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Early-life microbiome disturbance alters behaviour and HPA-axis diurnal rhythmicity 生命早期微生物群紊乱会改变行为和 HPA 轴的昼夜节律性
Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103988
N. Gavioli , G.S.S. Tofani , B.L. Sharvin , E. Guniggle , G. Clarke , J.F. Cryan
{"title":"Early-life microbiome disturbance alters behaviour and HPA-axis diurnal rhythmicity","authors":"N. Gavioli , G.S.S. Tofani , B.L. Sharvin , E. Guniggle , G. Clarke , J.F. Cryan","doi":"10.1016/j.nsa.2024.103988","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.103988","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 103988"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277240852400053X/pdfft?md5=db2fd601aa8325cd786f3dd1d601697d&pid=1-s2.0-S277240852400053X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140031114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of vagus nerve stimulation on circulating inflammatory parameters: A systematic review and meta-analysis 迷走神经刺激对循环炎症参数的影响：系统回顾与荟萃分析
Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103944
A. Bouzouina , C. Schiweck , S. Sausmekat , T. Zhao , L. Jacobsen , M. Aichholzer , A. Reif , S. Edwin Thanarajah
{"title":"The effect of vagus nerve stimulation on circulating inflammatory parameters: A systematic review and meta-analysis","authors":"A. Bouzouina , C. Schiweck , S. Sausmekat , T. Zhao , L. Jacobsen , M. Aichholzer , A. Reif , S. Edwin Thanarajah","doi":"10.1016/j.nsa.2024.103944","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.103944","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 103944"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524000097/pdfft?md5=71e9ec18e970f58c8f84c9dbd725f216&pid=1-s2.0-S2772408524000097-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accelerated biological aging during the Covid-19 pandemic – a twinlife epigenetic change satellite study Covid-19 大流行期间生物老化加速--双生子表观遗传变化卫星研究
Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104031
A. Schowe , D. Czamara , B. Moenkediek , D.V. Kuznetsov , T. Rohm , J. Instinske , C. Kandler , C. Pahnke , A. Forstner , C. Maj , M. Noethen , E.B. Binder
{"title":"Accelerated biological aging during the Covid-19 pandemic – a twinlife epigenetic change satellite study","authors":"A. Schowe , D. Czamara , B. Moenkediek , D.V. Kuznetsov , T. Rohm , J. Instinske , C. Kandler , C. Pahnke , A. Forstner , C. Maj , M. Noethen , E.B. Binder","doi":"10.1016/j.nsa.2024.104031","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.104031","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 104031"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524000966/pdfft?md5=760c7b54a9a39f91f1ad07f4886b7439&pid=1-s2.0-S2772408524000966-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early life adversity and adolescent internalising symptoms: the role of hippocampal volume 早期生活逆境与青少年内化症状：海马体体积的作用
Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103966
S. Kretzer , R. Pollard , A.J. Lawrence , P.J. Chen , X. Ma , M. Matter , C. Vallée , O. Johnson Trewick , C. Morgan , S. Harding , G. Schumann , C. Pariante , M. Mehta , G. Montana , C. Nosarti , A. Rodriguez-Mateos , M. Meaney , P. Dazzan
{"title":"Early life adversity and adolescent internalising symptoms: the role of hippocampal volume","authors":"S. Kretzer , R. Pollard , A.J. Lawrence , P.J. Chen , X. Ma , M. Matter , C. Vallée , O. Johnson Trewick , C. Morgan , S. Harding , G. Schumann , C. Pariante , M. Mehta , G. Montana , C. Nosarti , A. Rodriguez-Mateos , M. Meaney , P. Dazzan","doi":"10.1016/j.nsa.2024.103966","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.103966","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 103966"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524000310/pdfft?md5=8a662fbe2b93e24a5059583655367788&pid=1-s2.0-S2772408524000310-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel, non-opioid, selective orexin-1 receptor antagonist for the treatment of substance use disorders 一种用于治疗药物使用障碍的新型、非阿片类、选择性奥曲肽-1 受体拮抗剂
Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104053
Clare M. Murray , J. Craig Fox , Christian Heidbreder , Malcolm Young
{"title":"A novel, non-opioid, selective orexin-1 receptor antagonist for the treatment of substance use disorders","authors":"Clare M. Murray ,&nbsp;J. Craig Fox ,&nbsp;Christian Heidbreder ,&nbsp;Malcolm Young","doi":"10.1016/j.nsa.2024.104053","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.104053","url":null,"abstract":"<div><p>There is a pressing need for novel treatments for substance use disorders to address increasing rates of addiction and drug overdose. Preclinical studies have shown that the orexin (hypocretin) system in the brain, mediated primarily by the orexin 1 receptor, plays a role in reward-related behaviours and that selective blockade of this receptor is efficacious in rodent models of addiction for a wide range of substances including opioids, cocaine, nicotine, and alcohol. We report here the preclinical profile of C4X3256, a novel, selective oral antagonist of the orexin 1 receptor. In the rat, high levels of receptor occupancy were observed in the tenia tecta region of the brain for up to 8 h following oral dosing. Translation of brain receptor occupancy into pharmacological efficacy was demonstrated in rat models showing significantly reduced nicotine self-administration and diminished cue-induced reinstatement of nicotine seeking following an oral dose of 30 mg/kg C4X3256. In addition, C4X3256 significantly reduced reinstatement of cocaine seeking induced by presentation of tone/light cues in a rat model of relapse. In summary, the nonclinical profile of C4X3256 has supported the progression of this compound into human clinical trials as an investigational medicinal product for the treatment of substance use disorders.