Association of post-stroke depression with tryptophan hydroxylase 2 rs4641528 polymorphism and risk factors of post-stroke depression

Q4 Medicine

中华神经医学杂志 Pub Date : 2019-10-15 DOI:10.3760/CMA.J.ISSN.1671-8925.2019.10.003

Jia Hu, Zhiming Zhou, Qian Yang, Wanli Dong, Junfeng Xu

{"title":"Association of post-stroke depression with tryptophan hydroxylase 2 rs4641528 polymorphism and risk factors of post-stroke depression","authors":"Jia Hu, Zhiming Zhou, Qian Yang, Wanli Dong, Junfeng Xu","doi":"10.3760/CMA.J.ISSN.1671-8925.2019.10.003","DOIUrl":null,"url":null,"abstract":"Objective \nTo investigate the association of post-stroke depression (PSD) with tryptophan hydroxylase 2 (TPH2) gene polymorphism and related clinical risk factors of PSD. \n \n \nMethods \nThree hundred and seventy-six patients diagnosed as having acute ischemic stroke for the first time, admitted to our hospital from March 2015 to September 2017, were chosen in our study. According to Hamilton depression scale scores and Diagnostic and statisistical Manual of Mental Disorders, fourth edition (DSM-IV), these patients were divided into PSD group and non-PSD group. High-resolution melt analysis was used to complete the genotyping of TPH2 gene rs4641528 and rs1386494 in the enrolled patients. The correlations of single nucleotide polymorphisms and PSD were analyzed. Logistic regression analysis was performed on items with statistically significant differences in univariate analysis to identify independent factors affecting PSD. \n \n \nResults \nThere were 104 patients into the PSD group and 272 patients into the non-PSD group; there were statistically significant differences between the two groups in years of education and NIHSS scores (P 0.05); there were significant differences in rs4641528 genotype and allele frequency between the two groups (P> 0.05). The C allele in the chromosomes of PSD patients accounted for 54.3%, while the C allele in the chromosomes of non-PSD patients accounted for 43.4%; the presence of allele (C) increased the risk of PSD (OR=1.552, 95%CI: 1.126-2.141, P=0.007). The results of multivariate Logistic regression analysis showed that baseline NIHSS scores and genotypes of rs4641528 (C/C+C/T) were independent influencing factors of PSD. \n \n \nConclusion \nTPH2 rs4641528 gene polymorphism and baseline NIHSS scores are found to be associated with depression 3 months after stroke in south Anhui province. \n \n \nKey words: \nStroke; Post-stroke depression; Tryptophan kinase 2; Gene polymorphism","PeriodicalId":10104,"journal":{"name":"中华神经医学杂志","volume":"2 1","pages":"985-990"},"PeriodicalIF":0.0000,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华神经医学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1671-8925.2019.10.003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Objective To investigate the association of post-stroke depression (PSD) with tryptophan hydroxylase 2 (TPH2) gene polymorphism and related clinical risk factors of PSD. Methods Three hundred and seventy-six patients diagnosed as having acute ischemic stroke for the first time, admitted to our hospital from March 2015 to September 2017, were chosen in our study. According to Hamilton depression scale scores and Diagnostic and statisistical Manual of Mental Disorders, fourth edition (DSM-IV), these patients were divided into PSD group and non-PSD group. High-resolution melt analysis was used to complete the genotyping of TPH2 gene rs4641528 and rs1386494 in the enrolled patients. The correlations of single nucleotide polymorphisms and PSD were analyzed. Logistic regression analysis was performed on items with statistically significant differences in univariate analysis to identify independent factors affecting PSD. Results There were 104 patients into the PSD group and 272 patients into the non-PSD group; there were statistically significant differences between the two groups in years of education and NIHSS scores (P 0.05); there were significant differences in rs4641528 genotype and allele frequency between the two groups (P> 0.05). The C allele in the chromosomes of PSD patients accounted for 54.3%, while the C allele in the chromosomes of non-PSD patients accounted for 43.4%; the presence of allele (C) increased the risk of PSD (OR=1.552, 95%CI: 1.126-2.141, P=0.007). The results of multivariate Logistic regression analysis showed that baseline NIHSS scores and genotypes of rs4641528 (C/C+C/T) were independent influencing factors of PSD. Conclusion TPH2 rs4641528 gene polymorphism and baseline NIHSS scores are found to be associated with depression 3 months after stroke in south Anhui province. Key words: Stroke; Post-stroke depression; Tryptophan kinase 2; Gene polymorphism

查看原文本刊更多论文

脑卒中后抑郁与色氨酸羟化酶2 rs4641528多态性及脑卒中后抑郁危险因素的关系

目的探讨脑卒中后抑郁(PSD)与色氨酸羟化酶2 (TPH2)基因多态性的关系及相关临床危险因素。方法选取2015年3月至2017年9月我院收治的首次确诊急性缺血性脑卒中患者376例。根据汉密尔顿抑郁量表得分和第四版《精神障碍诊断与统计手册》(DSM-IV)将患者分为PSD组和非PSD组。采用高分辨率熔融分析完成入组患者TPH2基因rs4641528和rs1386494的基因分型。分析单核苷酸多态性与PSD的相关性。对单变量分析中差异有统计学意义的项目进行Logistic回归分析，以确定影响PSD的独立因素。结果PSD组104例，非PSD组272例;两组受教育年限、NIHSS评分比较，差异均有统计学意义(P < 0.05);两组间rs4641528基因型和等位基因频率差异均有统计学意义(P> 0.05)。PSD患者染色体中的C等位基因占54.3%，非PSD患者染色体中的C等位基因占43.4%;等位基因(C)的存在增加了PSD的风险(OR=1.552, 95%CI: 1.126 ~ 2.141, P=0.007)。多因素Logistic回归分析结果显示，NIHSS基线评分和rs4641528基因型(C/C+C/T)是PSD的独立影响因素。结论皖南地区脑卒中后3个月抑郁与TPH2 rs4641528基因多态性及基线NIHSS评分相关。关键词:卒中;中风后抑郁症;色氨酸激酶2;基因多态性

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