Next NanotechnologyPub Date : 2026-06-01Epub Date: 2025-12-16DOI: 10.1016/j.nxnano.2025.100345
Azad Yadav, Rahul Langyan, Rajesh Dhankhar
{"title":"Phytofabrication and characterization of ZnO NPs using Eucalyptus globulus leaves extract for remediation of heavy metal ions","authors":"Azad Yadav, Rahul Langyan, Rajesh Dhankhar","doi":"10.1016/j.nxnano.2025.100345","DOIUrl":"10.1016/j.nxnano.2025.100345","url":null,"abstract":"<div><div>The present research investigates the phytofabrication of Zinc Oxide nanoparticles (ZnO NPs) using <em>Eucalyptus globulus</em> leaf extract to eliminate harmful Pb<sup>2+</sup> and Cd<sup>2+</sup> ions from aqueous solutions. The fabricated ZnO NPs were analysed by numerous characterization techniques, including FESEM, XRD, HRTEM, EDX, FTIR, UV–Vis spectroscopy, Zeta potential, DLS, and elemental mapping. The results confirm the formation of spherical nanoparticles with a size range from 44 to 58 nm. Batch studies were carried out to evaluate the performance and optimal conditions for the adsorption of Pb<sup>2+</sup> and Cd<sup>2+</sup> ions. For Pb²⁺, maximum efficiency was achieved at pH 5 using a 0.02 g adsorbent dose. In contrast, Cd²⁺ removal was most effective at a pH of 6 with a lower adsorbent mass of 0.01 g. Both metal ions reached optimal removal at an initial concentration of 30 ppm and a short contact time of 20 min. The experimental data fitted the pseudo-second order kinetic model with R<sup>2</sup> values of 0.918 and 0.997 for Pb<sup>2+</sup> and Cd<sup>2+</sup> ions, respectively, indicating a chemisorption process. The adsorption data aligned more closely with the Langmuir isotherm, with maximum monolayer adsorption capacities of 434.78 mg/g and 526.31 mg/g for Pb<sup>2+</sup> and Cd<sup>2+</sup> ions, respectively. The potential for reusing the nanoparticles was assessed using Na<sub>2</sub>EDTA, double-distilled water, HCl, and NaOH, and the findings suggested that ZnO NPs can be employed to remediate Pb<sup>2+</sup> and Cd<sup>2+</sup> ions.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100345"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Next NanotechnologyPub Date : 2026-06-01Epub Date: 2026-01-13DOI: 10.1016/j.nxnano.2026.100365
Stylianos Vasileios Kontomaris , Ioannis Psychogios , Anna Malamou , Triantafyllos Stylianopoulos , Andreas Stylianou
{"title":"Mathematical modeling of tumor nanomechanical fingerprints: A weighted skew-normal distribution approach for cancer diagnosis and treatment monitoring","authors":"Stylianos Vasileios Kontomaris , Ioannis Psychogios , Anna Malamou , Triantafyllos Stylianopoulos , Andreas Stylianou","doi":"10.1016/j.nxnano.2026.100365","DOIUrl":"10.1016/j.nxnano.2026.100365","url":null,"abstract":"<div><div>Atomic Force Microscopy (AFM) is a key method for nanomechanical characterization of cells and tissues, with AFM-derived fingerprints proposed as biomarkers for cancer diagnosis and treatment monitoring. These signatures typically include a higher elasticity peak (HEP), reflecting extracellular matrix stiffening due to collagen overproduction, and a lower elasticity peak (LEP), indicative of cancer cell softening. Despite their potential, AFM elasticity spectra are often assessed qualitatively, and a standardized mathematical framework for quantitative analysis is lacking. Here, we provide a rigorous mathematical characterization of Young’s modulus distribution in normal and cancerous tissues, aiming to improve cancer diagnosis and treatment monitoring. Previously published AFM elasticity spectra from murine tumors were employed and analyzed to evaluate tumor nanomechanical changes at different time points, 14, 21, and 28 days after cell implantation, including both untreated controls and a tranilast-treated group, with tranilast being a drug known to reduce collagen levels. The weighted skew-normal distribution was employed to model AFM data due to its ability to capture the two-peak structure of cancerous tissue, reflecting a mixture of soft cancer cells and stiffer components. We hypothesized that tranilast treatment would progressively shift the HEP to lower values. Model accuracy was confirmed by high R² values and low Cramér–von Mises (CvM) criteria. Results revealed a transition from a two-peak distribution in controls (HEP and LEP) to peak convergence in tranilast-treated tissue at 28 days. We conclude that the weighted skew-normal distribution offers a robust method for quantifying tumor nanomechanics, which is related to therapeutic outcomes.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100365"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Next NanotechnologyPub Date : 2026-06-01Epub Date: 2026-01-05DOI: 10.1016/j.nxnano.2025.100360