</p></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 104053"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524001182/pdfft?md5=b072bd82cbe18b35a7a184fce339244a&pid=1-s2.0-S2772408524001182-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140103394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in brain structure in the course of depression: A longitudinal imaging study across multiple follow-ups 抑郁症病程中大脑结构的变化：多次随访的纵向成像研究
Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103956
A. Kraus , K. Dohm , D. Grotegerd , E. Schrammen , J. Goltermann , V. Enneking , E.J. Leehr , J. Böhnlein , J. Bauer , T. Hahn , U. Dannlowski , S. Meinert
{"title":"Changes in brain structure in the course of depression: A longitudinal imaging study across multiple follow-ups","authors":"A. Kraus ,&nbsp;K. Dohm ,&nbsp;D. Grotegerd ,&nbsp;E. Schrammen ,&nbsp;J. Goltermann ,&nbsp;V. Enneking ,&nbsp;E.J. Leehr ,&nbsp;J. Böhnlein ,&nbsp;J. Bauer ,&nbsp;T. Hahn ,&nbsp;U. Dannlowski ,&nbsp;S. Meinert","doi":"10.1016/j.nsa.2024.103956","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.103956","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 103956"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524000218/pdfft?md5=ca73365e58096da8a40cc6968dd08e27&pid=1-s2.0-S2772408524000218-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A double hit rat model of schizophrenia shows altered Behaviour and differences in thalamic FOXP2 expression 精神分裂症双击大鼠模型显示行为改变和丘脑 FOXP2 表达差异
Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.104000
B. Sánchez-Moreno , A.I. Fraga-Sánchez , D. Vega-Avelaira , J. Gilabert-Juan
{"title":"A double hit rat model of schizophrenia shows altered Behaviour and differences in thalamic FOXP2 expression","authors":"B. Sánchez-Moreno ,&nbsp;A.I. Fraga-Sánchez ,&nbsp;D. Vega-Avelaira ,&nbsp;J. Gilabert-Juan","doi":"10.1016/j.nsa.2024.104000","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.104000","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 104000"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524000656/pdfft?md5=e5547d2b0690f1f68e61756d62683927&pid=1-s2.0-S2772408524000656-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of methylphenidate treatment on default mode network connectivity in attention-deficit hyperactivity disorder 哌醋甲酯治疗对注意力缺陷多动障碍默认模式网络连接的影响
Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103999
E. Vansina , Z. Van der Pal , D. Boucherie , A. Kaiser , L. Douw , L. Reneman , A. Schrantee
{"title":"Effects of methylphenidate treatment on default mode network connectivity in attention-deficit hyperactivity disorder","authors":"E. Vansina ,&nbsp;Z. Van der Pal ,&nbsp;D. Boucherie ,&nbsp;A. Kaiser ,&nbsp;L. Douw ,&nbsp;L. Reneman ,&nbsp;A. Schrantee","doi":"10.1016/j.nsa.2024.103999","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.103999","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 103999"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524000644/pdfft?md5=0ecea0fc862d0d14d3fe3151e535f108&pid=1-s2.0-S2772408524000644-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disease course and white matter microstructure both individually influence cognitive performance in depressed patients 病程和白质微结构都会单独影响抑郁症患者的认知能力
Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103967
S. Meinert , K. Flinkenflügel , T. Kircher , U. Dannlowski
{"title":"Disease course and white matter microstructure both individually influence cognitive performance in depressed patients","authors":"S. Meinert ,&nbsp;K. Flinkenflügel ,&nbsp;T. Kircher ,&nbsp;U. Dannlowski","doi":"10.1016/j.nsa.2024.103967","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.103967","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 103967"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524000322/pdfft?md5=9e6be21f29b1406b8b126ba4dcd0a28c&pid=1-s2.0-S2772408524000322-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal tryptophan hydroxylase-1 genotype defines offspring’s cognition and behaviour 母体色氨酸羟化酶-1 基因型决定后代的认知和行为
Neuroscience Applied Pub Date : 2024-01-01 DOI: 10.1016/j.nsa.2024.103993
R. Rocha De Castro , M. Verheij , A.A. Vasquez , J. Buitelaar , J. Homberg
{"title":"Maternal tryptophan hydroxylase-1 genotype defines offspring’s cognition and behaviour","authors":"R. Rocha De Castro ,&nbsp;M. Verheij ,&nbsp;A.A. Vasquez ,&nbsp;J. Buitelaar ,&nbsp;J. Homberg","doi":"10.1016/j.nsa.2024.103993","DOIUrl":"https://doi.org/10.1016/j.nsa.2024.103993","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"3 ","pages":"Article 103993"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772408524000589/pdfft?md5=dc54b6570e3bc86eaf036af9f5ad71c4&pid=1-s2.0-S2772408524000589-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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