Neuroscience Applied最新文献

{"title":"Sulcal pits and their clinical symptoms associations reveal sex-specific neurodevelopmental mechanisms in schizophrenia","authors":"N. Hostalet , L. Cobos-Aumatell , A. Sotero-Moreno , I. París-Gómez , E.J. Canales-Rodríguez , E. Pomarol-Clotet , K. Im , M. Fatjó-Vilas","doi":"10.1016/j.nsa.2025.105435","DOIUrl":"10.1016/j.nsa.2025.105435","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105435"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of nutrition and insulin sensitivity on serotonergic brain functions in humans","authors":"M. Pu , L. Liu , S.O. Artigas , A. Ulrich , J. Tardu , B. Wilms , B. Koletzko , S. Schmid , S. Park","doi":"10.1016/j.nsa.2025.105430","DOIUrl":"10.1016/j.nsa.2025.105430","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105430"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal assessment of the frontostriatal circuitry in currently residential-reared adolescents","authors":"M. Nogueira , S. Silva Sousa , P. Moreira , S. Bouix , A. Mesquita , A. Sampaio","doi":"10.1016/j.nsa.2025.105441","DOIUrl":"10.1016/j.nsa.2025.105441","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105441"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schizophrenia management: Systematic review of current medications and Phase-3 agents (2008–2024)","authors":"Salma Abdelmoteleb ,&nbsp;Jayant Totlani ,&nbsp;Salma Ramadan ,&nbsp;Mohamed Salem ,&nbsp;Ashley Meyer ,&nbsp;Tiffany Chang ,&nbsp;Madeline Ewing ,&nbsp;Luiza Freire ,&nbsp;Nathalie Murphy ,&nbsp;Sabrina Renteria ,&nbsp;Romana Dymkoski ,&nbsp;Omer Liran ,&nbsp;Rebecca Hedrick ,&nbsp;Itai Danovitch ,&nbsp;Robert N. Pechnick ,&nbsp;Waguih William IsHak","doi":"10.1016/j.nsa.2025.105507","DOIUrl":"10.1016/j.nsa.2025.105507","url":null,"abstract":"<div><div>This systematic review evaluates psychiatric medications for schizophrenia approved between 2008 and 2024, considering regulatory practices and approvals across multiple regions, including the United States, Europe, and Asian countries. It details the mechanism of action, indications, efficacy, dosing, and adverse effects of each medication. The methodology involved a literature search of the PubMed database for studies published from 2008 to December 31, 2024 on FDA-approved psychiatric medications and Phase 3 pipeline medications, along with additional medications approved in Europe using the keywords “schizophrenia” OR “psychosis” AND “psychopharm∗” OR “medic∗” OR “pharm∗.” An independent assessment was conducted, followed by a consensus on eligible studies for inclusion in the systematic review. From 2008 to December 31, 2024, the FDA approved 29 medications for schizophrenia including 13 long-acting injectables (LAI), in addition to that there are additional three other medications that are available in Europe but not in the United States. Additionally, 8 pipeline medications are currently in Phase-3 clinical trials including one LAI. Each medication is analyzed, and its mechanisms of action, indications, dosing, efficacy, and adverse effects are described. The 13 approved LAIs and the one LAI in the pipeline are detailed in a separate manuscript. This review highlights a significant increase in approved medications for the treatment of schizophrenia, including long-acting injectable formulations that enhance the range of existing oral therapies. Furthermore, new treatments for medication-related movement disorders have been introduced. Innovative developments in Phase-3 trials for schizophrenia medications, including new mechanisms of action and administration routes, promise to transform treatment strategies and enhance patient outcomes.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105507"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The neurodevelopmental modulator wnt in attention-deficit hyperactivity disorder and the effects of methylphenidate","authors":"C.M. Yde Ohki ,&nbsp;N.M. Walter ,&nbsp;S. Walitza ,&nbsp;E. Grünblatt","doi":"10.1016/j.nsa.2025.105479","DOIUrl":"10.1016/j.nsa.2025.105479","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105479"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vesicular glutamate transporter 3 deletion in 5-hydroxytryptamine neurons impacts nucleus accumbens dopamine transients","authors":"L.S. Gullino ,&nbsp;L.M. Burgeno ,&nbsp;R. Smausz ,&nbsp;T. Akam ,&nbsp;T. Sharp ,&nbsp;D.M. Bannerman ,&nbsp;M.E. Walton","doi":"10.1016/j.nsa.2025.105463","DOIUrl":"10.1016/j.nsa.2025.105463","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105463"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional mapping of brain pathways involved in the gut microbial modulation of social behaviour","authors":"M. Depret ,&nbsp;N. Van Munsteren ,&nbsp;M. Thabault ,&nbsp;P. Fitzgerald ,&nbsp;J.F. Cryan ,&nbsp;L. Katona","doi":"10.1016/j.nsa.2025.105461","DOIUrl":"10.1016/j.nsa.2025.105461","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105461"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scale integration from neurons to brain regions of dopamine modulation","authors":"G. Casagrande ,&nbsp;D. Depannemaecker","doi":"10.1016/j.nsa.2025.105506","DOIUrl":"10.1016/j.nsa.2025.105506","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105506"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focused Neuroprotection in Parkinson's Disease: Effects of N-Acetylcysteine and MRI-guided Ultrasound Neuromodulation","authors":"R. Caridade Silva ,&nbsp;B. Araújo ,&nbsp;A.C. Vilaça-Ferreira ,&nbsp;C. Vilela ,&nbsp;C. Teixeira ,&nbsp;J. Martins-Macedo ,&nbsp;C. Soares-Guedes ,&nbsp;E.D. Gomes ,&nbsp;S. Mériaux ,&nbsp;B. Larrat ,&nbsp;R. Wade-Martins ,&nbsp;H.J. Fernandes ,&nbsp;F. Teixeira","doi":"10.1016/j.nsa.2025.105496","DOIUrl":"10.1016/j.nsa.2025.105496","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105496"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemogenetic manipulation of the prefrontal cortex exerts antidepressant effect and controls hippocampal neuroplasticity","authors":"M. Veleanu ,&nbsp;S. Vestring ,&nbsp;J. Weber ,&nbsp;C. Normann ,&nbsp;T. Serchov","doi":"10.1016/j.nsa.2025.105497","DOIUrl":"10.1016/j.nsa.2025.105497","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"4 ","pages":"Article 105497"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}