Nano TransMed最新文献

{"title":"Exploring the denaturations in cancer and non-cancer DNA molecules by optical absorption, thermal, and electric measurements: A case study","authors":"Owais I. Mir ,&nbsp;Upendra K. Gupta ,&nbsp;Iqbal Qasim ,&nbsp;Arshad A. Pandith ,&nbsp;Feroz A. Mir","doi":"10.1016/j.ntm.2024.100047","DOIUrl":"10.1016/j.ntm.2024.100047","url":null,"abstract":"<div><p>In this article, we carried out the temperature dependent UV-Visible (UV-Vis) spectroscopy, differential scanning calorimetry (DSC), and electrical studies for normal and cancerous (glioma) DNA samples of single patient. Based on this method, we were able to monitor the denaturation process and thermal stability in these molecules. From the temperature dependent optical absorption data, we calculated various optical parameters for these two types of samples. The optical band gap of these samples were also estimated and discussed as per the experimental conditions. The various optical parameters calculated indicate that mutated (tumor) DNA is less stable than the normal one. From the DSC data, clear melting peaks were observed for the tumor and normal samples. Also various thermodynamic parameters like change in enthalpy (Δ<em>H</em>), entropy (Δ<em>S</em>), and specific heat (Cp) were estimated. From the thermal study, it seems that the tumor DNA is less stable. Further from the electrical or current-voltage (I-V) characteristics data, the resistance for normal DNA decreases with temperature. But for tumor sample, it show anomalous behavior (like decreasing and then increasing trend) with temperature. For electrical transport, small polaron hopping could be the possible transport mechanism in the current sample. Here from these studies, the tumor sample seems more disordered, and structural fluctuations due to the speculated structure could be the best reason for this behavior. If such kind of molecular (at nano scale range) studied are done more vividly, then these calculated parameters of the molecule could be explored for further confirmation/diagnostics of the diseases in addition to clinical investigations.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100047"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000189/pdfft?md5=ea427fae22ef1c3e9c99d339cfb4d63e&pid=1-s2.0-S2790676024000189-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbots: Transforming the treatment of oral cancer","authors":"Gurudeva Chandrashekar,&nbsp;Danis Vijay. D,&nbsp;Gowtham Kumar Subbaraj","doi":"10.1016/j.ntm.2024.100043","DOIUrl":"10.1016/j.ntm.2024.100043","url":null,"abstract":"<div><p>Oral cancer incidence and mortality are high in India, Papua New Guinea, Taiwan, China, Eastern Europe, France, and parts of South America, where alcohol consumption and tobacco smoking are prevalent. Current oral cancer therapeutic techniques face limitations due to their inability to effectively target complex tumor locations and the associated adverse side effects. Microbots, tiny robots on a micrometre scale, offer a promising solution to these challenges. Microbots are constructed from biocompatible materials; these microbots can navigate the intricate mouth cavity and access deep tissues. Various agents, including fluorescent dyes for targeted tumor diagnosis, contrast agents for enhanced visualization in CT and MRI scans, and medicinal drugs, can equip them. The potential of microbots lies in their ability to specifically aggregate at tumor sites, which improves the efficacy of diagnostic agents and leads to more precise detection of oral cancer. Despite these difficulties, microbots provide a ground-breaking method for identifying oral cancer. Their ability to deliver diagnostic chemicals directly to the tumor site with minimal invasiveness has enormous potential for improving early identification and, eventually, patient outcomes. Large-scale clinical trials are required to demonstrate the safety and effectiveness of microbot assisted oral cancer diagnosis in humans. Further research is also necessary to create precise control mechanisms for microbot navigation within the mouth and optimal tumor site targeting.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100043"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000141/pdfft?md5=bf2d48fddc7e567fa79122573b74f597&pid=1-s2.0-S2790676024000141-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141950518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor microenvironment responsive nanozymes for multimodal imaging of tumors","authors":"Heng Wang ,&nbsp;Wenrui Ouyang ,&nbsp;Hongxing Liu","doi":"10.1016/j.ntm.2024.100032","DOIUrl":"https://doi.org/10.1016/j.ntm.2024.100032","url":null,"abstract":"<div><p>Nanozymes exhibit immense potential and promising prospects in the realm of diagnostic imaging and tumor therapy, owing to their inherent physicochemical properties and enzymatic activities. With the further development and application of nanotechnology, nanozymes are expected to become an important tool in the field of medicine, providing new solutions for disease diagnosis and treatment. This review provides an overview of recent studies over the past five years on the application of nanozymes capable of responding to the tumor microenvironment (TME) in multimodal imaging, with a focus on hypoxia, acid pH, excess GSH and ROS. In addition, we present the current status of the development of several common multimodal imaging and related contrast agents, such as MRI/CT, MRI/PET, MRI/SPECT, PET/CT. Moreover, some thoughts on the challenges, future development, and clinical translation of tumor microenvironment-responsive nanozymes in the field of multimodal imaging are shared. This review aims to provide an up-to-date theranostic nanomedicine reference for those who focus on related fields, promote the progress of this interdisciplinary subject, and accelerate clinical translation.