Ayodeji Folorunsho Ajayi , Ayomide Jonathan Jegede , Ubong Edem David , Olaniyi Azeez Soetan , Lateef Olabisi Okeleji
{"title":"The role of nanotechnology in male fertility assessment","authors":"Ayodeji Folorunsho Ajayi , Ayomide Jonathan Jegede , Ubong Edem David , Olaniyi Azeez Soetan , Lateef Olabisi Okeleji","doi":"10.1016/j.nxnano.2025.100360","DOIUrl":"10.1016/j.nxnano.2025.100360","url":null,"abstract":"<div><div>Male fertility assessment is critical for diagnosing infertility and optimizing assisted reproductive technologies (ART). Male infertility affects approximately 50 % of infertility cases worldwide, impacting an estimated 30 million men globally, with the male infertility market projected to grow from $3.1 billion in 2024 to $5.5 billion by 2030. Traditional semen analysis methods are limited by subjectivity, extended processing times, and inability to detect subcellular abnormalities such as DNA fragmentation and oxidative stress. Nanotechnology has emerged as a transformative tool offering high-precision sperm analysis through nanoparticles, biosensors, and microfluidic systems that enable real-time evaluation. This review explores current advancements including: quantum dot-based bioimaging, DNA fragmentation detection, oxidative stress measurement, microfluidic sperm sorting, and nano-biosensors for hormonal biomarker detection from non-invasive samples. Critically, these technologies could enhance diagnostic accuracy transitioning fertility care from static, single-visit assessments to dynamic, biomarker-guided interventions. However, clinical translation faces significant barriers. While global standardization bodies have established protocols for general nanoparticle characterization, diagnostic-specific standardization for fertility applications remains inadequate. Additional challenges include nanoparticle toxicity concerns, regulatory complexity, and economic barriers. Our comparative analysis indicates quantum dots and magnetic nanoparticles show particular promise for immediate clinical translation, while microfluidic systems demonstrate superior DNA integrity preservation. This review proposes a roadmap integrating nanotechnology into andrology practice, emphasizing diagnostic capabilities, with future directions including artificial intelligence integration and point-of-care device development.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100360"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Next NanotechnologyPub Date : 2026-06-01Epub Date: 2026-01-28DOI: 10.1016/j.nxnano.2026.100374
Joni Das , Kabirul Islam Mollah , Debajit Dewan , Sourav Ghosh , Subrata Das , Mayukh Jana , Suman Sahu , Biplab Debnath , Anup Kumar Sahoo , Soma Jana
{"title":"Mangrove-derived nanoparticles: A review of synthesis and biomedical applications","authors":"Joni Das , Kabirul Islam Mollah , Debajit Dewan , Sourav Ghosh , Subrata Das , Mayukh Jana , Suman Sahu , Biplab Debnath , Anup Kumar Sahoo , Soma Jana","doi":"10.1016/j.nxnano.2026.100374","DOIUrl":"10.1016/j.nxnano.2026.100374","url":null,"abstract":"<div><h3>Background</h3><div>A rich range of flora and animals that can adapt to terrestrial and marine habitats can be found in mangroves, which are regarded as hotspots for biodiversity. Among the resources developed to synthesize nanoparticles(NPs) using bioactive compounds, mangroves have attracted considerable attention due to their appealing properties: (i) biocompatibility, (ii) high surface area, (iii) non-toxicity, (iv) used as precursors for NPs synthesis, (v) act as reducing agents, (vi) possibility for green synthesis of NPs, (vii) eco-friendly, (viii) cost-efficient (ix) high porosity, (x) stable, and (xi) bio-friendly.</div></div><div><h3>Purpose</h3><div>This review presents different synthesis methods of mangrove-derived nanoparticles (MDNPs) from the methodological and mechanistic point of view. The enzymes are responsible for MDNP synthesis including nitrate reductase, nitrate-dependent reductases, and other enzymes, and the physicochemical behavior of MDNPs including drug loading, drug release, particle size, zeta potential, and stability are briefly discussed. This review also presents why mangroves have been chosen to design NPs in various biomedical applications.