Neuroscience Applied最新文献

{"title":"Treatment with JNJ-46356479, an mGluR2 positive allosteric modulator, modifies prefrontal cortex apoptotic protein levels in mice postnatally exposed to ketamine","authors":"D. Olivares Berjaga , A. Martinez-Pinteño , N. Rodríguez , J.I. Mena , L. Prohens , S. Mas , C. Morén , E. Parellada , P. Gassó","doi":"10.1016/j.nsa.2025.105556","DOIUrl":"10.1016/j.nsa.2025.105556","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105556"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional markers in substance use disorders: folate levels and subjective wellbeing by diagnosis and dual pathology","authors":"X. Arraztio Gurtubay , G. Domínguez , A. Distefano , C. Isern , F. Dinamarca","doi":"10.1016/j.nsa.2025.105542","DOIUrl":"10.1016/j.nsa.2025.105542","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105542"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to immune-based augmentation treatment for depression: a potential role of immunosenescence","authors":"Evelien Van Assche , Christa Hohoff , Sophia M. Wissing , Lea Steinbach , European College of Neuropsychopharmacology (ECNP) Pharmacogenomics & Transcriptomics Network , Bernhard T. Baune","doi":"10.1016/j.nsa.2026.106986","DOIUrl":"10.1016/j.nsa.2026.106986","url":null,"abstract":"<div><div>Immunological processes are increasingly in focus as factors contributing to major depressive disorder (MDD). Especially subtypes such as immunometabolic depression phenotypes have been linked to low-grade inflammation. Augmentation with immune-based therapies, e.g., celecoxib, is being tested for its efficacy in treating depression. Many physiological processes during life are also linked to immunological changes, particularly aging. As results from current trials with celecoxib augmentation remain inconclusive, we tested the hypothesis that age affects treatment efficacy. In total, 113 individuals with a diagnosis of major depressive disorder (<em>M</em><sub>age</sub> = 44, 56% women, <em>M</em><sub>MADRS</sub> = 27.7) had biomarkers available and were included in our analyses. Patients were recruited as part of a randomized controlled trial (RCT) and stratified by hsCRP (>3 mg/L or < 3 mg/L). All patients were treated with vortioxetine and randomized to receive either celecoxib (<em>N</em> = 55) or placebo (<em>N</em> = 58) by a randomized design. Patients were treated for 6 weeks (<em>M</em><sub>MADRS 6W</sub> = 20.2). We tested one main hypothesis: that age affects the treatment outcome of celecoxib as an immunomodulatory agent. To further explore the meaning of our results, we used epigenome-wide DNA methylation data (Illumina Infinium MethylationEPIC 850k BeadChip) available to estimate cell type compositions of neutrophils, monocytes, B-cells, CD4<sup>+</sup> and CD8<sup>+</sup> Lymphocytes, and natural killer cells (NK), using the Houseman method. The analyses were performed using linear regression and ANCOVA models, corrected for sex, hsCRP, years of education, BMI, and depression severity at baseline. Our analysis showed a statistically significant interaction between age and treatment condition on depression outcome (beta = −0.24; <em>p</em> = 0.045), with significant main effects for both variables in the model (intervention: beta = 10.88; <em>p</em> = 0.048, age: beta = 0.23; <em>p</em> = 0.01). Sex, hsCRP, and years of education were no statistically significant contributors. BMI was a marginally significant contributor in the model (beta = −0.25; <em>p</em> = 0.059). The intersection was identified at 45.5 years. Younger individuals treated with celecoxib showed a more pronounced reduction in MADRS than older individuals treated with celecoxib (<em>F</em>(1,52) = 5.74, <em>p</em> = 0.020). Further exploration showed that for individuals younger than 45 years, neutrophils at baseline might be associated with better treatment outcome (beta = 25.87; <em>p</em> = 0.051). For individuals older than 45 years, this was the case for B-cells, NK cells, and, suggestively, CD8<sup>+</sup> cells (beta = −146.29; <em>p</em> = 0.014, beta = 129.39; <em>p</em> < 0.001, and beta = −20.23; <em>p</em> = 0.055, respectively). Our results indicate that response to celecoxib as an augmentation treatment for depression can be age-dep","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 106986"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking inflammatory and structural neuroimaging biomarkers in treatment-resistant depression: Current evidence and emerging hypotheses","authors":"Simge Seren Kirlioglu Balcioglu ,&nbsp;Marco Paolini ,&nbsp;Bernhard T. Baune ,&nbsp;Igor Branchi ,&nbsp;Annamaria Cattaneo ,&nbsp;Marion Leboyer ,&nbsp;Benedetta Vai ,&nbsp;Livia De Picker","doi":"10.1016/j.nsa.2026.107015","DOIUrl":"10.1016/j.nsa.2026.107015","url":null,"abstract":"<div><div>Treatment-resistant depression (TRD) represents a major clinical challenge within major depressive disorder (MDD) and is currently defined primarily by inadequate response to antidepressant treatment rather than by underlying biological mechanisms. Despite extensive research, the absence of validated biomarkers continues to limit diagnostic precision, hamper cross-study comparability, and constrain the development of mechanism-based interventions. Growing evidence suggests that immune–inflammatory dysregulation and structural brain alterations are both prominent features of TRD and may represent