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Plasma Therapy and Transfusion Technology最新文献

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Routine high-yield, low-contamination platelet concentrates produced with eccentriplate 离心板制备的常规高产、低污染血小板浓缩液
Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 DOI: 10.1016/S0278-6222(87)80050-5
M. Valbonesi, R. Frisoni, P.A. Pittaluga, C. Capra, G. Lercari, L. Giuliano, G. Angelini, I. Panzani
{"title":"Routine high-yield, low-contamination platelet concentrates produced with eccentriplate","authors":"M. Valbonesi,&nbsp;R. Frisoni,&nbsp;P.A. Pittaluga,&nbsp;C. Capra,&nbsp;G. Lercari,&nbsp;L. Giuliano,&nbsp;G. Angelini,&nbsp;I. Panzani","doi":"10.1016/S0278-6222(87)80050-5","DOIUrl":"10.1016/S0278-6222(87)80050-5","url":null,"abstract":"<div><p>In 1986 a new machine for the production of low-contamination platelet concentrates (PC) was introduced in our hemapheresis unit. In 15 months 967 procedures were carried out. There were three different phases of our study: A) the learning period, B) the research, and C) the routine application. The results for the evaluable procedures are summarized in Table 1.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"8 4","pages":"Pages 391-395"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80050-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78630774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Kinetics modeling of plasma exchange: Intra- and post-plasma exchange 血浆交换动力学模型:血浆内和后交换
Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 DOI: 10.1016/S0278-6222(87)80032-3
Robert M. Kellogg PhD , Jeane P. Hester MD
{"title":"Kinetics modeling of plasma exchange: Intra- and post-plasma exchange","authors":"Robert M. Kellogg PhD ,&nbsp;Jeane P. Hester MD","doi":"10.1016/S0278-6222(87)80032-3","DOIUrl":"https://doi.org/10.1016/S0278-6222(87)80032-3","url":null,"abstract":"<div><p>Patient response to plasma exchange is variable. Clinical experience indicates that the outcome depends on the size of the exchange relative to the patient's plasma volume, the amount of material available for removal in both the intravascular and extravascular pools, and the mobility of the material between the pools. Post-exchange, the patient's course also depends on the mobility of the material between the pools as well as its production and catabolic rates. The work reported here is an attempt to construct a mathematical model that describes events occurring intra- and post-plasma exchange. An attempt to model the kinetics of plasma exchange promotes an understanding of the requirements of volume removal in individual exchange procedures for optimal results, and establishes the interval between exchanges required to sustain the response to each individual exchange procedure.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"8 4","pages":"Pages 283-289"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80032-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91975448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First results with the new Fresenius cell separator AS 104 新费森尤斯细胞分离器as104的初步结果
Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 DOI: 10.1016/S0278-6222(87)80035-9
V. Kretschmer , A. See , D. Söhngen , M. Bachem , J.G. Kadar , H. Borberg , H. Pelzer , P. Zöfel
{"title":"First results with the new Fresenius cell separator AS 104","authors":"V. Kretschmer ,&nbsp;A. See ,&nbsp;D. Söhngen ,&nbsp;M. Bachem ,&nbsp;J.G. Kadar ,&nbsp;H. Borberg ,&nbsp;H. Pelzer ,&nbsp;P. Zöfel","doi":"10.1016/S0278-6222(87)80035-9","DOIUrl":"10.1016/S0278-6222(87)80035-9","url":null,"abstract":"<div><p>In the last few years Fresenius has developed a new cell separator. The intention was to improve the existing systems by taking advantage of the extensive worldwide experience of cell separation in the past years. The first prototypes of this cell separator AS 104 were set up in Marburg and in Cologne. In a pilot study we performed 25 procedures with 2 to 3 liters of fresh whole blood. These results will not be considered here. We now present the results from the first clinical trial.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"8 4","pages":"Pages 298-301"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80035-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78903715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Clinical observations on the application of “Serum-preserve” in therapeutic plasma exchange of autoimmune diseases “血清保存”在自身免疫性疾病血浆交换治疗中的应用临床观察
Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 DOI: 10.1016/S0278-6222(87)80041-4
A. Gaczkowski, J. Kadar, H. Borberg
{"title":"Clinical observations on the application of “Serum-preserve” in therapeutic plasma exchange of autoimmune diseases","authors":"A. Gaczkowski,&nbsp;J. Kadar,&nbsp;H. Borberg","doi":"10.1016/S0278-6222(87)80041-4","DOIUrl":"10.1016/S0278-6222(87)80041-4","url":null,"abstract":"","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"8 4","pages":"Pages 342-350"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80041-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91495083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Generation of lymphokine activated killer cells in a totally closed system 淋巴因子激活的杀伤细胞在一个完全封闭的系统中产生
Plasma Therapy and Transfusion Technology Pub Date : 1987-12-01 DOI: 10.1016/S0278-6222(87)80047-5
A.J. Bell , M. Wrightham , F.K. Stevenson , T.J. Hamblin
{"title":"Generation of lymphokine activated killer cells in a totally closed system","authors":"A.J. Bell ,&nbsp;M. Wrightham ,&nbsp;F.K. Stevenson ,&nbsp;T.J. Hamblin","doi":"10.1016/S0278-6222(87)80047-5","DOIUrl":"10.1016/S0278-6222(87)80047-5","url":null,"abstract":"<div><p>We have assessed a totally closed system for the generation of lymphokine activated killer (LAK) cells in a district general hospital. The elements of the system are (1) collection of mononuclear cells using the Haemonetics V50 either by lymphocytapheresis and Ficoll-Hypaque separation or by the lymphocyte surge protocol, (2) culture of LAK cells in 1 liter plastic bags, and (3) connections between plastic tubes made with the sterile connecting device.</p><p>The lymphocyte surger protocol produces an acceptable lymphocyte concentrate more quickly than the standard lymphocytapheresis method. It was possible to generate LAK cells from patients with lymphoma even when their blood was heavily contaminated by circulating tumor cells.</p><p>Ways of using LAK cells in conjunction with monoclonal antibodies are discussed.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"8 4","pages":"Pages 371-376"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80047-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84222158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Self-sufficiency in blood products: Background and overview 血液制品的自给自足:背景和概述
