Nano TransMed最新文献

{"title":"Abutilon indicum-mediated green synthesis of NiO and ZnO nanoparticles: Spectral profiling and anticancer potential against human cervical cancer for public health progression","authors":"Vinotha Mani ,&nbsp;Keerthana Shrri Gopinath ,&nbsp;Nithya Varadharaju ,&nbsp;Dapkupar Wankhar ,&nbsp;Arjunan Annavi","doi":"10.1016/j.ntm.2024.100049","DOIUrl":"10.1016/j.ntm.2024.100049","url":null,"abstract":"<div><h3>Background</h3><div>Integrating nanomedicines for targeted cancer treatment and pursuing medicinally valuable components from nature are crucial for sustainable, potent alternatives to synthetic drugs in combating fatal diseases like cancer. Hence, a green synthesis of nickel oxide (NiO NPs) and zinc oxide nanoparticles (ZnO NPs) has been carried out by using the leaf extract of medicinally important plant <em>Abutilonindicum</em>. This sustainable approach to medical developments not only reduces the environmental effect of standard synthesis methods and offers new options for novel cancer therapeutics, but it also advances public health by using natural resources in a sustainable manner.</div></div><div><h3>Methods</h3><div>The synthesized nanoparticles were characterized by employing spectro-analytical techniques like UV–vis, FT-IR, SEM and powder XRD. Synthesized nanparticles were evaluated in the human cervical cancer cells (HeLa).</div></div><div><h3>Results</h3><div>Ni-O stretching vibrations were observed at 402 cm⁻¹, whereas that of Zn-O stretching was observed at 409 cm⁻¹in the FT-IR spectrum, confirming the formation of nanoparticles. The XRD pattern revealed the crystallite size range of 1.35–2.84 nm for NiO NPs and 7.71–56.80 nm for ZnO NPs. The morphology of the nanoparticles, as indicated by the SEM images, was rod-like for NiO NPs and rock-shaped for ZnO NPs. Further, the cancer cell growth inhibition activity of the nanoparticles was examined by MTT assay against human cervical cancer cells (HeLa) proliferation and compared with <em>cisplatin</em>. MTT assay elucidated the significant anticancer efficacy of the synthesized nanoparticles, showcasing low IC₅₀ values of 29±0.5 µg/ml for NiO NPs and 32±0.7 µg/ml for ZnO NPs. Furthermore, the anticancer activity of the NiO NPs was investigated using the Trypan blue dye exclusion technique, emphasizing the pronounced cytotoxic impact of NiO NPs on cancer cell viability. The outcomes underscore the notable anticancer properties of plant extract mediated metal nanoparticles as promising contenders for advancing cancer treatment modalities.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100049"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two heads are better than one: Unravelling the potential Impact of Artificial Intelligence in nanotechnology","authors":"Gaurav Gopal Naik ,&nbsp;Vijay A. Jagtap","doi":"10.1016/j.ntm.2024.100041","DOIUrl":"10.1016/j.ntm.2024.100041","url":null,"abstract":"<div><p>Artificial Intelligence (AI) and Nanotechnology are two cutting-edge fields that hold immense promise for revolutionizing various aspects of science, technology, and everyday life. This review delves into the intersection of these disciplines, highlighting the synergistic relationship between AI and Nanotechnology. It explores how AI techniques such as machine learning, deep learning, and neural networks are being employed to enhance the efficiency, precision, and scalability of nanotechnology applications. Furthermore, it discusses the challenges, opportunities, and future prospects of integrating AI with nanotechnology, paving the way for transformative advancements in diverse domains ranging from healthcare and materials science to environmental sustainability and beyond.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100041"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000128/pdfft?md5=1f0630424b11990f015c427fbaf85963&pid=1-s2.0-S2790676024000128-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141638486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoindentation: Introduction and applications of a non-destructive analysis","authors":"Zaid H. Mahmoud ,&nbsp;H.N.K. AL-Salman ,&nbsp;Ehsan Kianfar","doi":"10.1016/j.ntm.2024.100057","DOIUrl":"10.1016/j.ntm.2024.100057","url":null,"abstract":"<div><div>Nanoindentation test is known as a powerful method for non-destructive characterization and analysis of mechanical properties of nanoscale materials. In this method, the indenting tip penetrates the surface of the sample by applying a force of several millinewtons to the extent of several