Nano TransMedPub Date : 2023-03-01DOI: 10.26599/NTM.2023.9130016
Gaoli Xu , Ting Wang , Chenxi Shen , Jian Zhou , Ben Wan , Tymour Forouzanfar , Haiyan Lin , Gang Wu
{"title":"In-vitro physicochemical characterization of a novel type of bonedefect-filling granules—BpNcCaP in comparison to deproteinized bovine bone (Bio-Oss®)","authors":"Gaoli Xu , Ting Wang , Chenxi Shen , Jian Zhou , Ben Wan , Tymour Forouzanfar , Haiyan Lin , Gang Wu","doi":"10.26599/NTM.2023.9130016","DOIUrl":"10.26599/NTM.2023.9130016","url":null,"abstract":"<div><p>As alternatives to autografts, allografts, and xenografts, calcium phosphate (CaP)-based bone-defect-filling materials (e.g., deproteinized bovine bone (DBB, Bio-Oss®)) are widely used to repair large-volume bone defects (LVBDs) in clinic. However, most of these materials show a very low degradability due to a sintering process in their production. In this study, we synthesized a novel type of granules—biomimetically precipitated nanocrystalline calcium phosphate (BpNcCaP) by developing our previous biomimetic protocol. We evaluated the cytotoxicity of BpNcCaP by assessing the viability of L929 mouse fibroblasts using a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide (MTT) assay. To characterize the physicochemical properties of the novel BpNcCaP granules, we first compared the morphology and composition of BpNcCaP with those of Bio-Oss® using scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM) and energy dispersive X-ray spectroscopy (EDS). We further compared the surface area, pore size distribution, hydrophilicity behavior, and hardness of BpNcCaP with those of Bio-Oss® granules using specific surface area, contact angle, and Vickers hardness as parameters, respectively. BpNcCaP showed no obvious cytotoxicity. <em>In-vitro</em> characterization data showed that BpNcCaP and Bio-Oss® granules were both comprised of nanocrystalline hydroxyapatite (HAp). The Ca/P ratios of BpNcCaP and Bio-Oss® calculated from the EDS results were 1.34 and 1.66, respectively. Hence, BpNcCaP and Bio-Oss® were Ca-deficient HAp. Compared with Bio-Oss®, synthetic BpNcCaP had better hydrophilicity, higher specific surface area, lower crystallinity, and hardness. These data suggested a good performance of BpNcCaP granules in clinical applications.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 1","pages":"Article e9130016"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000341/pdfft?md5=1966e84281cb5081a5cf1234c0ceb647&pid=1-s2.0-S2790676023000341-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78824939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TransMedPub Date : 2023-03-01DOI: 10.26599/NTM.2023.9130014
Yongfei Tang, Jingping Yuan , Yabing Huang, Honglin Yan, Lin Liu, Na Zhan, Huihua He
{"title":"Nomograms for predicting overall survival and cancer-specific survival of patients with stage IV renal cell carcinoma: A SEER population-based study","authors":"Yongfei Tang, Jingping Yuan , Yabing Huang, Honglin Yan, Lin Liu, Na Zhan, Huihua He","doi":"10.26599/NTM.2023.9130014","DOIUrl":"10.26599/NTM.2023.9130014","url":null,"abstract":"<div><p>Background: The purpose of this study was to explore independent favorable prognostic factors for predicting 1-, 3-, and 5-year overall survival (OS) and cancer-specific survival (CSS) in patients with stage IV cell renal cell carcinoma (RCC) by constructing nomograms. Methods: A total of 2636 patients diagnosed with stage IV RCC from 2010 to 2015 were enrolled in the surveillance, epidemiology, and end results database. Multivariate Cox hazard regression and competing risk analysis were used for searching prognosis factors in the cohort. The nomograms were constructed for predicting 1-, 3-, and 5-year of OS and CSS. Concordance index (C-index) and the calibration curves were used to evaluate the discrimination and accuracy of the nomograms. Results: Age, nephrectomy, histology, N stage, and brain/liver/lung metastasis were identified as independent favorable prognostic factors in OS and CSS via univariate and multivariate analyses. Other variables were further selected by clinical practice and net reclassification improvement (NRI). Finally, age, nephrectomy, histology, grade, tumor size, T stage, N stage, and bone/brain/liver/lung metastasis were chosen to construct nomograms. The C-index of the OS and CSS in nomograms were 0.697 (95% confidence interval (CI), 0.683-0.711) and 0.655 (95% CI, 0.639-0.671), respectively. The calibration curves revealed high consistency between the nomograms prediction and actual observation. Conclusions: The nomograms may help clinicians to conveniently predict the survival of RCC patients with stage IV and provide guidance in choosing the suitable management.