</div></div><div><h3>Results and discussion</h3><div>An important result is the environmental sustainability of MDNP synthesis. Utilizing mangrove extracts, roots (pneumatophores), or soils enables the synthesis of NPs without toxic chemicals, supporting green chemistry initiatives and scalability. MDNPs act as multifunctional agents in biomedical application, while adhering to sustainability and environmental safety principles. Novelty includes green synthesis using mangrove extracts/soils, natural bioreduction, environmentally friendly production, natural organic coatings. Challenges include scalability, polydispersity, heterogeneity, reproducibility, incomplete reactions, purification difficulties. Future promise includes biomedical applications, drug delivery, sustainable nanomedicine, therapeutic and environmental use.</div></div><div><h3>Conclusion</h3><div>Mangrove ecosystems offer a promising, environmentally friendly, and economically viable source for the green synthesis of NPs. The scientific value of MDNPs lies in their unique bioactive compound-based synthesis, environmentally friendly production, and diverse biomedical applications. Mangroves produce bioactive compounds such as polyphenols, flavonoids, tannins, and other secondary metabolites, which serve as natural reducing and capping agents in the green synthesis of Ag-NPs and AuNPs. Their synthesis exploits natural biochemicals from mangrove plants, making them sustainable alternatives for biomedical, and pharmaceutical applications while supporting conservation of unique mangrove ecosystems.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100374"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent advances in high surface area porous materials for electrochemical energy storage devices","authors":"Anu Prathap Mylamparambil Udayan, Balwinder Kaur, Anandhakumar Sundaramurthy, Kirtanjot Kaur, Baljit Singh","doi":"10.1016/j.nxnano.2026.100517","DOIUrl":"10.1016/j.nxnano.2026.100517","url":null,"abstract":"<div><div>Electrochemical energy storage devices can be classified into two categories: supercapacitors and rechargeable batteries. These devices are designed to store and release energy, finding applications in both portable electronics and electrical vehicles. To remain competitive, a material must possess high energy density (E<sub>d</sub>) and power density (P<sub>d</sub>), allowing for higher mileage, faster charging, and slower discharge. Another crucial factor to consider is the overall weight/volume reduction and the material's high mechanical strength. Recently, porous carbon-based materials and multifunctional materials with high mechanical strength, flexibility, and electrical properties have garnered significant attention. This review summarizes recent developments in high surface area porous materials including porous carbon, metal-organic frameworks, and nanoporous materials for energy storage devices, highlighting their potential to enhance efficiency and overall performance, thereby support industrial application and commercialization.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100517"},"PeriodicalIF":3.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148523561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Next NanotechnologyPub Date : 2026-06-01Epub Date: 2026-06-05DOI: 10.1016/j.nxnano.2026.100518
Tuhina Ravindra Chakravarty, Naeem Mohammad, Pawan K. Khanna
{"title":"A review on doped quantum dots of Ag/CdTe: Synthesis, characterization and applications","authors":"Tuhina Ravindra Chakravarty, Naeem Mohammad, Pawan K. Khanna","doi":"10.1016/j.nxnano.2026.100518","DOIUrl":"10.1016/j.nxnano.2026.100518","url":null,"abstract":"<div><div>Semiconductor nanoparticles that show a strong quantum confinement effect are classified as quantum dots, e.g., a size domain below 10 nm in II-VI compound semiconductors. The optical properties of II-VI QDs, therefore, have become immensely attractive over the past three decades. Recently, doped QDs have attracted much attention in terms of their photonic behavior and chemical synthesis. Their plasmonic behaviour due to the presence of noble metals, such as silver has added further value to their chemical, biological, and physical properties. Silver-doped quantum dots, especially cadmium telluride is of tremendous interest to researchers because of its ability to cover a wide range of the visible spectrum, thus making it suitable for emission devices and imaging technology, alongside the possibility of effective photocatalytic behavior. The presence of silver nanoparticles in CdTe QDs can be expected either as inserted into the lattices of CdTe or as an adsorbed material on the surface or pores. Depending on their position, the alteration in CdTe properties can be tuned and exploited for a variety of applications. This review article provides ready material for researchers to understand the subject and availability of methodology and possible applications for Ag/CdTe type of quantum dots.