Nano TransMed最新文献_第4页

Integration of graphene quantum dots with 3D scaffolds for precision medicine and regenerative applications 石墨烯量子点与3D支架的集成，用于精准医疗和再生应用

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2025-09-15 DOI: 10.1016/j.ntm.2025.100095

Yuvaraj Muthu, Meenaloshini Gopalakrishnan, Prabakaran Sankar, Elizabeth Rani Edwin, Karthikeyan Elumalai

{"title":"Integration of graphene quantum dots with 3D scaffolds for precision medicine and regenerative applications","authors":"Yuvaraj Muthu, Meenaloshini Gopalakrishnan, Prabakaran Sankar, Elizabeth Rani Edwin, Karthikeyan Elumalai","doi":"10.1016/j.ntm.2025.100095","DOIUrl":"10.1016/j.ntm.2025.100095","url":null,"abstract":"<div><div>Integrated onto three-dimensional (3D) scaffolds, graphene quantum dots (GQDs) present a novel method for tissue creation and precision drug delivery. Among its special characteristics are photoluminescence, biocompatibility, and a large surface area fit for functionalizing. Targeting drug delivery, tissue regeneration, and diagnostic capability, GQD-functionalized 3D scaffolds provide. This review discusses the synthesis, characteristics, and functionalizing techniques of GQD-functionalized 3D scaffolds to achieve desired delivery. GQD-functionalized 3D scaffolds underscore their possible use by means of synergistic effects in cancer treatment, tissue engineering, wound healing, and chronic illness management. Even with real-time medication release and therapeutic effect monitoring allowed, GQD-functionalized 3D scaffolds can provide chemotherapeutic drugs, nucleic acids, and proteins to tumor locations. In tissue engineering, GQD-functionalized scaffolds help cells in proliferation, differentiation, and neovascularization. Moreover, GQD-functionalized 3D scaffolds speed wound healing and help avoid infections. GQD-functionalized 3D scaffolds indicate a promising method for continuous medicine administration and tissue regeneration for chronic diseases, including diabetes, cardiovascular diseases, and neurodegenerative diseases. Still, there are somewhat typical issues with long-term safety, mass production, and regulatory approval. Green synthesis methods, better functionalizing methods, and design-based stimuli-responsive scaffolds are among the future directions. Clinical application of this technology depends totally on cooperative efforts of material scientists, biomedical engineers, medical practitioners, and regulatory authorities. Depending on continuous development, GQD-functionalized 3D scaffold technology presents enormous possibilities to transform medicine delivery and regeneration.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanocarriers in skin cancer treatment: Emerging drug delivery approaches and innovations 纳米载体在皮肤癌治疗：新兴的药物输送方法和创新

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2024-12-17 DOI: 10.1016/j.ntm.2024.100068

Laxmi A. Jadhav, Satish K. Mandlik

{"title":"Nanocarriers in skin cancer treatment: Emerging drug delivery approaches and innovations","authors":"Laxmi A. Jadhav, Satish K. Mandlik","doi":"10.1016/j.ntm.2024.100068","DOIUrl":"10.1016/j.ntm.2024.100068","url":null,"abstract":"<div><h3>Background</h3><div>Skin cancer is a growing global health issue, with rising incidence rates, particularly among Caucasian populations. It is the most common malignancy, contributing significantly to mortality and decreased quality of life worldwide. While surgical interventions remain the primary treatment, there is a pressing need for innovative strategies to reduce the morbidity and mortality associated with the disease. As the burden of skin cancer continues to grow, the medical community is increasingly exploring novel therapeutic approaches to improve patient outcomes.</div></div><div><h3>Main body</h3><div>Nanotechnology has introduced new possibilities for treating skin cancer, offering advantages in targeted drug delivery, advanced imaging, and diagnostics. Nanomaterials are especially useful in dermatology, as they enhance the penetration and retention of therapeutic agents while minimizing side effects. Various nanomaterials have been studied for their potential in treating skin disorders, including cancer. This review examines the role of nanotechnology in skin cancer treatment, focusing on the development and design of nanocarriers for the precise delivery of drugs. We also discuss the advantages of nanotechnology over traditional treatments, such as improved bioavailability and targeted action. Additionally, we explore clinical trials, patents and FDA approved products related to nanocarrier-based treatments for cancer and skin cancer, highlighting advancements in the field.</div></div><div><h3>Conclusion</h3><div>Nanotechnology holds significant promise in revolutionizing skin cancer treatment. As research progresses, it is expected that more effective, personalized therapies will emerge, ultimately improving patient outcomes. Integrating nanotechnology into clinical practice could elevate the standard of care, offering new hope in managing skin cancer.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100068"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graphene nanomaterial-based electrochemical biosensors for salivary biomarker detection: A translational approach to oral cancer diagnostics 基于石墨烯纳米材料的唾液生物标志物检测电化学生物传感器：口腔癌诊断的转化方法

