Neuroscience Applied最新文献

{"title":"Prenatal maternal depression and child developmental, cognitive, and behavioural outcomes: an individual participant data meta-analysis","authors":"J. Hermans , D. Avraam , I.K. Schuurmans , T.G.M. Vrijkotte , A. Elhakeem , A.G. Soares , J. van der Waerden , B. Heude , C. Vainqueur , T.C. Yang , R.W. Cheung , D. Lewer , K. Strandberg-Larsen , T. Cadman , M. Popovic , F. Candelora , M. Lahti-Pulkkinen , P. Girchenko , J. Lahti , K. Raikkonen , H. El Marroun","doi":"10.1016/j.nsa.2025.105605","DOIUrl":"10.1016/j.nsa.2025.105605","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105605"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145868478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long non-coding RNAs and accelerated aging in bipolar disorder","authors":"Sultan Ekinci ,&nbsp;Hidayet Ece Arat Çelik ,&nbsp;İbrahim Fettahoğlu ,&nbsp;Alessio Squassina ,&nbsp;Deniz Ceylan","doi":"10.1016/j.nsa.2026.106990","DOIUrl":"10.1016/j.nsa.2026.106990","url":null,"abstract":"<div><div>Bipolar disorder (BD) has been associated with accelerated biological aging, potentially driven by genetic and environmental factors. Long non-coding RNAs (lncRNAs), key regulators of epigenetic, telomere attrition, and cellular aging processes, may play a role in accelerated aging in BD. This review summarizes current evidence on aging-associated lncRNAs and their relevance to BD. We searched PubMed for English-language original studies published up to June 2, 2025, using keywords related to lncRNAs, aging-related mechanisms, and aging-associated neuropsychiatric disorders. A total of 112 articles reported 163 lncRNAs, of which 19 were common to aging-related mechanisms and aging-associated neuropsychiatric disorders. Among these, ANRIL, HOTAIR, TUG1, MALAT1, NEAT1, and GAS5 have been reported in both aging-related contexts and BD; however, their relevance to BD requires further confirmation in independent and well-characterized cohorts. The remaining overlapping lncRNAs may represent additional candidates of interest for future investigation rather than established contributors to BD pathophysiology.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 106990"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual reality-based cognitive screening in psychiatry: Investigating optimal cut-offs for cognitive impairment in bipolar disorder","authors":"Andreas Elleby Jespersen ,&nbsp;Julie Marie Lindhardsen ,&nbsp;Anders Lumbye ,&nbsp;Viktoria Damgaard ,&nbsp;Johanna Mariegaard Schandorff ,&nbsp;Christina Mikkelsen ,&nbsp;Maria Didriksen ,&nbsp;Sisse Rye Ostrowski ,&nbsp;Lars Vedel Kessing ,&nbsp;Kamilla Woznica Miskowiak","doi":"10.1016/j.nsa.2025.106880","DOIUrl":"10.1016/j.nsa.2025.106880","url":null,"abstract":"<div><div>Cognitive impairment is a key treatment target across neuropsychiatric disorders, including bipolar disorder (BD), but standard neuropsychological tools often fail to capture real-world cognitive challenges. Virtual reality (VR) offers a more ecologically valid alternative. This study investigated the optimal cut-off score of the novel Cognition Assessment in Virtual Reality (CAVIR) test for detecting impaired functional cognitive capacity in BD. Cut-off scores on the CAVIR were investigated in a sample of outpatients with BD (primary clinical screening BD sample; <em>n</em> = 68), using the Screen for Cognitive Impairment in Psychiatry (SCIP) as the reference for objective cognitive impairment. Receiver operating characteristic (ROC) analyses were used to identify optimal cut-off scores for detecting cognitive impairment, defined as performance ≥1 SD below the healthy controls (HC) mean (<em>n</em> = 68). Analyses were replicated in an independent mixed sample of patients with mood or schizophrenia spectrum disorders (<em>n</em> = 70) and HCs (<em>n</em> = 70), using a full neuropsychological test battery as reference. Associations between CAVIR, SCIP and interviewer-rated functioning were also explored. In the primary clinical screening BD sample, a CAVIR total score cut-off of ≤64 showed fair sensitivity (74 %) and specificity (71 %) for detecting cognitive impairment with an area under the curve (AUC) of 0.74. This cut-off score proved robust, with the optimal cut-off in the mixed replication sample of ≤66 differing by only two points. CAVIR performance was weakly to moderately associated with SCIP and functioning. The CAVIR demonstrated fair sensitivity and specificity for detecting cognitive impairment, supporting its potential as an ecologically valid screening tool for impaired functional cognitive capacity.