interrelated dimensions of its pathophysiology. Over the past two decades, a number of studies have reported peripheral immune abnormalities in TRD, including alterations in acute-phase proteins, inflammatory cytokines, immune cell composition, and neuroendocrine–immune interactions. Elevated C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)–related signaling, and complement components have been observed in subsets of TRD patients; however, findings remain heterogeneous and non-linear across studies, suggesting that these markers may reflect inflammatory heterogeneity rather than a uniform immune phenotype. Importantly, responder–non-responder comparisons indicate that treatment resistance may not simply be associated with greater inflammatory burden, but rather with alterations in the resolution of immune activation. In addition, some studies suggest that clinical improvement is accompanied by partial normalization of central immune pathways, whereas persistent non-response has been associated with sustained inflammatory activity. In parallel, structural neuroimaging studies have reported reductions in hippocampal and caudate volumes, grey matter alterations, and white matter abnormalities in TRD, although many of these findings overlap with those observed in MDD more broadly. Emerging evidence further suggests potential associations between immune markers and neuroimaging features, including links between cytokines, CRP, kynurenine pathway metabolites, and brain structure.</div><div>Taken together, these findings are broadly consistent with models proposing that inflammation-related processes, altered neurotrophic signaling, glucocorticoid dysregulation, and disrupted immune–brain interactions may contribute to reduced neuroplasticity and treatment resistance. Overall, the literature points to TRD as a biologically heterogeneous condition, potentially encompassing inflammation-sensitive and inflammation-insensitive subgroups. However, current evidence remains insufficient for formal biological stratification. Future integrative approaches combining peripheral and central measures with longitudinal and interventional designs may help advance biologically informed classification and treatment strategies in TRD.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 107015"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148166378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in the impact of workplace bullying on depression, anxiety, and occupational stress among Korean employees","authors":"J.E. Park ,&nbsp;J. Choi ,&nbsp;S. Jung","doi":"10.1016/j.nsa.2025.105609","DOIUrl":"10.1016/j.nsa.2025.105609","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105609"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential psychobiotic L. reuteri Increases social behavior and alters stress hormones rhythms in a mouse model of chronic stress","authors":"C. Rosell Cardona ,&nbsp;G.S. Tofani ,&nbsp;G. Clarke ,&nbsp;S. Kittel-Schneider ,&nbsp;J.F. Cryan","doi":"10.1016/j.nsa.2025.105612","DOIUrl":"10.1016/j.nsa.2025.105612","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105612"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145872467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards personalized neuroscience: evaluating individual-level information in neural mass models","authors":"C. Barkhau ,&nbsp;C. Pellengahr ,&nbsp;Z. Wang ,&nbsp;L. Fisch ,&nbsp;R. Leenings ,&nbsp;N.R. Winter ,&nbsp;J. Ernsting ,&nbsp;M. Konowski ,&nbsp;D. Grotegerd ,&nbsp;S. Meinert ,&nbsp;J.M. Hubbert ,&nbsp;J. Krieger ,&nbsp;T. Borgers ,&nbsp;K. Flinkenflügel ,&nbsp;E.J. Leehr ,&nbsp;F. Stein ,&nbsp;F. Thomas-Odenthal ,&nbsp;P. Usemann ,&nbsp;L. Teutenberg ,&nbsp;I. Nenadic ,&nbsp;T. Hahn","doi":"10.1016/j.nsa.2025.105571","DOIUrl":"10.1016/j.nsa.2025.105571","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105571"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145872507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, incidence and therapy of (treatment-resistant) depression in Germany: a sickness funds analysis","authors":"M. Bayas ,&nbsp;J. Auerbach ,&nbsp;B. Diekamp ,&nbsp;B. Baune ,&nbsp;A. Reif ,&nbsp;C. Reif-Leonhard","doi":"10.1016/j.nsa.2025.105606","DOIUrl":"10.1016/j.nsa.2025.105606","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105606"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145872508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying cannabis use: an analysis of use amount in the \"züri can\" study","authors":"N. Heckel ,&nbsp;M. Buschner ,&nbsp;E.J.E. Engeli ,&nbsp;P. Dürler ,&nbsp;E.M. Havelka ,&nbsp;M. Haas ,&nbsp;M. Herdener ,&nbsp;C. Nordt","doi":"10.1016/j.nsa.2025.105537","DOIUrl":"10.1016/j.nsa.2025.105537","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105537"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145872522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma neurofilament light chain levels are associated with executive function in patients with methamphetamine use disorder","authors":"T.Y. Wang ,&nbsp;S.Y. Wei ,&nbsp;T.Y. Tsai ,&nbsp;H.H. Tseng ,&nbsp;P.S. Chen ,&nbsp;Y.K. Yang ,&nbsp;R.B. Lu ,&nbsp;Y.L. Liu","doi":"10.1016/j.nsa.2025.105541","DOIUrl":"10.1016/j.nsa.2025.105541","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105541"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145872717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}