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100518"},"PeriodicalIF":3.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148523668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Next NanotechnologyPub Date : 2026-06-01Epub Date: 2026-06-06DOI: 10.1016/j.nxnano.2026.100546
Mehmet Melikoglu
{"title":"Banana peel waste valorization for a circular bioeconomy: A global analysis","authors":"Mehmet Melikoglu","doi":"10.1016/j.nxnano.2026.100546","DOIUrl":"10.1016/j.nxnano.2026.100546","url":null,"abstract":"<div><div>The global transition toward a regenerative circular bioeconomy has catalyzed the transformation of banana peel waste (BPW) from an environmental liability into a high-performance precursor for advanced industrial applications. This systematic review synthesizes high-impact research from 2020 through early 2026, evaluating the technical evolution of BPW-derived materials across energy, environmental, and biomedical sectors. A critical analysis of the current scholarly landscape reveals that specialized thermochemical and biochemical modifications can produce functionalized carbons with ultra-high specific surface areas and hierarchical porous frameworks. These unique structural attributes facilitate exceptional remediation kinetics for emerging pharmaceutical contaminants, achieving rapid and complete sequestration. In the electrochemical domain, banana-derived electrodes demonstrate robust charge storage capabilities, characterized by elevated specific capacitances, high energy densities, and extended long-term cycling stability. Furthermore, material science innovations have yielded sustainable biocomposites that feature substantial enhancements in mechanical strength, facilitating a meaningful shelf-life extension for perishable goods while maintaining rapid, high-efficiency biodegradability. From a biotechnological perspective, multi-modal BPW biorefinery systems support the high-purity recovery of volatile metabolites and superior biohydrogen yields. The integration of advanced computational models, characterized by high predictive accuracy and robust correlation metrics, further underscores the scalability and optimization potential of these pathways. By bridging the gap between bench-scale successes and systemic engineering requirements, this study provides a strategic roadmap for the pilot-scale integration and standardization of banana-integrated solutions within a zero-waste industrial framework.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100546"},"PeriodicalIF":3.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148523669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Next NanotechnologyPub Date : 2026-06-01Epub Date: 2026-01-24DOI: 10.1016/j.nxnano.2026.100375
Hayyiratul Fatimah Mohd Zaid , Mohd Faridzuan Majid , Nur Ain Atiqah Mohd Amin , Siti Musliha Mat Ghani
{"title":"Rapid and deep diesel desulfurization using bimetallic Cu-Fe/TiO2 nano-photocatalysts optimized by response surface methodology","authors":"Hayyiratul Fatimah Mohd Zaid , Mohd Faridzuan Majid , Nur Ain Atiqah Mohd Amin , Siti Musliha Mat Ghani","doi":"10.1016/j.nxnano.2026.100375","DOIUrl":"10.1016/j.nxnano.2026.100375","url":null,"abstract":"<div><div>Sulfur compounds in diesel fuel pose environmental and industrial challenges, necessitating effective removal methods. In this study, a bimetallic Cu-Fe/TiO<sub>2</sub> nano-photocatalyst was developed for the photooxidation of dibenzothiophene (DBT) in model diesel oil. Response Surface Methodology (RSM) with Central Composite Design (CCD) was employed to optimize both the preparation parameters of Cu-Fe/TiO<sub>2</sub> and the photooxidation conditions for DBT in model diesel oil. The photocatalyst was synthesized via a wet-impregnation method. Four factors were optimized during catalyst preparation: calcination temperature (400–600 °C), calcination duration (1–3 h), Cu:Fe mass composition (1–0.82), and total metal loading (1.0–3.0 wt%). For the photooxidation process, two parameters were evaluated: the H<sub>2</sub>O<sub>2</sub>:S<sub>DBT</sub> molar