Two-dimensional nano-biomaterials in regulating the tumor microenvironment for immunotherapy

Guangyu Xu , Jie Li , Suming Zhang , Jinzhou Cai , Xiaoran Deng , Yuhong Wang , Pei Pei
{"title":"Two-dimensional nano-biomaterials in regulating the tumor microenvironment for immunotherapy","authors":"Guangyu Xu ,&nbsp;Jie Li ,&nbsp;Suming Zhang ,&nbsp;Jinzhou Cai ,&nbsp;Xiaoran Deng ,&nbsp;Yuhong Wang ,&nbsp;Pei Pei","doi":"10.1016/j.ntm.2024.100045","DOIUrl":null,"url":null,"abstract":"<div><p>Two-dimensional (2D) nanomaterials, characterized by their ultrathin profile and constructed from single or a few atomic layers, exhibit unique physical and chemical properties. These materials have recently emerged as a focal point in biomedicine, particularly in drug delivery, bio-sensing, and cancer therapy. Two-dimensional nanomaterials are widely employed in tumor immunotherapy due to their ability to modulate the tumor immune microenvironment and facilitate the delivery of crucial immunotherapeutic agents. Additionally, their integration with other therapeutic modalities can significantly enhance the overall effectiveness of cancer treatments. This review provides an initial overview of various 2D materials and their applications in tumor therapy. It progresses to a comprehensive analysis of how these nanomaterials influence the tumor microenvironment and immune cells, emphasizing their mechanisms and benefits in enhancing tumor immunotherapy. The review concludes by discussing prospective applications of 2D nanomaterials in cancer treatment, highlighting their substantial potential in advancing precision medicine and immune modulation.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100045"},"PeriodicalIF":0.0000,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000165/pdfft?md5=8da04210e37e43f515ca9ecce3c6e901&pid=1-s2.0-S2790676024000165-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano TransMed","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2790676024000165","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Two-dimensional (2D) nanomaterials, characterized by their ultrathin profile and constructed from single or a few atomic layers, exhibit unique physical and chemical properties. These materials have recently emerged as a focal point in biomedicine, particularly in drug delivery, bio-sensing, and cancer therapy. Two-dimensional nanomaterials are widely employed in tumor immunotherapy due to their ability to modulate the tumor immune microenvironment and facilitate the delivery of crucial immunotherapeutic agents. Additionally, their integration with other therapeutic modalities can significantly enhance the overall effectiveness of cancer treatments. This review provides an initial overview of various 2D materials and their applications in tumor therapy. It progresses to a comprehensive analysis of how these nanomaterials influence the tumor microenvironment and immune cells, emphasizing their mechanisms and benefits in enhancing tumor immunotherapy. The review concludes by discussing prospective applications of 2D nanomaterials in cancer treatment, highlighting their substantial potential in advancing precision medicine and immune modulation.

二维纳米生物材料在调节肿瘤微环境以促进免疫疗法中的应用
二维(2D)纳米材料以其超薄外形为特征,由单层或几层原子层构成,具有独特的物理和化学特性。最近,这些材料已成为生物医学领域的一个焦点,尤其是在药物输送、生物传感和癌症治疗方面。二维纳米材料能够调节肿瘤免疫微环境,促进重要免疫治疗药物的输送,因此被广泛应用于肿瘤免疫治疗。此外,二维纳米材料与其他治疗方式的结合可显著提高癌症治疗的整体效果。本综述初步概述了各种二维材料及其在肿瘤治疗中的应用。然后全面分析了这些纳米材料如何影响肿瘤微环境和免疫细胞,强调了它们在增强肿瘤免疫疗法方面的机制和优势。综述最后讨论了二维纳米材料在癌症治疗中的应用前景,强调了它们在推进精准医疗和免疫调节方面的巨大潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信