Neuroscience Applied最新文献

Testing the usefulness of a quality system in preclinical research 测试质量体系在临床前研究中的实用性

Neuroscience Applied Pub Date : 2024-11-13 DOI: 10.1016/j.nsa.2024.105395

René Bernard , Björn Gerlach , Magali Haas , Malcolm Macleod , Heidrun Potschka , Andrew S.C. Rice , Thomas Steckler , Vootele Voikar , Kimberley E. Wever

引用次数: 0

Telomere length and mitochondrial DNA copy number in association with trauma-focused psychotherapy efficacy 端粒长度和线粒体DNA拷贝数与创伤心理治疗疗效的关系

Neuroscience Applied Pub Date : 2024-10-23 DOI: 10.1016/j.nsa.2024.104095

Alessandra Minelli , Anna Meloni , Marco Bortolomasi , Claudia Pisanu , Elisa Zampieri , Donatella Congiu , Beatrice Lana , Mirko Manchia , Mattia Meattini , Pasquale Paribello

{"title":"Telomere length and mitochondrial DNA copy number in association with trauma-focused psychotherapy efficacy","authors":"Alessandra Minelli , Anna Meloni , Marco Bortolomasi , Claudia Pisanu , Elisa Zampieri , Donatella Congiu , Beatrice Lana , Mirko Manchia , Mattia Meattini , Pasquale Paribello","doi":"10.1016/j.nsa.2024.104095","DOIUrl":"10.1016/j.nsa.2024.104095","url":null,"abstract":"<div><div>Early life adversities (ELA) have been linked to a greater risk for major depressive disorder (MDD) and treatment-resistant depression (TRD). The molecular mechanisms underlying the link between ELA and MDD and/or TRD are yet unknown. It has been suggested that ELA induces an allostatic burden, which in turn promotes oxidative stress and an inflammatory response that are further intensified by the influence of maladaptive coping behaviour. In this study we explored the role of two markers of cellular aging and oxidative stress (leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNAcn)) in TRD and in response to trauma-focused psychotherapies. The study comprised 30 TRD patients receiving trauma-focused psychotherapies and 65 healthy controls. LTL and mtDNAcn were measured at baseline and four weeks after the end of the psychotherapy sessions. Response was defined based on reduction in the Montgomery-Åsberg Depression Rating Scale (MADRS). In the case control analysis, the logistic regression model showed that mtDNAcn but not LTL was a significant predictor of diagnosis (chi-square 92.108, p = 7.72e-20; contribution of mtDNAcn, B = −9-297, p = 0.00009). In the TRD sample, LTL and mtDNAcn were inversely correlated with MADRS score at baseline (LTL, Pearson's r = −0.478, p = 0.008; mtDNAcn, Pearson's r = −0.656, p = 0.00008), but there was no difference in either LTL or mtDNAcn between responders and non-responders. In conclusion, our findings support an involvement of cellular aging in TRD, and suggest that LTL and mtDNAcn are not predictors or mediators of response to trauma-focused psychotherapies.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 104095"},"PeriodicalIF":0.0,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety pharmacology of acute psilocybin administration in healthy participants 对健康参与者急性服用迷幻药的安全药理学研究

Neuroscience Applied Pub Date : 2024-03-01 DOI: 10.1016/j.nsa.2024.104060

I. Straumann, F. Holze, Anna M. Becker, L. Ley, Nepomuk Halter, M.E. Liechti

引用次数: 0

Longitudinal development of resting-state functional connectivity in adolescents with and without internalizing disorders 有内化障碍和无内化障碍青少年静息态功能连接的纵向发展

Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104090

Eline F. Roelofs , Janna Marie Bas-Hoogendam , Anderson M. Winkler , Nic J.A. van der Wee , Robert R.J. M. Vermeiren