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 106880"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145925522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Olfactory impairment in Huntington's disease: A systematic review and meta-analysis","authors":"Franco Di Cesare ,&nbsp;Cristiana Di Carlo ,&nbsp;Leonardo Di Cesare ,&nbsp;Jan Kottner ,&nbsp;Silvia Zaragoza-Domingo ,&nbsp;Rudy Schreiber","doi":"10.1016/j.nsa.2026.107016","DOIUrl":"10.1016/j.nsa.2026.107016","url":null,"abstract":"<div><div>Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder characterised by progressive impairment in cognitive, behavioural, and motor functions. Odour identification deficits have long been recognised as a non-motor impairment associated with HD and may thus represent a plausible biomarker candidate for use in the context of clinical trials evaluating novel disease-modifying therapies. This systematic review and meta-analysis aim to evaluate whether odour identification is reduced in persons with Huntington's disease (PwHD) compared to healthy controls (HC). The protocol was registered on PROSPERO (CRD420251019430) on April 5th, 2025. Comprehensive searches were conducted across PubMed, Embase, Web of Science, Google Scholar, BASE, and WorldCat, including grey literature, up to April 15, 2025. Included studies used case-control and cross-sectional designs involving human participants, comparing PwHD to HC, explicitly reporting sample sizes, documenting the use of psychophysical methods for odour identification, and providing sufficient data to calculate group differences. Eligible publications were peer-reviewed and available in English and non-English. Risk of bias was assessed independently by two reviewers using the Joanna Briggs Institute (JBI) checklists. Two reviewers independently screened and extracted data. The meta-analysis employed a random-effects model using restricted maximum likelihood estimation. Heterogeneity was evaluated via subgroup analyses and meta-regression, and sensitivity analyses examined the robustness of results. Results from all studies identified according to the specified criteria were merged into a single dataset and treated as a whole sample for review. Of the 43 eligible studies, 19 (44.2%) were included, comprising 1745 PwHD and 814 HC. Mean (SD) age at enrolment was 46.1 (5.3) years for PwHD and 44.1 (5.9) years for HC. Meta-analysis revealed a large negative overall difference (θ = −1.294; 95% CI: −1.626 to −0.962; 95% prediction interval: −2.704 to 0.116), confirming significantly lower odour identification accuracy in the PwHD group. Substantial heterogeneity (I² = 88%) was observed. The systematic review of the clinical evidence indicates that odour identification is impaired in HD. It also supports measures of odour identification as a plausible biomarker candidate for HD. Of note, the effect sizes are not fully consistent across studies. As the reported range of likely effects includes the possibility of no difference in some settings or clinical sub-groups, this limits the extent to which the findings of this systematic review can be applied. Further research is needed to define odour identification deficits and to improve assessment methodologies. Validating new odour identification measures as biomarkers within HD therapeutic trials represents a promising direction for future work.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 107016"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the invisible: a possible case of lupus psychosis","authors":"S. Herranz de las Heras ,&nbsp;M.M. Vilela Manyari ,&nbsp;E.B. Alonso-Sanchez ,&nbsp;P.J. Escobedo-Aedo ,&nbsp;H. Diaz Moreno","doi":"10.1016/j.nsa.2025.105619","DOIUrl":"10.1016/j.nsa.2025.105619","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105619"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145872731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between atomoxetine and OROS methylphenidate as an adjunctive to SSRIs in adult ADHD with comorbid partially responsive major depression","authors":"H.M. Sung ,&nbsp;W.M. Bahk ,&nbsp;B.H. Yoon ,&nbsp;J.H. Jeong ,&nbsp;S.Y. Lee ,&nbsp;S.H. Shim ,&nbsp;Y.S. Woo","doi":"10.1016/j.nsa.2025.105627","DOIUrl":"10.1016/j.nsa.2025.105627","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105627"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145872711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The negative impact of stigmatization by healthcare professionals in individuals with substance use disorders - a mixed methods study","authors":"M. Luderer ,&nbsp;D. Stockreiter ,&nbsp;A. Binder ,&nbsp;L.S. Müller ,&nbsp;F. Burger ,&nbsp;A. Reif","doi":"10.1016/j.nsa.2025.105548","DOIUrl":"10.1016/j.nsa.2025.105548","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105548"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145872682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relapse risk prediction in first-episode bipolar disorder: development, external validation, and pharmacotherapy associations of a machine learning model","authors":"J. Lieslehto ,&nbsp;J. Tiihonen ,&nbsp;M. Lähteenvuo ,&nbsp;A. Kautzky ,&nbsp;A. Akhtar ,&nbsp;R. Amin ,&nbsp;B. Ármannsdóttir ,&nbsp;S. Leucht ,&nbsp;C. Correll ,&nbsp;E. Mittendorfer-Rutz ,&nbsp;A. Tanskanen ,&nbsp;H. Taipale","doi":"10.1016/j.nsa.2025.105573","DOIUrl":"10.1016/j.nsa.2025.105573","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105573"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145872471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood body dysmorphic disorder:clinical characteristics of 52 children and adolescents","authors":"L. Larini ,&nbsp;S. Rashkovich ,&nbsp;C. Ferretti ,&nbsp;K. Phillips ,&nbsp;E. Hollander","doi":"10.1016/j.nsa.2025.105607","DOIUrl":"10.1016/j.nsa.2025.105607","url":null,"abstract":"","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 105607"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145872509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining varying number of intervention-modules and change in individual networks in young people remitted from depression or anxiety: Exploratory outcomes of the StayFine randomized clinical trial","authors":"S.J. Robberegt ,&nbsp;C.J. Albers ,&nbsp;B.E.A.M. Kooiman ,&nbsp;A.H. Vuuregge ,&nbsp;J.D. Mul ,&nbsp;N. Wilts ,&nbsp;M.H. Nauta ,&nbsp;Y.A.J. Stikkelbroek ,&nbsp;C.L.H. Bockting","doi":"10.1016/j.nsa.2026.107007","DOIUrl":"10.1016/j.nsa.2026.107007","url":null,"abstract":"<div><div>In network theory, symptoms of mental disorders constitute networks of interconnected nodes. Interventions can target (aspects of) networks. Assuming that combined intervention-modules target multiple aspects of networks simultaneously, we examined on average whether receiving more intervention-modules was associated with more baseline to post-intervention change in network characteristics. Between Dec-2019 and May-2024, 14-to-22-year-old individuals (89.8% female) remitted from depressive or anxiety disorders were randomized (1:1) to relapse prevention intervention-modules plus care as usual (M + CAU; <em>n</em> = 69), or CAU (<em>n</em> = 68). Participants completed baseline and post-intervention ecological momentary assessment (EMA; 2 weeks, 6 × /day) to construct contemporaneous partial correlation networks of 11 nodes (<em>anxiety, sadness, positive affect, anger, stress, fatigue, suppression, avoidance, loneliness, activity, social company</em>). Based on a data-driven advice, including the baseline network, six intervention-modules were offered in personalized varying combinations (psychoeducation, cognitive restructuring, positive affect, exposure, activation, sleep, wellness, relapse prevention plan). Using 45 univariate regression analyses (<em>α =</em> .05), associations were assessed between the number of completed intervention-modules (M[SD] = 4.29[1.70]; range = 0-6) and change in network density, and in intensity, instability, and centrality of 11 nodes. Randomization groups were compared using two-sample t-tests.</div><div>Results indicated that after multiple testing correction, a higher number of intervention-modules was not associated with significant change in network characteristics. Changes in networks were neither different between randomization groups. Some characteristics showed non-robust, small associations with a higher number of intervention-modules: centrality of <em>fatigue</em> decreased (<em>n</em> = 69;<em>β</em> = −0.061, 95%CI [-0.122,0.000], <em>p</em> = .037, <em>η</em>_<em>p</em>^<em>2</em> = 0.03), and network density decreased (<em>n</em> = 69; <em>β</em> = −0.008, 95%CI [-0.015,0.000], <em>p</em> = .015, <em>η</em>_<em>p</em>^<em>2</em> = 0.05). Change in centrality of <em>loneliness</em> was positive in the M + CAU-group and negative in the CAU-group (t[130.33] = -2.47, <em>p</em> = .015, d = −0.42). In conclusion, after multiple testing correction, more intervention-modules were not associated with more change in network characteristics across individuals. This initial examination provides a starting point for replication in confirmatory analyses, and for better mechanistic understanding of network change to prevent relapse over time.</div></div>","PeriodicalId":100952,"journal":{"name":"Neuroscience Applied","volume":"5 ","pages":"Article 107007"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147951323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}