Neuroscience Applied最新文献

{"title":"Factor analysis of the Hungarian version of the alcohol relapse risk scale: a recommendation of a shortened version","authors":"O. Bagi , F.F. Farkas , J. Gajdics , B.K. Kádár , B. Andó , B.A. Lázár , I.K. Pribék","doi":"10.1016/j.nsa.2025.105546","DOIUrl":"10.1016/j.nsa.2025.105546","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105546"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145872680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early transcriptomic changes predict long-term treatment outcome of ketamine versus midazolam in patients with treatment-resistant depression in the KADS study","authors":"S.M. Wissing , C. Hohoff , E. Van Assche , T. Lange , L. Steinbach , D. Barton , M. Berk , G.L. Carter , V. Dong , P.B. Fitzgerald , V. Galvez , N. Glozier , P. Glue , M.L. Hackett , D. Hadzi-Pavlovic , A.J. Harvey , S. Hood , D.M. Martin , P.B. Mitchell , N. Mills , B.T. Baune","doi":"10.1016/j.nsa.2025.105591","DOIUrl":"10.1016/j.nsa.2025.105591","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105591"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145872796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large nesting expression in deer mice remains stable despite dopamine and adenosine modulation: insights into the psychobiology of compulsive-like rigidity","authors":"D.W. Wolmarans , A. van Staden","doi":"10.1016/j.nsa.2025.105620","DOIUrl":"10.1016/j.nsa.2025.105620","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105620"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of repeated ketamine infusions on suicidal ideation in treatment-resistant depression and associated changes in plasma metabolites","authors":"M. Murao , Y. Matsumoto , D. Setoyama , T. Kato , H. Tachimori , T. Tada , Y. Imamura , H. Seki , T. Tsuboi , H. Uchida , K. Watanabe","doi":"10.1016/j.nsa.2025.105580","DOIUrl":"10.1016/j.nsa.2025.105580","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105580"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of multiscale entropy as a biomarker for autism spectrum disorder","authors":"J. Chaudet , A. Pedoux , J. Houenou , G. Dumas , E. Duchesnay , R. Delorme , A. Iftimovici , A. Lefebvre","doi":"10.1016/j.nsa.2025.105583","DOIUrl":"10.1016/j.nsa.2025.105583","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105583"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared genetic architecture between psychiatric and insulin-related traits in the general population","authors":"Barbara Šakić,&nbsp;Izel Erdogan,&nbsp;Giuseppe Fanelli,&nbsp;Marieke Klein,&nbsp;Martina Arenella,&nbsp;Nina Roth Mota,&nbsp;Janita Bralten","doi":"10.1016/j.nsa.2026.107017","DOIUrl":"10.1016/j.nsa.2026.107017","url":null,"abstract":"<div><div>Psychiatric conditions, like Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), and Obsessive-Compulsive Disorder (OCD) are complex heritable disorders that frequently co-occur with insulin resistance (IR)-related conditions, such as obesity and type 2 diabetes mellitus. Traditional genetic case-control comparisons are challenged by the extent of heterogeneity and comorbidity within and across these conditions. In this study we used psychiatry-related traits in the general population in multivariate analyses to explore the potential genetic links with insulin-related traits.</div><div>Using large-scale genetic studies (N = 17,666–697,734) genomic structural equation modeling was applied to identify the factor structure best representing the joint genetic architecture of traits in the population that are linked to ADHD, ASD, and OCD, and five IR-related measures: body mass index (BMI), fasting plasma glucose (FPG), fasting plasma insulin, glycated haemoglobin (HbA1c), and the Homeostatic Model assessment for IR (HOMA-IR). Next, multivariate genome-wide association analyses were performed on the psychiatry-IR related factors to explore genetic associations, followed by functional mapping and annotation of the genetic results.</div><div>Factor analyses indicated that a three-factor model fitted the data best (χ2(df = 9) = 18.79, AIC = 56.8, CFI = 0.99, SRMR = 0.068). Two of the three genetic factors included both psychiatric and insulin-related traits, one factor connected ADHD symptoms with three IR-related measures (BMI, FPG, HbA1c) and another factor OCD symptoms with HbA1c. Genetic analyses revealed 57 genes significantly associated with the ADHD-IR factor (p &lt; 2.961e-06) and one gene, <em>MTNR1B</em> (p = 3.44e-07), with the OCD/OCS-IR factor. Neurodevelopmental pathways were associated to the psychiatric and insulin-related factors and expression of the associated variants was enriched in brain tissues and during brain development.