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2025-01-22 DOI: 10.1016/j.ntm.2025.100073

D. Mahalakshmi , J. Nandhini , G. Meenaloshini , E. Karthikeyan , KK Karthik , J. Sujaritha , Vandhana V , C. Ragavendran

{"title":"Graphene nanomaterial-based electrochemical biosensors for salivary biomarker detection: A translational approach to oral cancer diagnostics","authors":"D. Mahalakshmi , J. Nandhini , G. Meenaloshini , E. Karthikeyan , KK Karthik , J. Sujaritha , Vandhana V , C. Ragavendran","doi":"10.1016/j.ntm.2025.100073","DOIUrl":"10.1016/j.ntm.2025.100073","url":null,"abstract":"<div><div>Graphene-based electrochemical biosensors have emerged as promising tools for the early detection and monitoring of oral cancer through salivary biomarker analysis. Graphene's exceptional properties, including high surface area, superior electrical conductivity, and excellent mechanical strength, enable the development of highly sensitive and specific biosensors. This review provides a comprehensive overview of the current state-of-the-art in graphene-based electrochemical biosensors for salivary biomarker detection in oral cancer. We discuss the unique advantages of saliva as a diagnostic medium and highlight the key salivary biomarkers associated with oral cancer, including proteins, DNA, and RNA. Various electrochemical detection techniques, such as cyclic voltammetry, differential pulse voltammetry, electrochemical impedance spectroscopy, field-effect transistors, amperometry, chronoamperometry, and photoelectrochemical methods, are explored in the context of graphene-based biosensors. The challenges associated with the development and clinical translation of these biosensors are also addressed, emphasizing the need for improved functionalization strategies, enhanced stability, and standardized validation protocols. Finally, we present a futuristic outlook on the integration of graphene-based biosensors with artificial intelligence, microfluidics, and telemedicine platforms to enable personalized diagnostics and treatment monitoring. With continued advancements in sensor technology and computational tools, graphene-based electrochemical biosensors have the potential to revolutionize oral cancer management, improving patient outcomes and quality of life.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100073"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-silico strategies in nano-drug design: Bridging nanomaterials and pharmacological applications 纳米药物设计中的硅策略：桥接纳米材料和药理学应用

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2025-07-09 DOI: 10.1016/j.ntm.2025.100091

Nagarjuna Prakash Dalbanjan , Karuna Korgaonkar , Manjunath P. Eelager , Basavaraj Neelappa Gonal , Arihant Jayawant Kadapure , Suresh B. Arakera , Praveen Kumar S.K.

{"title":"In-silico strategies in nano-drug design: Bridging nanomaterials and pharmacological applications","authors":"Nagarjuna Prakash Dalbanjan , Karuna Korgaonkar , Manjunath P. Eelager , Basavaraj Neelappa Gonal , Arihant Jayawant Kadapure , Suresh B. Arakera , Praveen Kumar S.K.","doi":"10.1016/j.ntm.2025.100091","DOIUrl":"10.1016/j.ntm.2025.100091","url":null,"abstract":"<div><div>Rapid advancements in nanotechnology have transformed drug design and delivery systems, allowing for precise and efficient therapeutic interventions. This review examines the transformative role of in-silico approaches in nano-drug design, focusing on their ability to predict, optimize, and refine nanomaterial properties for pharmacological applications. Key computational tools such as molecular modelling, machine learning, computational fluid dynamics, and bioinformatics are thoroughly investigated, with a focus on their contributions to understanding drug loading, toxicity, targeting strategies, and nano-bio interactions. Furthermore, the incorporation of emerging technologies like digital twins and quantum computing shows the potential to overcome current limitations in accuracy, scalability, and personalization. Despite significant progress, challenges remain, particularly in closing the gap between computational predictions and experimental validations, dealing with data quality issues, and navigating regulatory frameworks. This review emphasizes the importance of interdisciplinary collaboration and innovation in realizing the full potential of in-silico methods for advancing nanotherapeutics. Addressing these challenges positions the field to accelerate the development of safe, effective, and personalized medicines.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100091"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Photothermal/photodynamic antibacterial hydrogel embedded with copper carbon dots and Au nanoparticles” [Nano TransMed 3 (2024) 100034] “嵌入铜碳点和金纳米颗粒的光热/光动力抗菌水凝胶”的勘误表[Nano TransMed 3 (2024) 100034]

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2025-06-23 DOI: 10.1016/j.ntm.2025.100089

