Neuroscience Applied最新文献

筛选
英文 中文
A review of psychedelics trials completed in depression, informed by European regulatory perspectives 根据欧洲监管机构的观点,回顾已完成的抑郁症迷幻药试验
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105516
Francisca Silva , Florence Butlen-Ducuing , Lorenzo Guizzaro , Pavel Balabanov
{"title":"A review of psychedelics trials completed in depression, informed by European regulatory perspectives","authors":"Francisca Silva ,&nbsp;Florence Butlen-Ducuing ,&nbsp;Lorenzo Guizzaro ,&nbsp;Pavel Balabanov","doi":"10.1016/j.nsa.2025.105516","DOIUrl":"10.1016/j.nsa.2025.105516","url":null,"abstract":"<div><div>There is a growing body of clinical research on the therapeutic potential of psychedelics for the treatment of mental health disorders, notably depression. Accordingly, the new revision of the European Medicines Agency guideline on the clinical investigation of products for depression will incorporate a section covering specific regulatory recommendations for the design of studies with psychedelics. The present review investigated the methodological approaches adopted in completed controlled trials of psychedelics for depression in light of initial considerations included in the draft guideline revision. A systematic search conducted on scientific databases (Embase and Medline) and clinical trial registries (<span><span>clinicaltrials.gov</span><svg><path></path></svg></span> and WHO ICTPR) identified 8 completed trials as of February 2024. The trials tested psilocybin, LSD, Ayahuasca, and DMT, for major depressive disorder or treatment-resistant depression, and were all pahse 2 or 1/2. Patterns in pre-defined methodological variables pertaining to trial design, population, interventions, outcome measures and safety assessments were analysed and collated against considerations on unblinding and expectancy, choice of comparator, the definition of treatment frameworks, the characterisation of the subjective psychedelic experience and the specification of adverse events in relation to subjective psychedelic effects. Areas for future research, including long-term efficacy and safety and the influence of inter-individual differences, can be investigated in larger studies, necessary for marketing authorisation applications. Ultimately, balancing the intricacies of conducting trials with psychedelics with ensuring adherence to regulatory requirements can be facilitated by early dialogue with medicines regulators, and will be essential for the medical development of psychedelics to address unmet patient needs.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105516"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143570521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative effects of pharmacological interventions for weight loss in patients with psychotic disorders 药物干预对精神障碍患者减肥的比较效果
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105443
Z. Goetz-Kundera , B. Bogusława Przekopińska , P. Walichniewicz , M. Niewada , M. Lew-Starowicz
{"title":"Comparative effects of pharmacological interventions for weight loss in patients with psychotic disorders","authors":"Z. Goetz-Kundera ,&nbsp;B. Bogusława Przekopińska ,&nbsp;P. Walichniewicz ,&nbsp;M. Niewada ,&nbsp;M. Lew-Starowicz","doi":"10.1016/j.nsa.2025.105443","DOIUrl":"10.1016/j.nsa.2025.105443","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105443"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurodivergent strengths and wellbeing: new insights from attention-deficit/hyperactivity disorder 神经发散性优势和幸福感:来自注意力缺陷/多动障碍的新见解
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105427
L.D. Hargitai , E.L.M. Laan , L.M. Schippers , L.A. Livingston , G. Fairchild , P. Shah , M. Hoogman
{"title":"Neurodivergent strengths and wellbeing: new insights from attention-deficit/hyperactivity disorder","authors":"L.D. Hargitai ,&nbsp;E.L.M. Laan ,&nbsp;L.M. Schippers ,&nbsp;L.A. Livingston ,&nbsp;G. Fairchild ,&nbsp;P. Shah ,&nbsp;M. Hoogman","doi":"10.1016/j.nsa.2025.105427","DOIUrl":"10.1016/j.nsa.2025.105427","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105427"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computational markers of gastrointestinal interoception predict relapse and symptom severity in anorexia nervosa 胃肠间感受的计算标记预测神经性厌食症的复发和症状严重程度
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105416
