髓样2触发受体表达及其在阿尔茨海默病中的作用研究进展

Q4 Medicine

中华神经医学杂志 Pub Date : 2019-10-15 DOI:10.3760/CMA.J.ISSN.1671-8925.2019.10.017

Jinhuan Ning, Zhao-ji Liu, Jingzhou Li, D. Can

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引用次数: 0

摘要

髓样2 (TREM2)基因中表达的触发受体突变最近被发现与阿尔茨海默病(AD)和其他神经退行性疾病的发生密切相关。然而，TREM2参与AD等疾病发病机制的详细机制尚未完全阐明。在这篇综述中，我们讨论了目前对TREM2的结构和功能的了解，TREM2与AD的相关性，以及TREM2突变导致AD的可能原因。关键词:阿尔茨海默病;髓系2中表达的触发受体;DAP12

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Recent advances in triggering receptor expressed in myeloid 2 and its role in Alzheimer's disease

Mutations in the triggering receptor expressed in myeloid 2 (TREM2) gene have recently been found to be closely related to the development of Alzheimer's disease (AD) and other neurodegenerative diseases. However, the detailed mechanism underlying TREM2’s participation in the pathogenesis of AD and other diseases has yet to be fully elucidated. In this review, we discuss current understanding on the structure and function of TREM2, the relevance between TREM2 and AD, and the possible causes of AD by TREM2 mutations. Key words: Alzheimer's disease; Triggering receptor expressed in myeloid 2; DAP12

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来源期刊

中华神经医学杂志 Psychology-Neuropsychology and Physiological Psychology

CiteScore

0.30

自引率

0.00%

发文量

6272

期刊介绍：