Neuroscience Applied最新文献

{"title":"Exploring the potential role of metabolic equivalents of physical activity in ADHD patients with and without substance use disorder","authors":"P. Bauco , R.M. Fatica , F. Tassi , M. Servasi , L. Orsolini , U. Volpe","doi":"10.1016/j.nsa.2025.105533","DOIUrl":"10.1016/j.nsa.2025.105533","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105533"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145872528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating behavioral inertia in passively sensed smartphone parameters to differentiate affective episodes in patients with bipolar disorder","authors":"E.M. Langner,&nbsp;C. Bittendorf,&nbsp;E. Mühlbauer,&nbsp;W.E. Severus,&nbsp;M. Bauer,&nbsp;A.J. Cleare,&nbsp;A. Lasch,&nbsp;J. Martini,&nbsp;A. Pfennig,&nbsp;U.W. Ebner-Priemer,&nbsp;V.M. Ludwig","doi":"10.1016/j.nsa.2026.107018","DOIUrl":"10.1016/j.nsa.2026.107018","url":null,"abstract":"<div><div>Bipolar disorders are severe, recurrent mental illnesses characterized by distinct mood states associated with different behavioral patterns. While (emotional) inertia, the tendency of a system to persist or change, has been linked to depressive episodes, research on its role in hypomanic or manic states remains sparse. Moreover, behavioral inertia, assessed via passive sensing using smartphone parameters is equally underexplored.</div><div>This study investigated the temporal dynamics during (hypo-)manic and depressive episodes in passively sensed data in patients with bipolar disorder, complementing previous research on depression and using autocorrelation (AR) and moving averages (Mov.AVG) as dynamic measures. Data were drawn from the BipoSense study (N = 29), with 10 587 observed patient days including 20 (hypo)manic and 30 depressive episodes. Multilevel logit models were used to analyse AR and Mov.AVG across several parameters of activity, communication, sleep and phone use.</div><div>During depressive episodes, AR was significantly increased in activity and communication domains, particularly in later depressive weeks, reflecting heightened behavioural inertia. In contrast, Mov.AVG showed consistent decreases across activity, communication and sleep domains. For (hypo-)manic episodes, AR patterns were more heterogenous (both, elevated and decreased values), suggesting inconsistent temporal dynamics. However, Mov.AVG revealed a coherent pattern of increased activity, communication and phone use and reduced sleep, aligning with the clinical picture of (hypo-)mania. Concomitant analyses revealed that AR and Mov.AVG seem to explain different variance in the dynamic of patients experiencing bipolar episodes.</div><div>This study provides the first insight of behavioural inertia in patients with BD using passive sensing smartphone parameters. It underscores the importance of future research investigating behavioral inertia and especially the dynamics during (hypo-)manic episodes on larger cohorts and longer observation periods.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 107018"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13333381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148440677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk and protective factors for anxiety, depression, and PTSS symptoms following the october 7th attacks in israel","authors":"Y. Stukalin ,&nbsp;N. Eliyahu ,&nbsp;O. Ashkenazi ,&nbsp;T. Tarkay ,&nbsp;O. Elkana","doi":"10.1016/j.nsa.2025.105562","DOIUrl":"10.1016/j.nsa.2025.105562","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105562"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145869177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Old enough to be a model? On the role of maturity in stem cell-based models for neuropsychiatric disorders","authors":"Bingqing He ,&nbsp;Erik Smedler","doi":"10.1016/j.nsa.2026.106982","DOIUrl":"10.1016/j.nsa.2026.106982","url":null,"abstract":"<div><div>Mental disorders profoundly influence cognition, emotion, and self-perception, and collectively represent a major cause of global disability. Their onset spans distinct developmental periods, from early childhood in neurodevelopmental conditions such as autism spectrum disorder, through adolescence in eating and obsessive-compulsive disorders, to early adulthood in bipolar disorder and schizophrenia. Twin and family studies have established that these disorders are substantially heritable, and large-scale genomic analyses have identified numerous common and rare risk variants. Yet, the biological mechanisms through which genetic and environmental factors converge to shape disease trajectories remain elusive. Patient-derived induced pluripotent stem cells (iPSCs) have emerged as a promising tool for investigating disease-relevant mechanisms in human neurons and neural circuits. However, most iPSC-derived neural cells and organoids resemble embryonic/fetal-stage brain tissue in both molecular and functional characteristics, raising questions about their relevance for disorders that manifest later in life. In this narrative review, we discuss how developmental timing, both in disease onset and in cellular models, shapes the interpretation of iPSC-based findings. We outline how differences in neuronal maturity may constrain or enable mechanistic insight, summarize emerging methods for accelerating or extending neuronal aging <em>in vitro</em>, and consider how leveraging developmental immaturity might illuminate early pathogenic processes underlying mental disorders.