Ju Lv, Yuheng Qiu, Lang Pan, Xinyue Zhang, Mengting Li, Xueqiong Yin

引用次数: 0

Application and recent progress of MXene-based bioactive materials in wound management mxeni基生物活性材料在伤口治疗中的应用及最新进展

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2025-03-17 DOI: 10.1016/j.ntm.2025.100079

Jiahao Guo , Xiaodong Zhu , Beibei Liang , Xuelian Gu , Cong Wu , Ang Li , Wei Li

{"title":"Application and recent progress of MXene-based bioactive materials in wound management","authors":"Jiahao Guo , Xiaodong Zhu , Beibei Liang , Xuelian Gu , Cong Wu , Ang Li , Wei Li","doi":"10.1016/j.ntm.2025.100079","DOIUrl":"10.1016/j.ntm.2025.100079","url":null,"abstract":"<div><div>Wound management is one of the major challenges in the biomedical field, where wound ulceration and bacterial infections cause systemic inflammatory reactions or scarring in patients, seriously affecting the quality of life and causing great economic pressure. Smart bioactive materials offer new therapeutic strategies for wound management and monitoring, providing a tailored option for wound repair. MXene, as a 2D functional and tunable material, exhibits unique advantages and enormous potential in promoting cell growth, angiogenesis, recruiting immune cells, avoiding infections, and biological signal transmission. This review details the benefits of MXene-based materials in the field of tissue repair and addresses the key challenges faced by different wounds, reflecting excellent bioactivity and organismal suitability. Notably, MXene can function as a smart surrogate device, enabling precise assessments for wound monitoring and care. This development signifies a paradigm shift towards a novel era of non-invasive monitoring of the healing cycle. Nevertheless, strategies for regenerative tissue engineering employing MXene-based materials encounter certain challenges and difficulties, which include ensuring long-term bioactive function, developing novel material types, and meeting individual clinical needs. Finally, the future research directions and technological developments of MXene-based materials in wound management were briefly discussed.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100079"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eco-friendly nanoparticle phytosynthesis via plant extracts: Mechanistic insights, recent advances, and multifaceted uses 生态友好的纳米颗粒植物合成通过植物提取物：机械的见解，最近的进展，和多方面的用途

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2025-03-21 DOI: 10.1016/j.ntm.2025.100080

Great Iruoghene Edo , Alice Njolke Mafe , Ali B.M. Ali , Patrick Othuke Akpoghelie , Emad Yousif , Endurance Fegor Isoje , Ufuoma Augustina Igbuku , Khalid Zainulabdeen , Joseph Oghenewogaga Owheruo , Arthur Efeoghene Athan Essaghah , Huzaifa Umar , Dina S. Ahmed , Ahmed A. Alamiery

{"title":"Eco-friendly nanoparticle phytosynthesis via plant extracts: Mechanistic insights, recent advances, and multifaceted uses","authors":"Great Iruoghene Edo , Alice Njolke Mafe , Ali B.M. Ali , Patrick Othuke Akpoghelie , Emad Yousif , Endurance Fegor Isoje , Ufuoma Augustina Igbuku , Khalid Zainulabdeen , Joseph Oghenewogaga Owheruo , Arthur Efeoghene Athan Essaghah , Huzaifa Umar , Dina S. Ahmed , Ahmed A. Alamiery","doi":"10.1016/j.ntm.2025.100080","DOIUrl":"10.1016/j.ntm.2025.100080","url":null,"abstract":"<div><div>This review explores the phytosynthesis of nanoparticles (NPs) using plant extracts, emphasizing mechanistic insights, recent advancements, and their diverse applications. The green and cost-effective nature of phytosynthesis makes it an attractive alternative to conventional nanoparticle synthesis, with phytochemicals such as flavonoids, phenolics, and alkaloids facilitating metal ion reduction and stabilization. The review highlights key medical applications, including the anticancer potential of gold nanoparticles, which have demonstrated apoptosis induction in cancer cells, and their use in theranostic structures for simultaneous diagnosis and treatment. In environmental science, phytosynthesized iron and silver nanoparticles have shown over 90 % efficiency in heavy metal adsorption and pollutant degradation, contributing to sustainable remediation strategies. In agriculture, nanofertilizers synthesized via phytosynthesis have enhanced crop yields by up to 30 % while reducing chemical fertilizer dependence. Despite these advancements, obstacles persist in scaling up production, ensuring batch-to-batch reproducibility, and fully elucidating nanoparticle interactions at the molecular level. Standardizing synthesis protocols, optimizing plant metabolite compositions, and conducting extensive in vivo studies will be crucial in translating laboratory findings into real-world applications. By resolving these difficulties through interdisciplinary collaborations, phytosynthesized nanoparticles can revolutionize nanomedicine, agriculture, and environmental sustainability, paving the way for the next generation of eco-friendly technological innovations.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100080"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The delivery and transmembrane transport mechanism of SVCV nanovaccine SVCV纳米疫苗的传递和跨膜转运机制

