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Development of β-arrestin biased positron emission tomography radioligands for the cerebral serotonin 2A receptor 脑5 -羟色胺2A受体β-抑制蛋白偏置正电子发射断层成像放射配体的研究进展
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105475
C. Varlow , M. Zabrocki , C.A. Madsen , U. Battisti , A. Nasser , M.M. Herth , G.M. Knudsen
{"title":"Development of β-arrestin biased positron emission tomography radioligands for the cerebral serotonin 2A receptor","authors":"C. Varlow , M. Zabrocki , C.A. Madsen , U. Battisti , A. Nasser , M.M. Herth , G.M. Knudsen","doi":"10.1016/j.nsa.2025.105475","DOIUrl":"10.1016/j.nsa.2025.105475","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105475"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of an assay for measuring the functional effects of novel compounds at extrasynaptic GABA-A receptors 新化合物对突触外GABA-A受体功能影响的测定方法的建立
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105470
H. Fagan , J.R. Atack , K.T. Elvers
{"title":"Development of an assay for measuring the functional effects of novel compounds at extrasynaptic GABA-A receptors","authors":"H. Fagan , J.R. Atack , K.T. Elvers","doi":"10.1016/j.nsa.2025.105470","DOIUrl":"10.1016/j.nsa.2025.105470","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105470"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experience sampling method study in patients with psychosis: associations between smoking, stress and negative affect 精神病患者的经验抽样法研究：吸烟、压力和负面情绪之间的关系
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105411
D. Van Der Velde , S. van der Heijden , F. Schirmbeck , J. Vermeulen , L. de Haan
{"title":"Experience sampling method study in patients with psychosis: associations between smoking, stress and negative affect","authors":"D. Van Der Velde , S. van der Heijden , F. Schirmbeck , J. Vermeulen , L. de Haan","doi":"10.1016/j.nsa.2025.105411","DOIUrl":"10.1016/j.nsa.2025.105411","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105411"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Curbing the appetites and restoring the capacity for satisfaction: The impact of GLP-1 agonists on the reward circuitry 抑制食欲和恢复满足能力：GLP-1激动剂对奖赏回路的影响
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105512
Anna Julia Krupa
{"title":"Curbing the appetites and restoring the capacity for satisfaction: The impact of GLP-1 agonists on the reward circuitry","authors":"Anna Julia Krupa","doi":"10.1016/j.nsa.2025.105512","DOIUrl":"10.1016/j.nsa.2025.105512","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105512"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143562323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtual reality interventions for cognitive remediation in severe mental illness 虚拟现实对严重精神疾病认知修复的干预
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105513
Anna Julia Krupa
{"title":"Virtual reality interventions for cognitive remediation in severe mental illness","authors":"Anna Julia Krupa","doi":"10.1016/j.nsa.2025.105513","DOIUrl":"10.1016/j.nsa.2025.105513","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105513"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing brain-derived extracellular vesicles to support RDoC-based drug development 利用脑源性细胞外囊泡支持基于rdoc的药物开发
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2024.105406
I. Magaraggia , J. Krauskopf , J.G. Ramaekers , Y. You , L. de Nijs , J.J. Briedé , R. Schreiber
{"title":"Harnessing brain-derived extracellular vesicles to support RDoC-based drug development","authors":"I. Magaraggia ,&nbsp;J. Krauskopf ,&nbsp;J.G. Ramaekers ,&nbsp;Y. You ,&nbsp;L. de Nijs ,&nbsp;J.J. Briedé ,&nbsp;R. Schreiber","doi":"10.1016/j.nsa.2024.105406","DOIUrl":"10.1016/j.nsa.2024.105406","url":null,"abstract":"<div><div>The Research Domain Criteria (RDoC) framework offers a dimensional and transdiagnostic approach to understanding complex neuropsychiatric and neurological disorders, facilitating the development of novel therapeutics. However, the integration of cellular and molecular brain processes into the RDoC framework is hindered by the lack of adequate biomarkers. This review explores the potential of brain-derived extracellular vesicles (BDEVs) isolated from biofluids as a source of non-invasive mechanistic biomarkers in RDoC-based drug discovery. We provide an overview of BDEVs, including their classification, biological functions, and current