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100032"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000037/pdfft?md5=3d842eca16e677c7e3a844d36a3070b5&pid=1-s2.0-S2790676024000037-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139719744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quercetin-encapsulated GelMa hydrogel microneedle reduces oxidative stress and facilitates wound healing","authors":"Yi Yi ,&nbsp;Zihui Yang ,&nbsp;Chuchao Zhou ,&nbsp;Yanqing Yang ,&nbsp;Yiping Wu ,&nbsp;Qi Zhang","doi":"10.1016/j.ntm.2024.100030","DOIUrl":"10.1016/j.ntm.2024.100030","url":null,"abstract":"<div><h3>Background</h3><p>Delayed wound healing brings additional physical, mental, and financial burdens. Microneedles (MNs) are a novel dressing form and can incorporate drug delivery systems. Quercetin is known for its remarkable antioxidant capacity and may have a distinctive effect on wound healing.</p></div><div><h3>Methods</h3><p>We designed and constructed gelatin methacryloyl (GelMa) MNs carrying Quercetin (Q-MNs). In vitro, the physical properties, cell safety, cell migration, angiogenesis, collagen formation, and oxidative stress levels, were performed to characterize Q-MNs. In vivo, the full-thickness skin wound models were established to evaluate the re-epithelialization and oxidative stress impact of the control, MN, and Q-MN groups.</p></div><div><h3>Results</h3><p>The Q-MNs were mechanically strong enough to penetrate the skin for sustained drug delivery and possessed good biocompatibility. Moreover, the Q-MNs evidently facilitated wound healing both in vitro and in vivo, and promoted collagen formation and neo-angiogenesis, and the reduction of oxidative stress levels.</p></div><div><h3>Conclusions</h3><p>The Q-MNs could motivate wound healing with enhanced collagen formation and vascularization and decreased oxidative stress levels, thus providing a feasible strategy for wound healing.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100030"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000013/pdfft?md5=c89128155b14ae18cb6e30a1c9431341&pid=1-s2.0-S2790676024000013-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139392454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biogenic silver nanoparticles from Simarouba glauca DC leaf extract: Synthesis, characterization, and anticancer efficacy in lung cancer cells with protective effects in Caenorhabditis elegans","authors":"Santosh Mallikarjun Bhavi ,&nbsp;Akshata Choudhari Padti ,&nbsp;Bothe Thokchom ,&nbsp;Sapam Riches Singh ,&nbsp;Shivanand S. Bhat ,&nbsp;Sukesh Kumar Bajire ,&nbsp;Rajesh P. Shastry ,&nbsp;B.S. Srinath ,&nbsp;Sushma Subraya Gummani ,&nbsp;B.P. Harini ,&nbsp;Ramesh Babu Yarajarla","doi":"10.1016/j.ntm.2024.100052","DOIUrl":"10.1016/j.ntm.2024.100052","url":null,"abstract":"<div><div>This study explores the synthesis, characterization, and biomedical applications of silver nanoparticles (AgNPs) synthesized using <em>Simarouba glauca</em> leaf extract. The biogenic AgNPs were characterized through UV–visible spectroscopy, X-ray diffraction (XRD), particle size analysis, zeta potential analysis, energy dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), and high-resolution transmission electron microscopy (HR-TEM). The nanoparticles exhibited a distinct absorbance peak at 413.5 nm, confirming their synthesis and surface plasmon resonance. XRD and HR-TEM analyses revealed a face-centered cubic structure with an average size of 12.45 nm, while AFM indicated a mean particle size of 18.34 nm. The particles demonstrated moderate stability with a zeta potential of −41.4 mV and exhibited various elemental compositions as confirmed by EDX. In the biomedical evaluation, the anticancer potential of SG-AgNPs was tested on L-132 and A549 cell lines using MTT, live/dead, and DNA damage assays. Results showed dose-dependent cytotoxicity, with significant effects observed at higher concentrations, particularly against A549 cells. Additionally, the protective effects of SG-AgNPs were assessed in <em>Caenorhabditis elegans</em> using survival and paralysis assays. The nanoparticles significantly improved survival rates and reduced paralysis in worms infected with <em>Pseudomonas aeruginosa</em> PAO1 and <em>Staphylococcus aureus</em>. These findings highlight the potential of biogenic SG-AgNPs as effective agents with both anticancer and antimicrobial properties. Future research should focus on elucidating the mechanisms underlying these effects and optimizing their therapeutic applications.