Nano TransMed最新文献

{"title":"Green synthesis of palladium nanoparticles using Asterarcys sp. and their applications","authors":"Sunita Choudhary ,&nbsp;Geetanjali Kumawat ,&nbsp;Krishna Kher ,&nbsp;P.K. Baroliya ,&nbsp;Amit Kumar Gupta ,&nbsp;Manas K. Tripathy ,&nbsp;Harish","doi":"10.1016/j.ntm.2024.100046","DOIUrl":"10.1016/j.ntm.2024.100046","url":null,"abstract":"<div><p><em>Asterarcys</em>-mediated algal extract, which is non-toxic and renewable, was used to synthesize palladium nanoparticles (PdNPs) efficiently and ecologically friendly. The palladium nanoparticle's fabrication was seen within two hours. UV spectroscopy, FTIR, XRD, SEM, EDX and TEM with SAED pattern were used to confirm the properties of the synthesized nanoparticles. Palladium nanoparticles have been developed, indicated by their deep brown color and broad UV-visible absorption spectra. The SAED and XRD patterns of the manufactured nanoparticles provided evidence of their face-centred cubic crystal structure. Because of reflections from the (1 1 1), (2 0 0), (2 2 0), (3 1 1), and (2 2 2) planes, the XRD pattern is broad, indicating that the FCC nanoparticles are crystalline in nature. The biomolecule responsible for Pd²⁺ reduction and PdNPs capping has been found by analyzing the FTIR spectra of dried PdNPs and dry algal powder. The average particle size, according to a TEM image, is 13 nm, whereas it ranges from 4 to 24 nm. In moderate reaction conditions, the catalytic activity of PdNPs was investigated in C-C cross-coupling processes including Mizoroki-Heck and Suzuki-Miyaura reactions. ¹H NMR and ¹³C NMR were used to characterize the isolated product. The PdNPs exhibited strong catalytic activity and produced excellent conversion of the corresponding products.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100046"},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000177/pdfft?md5=25fcb9815b27e8d2055f358cf1d61283&pid=1-s2.0-S2790676024000177-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-dimensional nano-biomaterials in regulating the tumor microenvironment for immunotherapy","authors":"Guangyu Xu ,&nbsp;Jie Li ,&nbsp;Suming Zhang ,&nbsp;Jinzhou Cai ,&nbsp;Xiaoran Deng ,&nbsp;Yuhong Wang ,&nbsp;Pei Pei","doi":"10.1016/j.ntm.2024.100045","DOIUrl":"10.1016/j.ntm.2024.100045","url":null,"abstract":"<div><p>Two-dimensional (2D) nanomaterials, characterized by their ultrathin profile and constructed from single or a few atomic layers, exhibit unique physical and chemical properties. These materials have recently emerged as a focal point in biomedicine, particularly in drug delivery, bio-sensing, and cancer therapy. Two-dimensional nanomaterials are widely employed in tumor immunotherapy due to their ability to modulate the tumor immune microenvironment and facilitate the delivery of crucial immunotherapeutic agents. Additionally, their integration with other therapeutic modalities can significantly enhance the overall effectiveness of cancer treatments. This review provides an initial overview of various 2D materials and their applications in tumor therapy. It progresses to a comprehensive analysis of how these nanomaterials influence the tumor microenvironment and immune cells, emphasizing their mechanisms and benefits in enhancing tumor immunotherapy. The review concludes by discussing prospective applications of 2D nanomaterials in cancer treatment, highlighting their substantial potential in advancing precision medicine and immune modulation.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100045"},"PeriodicalIF":0.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000165/pdfft?md5=8da04210e37e43f515ca9ecce3c6e901&pid=1-s2.0-S2790676024000165-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142122959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracellular vesicles: Novel nanovesicles superior to extracellular vesicles in translational medicine and clinical applications","authors":"Qingsong Ye PhD, DDS ,&nbsp;Rui Zhang","doi":"10.1016/j.ntm.2024.100044","DOIUrl":"10.1016/j.ntm.2024.100044","url":null,"abstract":"","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100044"},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000153/pdfft?md5=5eb0006b5a6f4f06161ec161376bee47&pid=1-s2.0-S2790676024000153-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbots: Transforming the