methodologies for isolation and characterization. We then discuss studies that have investigated BDEV cargo as mechanistic biomarkers in CNS drug studies, focusing on target engagement, treatment response, and toxicity. Additionally, we address important considerations and open questions regarding the characterization and validation of BDEVs in neuroscience research. Special emphasis is placed on the use of miRNA cargo within BDEVs as molecular readouts, highlighting their stability, regulatory roles, and potential to reflect dynamic changes in brain function. Finally, the review proposes strategies to further investigate the use of BDEV miRNA cargo as molecular readouts, underscoring its ability to provide insights into the molecular mechanisms underlying drug effects and their relevance to CNS drug discovery within the RDoC framework. Despite existing methodological and conceptual challenges, BDEVs represent a promising tool for advancing RDoC-based drug discovery.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105406"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human single neural and columnar dynamics recorded by intraoperative high-density penetrating electrodes 术中高密度穿透电极记录人类单神经和柱状神经动态
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105433
D. Meszena , A. Paulk , W. Munoz , M. Jamali , I. Caprara , B. Coughlin , C. Windolf , E. Varol , I. Ulbert , Z. Williams , S. Cash
{"title":"Human single neural and columnar dynamics recorded by intraoperative high-density penetrating electrodes","authors":"D. Meszena ,&nbsp;A. Paulk ,&nbsp;W. Munoz ,&nbsp;M. Jamali ,&nbsp;I. Caprara ,&nbsp;B. Coughlin ,&nbsp;C. Windolf ,&nbsp;E. Varol ,&nbsp;I. Ulbert ,&nbsp;Z. Williams ,&nbsp;S. Cash","doi":"10.1016/j.nsa.2025.105433","DOIUrl":"10.1016/j.nsa.2025.105433","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105433"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of oral contraception on serotonin 4 receptor binding and verbal memory: a randomized, placebo-controlled trial 口服避孕药对血清素4受体结合和言语记忆的影响：一项随机、安慰剂对照试验
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105428
S.V. Larsen , A. Kauffmann , M.C. Hochheim , S. Hvitved , A.L. Rasmussen , M. Clausen , S. Olsen , K.R. Jensen , S. Keller , C. Svarer , B. Ozenne , Ø. Lidegaard , A.G.E. Giraldi , V.H. Dam , V.G. Frokjaer
{"title":"Effect of oral contraception on serotonin 4 receptor binding and verbal memory: a randomized, placebo-controlled trial","authors":"S.V. Larsen ,&nbsp;A. Kauffmann ,&nbsp;M.C. Hochheim ,&nbsp;S. Hvitved ,&nbsp;A.L. Rasmussen ,&nbsp;M. Clausen ,&nbsp;S. Olsen ,&nbsp;K.R. Jensen ,&nbsp;S. Keller ,&nbsp;C. Svarer ,&nbsp;B. Ozenne ,&nbsp;Ø. Lidegaard ,&nbsp;A.G.E. Giraldi ,&nbsp;V.H. Dam ,&nbsp;V.G. Frokjaer","doi":"10.1016/j.nsa.2025.105428","DOIUrl":"10.1016/j.nsa.2025.105428","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105428"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors of treatment response to adjunctive vagus nerve stimulation in difficult-to-treat depression 辅助迷走神经刺激对难治性抑郁症治疗反应的预测因素
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105499
A. Gramser , J. Saelens , M. Treiber , N. Grüll , K. Rössler , K. Novak , C. Kraus
{"title":"Predictors of treatment response to adjunctive vagus nerve stimulation in difficult-to-treat depression","authors":"A. Gramser ,&nbsp;J. Saelens ,&nbsp;M. Treiber ,&nbsp;N. Grüll ,&nbsp;K. Rössler ,&nbsp;K. Novak ,&nbsp;C. Kraus","doi":"10.1016/j.nsa.2025.105499","DOIUrl":"10.1016/j.nsa.2025.105499","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105499"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perinatal maternal microbiota disruption leads to changes in blood-cerebrospinal fluid barrier integrity 围产期母体微生物群破坏导致血-脑脊液屏障完整性的改变
Neuroscience Applied Pub Date : 2025-01-01 DOI: 10.1016/j.nsa.2025.105491
J. Morael , V. Turpin , A. Cergneux , L. Morales , H. Blair , A. Ratsika , J. Cryan , M. Aburto
{"title":"Perinatal maternal microbiota disruption leads to changes in blood-cerebrospinal fluid barrier integrity","authors":"J. Morael ,&nbsp;V. Turpin ,&nbsp;A. Cergneux ,&nbsp;L. Morales ,&nbsp;H. Blair ,&nbsp;A. Ratsika ,&nbsp;J. Cryan ,&nbsp;M. Aburto","doi":"10.1016/j.nsa.2025.105491","DOIUrl":"10.1016/j.nsa.2025.105491","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105491"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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