Neuroscience Applied最新文献_第2页

Exploring the molecular basis of treatment-resistant depression: Discoveries from a rat model and psilocybin therapy 探索耐药性抑郁症的分子基础：大鼠模型和迷幻药疗法的发现

Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104020

A. Korlatowicz , K. Latocha , P. Pabian , R. Bugno , A. Hogendorf , T. Kovács , A.J. Bojarski , Z. Varga , A. Faron-Górecka

引用次数: 0

Graphene nanoparticles: An innovative approach to preventing α-synuclein aggregations in diverse neuron types 石墨烯纳米粒子：防止α-突触核蛋白在不同类型神经元中聚集的创新方法

Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104034

A. Alwani , K. Maziarz , M. Figiel , M. Kujawska , P. Chmielarz

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Social dysfunction is associated with altered facial emotion neural processing across diverse neuropsychiatric disorders 社交功能障碍与各种神经精神疾病的面部情绪神经处理改变有关

Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103977

S. Braak , G. Bakker , T. Su , Y. Pijnenburg , A.V. Campos , A. De la Torre-Luque , A. Beckenstrom , A. Malik , G.R. Dawson , H. Marston , J. Alvarez-Linera , J.L. Ayuso-Mateos , C. Arango , M.J. Van Tol , N. Van der Wee , M.J. Kas , M. Aghajani , B.W.J.H. Penninx

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Anxiolytic-like and activating effect of a novel mRNA m6A methylation activator in the rat 一种新型 mRNA m6A 甲基化激活剂对大鼠的抗焦虑和激活作用

Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103978

I. Teino , M. Kanarik , K. Liiver , M. Školnaja , T. Org , K. Laugus , R. Shimmo , M. Karelson , M. Saarma , J. Harro

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Characterizing the effects of psychedelics and polydrug abuse on the blood-brain barrier properties 描述迷幻剂和多种药物滥用对血脑屏障特性的影响

Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104021

R. Alarcão , V. Neves , A.M. Sebastião

引用次数: 0

Role of histone deacetylases in neuroplasticity impairments and inflammation in major depression 组蛋白去乙酰化酶在重度抑郁症的神经可塑性损伤和炎症中的作用

Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104081

A. Garayo-Larrea , A. Azqueta , R.M. Tordera

{"title":"Role of histone deacetylases in neuroplasticity impairments and inflammation in major depression","authors":"A. Garayo-Larrea , A. Azqueta , R.M. Tordera","doi":"10.1016/j.nsa.2024.104081","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.104081","url":null,"abstract":"<div><p>This paper critically reviews the interesting and extensive knowledge regarding the role of some HDACs in major depression. MD is associated with neuroplasticity failure and inflammatory events, in which, several histone deacetylase (HDACs) enzymes play a key role. Specifically, increased expression of specific HDACs are linked to depressive-like behaviour, repress the expression of the brain derived neurotrophic factor (BDNF), and induce a pro-inflammatory response. Conversely, other HDACs exert an antidepressant action, promote dendritic growth and protect neurons or immune cells from inflammatory events. The right balance between both types is needed to respond correctly to the different physiological/pathological stimuli. However, aberrant expressions or activities of specific HDACs could be associated with MD. Further studies should identify the mechanism by which MD regulates specific HDAC subtypes both in post-mortem brain tissue and in peripheral immune cells.</p></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 104081"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524001467/pdfft?md5=bf082b97c279424d76829933b649a26b&pid=1-s2.0-S2772408524001467-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141593564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social isolation during adolescence causes increased generalised anxiety-like behaviour in male rats and increased sociability in male and female rats 青春期的社会隔离会导致雄性大鼠的广泛焦虑行为增加，并提高雄性和雌性大鼠的交际能力

Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104068

Marina Manojlović , Filip Milosavljević , Andrea Atanasov , Bojan Batinić , Pavle Sitarica , Vesna Pešić , Marin M. Jukić

{"title":"Social isolation during adolescence causes increased generalised anxiety-like behaviour in male rats and increased sociability in male and female rats","authors":"Marina Manojlović , Filip Milosavljević , Andrea Atanasov , Bojan Batinić , Pavle Sitarica , Vesna Pešić , Marin M. Jukić","doi":"10.1016/j.nsa.2024.104068","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.104068","url":null,"abstract":"<div><p>As one of the main characteristics of adolescence is the increased desire for social interaction and formation of meaningful relationships, it represents a particularly vulnerable period for social stressors. Moreover, social isolation during adolescence can significantly alter brain function and increase the likelihood of anxiety disorders in early adulthood. The aim of this retrospective meta-analysis and prospective behavioural experiment was to investigate whether chronic isolation stress during adolescence causes generalised and social anxiety-like behaviour in rodents. The meta-analysis of previously published data showed that social isolation during adolescence leads to an increase in generalised anxiety-like behaviour exclusively in male isolated rodents and has ambiguous effect on social anxiety-like behaviour. In the subsequent prospective experiment, Sprague-Dawley rats of both sexes were subjected to six weeks of social isolation and their behaviour was investigated in the open field, elevated plus maze, and three-chamber test. Consistent with the retrospective literature analysis, social isolation in adolescence increased generalised anxiety-like behaviour exclusively in males, as indicated by a decrease in time spent in the centre of the open field and open arms of the elevated plus maze, compared to controls. Both male and female isolated rats showed an increase in sociability in the three-chamber test, as indicated by the increase in the preference ratio for social versus neutral stimuli, compared to controls. Altogether, social isolation leads to an increase in generalised anxiety-like behaviour exclusively in males and to increased sociability in both males and females.</p></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 104068"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524001339/pdfft?md5=523bd7267bcc2a25e8e4a44fd8dcbe8d&pid=1-s2.0-S2772408524001339-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140645488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BehavioUral profiling predicts vulnerability and resilience to stress exposure 行为特征分析可预测面对压力时的脆弱性和复原力

Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104016

F. Marsili , G. Matte Bon , A. Viglione , C. Delli Colli , S. Poggini , I. Branchi

引用次数: 0

Positive allosteric modulation of α5 GABAA receptors effects on binge eating and hyperactivity in two-hit model 在两击模型中，α5 GABAA 受体的正异构调节对暴食和多动的影响

Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104018

K. Mirković , J. Aranđelović , J. Kojić , B. Batinić , B. Divović Matović , M. Savić

引用次数: 0

Impact of maternal microbiome disruption on early-life brain barriers: insights from caesarean-section offspring 母体微生物群紊乱对生命早期大脑屏障的影响：剖腹产后代的启示

Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104039

V. Turpin , A. Cergneux , L. Morales , J. Morael , H. Blair , A. Ratsika , J. Shearer , C. Tessier , E. Cintado , J.F. Cryan , M.R. Aburto

引用次数: 0