Neuroscience Applied最新文献

{"title":"Development of murine intermale aggression depends on contextual specificity of hypothalamic neuronal activity","authors":"L. Heikkinen , D. Masini , C. Broberger","doi":"10.1016/j.nsa.2024.103992","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.103992","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 103992"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524000577/pdfft?md5=cf435bb3bb04d90414c8dc53e76d009d&pid=1-s2.0-S2772408524000577-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who pays for the scratch cards? The prevalence of pathological gambling among adult scratchcard players in Portugal","authors":"P. Coelho , P. Morgado","doi":"10.1016/j.nsa.2024.104006","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.104006","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 104006"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524000711/pdfft?md5=09683a66c8feed97cf42a3ec1f008bca&pid=1-s2.0-S2772408524000711-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The real-world use of mood stabilisers as an augmentation strategy in Psychosis: a mirror design","authors":"E. Butler , D. Kornblum , O. Howes , A. Egerton","doi":"10.1016/j.nsa.2024.104007","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.104007","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 104007"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524000723/pdfft?md5=85b3516a73437b6c693ef5144d22d2d1&pid=1-s2.0-S2772408524000723-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA methylation patterns associated with suicide attempts in bipolar disorder","authors":"M. Acosta , M. Mitjans , M. Zafrilla , A. Giménez-Palomo , P.A. Saiz , C. Barrot , E. Jiménez , S. Papiol , V. Ruiz , P. Gavín , M.P. García-Portilla , L. González-Blanco , J. Bobes , T.G. Schulze , E. Vieta , A. Benabarre , B. Arias","doi":"10.1016/j.nsa.2024.104029","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.104029","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 104029"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524000942/pdfft?md5=4996e3019d1f982e70b6539a89cb7071&pid=1-s2.0-S2772408524000942-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140031029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychoneuroendocrine profiles of unmedicated men with major depressive disorder and associations to treatment effects and sexual side-effects","authors":"Kristian H.Reveles Jensen ,&nbsp;Malene Ravn Aarestrup ,&nbsp;Søren Vinther Larsen ,&nbsp;Kristin Köhler-Forsberg ,&nbsp;Gitte Moos Knudsen ,&nbsp;Martin Balslev Jørgensen ,&nbsp;Vibe G. Frokjaer","doi":"10.1016/j.nsa.2024.104050","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.104050","url":null,"abstract":"<div><p>Sex hormones are potentially involved in major depressive disorder (MDD) as there are sex differences in risk for depression, symptomatology and treatment efficacy. Such hormonal contributions to MDD have mainly been studied in women and scarcely in men. We, therefore, investigate whether testosterone and estradiol levels in unmedicated men with MDD are associated with depressive symptom profiles, SSRI treatment response, and sexual side-effects. Pretreatment plasma testosterone and estradiol were available from 26 unmedicated men (age 18–49). The patients were treated with 10–20 mg escitalopram for 12 weeks. Depression severity was measured by Hamilton Depression Rating Scale 17 (HAMD17), and treatment response was the change in HAMD6 from baseline. Sexual side-effects were assessed with a standardized clinician-rated scale. Pretreatment testosterone was positively associated with depression severity (<em>p</em> = 0.016), the association was primarily driven by vegetative symptoms: weight loss, gastrointestinal symptoms, and insomnia (<em>p</em> ≤ 0.027). Pretreatment sex hormone levels were not associated with antidepressant treatment outcome. However, pretreatment sex hormones were lower in patients who experienced sexual side-effects after 8–12 weeks of escitalopram treatment; low estradiol was associated with erectile and ejaculatory dysfunction (<em>p</em> = 0.039) and low testosterone and low estradiol were both associated with decreased libido (<em>p</em> ≤ 0.004). In conclusion, we find low testosterone in men with MDD coupled with depression severity, particularly vegetative symptoms. However, pretreatment sex hormone levels were not associated with treatment efficacy but with sexual side-effects. Taken together, our findings highlight sex hormone profiles as potential prognostic biomarkers of SSRI-induced sexual dysfunction.</p></div><div><h3>Data from</h3><p>Clinical study (NCT02869035).</p></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 104050"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524001157/pdfft?md5=afc7c64b65c8d5f33088b8070a147163&pid=1-s2.0-S2772408524001157-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140052685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute and chronic cocaine and nicotine change expression of genes involved in cholesterol metabolism in the rat Striatum","authors":"T. Aupy ,&nbsp;E. Dugast ,&nbsp;V. Lardeux ,&nbsp;S. Desmercières ,&nbsp;P. Belujon ,&nbsp;M. Solinas ,&nbsp;N. Thiriet","doi":"10.1016/j.nsa.2024.104038","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.104038","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 104038"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524001030/pdfft?md5=bb634e42517f90935e3e4cebf3e241a6&pid=1-s2.0-S2772408524001030-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"behavioural outcomes following early life stress: role of the microbiota-gut-brain axis in resilience and vulnerability","authors":"L. Wilmes ,&nbsp;V. Caputi ,&nbsp;T. Bastiaanssen ,&nbsp;J. Collins ,&nbsp;J. Cryan ,&nbsp;S. O'Mahony ,&nbsp;G. Clarke","doi":"10.1016/j.nsa.2024.104019","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.104019","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 104019"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277240852400084X/pdfft?md5=64099568650720121f40b127d5e59eb2&pid=1-s2.0-S277240852400084X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and age-dependent outcomes of perinatal serotonin manipulation: Exploring the dynamics of sensitive periods","authors":"M.T. Gallo ,&nbsp;P. Brivio ,&nbsp;F. Fumagalli ,&nbsp;F. Calabrese","doi":"10.1016/j.nsa.2024.104024","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.104024","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 104024"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524000899/pdfft?md5=a3743f5034c368859890178b50b4647e&pid=1-s2.0-S2772408524000899-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BDNF/TrkB signalling in tolerance development to diazepam in mice","authors":"A. Schäfer ,&nbsp;J. Lenius ,&nbsp;J. Umemori ,&nbsp;T. Aitta-aho","doi":"10.1016/j.nsa.2024.104003","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.104003","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 104003"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524000681/pdfft?md5=8a9559bcd821618ce258ae23633a100e&pid=1-s2.0-S2772408524000681-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semaglutide exhibits antihyperalgesic effects in an animal model of chronic migraine","authors":"K. Sićović ,&nbsp;K. Nastić ,&nbsp;U. Pecikoza ,&nbsp;A. Micov","doi":"10.1016/j.nsa.2024.104004","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.104004","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 104004"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524000693/pdfft?md5=167beb447d5f921212c2676d08fadad7&pid=1-s2.0-S2772408524000693-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}