Neuroscience Applied最新文献

{"title":"Contribution of neural circuits of the insular cortex in obesity-induced anxiety","authors":"P. Léa , E. Ducourneau , L. Rouzoul , V. Gomez , R. Fayad , M. Lafourcade , Y. Couderc , L. Wilmes , T. Bittar , T. Habchi , D. Ricci , J. Bordes , C. Penet , G. Ferreira , A. Beyeler","doi":"10.1016/j.nsa.2026.106977","DOIUrl":"10.1016/j.nsa.2026.106977","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 106977"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147991145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tiny infections, big consequences: early-life bacteria, tryptophan–serotonin disruption, and autism-like traits","authors":"W.K. Chan , S.M. Jabbari Shiadeh , C. Mallard , M. Ardalan","doi":"10.1016/j.nsa.2026.106981","DOIUrl":"10.1016/j.nsa.2026.106981","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 106981"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147991156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating role of perceived stress in the influence of gender-related variables on resting-state brain networks","authors":"P. Ariño-Braña , E. Motos-Castellote , G. García-Galvez , R. Moreira , M. Picó-Pérez","doi":"10.1016/j.nsa.2026.106891","DOIUrl":"10.1016/j.nsa.2026.106891","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 106891"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147991485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A role for prefrontal dopamine signaling in behavioral flexibility","authors":"A. Petitbon , A. Contini , R. Walle , M.C. Allichon , L. Hardt , M.F. Angelo , M. Cazala , M. Depret , Y. Harouna , A. Ilie , F. Acedo , J. Correa-Vazquez , R. Ortole , R. Thebeaud , A. Andrianarivelo , G. Ferreira , J. Barik , P. Vanhoutte , P. Trifilieff","doi":"10.1016/j.nsa.2026.106902","DOIUrl":"10.1016/j.nsa.2026.106902","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 106902"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147991493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal administration of transforming growth factor-β1 and its effect on the monoaminergic neurons in the rat brain","authors":"M. Račický , R. Paliokha , E. Dremencov , D. Grinchii","doi":"10.1016/j.nsa.2026.106922","DOIUrl":"10.1016/j.nsa.2026.106922","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 106922"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147991501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of omega-3 fatty acids on Wnt activity in iPSC-derived neural stem cells from adult ADHD patients","authors":"Cristine M. Yde Ohki ,&nbsp;Natalie M. Walter ,&nbsp;Louisa C. Dury ,&nbsp;Letizia Del Campana ,&nbsp;Romane Lasmarrigues ,&nbsp;Rhiannon V. McNeill ,&nbsp;Zora Schickardt ,&nbsp;Lukasz Smigielski ,&nbsp;Susanne Walitza ,&nbsp;Sarah Kittel-Schneider ,&nbsp;Edna Grünblatt","doi":"10.1016/j.nsa.2026.107005","DOIUrl":"10.1016/j.nsa.2026.107005","url":null,"abstract":"<div><div>The canonical Wnt signaling pathway plays a key role in neurodevelopment and in maintaining cellular homeostasis of the central nervous system in adulthood. It regulates essential processes, such as cell proliferation, differentiation, and synaptogenesis. <em>In vivo</em> and genetic evidence suggests an association between attention-deficit/hyperactivity disorder (ADHD) and abnormalities in the Wnt pathway. Prior research from our group indicated heightened basal Wnt activity in neural stem cells (NSCs) derived from induced pluripotent stem cells (iPSCs) of pediatric ADHD patients and showed that methylphenidate (MPH) and omega-3 polyunsaturated fatty acids (ω-3 PUFAs) can modulate this pathway. While MPH is a first-line treatment for ADHD, ω-3 PUFAs are under investigation as a potential non-pharmacological supplement. Using the same functionality-based reporter technology, we assessed Wnt activity in iPSC-derived NSCs from 5 adult ADHD patients and 5 healthy controls. We examined whether ω-3 fatty acids (EPA and DHA), alone or combined, and DHA with MPH can modulate Wnt activity in these NSCs. Basal Wnt responsiveness did not differ between adult ADHD and control lines, although genetic risk for ADHD was associated with increased Wnt activity. EPA showed no statistically significant effects, while DHA strongly increased Wnt activity in both groups. DHA combined with EPA increased Wnt activity in ADHD lines, whereas DHA with MPH caused group-specific responses: enhancing Wnt signaling in ADHD but reducing it in controls. Compared to NSCs derived from children, adult-derived NSCs behave differently and show distinct responses to EPA and DHA, suggesting a potential route toward refined therapeutic strategies for adults.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 107005"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A national approach in a European context: Multidisciplinary and multiprofessional recommendations on the clinical use of psychedelic substances","authors":"Carolina Seybert,&nbsp;Ana Matos Pires,&nbsp;Luís Madeira,&nbsp;Maria João Heitor,&nbsp;João M. Bessa,&nbsp;Miguel Ricou,&nbsp;Helder Mota- Filipe,&nbsp;Albino J. Oliveira-Maia","doi":"10.1016/j.nsa.2026.107028","DOIUrl":"10.1016/j.nsa.2026.107028","url":null,"abstract":"<div><div>The therapeutic benefits of psychedelics for neuropsychiatric conditions have gathered significant attention in Europe and around the world, with treatments using psilocybin, MDMA, and ketamine as notable examples. However, the mind-altering effects of these substances, and the complexity of their regulatory frameworks, both within and outside of therapeutic use, imply careful clinical guidance. Across Europe, associations