nanometers, and the resulting force-displacement curve is used as the output of the test to calculate the mechanical characteristics of the sample, including hardness and elastic modulus, as well as to identify various mechanical phenomena such as Creep, strain hardening, surface cracking, phase transformations, creep and fracture toughness of the material are used. In this article, the Nanoindentation method is briefly introduced and its principles and basics are discussed. The application of this method is valid for analyzing the mechanical properties of a wide range of materials. The purpose of this article is to familiarize researchers and experts in engineering fields with the nanoindentation method as a non-destructive analysis and its effective use in their respective fields of application.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100057"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytomedicine meets nanotechnology: A cellular approach to rheumatoid arthritis treatment","authors":"Vikas Shukla ,&nbsp;Devika Tripathi ,&nbsp;Sakshi Sharma ,&nbsp;Ayushi Purohit ,&nbsp;Pratibha Singh","doi":"10.1016/j.ntm.2024.100051","DOIUrl":"10.1016/j.ntm.2024.100051","url":null,"abstract":"<div><div>Rheumatoid arthritis (RA) is an autoimmune condition causing synovitis, joint dysfunction, and tissue deterioration. This review highlights the pathophysiology of RA, including the involvement of cellular components, cytokines, and oxidative stress, and discusses the increased cardiovascular disease (CVD) risks for RA patients. It also explores the role of lysophosphatidic acid (LPA) in RA progression. Current treatments like Disease-Modifying Anti-Rheumatic Drugs (DMRDs), biological DMARDs, and (Non-steroidal Anti-inflammatory Drugs) NASAIDs along with emerging nanomedicine strategies, are examined. The article emphasizes the potential of nanotechnology in enhancing drug delivery, aiming to improve treatment efficacy and safety for RA. This comprehensive review provides insight into complexity of RA and the promising future of nanomedicine in its management.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100051"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances of calcium phosphate nanoceramics for the osteoinductive potential and mechanistic pathways in maxillofacial bone defect repair","authors":"Yifan Gou ,&nbsp;Kailong Qi ,&nbsp;Yige Wei ,&nbsp;Zhipeng Gu ,&nbsp;Huixu Xie","doi":"10.1016/j.ntm.2024.100033","DOIUrl":"https://doi.org/10.1016/j.ntm.2024.100033","url":null,"abstract":"<div><p>Maxillofacial bone defects, arising from congenital malformations, tumors, infections, and traumas, represent a common clinical condition that impairs patients' appearance, speech, and motor functions. Calcium phosphate nanoceramics, which bear a chemical composition similar to autologous bone, demonstrate strong biocompatibility and osteoconductivity, making them an extensively applied material in bone defect repairing. Notably, these nanoceramics exhibit inherent osteoinductive properties ，which can stimulate osteogenesis at non-osseous sites ，without the need for additional cells or growth factors， these aspects further expand their application in bone repair. Nevertheless, the precise osteoinductive mechanism of calcium phosphate nanoceramics remains elusive, and differences in vivo individual persist, thereby academic communities need to resolve the pressing issues that restrict their use. This paper reviews the advancements in research on the properties of calcium phosphate nanoceramics and the factors affecting the biological process of bone formation, aiming to provide new insights for the treatment of maxillofacial bone defects.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100033"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000049/pdfft?md5=cce421841e6722b30556c7033a866b71&pid=1-s2.0-S2790676024000049-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139727006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes for skin treatment: Therapeutic and cosmetic applications","authors":"Harsha Sreeraj ,&nbsp;R. AnuKiruthika ,&nbsp;K.S. Tamilselvi ,&nbsp;D. Subha","doi":"10.1016/j.ntm.2024.100048","DOIUrl":"10.1016/j.ntm.2024.100048","url":null,"abstract":"<div><p>The therapeutic potential of exosomes, which are nano-sized extracellular vesicles derived from various cell types, have drawn substantial interest in the field of dermatology. Exosomes have distinctive capabilities, including facilitating intercellular communication, delivering bioactive molecules, and modulating immune