Plasma Therapy and Transfusion Technology Pub Date : 1987-09-01 DOI: 10.1016/S0278-6222(87)80056-6
Juhani Leikola MD
{"title":"Self-sufficiency in blood products: Background and overview","authors":"Juhani Leikola MD","doi":"10.1016/S0278-6222(87)80056-6","DOIUrl":"10.1016/S0278-6222(87)80056-6","url":null,"abstract":"<div><p>Countries started looking at national self-sufficiency after large-scale importation of human plasma from developing countries was revealed in the early 1970s. Many international organizations have recommended national self-sufficiency. Several examples have shown that a country can be self-sufficient in practical terms by supplementing national blood supply with voluntary plasmapheresis programs. National or regional self-sufficiency should be one of the goals of a national policy.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"8 3","pages":"Pages 215-220"},"PeriodicalIF":0.0,"publicationDate":"1987-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80056-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75916722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Immunomorphologic characterization of SpA-Sepharose beads exposed to monomeric, aggregated, and immune complex-bound human IgG SpA-Sepharose珠暴露于单体、聚合和免疫复合物结合的人IgG的免疫形态学特征
Plasma Therapy and Transfusion Technology Pub Date : 1987-09-01 DOI: 10.1016/S0278-6222(87)80061-X
J. Hed, O. Groth, L. Hakansson, G. Liedén
{"title":"Immunomorphologic characterization of SpA-Sepharose beads exposed to monomeric, aggregated, and immune complex-bound human IgG","authors":"J. Hed,&nbsp;O. Groth,&nbsp;L. Hakansson,&nbsp;G. Liedén","doi":"10.1016/S0278-6222(87)80061-X","DOIUrl":"10.1016/S0278-6222(87)80061-X","url":null,"abstract":"<div><p>Staphylococcal protein A (SpA)-coupled gels have recently been used to eliminate or isolate immune complexes from patients. In this study we could show, by using immunofluorescence technology, that soluble heat-aggregated human IgG and tetanus/antitetanus immune complexes only reached the outer part of the beads of a SpA-Sepharose MB gel. This indicates that the exclusion limits are altered after coupling with the SpA-ligand. The higher avidity of immune complexes, compared to monomeric IgG, is not efficiently used since only monomeric IgG can reach the interior of the beads. Finally, the results point to the importance of using a solid matrix with a large surface area where the SpA-molecules are available for the immune complexes.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"8 3","pages":"Pages 247-252"},"PeriodicalIF":0.0,"publicationDate":"1987-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80061-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80689966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
National self-sufficiency: Goal or illusion? 国家自给自足:目标还是幻想?
Plasma Therapy and Transfusion Technology Pub Date : 1987-09-01 DOI: 10.1016/S0278-6222(87)80052-9
John Verrier Jones BM, FRCP, FRCP(C)
{"title":"National self-sufficiency: Goal or illusion?","authors":"John Verrier Jones BM, FRCP, FRCP(C)","doi":"10.1016/S0278-6222(87)80052-9","DOIUrl":"10.1016/S0278-6222(87)80052-9","url":null,"abstract":"","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"8 3","pages":"Pages 191-192"},"PeriodicalIF":0.0,"publicationDate":"1987-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80052-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"96553895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Literature update 文献更新
Plasma Therapy and Transfusion Technology Pub Date : 1987-09-01 DOI: 10.1016/S0278-6222(87)80062-1
{"title":"Literature update","authors":"","doi":"10.1016/S0278-6222(87)80062-1","DOIUrl":"https://doi.org/10.1016/S0278-6222(87)80062-1","url":null,"abstract":"","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"8 3","pages":"Pages 253-264"},"PeriodicalIF":0.0,"publicationDate":"1987-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80062-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136555263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma and blood component procurement 血浆和血液成分采购
Plasma Therapy and Transfusion Technology Pub Date : 1987-09-01 DOI: 10.1016/S0278-6222(87)80053-0
E. Angela E. Robinson MB, BS, FRC Path
{"title":"Plasma and blood component procurement","authors":"E. Angela E. Robinson MB, BS, FRC Path","doi":"10.1016/S0278-6222(87)80053-0","DOIUrl":"10.1016/S0278-6222(87)80053-0","url":null,"abstract":"<div><p>This article discusses the global, national (United Kingdom), and regional (Yorkshire) situation with regard to source plasma supply for the production of albumin and factor VIII. The U.K. decision to become self-sufficient in blood and blood products from a voluntary-based transfusion service has led to the introduction of automated machine plasmapheresis units. Operational protocol, staffing structure, donor recruitment and attendance, and the recommended guidelines for automated machine plasmapheresis centers is described. The flexibility of the system, utilizing combined platelet and plasma collection procedures, is discussed, illustrating how both local and national requirements can be met with automated apheresis programs. Finally, a comparative costing of commercial (manual) plasmapheresis and voluntary (machine) plasmapheresis is reviewed.</p></div>","PeriodicalId":101030,"journal":{"name":"Plasma Therapy and Transfusion Technology","volume":"8 3","pages":"Pages 193-203"},"PeriodicalIF":0.0,"publicationDate":"1987-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0278-6222(87)80053-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90934854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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