treatment of oral cancer","authors":"Gurudeva Chandrashekar,&nbsp;Danis Vijay. D,&nbsp;Gowtham Kumar Subbaraj","doi":"10.1016/j.ntm.2024.100043","DOIUrl":"10.1016/j.ntm.2024.100043","url":null,"abstract":"<div><p>Oral cancer incidence and mortality are high in India, Papua New Guinea, Taiwan, China, Eastern Europe, France, and parts of South America, where alcohol consumption and tobacco smoking are prevalent. Current oral cancer therapeutic techniques face limitations due to their inability to effectively target complex tumor locations and the associated adverse side effects. Microbots, tiny robots on a micrometre scale, offer a promising solution to these challenges. Microbots are constructed from biocompatible materials; these microbots can navigate the intricate mouth cavity and access deep tissues. Various agents, including fluorescent dyes for targeted tumor diagnosis, contrast agents for enhanced visualization in CT and MRI scans, and medicinal drugs, can equip them. The potential of microbots lies in their ability to specifically aggregate at tumor sites, which improves the efficacy of diagnostic agents and leads to more precise detection of oral cancer. Despite these difficulties, microbots provide a ground-breaking method for identifying oral cancer. Their ability to deliver diagnostic chemicals directly to the tumor site with minimal invasiveness has enormous potential for improving early identification and, eventually, patient outcomes. Large-scale clinical trials are required to demonstrate the safety and effectiveness of microbot assisted oral cancer diagnosis in humans. Further research is also necessary to create precise control mechanisms for microbot navigation within the mouth and optimal tumor site targeting.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100043"},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000141/pdfft?md5=bf2d48fddc7e567fa79122573b74f597&pid=1-s2.0-S2790676024000141-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141950518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel drug delivery systems: Insight into self-powered and nano-enabled drug delivery systems","authors":"Ugochi E. Ewii ,&nbsp;Adaeze L. Onugwu ,&nbsp;Victor C. Nwokpor ,&nbsp;Ikanke-abasi Akpaso ,&nbsp;Toochukwu E. Ogbulie ,&nbsp;Bibiana Aharanwa ,&nbsp;Chinonye Chijioke ,&nbsp;Ngozi Verla ,&nbsp;Callistus Iheme ,&nbsp;Cosmas Ujowundu ,&nbsp;Chioma Anyiam ,&nbsp;Anthony A. Attama","doi":"10.1016/j.ntm.2024.100042","DOIUrl":"10.1016/j.ntm.2024.100042","url":null,"abstract":"<div><p>Novel drug delivery systems comprise sophisticated technology merged into drug delivery systems. These systems are created with the aim of addressing the limitations of conventional drug delivery systems. For instance, conventional drug delivery systems are inefficient in tackling challenging human diseases such as cancer. These systems are thus formed with materials to enhance permeation to target cells. They improve patients' compliance and efficacy. Novel drug delivery systems include self-powered drug delivery systems and microelectromechanical systems. Nanotechnology is a rapidly growing and promising field, especially in drug delivery system development and disease therapy. Novel drug delivery systems often utilise nanocarriers due to their numerous advantages. One of the benefits of nanocarriers is the ability to manipulate their size and surface functionalisation to achieve site-specific targeting. Many researchers have reported their controlled and targeted drug release profiles. Nanocarriers are propelled to their target tissues, where the entrapped drugs are released, prolonging therapeutic efficacy and decreasing undesired side effects. Hence, these systems offer the benefits of targeted and controlled drug delivery, low toxicity, high bioavailability and improved therapeutic efficiency. It is essential to understand the mechanisms of drug release and toxicity of these systems in order to develop efficient and safe drug delivery systems. This review describes the utilisation of novel drug delivery systems. It also dwells on the drug loading, targeting and drug release from nanocarriers. The primary concerns of clinical applications and the potential toxicity of these systems are also presented. It is expected that this review will be helpful to drug formulation researchers seeking solutions to challenging diseases such as cancer and cardiovascular diseases.