</div><div>These findings suggest a shared genetic liability between psychiatric symptoms and IR-related measures in the general population, indicating that the link between insulin resistance and psychiatry is not solely driven by disorder status and offering new perspectives on the underlying molecular genetics between them.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 107017"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating physical healthcare into psychiatry for severe mental illness: A narrative review and position statement from the ECNP PAN-Health group","authors":"René Ernst Nielsen ,&nbsp;Heidi Taipale ,&nbsp;Samuele Cortese ,&nbsp;Elena Dragioti ,&nbsp;Ebba Du Rietz ,&nbsp;Joseph Firth ,&nbsp;Paolo Fusar-Poli ,&nbsp;Catharina Hartman ,&nbsp;Richard IG. Holt ,&nbsp;Anne Høye ,&nbsp;Ai Koyanagi ,&nbsp;Henrik Larsson ,&nbsp;Kelli Lehto ,&nbsp;Peter Lindgren ,&nbsp;Mirko Manchia ,&nbsp;Merete Nordentoft ,&nbsp;Karolina Skonieczna-Żydecka ,&nbsp;Brendon Stubbs ,&nbsp;Davy Vancampfort ,&nbsp;Lasse Brandt ,&nbsp;Marco Solmi","doi":"10.1016/j.nsa.2026.106993","DOIUrl":"10.1016/j.nsa.2026.106993","url":null,"abstract":"<div><div>Individuals with severe mental illness (SMI) face significantly reduced life expectancy, mainly driven by natural causes such as cardiovascular disease, pulmonary disease, cancer, and stroke. Although medical care has advanced, the mortality gap between individuals with SMI and the general population has continued to expand in many countries over recent decades. This disparity is exacerbated by systemic healthcare inequities, fragmented healthcare, insufficient use of preventive measures, and the burden of multimorbidity.</div><div>This paper proposes six actionable strategies to reduce the excess mortality associated with SMI by integrating physical healthcare into psychiatric services. Across all recommendations, we explicitly embed lifestyle interventions, especially structured physical activity given its comparatively stronger evidence base in SMI, alongside sleep and nutrition support delivered through pragmatic, accessible programs. First, psychoeducation should be expanded to include physical health literacy. Second, structured smoking cessation programs must be implemented. Third, early identification and management of obesity, including pharmacological interventions, should be prioritized. Fourth, hypertension should be routinely screened and treated within psychiatric settings. Fifth, dyslipidaemia and diabetes require systematic monitoring and timely initiation of statins, metformin and GLP-1 receptor agonists. Sixth, these interventions must be delivered through integrated care models that ensure continuity, optimal self-management, and long-term outcome monitoring. Together, these six approaches offer a framework to narrow the mortality gap between people with SMI and the general population, as well as support a shift toward holistic, person-centered care. We synthesise the evidence on physical health disparities in SMI and provide practical, evidence-based recommendations for psychiatric settings. Together, these strategies offer a feasible, person-centered framework to improve health outcomes and reduce premature mortality in individuals with SMI.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 106993"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147395772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin: A narrative review of sleep and circadian regulation, neurobiology, and therapeutic potential in obsessive-compulsive disorder (OCD).","authors":"C. Lochner ,&nbsp;A. Lochner","doi":"10.1016/j.nsa.2025.105621","DOIUrl":"10.1016/j.nsa.2025.105621","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105621"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-brain axis dysregulation in schizophrenia: role of microbiota, permeability, and inflammation","authors":"D. Rodrigues ,&nbsp;M. Lavrador ,&nbsp;T.G. Lopes ,&nbsp;B.M. Ramos","doi":"10.1016/j.nsa.2025.105613","DOIUrl":"10.1016/j.nsa.2025.105613","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105613"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrospinal fluid amino acid profiles and their relevance to monoamine metabolites and proinflammatory cytokines in psychiatric disorders","authors":"T. Enokida ,&nbsp;K. Hattori ,&nbsp;T. Noda ,&nbsp;K. Okabe ,&nbsp;S. Ogawa ,&nbsp;M. Tatsumi ,&nbsp;H. Kunugi ,&nbsp;K. Nakagome","doi":"10.1016/j.nsa.2025.105575","DOIUrl":"10.1016/j.nsa.2025.105575","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105575"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}