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100052"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-dimensional nano-biomaterials in regulating the tumor microenvironment for immunotherapy","authors":"Guangyu Xu ,&nbsp;Jie Li ,&nbsp;Suming Zhang ,&nbsp;Jinzhou Cai ,&nbsp;Xiaoran Deng ,&nbsp;Yuhong Wang ,&nbsp;Pei Pei","doi":"10.1016/j.ntm.2024.100045","DOIUrl":"10.1016/j.ntm.2024.100045","url":null,"abstract":"<div><p>Two-dimensional (2D) nanomaterials, characterized by their ultrathin profile and constructed from single or a few atomic layers, exhibit unique physical and chemical properties. These materials have recently emerged as a focal point in biomedicine, particularly in drug delivery, bio-sensing, and cancer therapy. Two-dimensional nanomaterials are widely employed in tumor immunotherapy due to their ability to modulate the tumor immune microenvironment and facilitate the delivery of crucial immunotherapeutic agents. Additionally, their integration with other therapeutic modalities can significantly enhance the overall effectiveness of cancer treatments. This review provides an initial overview of various 2D materials and their applications in tumor therapy. It progresses to a comprehensive analysis of how these nanomaterials influence the tumor microenvironment and immune cells, emphasizing their mechanisms and benefits in enhancing tumor immunotherapy. The review concludes by discussing prospective applications of 2D nanomaterials in cancer treatment, highlighting their substantial potential in advancing precision medicine and immune modulation.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100045"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000165/pdfft?md5=8da04210e37e43f515ca9ecce3c6e901&pid=1-s2.0-S2790676024000165-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142122959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent plant-synthesized gold nanoparticle advancements for gastric cancer therapy","authors":"Marco A. Rojas-Cessa","doi":"10.1016/j.ntm.2024.100050","DOIUrl":"10.1016/j.ntm.2024.100050","url":null,"abstract":"<div><p>Gastric cancer is the fifth most common form of cancer across the globe, according to the latest WHO GLOBO-CAN 2022 report. Metal nanoparticles (MNPs) have been attracting attention for cancer therapy due to the many advantages they provide compared to traditional cancer treatment drug delivery systems. Specifically, gold nanoparticles (AuNPs) are potentially advantageous for clinical applications because of their biocompatibility and their application in biomedical imaging. A drawback of AuNPs is that their synthesis is typically very hazardous and produces a lot of toxic byproducts. However, the green synthesis of AuNPs overcomes this issue by using natural and biological derivatives (from microorganisms, fungi, plants, etc.). This allows for a safer and less toxic procedure, while maintaining the reliability and reproducibility of AuNP synthesis. Plant-synthesized AuNPs (PAuNPs) in particular present a greatly efficient and fast method for AuNP synthesis, due to the presence of reducing agents and capping agents in plant extracts to support the nucleation and formation of AuNPs. Herein, we review existing literature to summarize recent <em>in vitro</em> and <em>in vivo</em> developments of PAuNPs against gastric cancer. Categorization of the reviewed literature includes their physiochemical characterization, cytotoxic IC₅₀’s against gastric cancer cell lines, methods of gastric cancer cell death, and the change in relevant biomarker expressions due to PAuNP presence. A generalized gastric cancer cell death mechanism is concluded, which stems from the endocytotic uptake of PAuNPs that eventually leads to mitochondria dysfunction, nuclear fragmentation, autophagy expression alteration, apoptosis, and/or ferroptosis. Although <em>in vivo</em> developments for PAuNPs against gastric cancer are limited, studies have indicated PAuNPs’ ability to cause angiogenesis inhibition and tumor size reduction. The discussion includes comments on remaining challenges and additional work for the pre-clinical development of PAuNPs against gastric cancer.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100050"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000219/pdfft?md5=5f109a716b523012f28e03a106eabe30&pid=1-s2.0-S2790676024000219-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green synthesis of palladium nanoparticles using Asterarcys sp. and their applications","authors":"Sunita Choudhary ,&nbsp;Geetanjali Kumawat ,&nbsp;Krishna Kher ,&nbsp;P.K. Baroliya ,&nbsp;Amit Kumar Gupta ,&nbsp;Manas K. Tripathy ,&nbsp;Harish","doi":"10.1016/j.ntm.2024.100046","DOIUrl":"10.1016/j.ntm.2024.100046","url":null,"abstract":"<div><p><em>Asterarcys</em>-mediated algal extract, which is non-toxic and renewable, was used to synthesize palladium nanoparticles (PdNPs) efficiently and ecologically friendly. The palladium nanoparticle's fabrication was seen within two hours. UV spectroscopy, FTIR, XRD, SEM, EDX and TEM with SAED pattern were used to confirm the properties of the synthesized nanoparticles. Palladium nanoparticles have been developed, indicated by their deep brown color and broad UV-visible absorption spectra. The SAED and XRD