C. Verdonk , K. Mink , E.M. Choquette , A. Mayeli , J.L. Stewart , M.P. Paulus , R. Smith , S.S. Khalsa
{"title":"Computational markers of gastrointestinal interoception predict relapse and symptom severity in anorexia nervosa","authors":"C. Verdonk ,&nbsp;K. Mink ,&nbsp;E.M. Choquette ,&nbsp;A. Mayeli ,&nbsp;J.L. Stewart ,&nbsp;M.P. Paulus ,&nbsp;R. Smith ,&nbsp;S.S. Khalsa","doi":"10.1016/j.nsa.2025.105416","DOIUrl":"10.1016/j.nsa.2025.105416","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105416"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stimulating the left ventromedial prefrontal cortex compensates for apathy after levodopa withdrawal in PD 刺激左腹内侧前额叶皮层补偿PD患者左旋多巴戒断后的冷漠
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105494
J. De Bruin , K.S. Choi , H. Mayberg , J. Jimenez-Shahed , C. Palmese , J. Khang , H.N. Song , B. Kopell , M. Figee
{"title":"Stimulating the left ventromedial prefrontal cortex compensates for apathy after levodopa withdrawal in PD","authors":"J. De Bruin ,&nbsp;K.S. Choi ,&nbsp;H. Mayberg ,&nbsp;J. Jimenez-Shahed ,&nbsp;C. Palmese ,&nbsp;J. Khang ,&nbsp;H.N. Song ,&nbsp;B. Kopell ,&nbsp;M. Figee","doi":"10.1016/j.nsa.2025.105494","DOIUrl":"10.1016/j.nsa.2025.105494","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105494"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional connectivity changes after a meditation retreat including administration of an ayahuasca-inspired formulation 功能连接变化后,冥想撤退包括管理死藤水启发配方
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105413
K. Egger , M. Daniel , F. Polat , M. Avram , M. Scheidegger
{"title":"Functional connectivity changes after a meditation retreat including administration of an ayahuasca-inspired formulation","authors":"K. Egger ,&nbsp;M. Daniel ,&nbsp;F. Polat ,&nbsp;M. Avram ,&nbsp;M. Scheidegger","doi":"10.1016/j.nsa.2025.105413","DOIUrl":"10.1016/j.nsa.2025.105413","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105413"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ceramide pathway in obsessive compulsive disorder: a lipidomic research 强迫症的神经酰胺通路:脂质组学研究
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105481
E. Ozdemır , F. Kulacaoglu , M. Atakay , O. Senol
{"title":"The ceramide pathway in obsessive compulsive disorder: a lipidomic research","authors":"E. Ozdemır ,&nbsp;F. Kulacaoglu ,&nbsp;M. Atakay ,&nbsp;O. Senol","doi":"10.1016/j.nsa.2025.105481","DOIUrl":"10.1016/j.nsa.2025.105481","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105481"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NeuroFit intervention trial: effects of exercise on cognition and hippocampal neurogenesis in middle-aged adults NeuroFit干预试验:运动对中年人认知和海马神经发生的影响
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105483
S. Farmand , A. Du Preez , C. Kim , B. Stubbs , S. Thuret
{"title":"NeuroFit intervention trial: effects of exercise on cognition and hippocampal neurogenesis in middle-aged adults","authors":"S. Farmand ,&nbsp;A. Du Preez ,&nbsp;C. Kim ,&nbsp;B. Stubbs ,&nbsp;S. Thuret","doi":"10.1016/j.nsa.2025.105483","DOIUrl":"10.1016/j.nsa.2025.105483","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105483"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of forceps minor connectivity reduces social behaviour in mice 对小连接的抑制会减少小鼠的社会行为
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105466
M. Van Dijk , V. Siozos , R. Havekes , M. Kas
{"title":"Inhibition of forceps minor connectivity reduces social behaviour in mice","authors":"M. Van Dijk ,&nbsp;V. Siozos ,&nbsp;R. Havekes ,&nbsp;M. Kas","doi":"10.1016/j.nsa.2025.105466","DOIUrl":"10.1016/j.nsa.2025.105466","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105466"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemogenetic modulation of hippocampal circuits reveals a link between fear memory and depressive-like behavior 海马体回路的化学发生调节揭示了恐惧记忆和抑郁行为之间的联系
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105452
L. Parada Iglesias , S. Joca , G. Wegener
{"title":"Chemogenetic modulation of hippocampal circuits reveals a link between fear memory and depressive-like behavior","authors":"L. Parada Iglesias ,&nbsp;S. Joca ,&nbsp;G. Wegener","doi":"10.1016/j.nsa.2025.105452","DOIUrl":"10.1016/j.nsa.2025.105452","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105452"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信