responses, which make them promising candidates for skin regeneration, wound healing, and treating dermatological disorders. Specifically, exosomes derived from the stem cells of mesenchymal and adipose cells, have numerous applications in skin repair and regeneration. Exosomes also find expanded applications in treatments and therapies related to hair. Exosomes emit signals and growth factors that impact the activity of nearby epithelial cells, encouraging their growth, specialization, and the development of hair formations. This review explores the efficacy of topical and transdermal applications of exosomes in skin and hair and highlight the transformative potential of exosome-based therapies in dermatology and pave the way for future research and clinical applications.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100048"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000190/pdfft?md5=af9cb93c91c00252a9275cd171920cd7&pid=1-s2.0-S2790676024000190-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photothermal/photodynamic antibacterial hydrogel embedded with copper carbon dots and Au nanoparticles","authors":"Ju Lv,&nbsp;Yuheng Qiu,&nbsp;Lang Pan,&nbsp;Xinyue Zhang,&nbsp;Mengting Li,&nbsp;Xueqiong Yin","doi":"10.1016/j.ntm.2024.100034","DOIUrl":"https://doi.org/10.1016/j.ntm.2024.100034","url":null,"abstract":"<div><p>In this paper, we created a hydrogel (named AuNPs-CuCCDs@Gel) with photothermal and photodynamic performance through incorporating copper carbon dots (CuCCDs) and Au nanoparticles (AuNPs) into gelatin and chitosan hydrogels. The thus-obtained hydrogel exhibited a high photothermal and photodynamic antibacterial activity with a superior singlet oxygen yield (0.70), which was better than that of methylene blue (0.52). After laser irradiation at 808 nm for 6 min, the temperature of AuNPs-CuCCDs@Gel rose from room temperature to 50 °C, which manifested good effects for avoiding local heat damage and protecting normal cells. AuNPs-CuCCDs@Gel exhibited the highest antibacterial efficacy of 96.46% and 97.48% against <em>S. aureus</em> and <em>E. coli</em> respectively. The significantly improved bactericidal performance was attributed to the synergistic effects of hyperthermia and reactive oxygen species (ROS). This work suggests that photothermal/photodynamic antibacterial hydrogel is a promising agent for treating wound infection.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100034"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000050/pdfft?md5=933d0638f51ac9ed7eaf1de040c39b9f&pid=1-s2.0-S2790676024000050-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140066914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in clinical application of nanoparticle-based therapy for cancer treatment: A systematic review","authors":"Pingchuan Ma ,&nbsp;Guanru Wang ,&nbsp;Ke Men ,&nbsp;Chunjie Li ,&nbsp;Ning Gao ,&nbsp;Longjiang Li","doi":"10.1016/j.ntm.2024.100036","DOIUrl":"10.1016/j.ntm.2024.100036","url":null,"abstract":"<div><h3>Background</h3><p>Due to the rapid development of nanotechnology and nanocomplex synthetic techniques, a large number of nanoparticle-based cancer medicines have been evaluated or applied in clinical trials for utility. However, the quality, efficiency and adverse events of these trials are sometimes controversial. Our systematic review aimed to better summary the current nanoparticle-related randomized controlled trials for cancer treatment, assess their quality and analyze the outcomes reported.</p></div><div><h3>Methods</h3><p>A comprehensive search was performed in electronic database as follows: PubMed, Embase, the Cochrane Library and Web of Science, until February 2024. We then identified the randomized controlled trials (RCTs) that investigate the nanoparticle-based therapy versus placebo, ordinary chemotherapy, standard of care or different doses of nanoparticles in cancer patients. The information, primary outcomes and adverse events records of trials were extracted.</p></div><div><h3>Results</h3><p>31 RCTs were included, Inside, 22 studies used paclitaxel related nanoparticle in their RCTs, including 18 trials of nanoparticle albumin-bound (nab)-paclitaxel. A total of 10399 patients were enrolled for evaluation. Most of the included trials were ranked as excellent or good quality after assessed according to CONSORT checklist. The treatment efficiency reflected via progression-free survival (PFS), overall survival (OS), and pathological complete response (pCR) were not significantly superior to control arm. Lymphopenia, leucopenia and neutropenia were the most common complications in paclitaxel-related therapies.