patterns of the manufactured nanoparticles provided evidence of their face-centred cubic crystal structure. Because of reflections from the (1 1 1), (2 0 0), (2 2 0), (3 1 1), and (2 2 2) planes, the XRD pattern is broad, indicating that the FCC nanoparticles are crystalline in nature. The biomolecule responsible for Pd²⁺ reduction and PdNPs capping has been found by analyzing the FTIR spectra of dried PdNPs and dry algal powder. The average particle size, according to a TEM image, is 13 nm, whereas it ranges from 4 to 24 nm. In moderate reaction conditions, the catalytic activity of PdNPs was investigated in C-C cross-coupling processes including Mizoroki-Heck and Suzuki-Miyaura reactions. ¹H NMR and ¹³C NMR were used to characterize the isolated product. The PdNPs exhibited strong catalytic activity and produced excellent conversion of the corresponding products.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100046"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000177/pdfft?md5=25fcb9815b27e8d2055f358cf1d61283&pid=1-s2.0-S2790676024000177-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel drug delivery systems: Insight into self-powered and nano-enabled drug delivery systems","authors":"Ugochi E. Ewii ,&nbsp;Adaeze L. Onugwu ,&nbsp;Victor C. Nwokpor ,&nbsp;Ikanke-abasi Akpaso ,&nbsp;Toochukwu E. Ogbulie ,&nbsp;Bibiana Aharanwa ,&nbsp;Chinonye Chijioke ,&nbsp;Ngozi Verla ,&nbsp;Callistus Iheme ,&nbsp;Cosmas Ujowundu ,&nbsp;Chioma Anyiam ,&nbsp;Anthony A. Attama","doi":"10.1016/j.ntm.2024.100042","DOIUrl":"10.1016/j.ntm.2024.100042","url":null,"abstract":"<div><p>Novel drug delivery systems comprise sophisticated technology merged into drug delivery systems. These systems are created with the aim of addressing the limitations of conventional drug delivery systems. For instance, conventional drug delivery systems are inefficient in tackling challenging human diseases such as cancer. These systems are thus formed with materials to enhance permeation to target cells. They improve patients' compliance and efficacy. Novel drug delivery systems include self-powered drug delivery systems and microelectromechanical systems. Nanotechnology is a rapidly growing and promising field, especially in drug delivery system development and disease therapy. Novel drug delivery systems often utilise nanocarriers due to their numerous advantages. One of the benefits of nanocarriers is the ability to manipulate their size and surface functionalisation to achieve site-specific targeting. Many researchers have reported their controlled and targeted drug release profiles. Nanocarriers are propelled to their target tissues, where the entrapped drugs are released, prolonging therapeutic efficacy and decreasing undesired side effects. Hence, these systems offer the benefits of targeted and controlled drug delivery, low toxicity, high bioavailability and improved therapeutic efficiency. It is essential to understand the mechanisms of drug release and toxicity of these systems in order to develop efficient and safe drug delivery systems. This review describes the utilisation of novel drug delivery systems. It also dwells on the drug loading, targeting and drug release from nanocarriers. The primary concerns of clinical applications and the potential toxicity of these systems are also presented. It is expected that this review will be helpful to drug formulation researchers seeking solutions to challenging diseases such as cancer and cardiovascular diseases.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100042"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S279067602400013X/pdfft?md5=f2b932a7131fcff51a8d33d7b223b6aa&pid=1-s2.0-S279067602400013X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association and enterprise standard for producing and monitoring of quality extracellular vesicles /exosomes derived from human mesenchymal stem cells","authors":"Qilong Cao ,&nbsp;Rui Zhang ,&nbsp;Association & Enterprise Standard Drafting Committee,&nbsp;Qingsong Ye","doi":"10.1016/j.ntm.2024.100058","DOIUrl":"10.1016/j.ntm.2024.100058","url":null,"abstract":"<div><div>This document is drafted in accordance with GB/T 1.1–2020 \"<em>Standardization work guidelines Part 1: Structure and drafting rules for standardization documents</em>\" to specify the identification methods, inspection rules, label, package,storage, transportation and waste disposal requirement of extracellular vesicles (EVs)/exosomes derived from human mesenchymal stem cells. Please note that certain contents of this document may refer to patents, and the issuing institution of this document does not assume responsibility for identifying patents. This document is led by Qingdao Haier Biotechnology Co. Ltd. in collaboration with other 80 biological companies, institutions and hospitals in China. This document is collectively contributed by 122 experts in stem cell field, and officially released by China Food and Drug Corporation Quality and Safety Promotion Association. Publication of this document in current version has been approved by the group leader Qingdao Haier Biotechnology Co, Ltd.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100058"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}