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 106982"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep, Steps, and Screens: Between- and within-person effects of digital markers of daily life behaviors on smartphone-based assessments of cognitive functioning in depression","authors":"Marcos Ross-Adelman ,&nbsp;George Aalbers ,&nbsp;Faith Matcham ,&nbsp;Daniel Leightley ,&nbsp;Carolin Oetzmann ,&nbsp;Ewan Carr ,&nbsp;Sara Siddi ,&nbsp;Josep M. Haro ,&nbsp;Peter Annas ,&nbsp;Maria Dalby ,&nbsp;Vaibhav A. Narayan ,&nbsp;Matthew Hotopf ,&nbsp;Inez Myin-Germeys ,&nbsp;Femke Lamers ,&nbsp;Brenda W.J.H. Penninx ,&nbsp;RADAR-CNS consortium","doi":"10.1016/j.nsa.2026.106985","DOIUrl":"10.1016/j.nsa.2026.106985","url":null,"abstract":"<div><div>Cognitive impairment represents a core feature of major depressive disorder (MDD), often persisting after mood symptoms remit and not addressed by usual antidepressant treatments. Despite its relevance, cognition is typically assessed with infrequent tests in clinical settings, overlooking its contextual nature. Smartphones and wearables enable ecologically valid, repeated measurements of cognition and daily life behaviors that may impact it. We examined whether sleep duration, step count, and smartphone screen time are associated with cognitive functioning in MDD.</div><div>We conducted secondary analyses of RADAR-MDD, a multicenter study following individuals with recurrent MDD. Cognitive functioning – self-reported and performance-based – was assessed with the THINC-it® app. Sleep duration and step count were measured with Fitbit devices, and screen time with the RADAR-Base app. Cognitive assessments (outcomes) were linked to behavioral measures (predictors) from the day of and the day preceding each assessment. Two-level multilevel models estimated between-person (differences in participant means) and within-person (deviations from participant means) effects. The sample included 502 participants, further subdivided by behavior–cognitive outcome pair.</div><div>For performance-based cognitive assessments, positive associations at the between-person level were found for step count (β = 0.104, SE = 0.031, p &lt; 0.001) and screen time (β = 0.075, SE = 0.036, p = 0.038), and sleep duration showed a quadratic negative effect (β = −0.080, SE = 0.018, p &lt; 0.001). No within-person effects were detected. For self-reported cognitive functioning, step count showed positive associations both between (β = 0.161, SE = 0.037, p &lt; 0.001) and within persons (β = 0.027, SE = 0.010, p = 0.005), while screen time was negatively associated within persons (β = −0.033, SE = 0.011, p = 0.002).</div><div>Our findings illustrate that smartphones and wearables can collect meaningful daily life data of MDD patients that can be used to support cognitive health. Step count emerges as a promising behavioral target as it is simple to track and is correlated with better cognitive outcomes.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 106985"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycemic controls and mental health in patients with diabetes","authors":"J.H. Jeong ,&nbsp;S.Y. Lee ,&nbsp;M.D. Kim ,&nbsp;K.J. Min ,&nbsp;H.M. Sung","doi":"10.1016/j.nsa.2025.105632","DOIUrl":"10.1016/j.nsa.2025.105632","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105632"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and predictors of problem gambling in first-episode psychosis: a prospective multicenter cohort study","authors":"O. Corbeil ,&nbsp;M. Huot-Lavoie ,&nbsp;L. Béchard ,&nbsp;S. Brodeur ,&nbsp;A. Abdel-Baki ,&nbsp;C. Jacques ,&nbsp;M. Solmi ,&nbsp;D. Talbot ,&nbsp;M. Dorval ,&nbsp;I. Giroux ,&nbsp;M.A. Roy ,&nbsp;M.F. Demers","doi":"10.1016/j.nsa.2025.105545","DOIUrl":"10.1016/j.nsa.2025.105545","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105545"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dual-lever operant approach to ethanol and cocaine co-administration","authors":"G.V.L. Costa ,&nbsp;L. Teodoro ,&nbsp;P. Palombo ,&nbsp;B.T. Rodolpho ,&nbsp;V. Nascimento-Rocha ,&nbsp;J. Castelani ,&nbsp;C. Estevam ,&nbsp;C.J. Farias ,&nbsp;R.M. Leão ,&nbsp;F.C. Cruz","doi":"10.1016/j.nsa.2025.105543","DOIUrl":"10.1016/j.nsa.2025.105543","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105543"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal and early postnatal immune activation and supplementation with lactiplantibacillus plantarum modify adult mouse behavioural response to lipopolysaccharide immunostimulation","authors":"A. Ottomana ,&nbsp;A. Racca ,&nbsp;M.A. Marconi ,&nbsp;N. Battista ,&nbsp;A. Corsetti ,&nbsp;N. Ciano Albanese ,&nbsp;G. Calamandrei ,&nbsp;L. Ricceri","doi":"10.1016/j.nsa.2025.105557","DOIUrl":"10.1016/j.nsa.2025.105557","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105557"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated biological aging in bipolar disorder as determined by artificial intelligence-based electrocardiographic assessment","authors":"A. Miola ,&nbsp;B.J. Medina-Inojosa ,&nbsp;A.B. Cuellar-Barboza ,&nbsp;M.L. Prieto ,&nbsp;R.J. Morgan ,&nbsp;B.J. Coombes ,&nbsp;M. Veldic ,&nbsp;A. Ozerdem ,&nbsp;B. Singh ,&nbsp;M. Gardea-Reséndez ,&nbsp;M. Ercis ,&nbsp;L. Suarez Pardo ,&nbsp;F. Romo-Nava ,&nbsp;S.L. McElroy ,&nbsp;J.M. Biernacka ,&nbsp;J.R. Medina-Inojosa ,&nbsp;K.M. Lara–Breitinger ,&nbsp;M.A. Frye ,&nbsp;F. Lopez-Jimenez","doi":"10.1016/j.nsa.2025.105588","DOIUrl":"10.1016/j.nsa.2025.105588","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105588"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}