":"202-207"},"PeriodicalIF":0.0000,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recent advance in mesenchymal stem cell-derived exosomes in treatment of central nervous system diseases\",\"authors\":\"Yesheng Sun, Zhi-qian Yang\",\"doi\":\"10.3760/CMA.J.ISSN.1671-8925.2020.02.018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The treatment of central nervous system diseases has always been a hot topic, owning to its complexity and existence of blood-brain barrier. In recent years, studies on mesenchymal stem cells-derived exosomes (MSCs-EVS) showed that MSCs-EVS are not only potential therapeutic drugs for central nervous system diseases, but also natural carriers of therapeutic drugs due to their good biocompatibility and ability to cross the blood-brain barrier. This paper reviews the application and underling mechanism of MSCs-EVS in treatment of central nervous system diseases, and looks forward to its applications in central nervous system disease. \\n \\n \\nKey words: \\nMesenchymal stem cell; Exosome; Central nervous system disease\",\"PeriodicalId\":10104,\"journal\":{\"name\":\"中华神经医学杂志\",\"volume\":\"65 1\",\"pages\":\"202-207\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-02-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华神经医学杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.018\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华神经医学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2020.02.018","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

由于中枢神经系统疾病的复杂性和血脑屏障的存在，其治疗一直是一个热门话题。近年来对间充质干细胞衍生外泌体(mesenchymal stem cells-derived exosomes, MSCs-EVS)的研究表明，MSCs-EVS不仅是中枢神经系统疾病的潜在治疗药物，而且由于其良好的生物相容性和跨越血脑屏障的能力，是治疗药物的天然载体。本文综述了MSCs-EVS在中枢神经系统疾病治疗中的应用及其作用机制，并对其在中枢神经系统疾病中的应用前景进行了展望。关键词:间充质干细胞;外来体;中枢神经系统疾病

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Recent advance in mesenchymal stem cell-derived exosomes in treatment of central nervous system diseases

The treatment of central nervous system diseases has always been a hot topic, owning to its complexity and existence of blood-brain barrier. In recent years, studies on mesenchymal stem cells-derived exosomes (MSCs-EVS) showed that MSCs-EVS are not only potential therapeutic drugs for central nervous system diseases, but also natural carriers of therapeutic drugs due to their good biocompatibility and ability to cross the blood-brain barrier. This paper reviews the application and underling mechanism of MSCs-EVS in treatment of central nervous system diseases, and looks forward to its applications in central nervous system disease. Key words: Mesenchymal stem cell; Exosome; Central nervous system disease

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

中华神经医学杂志 Psychology-Neuropsychology and Physiological Psychology

CiteScore

0.30

自引率

0.00%

发文量

6272

期刊介绍：