Nano TransMed最新文献

{"title":"Nanotechnology: Paving the way for advanced healthcare and beyond","authors":"Chang Lei","doi":"10.1016/j.ntm.2023.100023","DOIUrl":"https://doi.org/10.1016/j.ntm.2023.100023","url":null,"abstract":"","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 4","pages":"Article 100023"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000572/pdfft?md5=a7135976adee78320efa25f6a7780124&pid=1-s2.0-S2790676023000572-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138739324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The challenges to develop antibody-conjugated nanomedicine products","authors":"Liwei Hui ,&nbsp;Wei Chen ,&nbsp;Mohammad Najlah","doi":"10.1016/j.ntm.2023.100018","DOIUrl":"10.1016/j.ntm.2023.100018","url":null,"abstract":"<div><p>Nanomedicine becomes a key player especially as next generation medicine. Antibody-conjugated nanomedicine could significantly upgrade the treatment and expand application areas. However, there are extensive challenges of manufacturing those formulations as a final drug product. Here we provided the general technical guidance from the initial formulation construction including antibody conjugation to the downstream formulation development. We hope this technical note can help accelerate the translation of productizing the antibody-conjugated nanomedicines.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 4","pages":"Article 100018"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000523/pdfft?md5=239e4ccba6589ed82bf5512a0b9ae7fe&pid=1-s2.0-S2790676023000523-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138626553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet lysate promotes proliferation and angiogenic activity of dental pulp stem cells via store-operated Ca2+ entry","authors":"Xiangyan Liao ,&nbsp;Min Chen ,&nbsp;Yuan Zhang ,&nbsp;Shengcun Li ,&nbsp;Yejian Li ,&nbsp;Yan He ,&nbsp;Yanteng Zhao ,&nbsp;Lihua Luo","doi":"10.1016/j.ntm.2023.100021","DOIUrl":"https://doi.org/10.1016/j.ntm.2023.100021","url":null,"abstract":"<div><h3>Aims</h3><p>Dental pulp stem cells (DPSCs) had been widely used in nerve tissue engineering. However, the low cell survival and invalid differentiation were urgent problems to be solved for cell-based therapy. Platelet lysate (PL) had attracted attentions for its good biocompatibility, low side effects and abundant growth factors. In this study, we aimed to evaluate the effect and mechanism of PL on the proliferation and angiogenesis of DPSCs.</p></div><div><h3>Materials and methods</h3><p>In our study, PL was prepared by repeated freeze-thaw methods. The effect of PL on the viability of DPSCs was screened by the Cell Counting Kit-8 (CCK-8) and Live/Dead assays. Then the store-operated Ca²⁺ entry (SOCE) agonist endothelin-1 (ET-1) and inhibitor 2-aminoethoxydiphenyl borate (2-APB) were used to clarify the biological functions of PL on DPSCs. We detected the mitosis of DPSCs by KI67 immunofluorescence staining. Moreover, Ca²⁺ influx in DPSCs was evaluated by fluorescence microscopy and a flow cytometry. The expression of p-SRC, VEGFA and CD31 as well as the number of formed tubules in each group were investigated, so as to further reveal the influence of PL on the DPSCs angiogenic activity.</p></div><div><h3>Results</h3><p>As for CCK-8 and Live/Dead assays, the results indicated the 0.5% concentration of PL was better than that of 20 ng/ml bFGF and 10% FBS in promoting cell survival within 24 h. KI67 staining showed that 0.5% PL promoted SOCE and cell proliferation. The expression levels of SRC phosphorylation (p-SRC) were increased in the 0.5% PL and ET-1 + 0.5% PL groups, as well as the expressions of endothelial markers CD31 and VEGFA were also increased in the ET-1, 0.5% PL and ET-1 + 0.5% PL groups. However, CD31 and VEGFA were not detected in 2-APB and 2-APB + 0.5% PL groups. After angiogenesis induction, capillary-like structures were observed in ET-1, 0.5% PL and ET-1 + 0.5% PL groups, whereas no vascular structures were observed in 2-APB and 2-APB + 0.5% PL groups.</p></div><div><h3>Conclusion</h3><p>Our results indicated that PL promoted the proliferation and vessel-formation of DPSCs via the activation of SOCE and the upregulation of p-SRC and VEGFA expressions, respectively. PL might act as a promising cell supplement in DPSCs survival and differentiation, furtherly applied for the repair and regeneration of peripheral nerve injury.