{"title":"Longitudinal development of resting-state functional connectivity in adolescents with and without internalizing disorders","authors":"Eline F. Roelofs , Janna Marie Bas-Hoogendam , Anderson M. Winkler , Nic J.A. van der Wee , Robert R.J. M. Vermeiren","doi":"10.1016/j.nsa.2024.104090","DOIUrl":"10.1016/j.nsa.2024.104090","url":null,"abstract":"<div><div>Longitudinal studies using resting-state functional magnetic resonance imaging (rs-fMRI) focused on adolescent internalizing psychopathology are scarce and have mostly investigated standardized treatment effects on functional connectivity (FC) of the full amygdala. The role of amygdala subregions and large resting-state networks had yet to be elucidated, and treatment is in practice often personalized. Here, longitudinal FC development of amygdala subregions and whole-brain networks are investigated in a clinically representative sample.</div><div>Treatment-naïve adolescents with clinical depression and comorbid anxiety who started care-as-usual (n = 23; INT) and healthy controls (n = 24; HC) participated in rs-fMRI scans and questionnaires at baseline (before treatment) and after three months. Changes between and within groups over time in FC of the laterobasal amygdala (LBA), centromedial amygdala (CMA) and whole-brain networks derived from independent component analysis (ICA) were investigated.</div><div>Groups differed significantly in FC development of the right LBA to the postcentral gyrus and the left LBA to the frontal pole. Within INT, FC to the frontal pole and postcentral gyrus changed over time while changes in FC of the right LBA were also linked to symptom change. No significant interactions were observed when considering FC from CMA bilateral seeds or within ICA-derived networks.</div><div>Results in this cohort suggest divergent longitudinal development of FC from bilateral LBA subregions in adolescents with internalizing disorders compared to healthy peers, possibly reflecting nonspecific treatment effects. Moreover, associations were found with symptom change. These results highlight the importance of differentiation of amygdala subregions in neuroimaging research in adolescents.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 104090"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral blood flow in treatment resistant schizophrenia and during clozapine treatment 耐药性精神分裂症和氯氮平治疗期间的脑血流量

Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103949

J. Sun , F. Zelaya , K.V. Sendt , G. Mcqueen , A. Gillespie , O. Howes , G. Barker , J. Maccabe , A. Egerton

引用次数: 0

ADHD treatment landscape: Conventional, alternative, and their self-rated effectiveness 多动症治疗现状：传统疗法、替代疗法及其自评疗效

Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103959

E. Haijen , P. Hurks , K. Kuypers

引用次数: 0

Effect of four antidepressant treatments on human dentate gyrus: a multisite longitudinal MRI study 四种抗抑郁治疗对人类齿状回的影响：多部位纵向磁共振成像研究

Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103945

A. Takamiya , J. Hirano , K. Kamiya , R. Ueda , M. Tajima , Y. Kobayashi , N. Katayama , B. Yamagata , T. Kishimoto , T. Suwa , J. Miyata , T. Noda , T. Murai , K. Nakagome , M. Mimura

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Lipoproteome dysregulation precedes conversion to psychosis in ultra-high-risk subjects 脂蛋白组失调先于超高风险受试者转为精神病

Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103948

M.T. Avella , G. Bertho , O. Kébir , C. Caradeuc , M.O. Krebs , N. Giraud , B. Chaumette , A. Frajerman

引用次数: 0

The impact of methylation patterns and epigenetic aging in lithium response 甲基化模式和表观遗传老化对锂反应的影响

Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104032

M. Zafrilla López , M. Acosta-Díez , A. Giménez-Palomo , P.A. Saiz , C. Barrot-Feixat , E. Jiménez , S. Papiol , V. Ruiz , P. Gavín , M.P. García-Portilla , L. González-Blanco , J. Bobes , T.G. Schulze , E. Vieta , A. Benabarre , M. Mitjans , B. Arias

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Unveiling the role of gut microbiota in shaping food addiction-like behaviour in mice 揭示肠道微生物群在塑造小鼠食物成瘾行为中的作用

Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103983

S. Samulenaite , A. Burokas , E. Martín-García , R. Maldonado

引用次数: 0