Recent advance in mesenchymal stem cell-derived exosomes in treatment of central nervous system diseases

Abstract

The treatment of central nervous system diseases has always been a hot topic, owning to its complexity and existence of blood-brain barrier. In recent years, studies on mesenchymal stem cells-derived exosomes (MSCs-EVS) showed that MSCs-EVS are not only potential therapeutic drugs for central nervous system diseases, but also natural carriers of therapeutic drugs due to their good biocompatibility and ability to cross the blood-brain barrier. This paper reviews the application and underling mechanism of MSCs-EVS in treatment of central nervous system diseases, and looks forward to its applications in central nervous system disease. Key words: Mesenchymal stem cell; Exosome; Central nervous system disease