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 4","pages":"Article 100021"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000559/pdfft?md5=66d693ff68adb4c27b9c73a02a05430a&pid=1-s2.0-S2790676023000559-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138739411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoic acid-based poly(disulfide)s: Synthesis and biomedical applications","authors":"Ivan O. Levkovskyi ,&nbsp;Shota Mochizuki ,&nbsp;Ajay Zheng ,&nbsp;Xiao Zhang ,&nbsp;Fuwu Zhang","doi":"10.1016/j.ntm.2023.100006","DOIUrl":"https://doi.org/10.1016/j.ntm.2023.100006","url":null,"abstract":"<div><p>Biodegradable and adaptable polymeric materials are currently being studied due to their wide scope of potential applications, from nanomedicine to novel multifunctional materials. One such class of polymers are poly(disulfide)s, which contain repeating disulfide bonds in their main chain. Lipoic acid, or thioctic acid, is a biologically derived small molecule containing a 1,2-dithiolane ring capable of undergoing ring opening polymerization to yield poly(disulfide)s. In this review, we highlight the synthesis of lipoic acid-based poly(disulfide)s through thermal and thiolate-initiated ring opening polymerizations, and the development of methodology pertaining to the synthetic methods. We further discuss the biomedical applications of poly(disulfide)s, which have been widely used to construct various responsive biomaterials, including polymer-drug conjugates, nanoparticles, hydrogels, and adhesives.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 2","pages":"Article 100006"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67740137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in clinical detection methods and nanomaterials for autoimmune liver diseases","authors":"Jingjing Chen ,&nbsp;Yaqi Zhu ,&nbsp;Qingcui Wang ,&nbsp;Jinya Ding ,&nbsp;Xiaohua Chen","doi":"10.1016/j.ntm.2023.100003","DOIUrl":"https://doi.org/10.1016/j.ntm.2023.100003","url":null,"abstract":"<div><p>Autoimmune liver disease (AILD) is a kind of chronic liver disease, due to the autoimmune tolerance of the liver break-down, as well as the imbalance of immune cell numbers and functions led to persistent inflammatory damage of the liver. With the rapid development of diagnoses and treatments, the proportion of liver diseases has changed significantly. Autoimmune liver diseases have gradually become one of the focuses of scholars worldwide. The specificity and sensitivity of diagnostic and prognostic evaluation methods of AILD have always been social concerns of the researchers owing to the variety of etiology, incompletely understood pathogenesis and different clinical phenotypes. This article reviews the current research status and summarizes the research advances and nanomaterials of the diagnosis and prognosis evaluation methods of AILDs.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 2","pages":"Article 100003"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000031/pdfft?md5=0ff38ef38b9c54c7cf830dad26a54f0a&pid=1-s2.0-S2790676023000031-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92047743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferrostatin-1 loaded Gelatin methacrylate scaffold promotes recovery from spinal cord injury via inhibiting apoptosis and ferroptosis","authors":"Shuili Jing ,&nbsp;Ye Liu ,&nbsp;Zhifei Ye ,&nbsp;Abdullkhaleg Ali Ghaleb Al-bashari ,&nbsp;Heng Zhou ,&nbsp;Yan He","doi":"10.1016/j.ntm.2023.100005","DOIUrl":"https://doi.org/10.1016/j.ntm.2023.100005","url":null,"abstract":"<div><p>Spinal cord injury (SCI) is a traumatic disease that seriously damages the central nervous system, which will bring a heavy burden to patients physically, mentally and economically. Ferroptosis is a newly discovered mode of cell death in recent years. It has been found that ferroptosis is related to a variety of diseases (stroke, traumatic brain injury, neurodegenerative diseases, etc.), and plays a major role in secondary injury after spinal cord injury. Ferrostatin-1 (Fer-1) is a potent inhibitor of ferroptosis that has been shown to improve functional recovery after SCI by alleviating white matter damage. Gelatin methacrylate (GelMA) hydrogels can carry drugs/nanomaterials into the body and have a slow release and physical support. However, the specific role of the GelMA hydrogel-based Fer1 slow-release system in neuronal iron death after SCI remains unknown. In this study, we demonstrate for the first time that the Fer@GelMA slow-release system inhibits apoptosis and promotes neuronal survival by inhibiting ferroptosis, ultimately rescuing damaged tissue and promoting recovery of SCI motor function. This discovery may provide a new treatment strategy for SCI.