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100042"},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S279067602400013X/pdfft?md5=f2b932a7131fcff51a8d33d7b223b6aa&pid=1-s2.0-S279067602400013X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Barbara Krystyna Pierscionek","doi":"10.1016/j.ntm.2024.100039","DOIUrl":"10.1016/j.ntm.2024.100039","url":null,"abstract":"","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100039"},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000104/pdfft?md5=a8c489fa3ac9097533a960326bb54298&pid=1-s2.0-S2790676024000104-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141955698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two heads are better than one: Unravelling the potential Impact of Artificial Intelligence in nanotechnology","authors":"Gaurav Gopal Naik ,&nbsp;Vijay A. Jagtap","doi":"10.1016/j.ntm.2024.100041","DOIUrl":"10.1016/j.ntm.2024.100041","url":null,"abstract":"<div><p>Artificial Intelligence (AI) and Nanotechnology are two cutting-edge fields that hold immense promise for revolutionizing various aspects of science, technology, and everyday life. This review delves into the intersection of these disciplines, highlighting the synergistic relationship between AI and Nanotechnology. It explores how AI techniques such as machine learning, deep learning, and neural networks are being employed to enhance the efficiency, precision, and scalability of nanotechnology applications. Furthermore, it discusses the challenges, opportunities, and future prospects of integrating AI with nanotechnology, paving the way for transformative advancements in diverse domains ranging from healthcare and materials science to environmental sustainability and beyond.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100041"},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000128/pdfft?md5=1f0630424b11990f015c427fbaf85963&pid=1-s2.0-S2790676024000128-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141638486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan nanoparticle delivery systems: An effective approach to enhancing efficacy and safety of anticancer drugs","authors":"Anil Kumar Grewal,&nbsp;Raj Kumar Salar","doi":"10.1016/j.ntm.2024.100040","DOIUrl":"https://doi.org/10.1016/j.ntm.2024.100040","url":null,"abstract":"<div><p>Currently, cancer is the leading cause of death globally. In the absence of specific treatment and early diagnosis, procedures like surgery, chemotherapy, and radiation therapy are often used to manage the disease. However, these approaches often fail to control cancer due to inefficacy, nonspecific distribution, and side effects of the drugs. Anticancer drugs are essential in reducing cancer cell growth and helping damage those cells. Anticancer drugs often cause severe side effects and have limited bioavailability due to their nonspecific distribution throughout the body. Therefore, the development of intelligent drug release systems is essential. Nanoparticle delivery systems are promising strategies to improve therapeutic efficacy and safety, overcoming challenges. Among these systems, a natural polysaccharide called chitosan, a derivative of chitin, has gained considerable attention as a biocompatible, biodegradable, and mucoadhesive material for creating nanoparticles. Chitosan nanoparticles provide several advantages, including improved stability, cellular uptake, solubility of anticancer drugs, modulation of release kinetics, and biodistribution. Additionally, chitosan nanoparticles can be modified on their surface with ligands or stimuli-responsive moieties to achieve targeted delivery to specific cancer cells or tissues. This review explores recent advances in chitosan-based nanoparticle drug delivery, efficacy, and their applications in cancer therapy.