Nano TransMed Pub Date : 2025-12-01 Epub Date: 2025-03-03 DOI: 10.1016/j.ntm.2025.100077

Han Zhang , Pan-pan Zhang , Xin-Xin Liu , Hai-hua Peng , Qun Liu , Jun Wang , Bin Zhu , Yong-Can Zhou , Yun Sun , Chen Zhang

{"title":"The delivery and transmembrane transport mechanism of SVCV nanovaccine","authors":"Han Zhang , Pan-pan Zhang , Xin-Xin Liu , Hai-hua Peng , Qun Liu , Jun Wang , Bin Zhu , Yong-Can Zhou , Yun Sun , Chen Zhang","doi":"10.1016/j.ntm.2025.100077","DOIUrl":"10.1016/j.ntm.2025.100077","url":null,"abstract":"<div><div>Spring viremia of carp virus (SVCV) is a fatal microorganism for a variety of cyprinid fish species, sparking off enormous economic losses in freshwater fish aquaculture. For alleviating losses, immersion vaccination is an extremely promising maneuver to prevent and curb on SVCV infection. In our previous research, we designed a modular immersion nanovaccine (LSG-TDH) targeting SVCV, and found that it could induce not merely mucosal immunity but systemic immune responses in zebrafish. Nevertheless, our previous research was unable to elaborate on how LSG-TDH were taken up by the cells. Thereby, this study aimed to investigate its transmembrane transport mechanism <em>in vitro</em> using epithelioma papulosum cyprini (EPC) cells and macrophages as models. The transmembrane transport mechanism of LSG-TDH on EPC cells and macrophages was analyzed by cell fluorescence, flow cytometry and chemical inhibitor experiments. The results showed that the entry of LSG-TDH into cells was time-dependent and energy-dependent. Chlorpromazine significantly inhibited the transmembrane transport of LSG-TDH. The contents of LSG-TDH into EPC cells and macrophages after treated with chlorpromazine decreased by 80 % and 71 %, respectively. It is indicated that the transmembrane transport of LSG-TDH was mainly achieved through clathrin-mediated endocytosis pathway. This study provides a reference for the delivery mechanism of aquatic nanovaccine, which has important scientific significance and application prospect.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100077"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid detection of spermine by using a cost-effective carbon nanostructured aptasensor 利用经济高效的碳纳米结构光电传感器快速检测精液

Nano TransMed Pub Date : 2024-12-01 Epub Date: 2024-06-04 DOI: 10.1016/j.ntm.2024.100037

Howyn Tang , Hossein Pouri , Chao Lu , Jin Zhang

{"title":"Rapid detection of spermine by using a cost-effective carbon nanostructured aptasensor","authors":"Howyn Tang , Hossein Pouri , Chao Lu , Jin Zhang","doi":"10.1016/j.ntm.2024.100037","DOIUrl":"10.1016/j.ntm.2024.100037","url":null,"abstract":"<div><p>Spermine is a polyamine that participates in ion channel regulation and cell proliferation. It is considered a biomarker for pancreatic cancer. In this study, a carbon nanostructure-based aptasensor has been developed to rapidly detect spermine in solution by relying on Förster resonance energy transfer (FRET). The FRET donor, carbon quantum dots (CDs), are bioconjugated to aptamers specific for spermine. CDs have an average diameter of 5.0 ± 2.5 nm and have the maximum fluorescence intensity emitting at 510 nm when excited at 400 nm. Due to the π-π* interaction between DNA-based aptamer and GO, a FRET quencher, CDs bioconjugated with aptamer (CDs-aptamer) can directly attach on the surface of GO, resulting in significant FRET quenching. In the presence of spermine, GO and CDs-Aptamer separate, and the fluorescence intensity of CDs is restored. The restored fluorescence intensity of CD-aptamer can be observed when the concentration of spermine increases from 0.1 to 250 nM. The sensing system in this study could be a cost-effective, user-friendly method to quickly detect spermine, a biomarker for pancreatic cancer.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100037"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000086/pdfft?md5=a86dc65e814c10ca90541b6bcad31a0d&pid=1-s2.0-S2790676024000086-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141277878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracellular vesicles: Novel nanovesicles superior to extracellular vesicles in translational medicine and clinical applications 细胞内囊泡：在转化医学和临床应用中优于细胞外囊泡的新型纳米囊泡

Nano TransMed Pub Date : 2024-12-01 Epub Date: 2024-08-15 DOI: 10.1016/j.ntm.2024.100044

Qingsong Ye PhD, DDS , Rui Zhang

引用次数: 0