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 2","pages":"Article 100005"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000055/pdfft?md5=84145b73f85219965ae61d5823ef6238&pid=1-s2.0-S2790676023000055-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91968661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of nanomaterials with sulfur vacancy for enhanced cancer theranostics","authors":"Chenyu Wang ,&nbsp;Yingqi Wang ,&nbsp;Wei Tian ,&nbsp;Song Li ,&nbsp;Jixian Wan ,&nbsp;Yidan Wang ,&nbsp;Liya Tian ,&nbsp;Xue Wang ,&nbsp;Changzhong Li ,&nbsp;Jipeng Wan ,&nbsp;Xiao Sun","doi":"10.1016/j.ntm.2023.100007","DOIUrl":"https://doi.org/10.1016/j.ntm.2023.100007","url":null,"abstract":"<div><p>Nanomaterials with excellent optical, electric, magnetic, and other physicochemical properties, are generally used in photodynamic therapy, chemodynamic therapy, and photothermal therapy of cancer. To enhance nanomaterials’ superior physicochemical properties and improve cancer theranostic efficiency, various strategies have been proposed. Among them, the introduction of sulfur vacancy defects is a promising strategy for enhanced cancer theranostics. In this review, the formation and action mechanism of sulfur vacancy nanomaterials, as well as their application in cancer theranostics are first summarized. Then, the principle and application of various sulfur vacancy based-nanomaterials such as molybdenum, bismuth, zinc, copper, iron, ruthenium, silver, cobalt, cadmium, and polythionine in enhancing cancer therapy are highlighted. Finally, the future development prospect and current challenges of sulfur vacancy nanomaterials are also discussed. This review will help researchers quickly understand the information related to various sulfur vacancy-based nanomaterials in cancer therapy, promoting the further development of anti-cancer nanomedicine.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 2","pages":"Article 100007"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67739258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A brighter future for the Nano TransMed","authors":"Qingsong Ye Editor-in-Chief, Nano TransMed","doi":"10.1016/j.ntm.2023.100009","DOIUrl":"https://doi.org/10.1016/j.ntm.2023.100009","url":null,"abstract":"","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 2","pages":"Article 100009"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000092/pdfft?md5=1a52e64de9a00f52e40e76ddb0f0d854&pid=1-s2.0-S2790676023000092-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91964840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticle-Based Therapeutics: A Comprehensive Guide to Cancer Treatment – A book introduction","authors":"Barbara Pierscionek","doi":"10.1016/j.ntm.2023.100010","DOIUrl":"https://doi.org/10.1016/j.ntm.2023.100010","url":null,"abstract":"","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 2","pages":"Article 100010"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000109/pdfft?md5=26ccad2df2df23b36f5910a4911b1d1c&pid=1-s2.0-S2790676023000109-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91964841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Edible plant-derived extracellular vesicles serve as promising therapeutic systems","authors":"Chun Yang ,&nbsp;Wenjing Zhang ,&nbsp;Muran Bai ,&nbsp;Qiyuan Luo ,&nbsp;Qing Zheng ,&nbsp;Yao Xu ,&nbsp;Xiaoya Li ,&nbsp;Cheng Jiang ,&nbsp;William C. Cho ,&nbsp;Zhijin Fan","doi":"10.1016/j.ntm.2023.100004","DOIUrl":"https://doi.org/10.1016/j.ntm.2023.100004","url":null,"abstract":"<div><p>Extracellular vesicles (EVs), which are natural nanocarriers characterized by a phospholipid bilayer structure, are released by living cells. They play a crucial role in the intercellular transport of proteins, nucleic acids, lipids, and metabolites, facilitating substance delivery and information exchange between cells. In light of recent numerous studies, EVs has been found to transcend their basic role as mere delivery vehicle. Instead, they demonstrate an impressive array of biological activities, displaying preventive and therapeutic potential in mitigating various pathological processes encompassing cancer, neoplastic proliferation, infectious diseases, and oxidative trauma. Particularly, EVs derived from edible plants (EPDEVs) have been emphasized for their extensive range of physiological regulatory functions in animals and humans, with the potential for targeted drug delivery through oral administration. Leveraging these advantages, EPDEVs are expected to have excellent competitiveness in clinical applications or preventive healthcare products. This review provides a brief overview of the biogenesis, structure, and composition of EPDEVs, and summarizes their biological functions and mechanisms. It also analyzes the methods for isolating and purifying plant-EVs, assessing their advantages and disadvantages; discusses the latest advancements in biomedical applications, and concludes with a prospective insight into the research and development directions of EPDEVs.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 2","pages":"Article 100004"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000043/pdfft?md5=f40cd54797396f51aa096263d39188d0&pid=1-s2.0-S2790676023000043-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91968662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}