</p></div><div><h3>Conclusions</h3><p>According to current trials, the advantages of nanoparticles-based therapy were not significant compared to ordinary chemotherapy schedule no matter in efficiency or safety for cancer treatment. The majority of nanomedicine currently in evaluation is chemotherapy medicine related, lacking of the attempts of other treatment strategy. Thus, it is urgent to broaden the therapy strategy applied in nanoparticle utility for cancer treatment exploration.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100036"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000074/pdfft?md5=e5e8a78b1476c8509b52e958fe02378d&pid=1-s2.0-S2790676024000074-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology-based advancements for effective delivery of phytoconstituents for Ocular diseases","authors":"Venkateshwaran Krishnaswami ,&nbsp;Dhilin Pathayappurakkal Mohanan ,&nbsp;S.A. Jacob Raja ,&nbsp;Balakrishnan Natarajan ,&nbsp;Shankarananth Velusamy","doi":"10.1016/j.ntm.2024.100056","DOIUrl":"10.1016/j.ntm.2024.100056","url":null,"abstract":"<div><div>Phytomedicines has been globally utilized in ancient times. Phytoconstituents such as flavonoids, glycosides, peptides, carbohydrates, lipids, alkaloids, tannins, and terpenoids are holding medicinal properties. Previous reports have documented the various therapeutic activities of plant extracts/isolated fractions/pure phytoconstituents especially at in vitro levels. But the relevance towards the in vivo level and upmost towards the clinical trials for these phytomedicines was facing numerous challenges in the current scenario. The challenges associated with phytomedicines are standardization issues, ineffective against serious ailments, poor reproducibility of biological activities and interferences with associated phytoconstituents. But recently nanoscale based phytomedicine is paving more interest towards the scientific community for ocular delivery. In order to overcome these issues the nanoscale base phytomedicines delivery systems are recently developed by researchers. Nanoscale delivery systems of various phytoconstituents may potentiate the therapeutic effect, improves the bioavailability, reduces adverse effects and decreases the effective dose. The scope of this paper will focus towards the nanotechnology based phytomedicine delivery systems for various therapeutic applications in eye. The various phytomedicine loaded nanoscale delivery systems such as nanoparticles, nanomicelles, nanodispersions, lipid based nanoparticles for various ocular diseases has been reviewed. Special focus has been emphasized towards the carriers utilized for those delivery systems. Additionally, the future perspectives relating to development of novel phytomedicine based nano formulations has been discussed.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100056"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer lipid-based drug delivery systems: Basic knowledge and recent applications","authors":"Mohamed M. Shehata","doi":"10.1016/j.ntm.2024.100054","DOIUrl":"10.1016/j.ntm.2024.100054","url":null,"abstract":"<div><div>Cancer is a complicated disease that thrives on certain features collectively known as cancer hallmarks (e.g. growth signals autonomy, evading apoptosis, evading immune system, ability of metastasis, etc.). Anticancer drugs suffer from low bioavailability and severe side effects due to the arsenal of barriers (e.g. tumor microenvironment, efflux proteins, etc.) cancer have to hinder their delivery. Consequently, passive and active targeting of anticancer drugs is a necessity. Lipid based nano drug delivery systems (DDS) (e.g. liposomes, niosomes, self-emulsifying DDS, solid lipid nanoparticles and nanostructured lipid carriers), emerges as an approach of smart delivery of the anticancer drug. Therefore, achieving targetability, safety and efficacy. Lipid based DDS proved applicability and did not stop at the point of delivering anticancer drugs. They extended their mission to fighting anticancer multiple drug resistance, protection of cancer vaccination agents and therapeutic nucleic acids molecules. Furthermore, they achieved additional diagnostic roles (i.e. theranostics) and showed flexibility to be formulated for different routes of administration. They combined physical stimuli responsive therapy with pharmacological therapy, to name a few.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100054"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}