dedicated to therapeutic use of psychedelics are flourishing, and have produced clinical recommendations, while more generalist professional boards have contributed with various clinical reports, statements and guidelines. In Portugal this prompted a unique collaborative movement of professional associations of Pharmacists, Psychologists and Physicians to work with national ethics authorities, scientific societies and both research and clinical stakeholders, to produce a consensual recommendation addressing core aspects of psychedelic treatments. This statement reflects positions regarding informed consent, the determinants of medical and psychological interventions, ethical considerations and regulatory recommendations. The initial document was open for public consultation, inviting other stakeholders to contribute to the final version, published in Portuguese and translated here into English towards broader access. The statement underscores the importance of multidisciplinary and multiprofessional collaboration among psychiatrists, psychologists and pharmacists, towards establishing common guidelines and regulations to ensure safe and effective clinical applications. By addressing these factors, the recommendations aim to foster responsible therapeutic use, while safeguarding patient well-being.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 107028"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148950943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bipolar disorder and somatic diseases: Focus on oxidative stress markers","authors":"Sinem Balaç ,&nbsp;İzel Cemre Aksahin ,&nbsp;Hidayet Ece Arat-Çelik ,&nbsp;Şermin Genc ,&nbsp;Deniz Ceylan","doi":"10.1016/j.nsa.2026.107002","DOIUrl":"10.1016/j.nsa.2026.107002","url":null,"abstract":"<div><div>Bipolar disorder (BD) is associated with a substantial burden of somatic diseases, including cardiovascular, neurodegenerative, and inflammatory conditions. However, the biological continuity linking the core pathophysiology of BD to these somatic manifestations remains poorly understood. Oxidative stress is increasingly recognized as a shared biological process across many medical conditions that commonly co-occur with BD and has been extensively investigated using diverse biomarkers, consistently demonstrating redox imbalance across illness stages and mood states. This evidence supports oxidative stress as a core biological process contributing to multisystem vulnerability rather than merely a secondary consequence of affective episodes.</div><div>This review employed a narrative synthesis approach. Somatic diseases most frequently observed in BD were identified through systematic reviews and meta-analyses, and oxidative stress–related biomarkers associated with BD were examined alongside their alterations in commonly comorbid somatic diseases. Evidence from epidemiological syntheses, biomarker studies, and mechanistic research was integrated to identify converging findings, inconsistencies, and key research gaps. Across systematic syntheses, thirteen major non-communicable somatic disease categories were consistently associated with BD, particularly cardiometabolic, cardiovascular, endocrine, inflammatory, and neurodegenerative conditions. In parallel, BD research demonstrates alterations across multiple oxidative stress domains, with the most consistent findings observed for lipid peroxidation markers (e.g., TBARS, MDA) and oxidative nucleic acid damage (e.g., 8-oxo-dG, 8-OHGuo), whereas evidence for protein oxidation and antioxidant enzyme activity is more heterogeneous and state dependent. Notably, no studies directly examine associations between oxidative stress markers and objectively measured somatic comorbidity or multimorbidity in BD, and current evidence therefore relies on indirect triangulation between robust redox alterations in BD and oxidative stress mechanisms established in general medical populations.</div><div>Overall, oxidative stress appears to represent a systemic biological feature of BD that aligns mechanistically with the somatic diseases contributing to its mortality gap. However, biomarker heterogeneity, predominantly cross-sectional study designs, and the lack of integrated somatic phenotyping limit clinical interpretation. Longitudinal, state-sensitive studies linking redox dysregulation with somatic outcomes are needed to determine whether oxidative stress reflects cumulative systemic vulnerability rather than episodic illness activity.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 107002"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148231058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct structural covariance network architectures in machine-learning–derived subtypes of schizophrenia","authors":"I. Sungur ,&nbsp;S. Selek ,&nbsp;A.S. Gonul","doi":"10.1016/j.nsa.2026.106911","DOIUrl":"10.1016/j.nsa.2026.106911","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 106911"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147991099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capsaicin and cinnamaldehyde as TRPV1 and TRPA1 agonists in a human migraine model: pharmacodynamic evaluation","authors":"L.F. Iannone ,&nbsp;E.M. Mancuso ,&nbsp;B. Pasquini ,&nbsp;E. Lombardo ,&nbsp;M. Romozzi ,&nbsp;R. Nassini ,&nbsp;P. Geppetti ,&nbsp;F. Petraglia ,&nbsp;F. De Cesaris ,&nbsp;S. Fiani ,&nbsp;N. Mennini ,&nbsp;V. Seravalli","doi":"10.1016/j.nsa.2026.106912","DOIUrl":"10.1016/j.nsa.2026.106912","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 106912"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147991100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}