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100040"},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000116/pdfft?md5=0baa56eb81fcc0719501f737fb598489&pid=1-s2.0-S2790676024000116-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141480964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and application of a brain cell line derived from Plectropomus leopardus","authors":"Zhiru Liu ,&nbsp;Qiaoli Yang ,&nbsp;Minjie Kang ,&nbsp;Caoying Wei ,&nbsp;Tao Li ,&nbsp;Yongcan Zhou ,&nbsp;Zhenjie Cao ,&nbsp;Yun Sun","doi":"10.1016/j.ntm.2024.100038","DOIUrl":"10.1016/j.ntm.2024.100038","url":null,"abstract":"<div><p><em>Plectropomus leopardus</em> is an economically valuable marine farmed fish. However, diseases have seriously restricted the healthy development of its breeding industry. Cell line is an important <em>in vitro</em> research system in the fields of disease control, environmental toxicology, nanotechnology, and so on. However, the application of marine fish cell lines is far from the expected level, and many species have not yet been reported to establish cell lines. In our study, we developed a brain cell line derived from P. leopardus, designated as PLB, and investigated its susceptibility to bacterial agents and heavy metal exposure. The findings indicated that PLB cell lines grew fastest in L-15 medium supplemented with 20 % fetal bovine serum (FBS) at 26 °C. The established cell line was identified by 18 S rRNA gene sequencing as being derived from <em>P. leopardus</em>. Chromosome analysis revealed that the PLB cell line had a chromosome count of 48. The transfection efficiency of PLB cells was about 27 % by liposome transfection method, indicating that PLB cell lines offer utility for conducting functional investigations of exogenous genes. In addition, the bacterial sensitivity analysis results indicated that PLB cells exhibited susceptibility to both <em>Vibrio harveyi</em> and <em>Edwardsiella tarda</em>, furthermore, PLB cells displayed heightened sensitivity towards <em>V. harveyi</em> in comparison to <em>E. tarda</em>. The outcomes from the heavy metal toxicity experiments demonstrated significant toxicity of three heavy metals (Hg²⁺, Cu²⁺ and Cd²⁺) towards PLB cells, with Hg²⁺ exhibiting the highest degree of toxicity among them. Moreover, there was a dose-dependent relationship between cell survival rate of PLB and heavy metal concentration. In summary, PLB cell lines represent a promising tool for conducting in vitro analyses of foreign gene functionality, bacterial susceptibility, and heavy metal toxicity. It helps ensure the safety of aquatic breeding environments and also supports genetic enhancements in fish fry, promoting the development of traits such as increased growth and disease resistance, which are vital for aquaculture progress.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100038"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000098/pdfft?md5=d0b67bbd1e3d1577cec6d01dbd754da7&pid=1-s2.0-S2790676024000098-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141400598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid detection of spermine by using a cost-effective carbon nanostructured aptasensor","authors":"Howyn Tang ,&nbsp;Hossein Pouri ,&nbsp;Chao Lu ,&nbsp;Jin Zhang","doi":"10.1016/j.ntm.2024.100037","DOIUrl":"10.1016/j.ntm.2024.100037","url":null,"abstract":"<div><p>Spermine is a polyamine that participates in ion channel regulation and cell proliferation. It is considered a biomarker for pancreatic cancer. In this study, a carbon nanostructure-based aptasensor has been developed to rapidly detect spermine in solution by relying on Förster resonance energy transfer (FRET). The FRET donor, carbon quantum dots (CDs), are bioconjugated to aptamers specific for spermine. CDs have an average diameter of 5.0 ± 2.5 nm and have the maximum fluorescence intensity emitting at 510 nm when excited at 400 nm. Due to the π-π* interaction between DNA-based aptamer and GO, a FRET quencher, CDs bioconjugated with aptamer (CDs-aptamer) can directly attach on the surface of GO, resulting in significant FRET quenching. In the presence of spermine, GO and CDs-Aptamer separate, and the fluorescence intensity of CDs is restored. The restored fluorescence intensity of CD-aptamer can be observed when the concentration of spermine increases from 0.1 to 250 nM. The sensing system in this study could be a cost-effective, user-friendly method to quickly detect spermine, a biomarker for pancreatic cancer.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100037"},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000086/pdfft?md5=a86dc65e814c10ca90541b6bcad31a0d&pid=1-s2.0-S2790676024000086-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141277878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}