ratio (2−6) and catalyst dosage (0.5–1.5 g L<sup>−1</sup>). Both RSM models were statistically significant (p < 0.0001). ANOVA results showed lack-of-fit values of 47.67 and 70.64, with R<sup>2</sup> values of 0.9892 and 0.9695 for catalyst preparation and photooxidation, respectively, confirming strong model reliability. Complete DBT conversion was achieved when the catalyst was prepared using a Cu:Fe mass composition of 0.91 (10:1), a metal loading of 2.0 wt%, a calcination temperature of 502 °C, and a calcination duration of 1.02 h. For the photooxidation reaction, full DBT conversion occurred at a H<sub>2</sub>O<sub>2</sub>: S<sub>DBT</sub> molar ratio of 4 and a catalyst dosage of 1.0 g L<sup>−1</sup>. These findings demonstrate the high efficiency of Cu-Fe/TiO<sub>2</sub> and highlight its potential as a promising photocatalyst for sulfur removal applications.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100375"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Next NanotechnologyPub Date : 2026-06-01Epub Date: 2026-02-03DOI: 10.1016/j.nxnano.2026.100371
Sewera Marriam , Gull e Rana Khalid
{"title":"The chemo-biochemical convergence in nanomedicine: A review of tailored therapeutic strategies","authors":"Sewera Marriam , Gull e Rana Khalid","doi":"10.1016/j.nxnano.2026.100371","DOIUrl":"10.1016/j.nxnano.2026.100371","url":null,"abstract":"<div><div>This review examines the emerging concept of \"chemo-biochemical convergence\" within the field of nanomedicine, which represents a synergistic integration of synthetic chemistry and biological principles aimed at developing advanced therapeutic systems. The primary objective is to investigate how the meticulous chemical engineering of nanoplatformsestablishes a robust foundation for complex biological functionality. Key findings from this domain indicate that this approach facilitates both passive targeting via the Enhanced Permeability and Retention effect and active targeting through the use of surface-conjugated ligands. Additionally, it supports the creation of \"smart\" systems that enable on-demand drug release in response to distinct microenvironmental stimuli such as pH, redox potential, and temperature. This is exemplified by the clinical application of Doxorubicin (DOX) nanocarriers, which demonstrate improved efficacy and diminished systemic toxicity. The potential for future integration with artificial intelligence and synthetic biology suggests transformative opportunities for the development of highly personalized, adaptive, and effective treatments.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100371"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146188011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Next NanotechnologyPub Date : 2026-06-01Epub Date: 2025-12-09DOI: 10.1016/j.nxnano.2025.100336
Akash Srivastava, Asad Ahmad, Shaiber Siddiqui, Anas Islam
{"title":"Innovations in targeted drug delivery: From nanotechnology to clinical applications","authors":"Akash Srivastava, Asad Ahmad, Shaiber Siddiqui, Anas Islam","doi":"10.1016/j.nxnano.2025.100336","DOIUrl":"10.1016/j.nxnano.2025.100336","url":null,"abstract":"<div><div>Targeted drug delivery systems (TDDS) have emerged as transformative platforms for enhancing therapeutic precision while minimizing systemic toxicity. By exploiting mechanisms such as the enhanced permeability and retention (EPR) effect, ligand-based active targeting, and stimulus-responsive release, these systems offer improved pharmacokinetics and site-specific action. Clinical success stories underscore their translational impact—liposomal formulations like Doxil® reduce doxorubicin-related cardiotoxicity by nearly 50 %, while lipid nanoparticle-based Onpattro® became the first FDA-approved RNA interference therapy, paving the way for mRNA vaccine technologies. Despite such milestones, challenges persist, including tumor heterogeneity, immunogenicity, and regulatory complexities, which hinder broader clinical adoption. Emerging strategies—hybrid nanocarriers, AI-driven drug release, and integration with digital health—are reshaping the future of personalized medicine. This review provides a comprehensive analysis of current nanocarrier platforms, clinical progress, regulatory trends, and innovations driving the next generation of targeted drug delivery.</div></div>","PeriodicalId":100959,"journal":{"name":"Next Nanotechnology","volume":"9 ","pages":"Article 100336"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}