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 1","pages":"Article e9130014"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000328/pdfft?md5=e6fa38c198f1156065982fb433decf53&pid=1-s2.0-S2790676023000328-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77980829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TransMedPub Date : 2023-03-01DOI: 10.26599/NTM.2023.9130020
Wei Chen
{"title":"On nano-solutions to overcome cancer hypoxia and resistance","authors":"Wei Chen","doi":"10.26599/NTM.2023.9130020","DOIUrl":"10.26599/NTM.2023.9130020","url":null,"abstract":"<div><p>Cancer is a leading cause of death globally, and current cancer therapies often fall short in reducing death and improving quality of life. Early detection of cancer cells and targeted drug application is crucial to optimal treatment. Nanotechnology shows promise in improving cancer diagnosis and treatment by reducing toxicity and refractory disease. In this essay, we focus on how nanotechnology can overcome resistance and hypoxic issues in cancer treatment.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 1","pages":"Article e9130020"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000389/pdfft?md5=b2eb552a40af6c6963fec235def42457&pid=1-s2.0-S2790676023000389-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78226208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TransMedPub Date : 2023-03-01DOI: 10.26599/NTM.2023.9130017
Li Mei , Guangzhao Guan
{"title":"Profilometry and atomic force microscopy for surface characterization","authors":"Li Mei , Guangzhao Guan","doi":"10.26599/NTM.2023.9130017","DOIUrl":"10.26599/NTM.2023.9130017","url":null,"abstract":"<div><p>Aim: This study aims to evaluate and compare the profilometry and atomic force microscopy (AFM) for characterization of biomaterial surfaces. Method: The clinically commonly used titanium (Ti) was used as the specimen. Each of the specimen was prepared by different grits of sandpapers, including 2000, 1000, 800, 600, 400, 220, 180, and 100 grits. An unpolished Ti plate served as the control. Surface characterization of the Ti specimens was examined using profilometry and AFM. Results: Both profilometry and AFM were capable of producing two-dimensional (2D) and three-dimensional (3D) topography. The scanning speed of profilometry (12 ± 5 s/image) was faster than that of AFM (250 ± 50 s/image) <em>(p</em> < 0.01). The resolution of AFM was relatively higher than profilometry. AFM produced more precise value, especially at nano-scale. When the Ti surface roughness was less than 0.2 μm, the results of surface roughness measured by profilometry and AFM were similar (mean difference = 0.01 ± 0.03, <em>p</em> = 0.81). When the Ti surface μm, the surface roughness measured by profilometry was slightly higher than that by AFM (mean difference = 0.43 ± 0.15, <em>p</em> = 0.04). Conclusion: Profilometry and AFM are both useful techniques for the characterization of biomaterial surfaces. Profilometry scanned faster than the AFM but produced less detailed surface topography. Both technologies provided similar measurement when the roughness was less than 0.2 μm. When the Ti surface roughness was more than 0.3 μm, the surface roughness measured by profilometry was slightly higher than that by AFM.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 1","pages":"Article e9130017"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000353/pdfft?md5=f92c7f7b4622dc91bc69f207c3222399&pid=1-s2.0-S2790676023000353-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78707244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TransMedPub Date : 2023-03-01DOI: 10.26599/NTM.2023.9130018
Yuting Lu , Tangye Zeng , Huamiao Zhang , Yang Li , Xiaoling Zhu , Huiping Liu , Beibei Sun , Chaoran Ji , Ting Li , Leyi Huang , Kesong Peng , Zhe Tang , Longguang Tang
{"title":"Nano-immunotherapy for lung cancer","authors":"Yuting Lu , Tangye Zeng , Huamiao Zhang , Yang Li , Xiaoling Zhu , Huiping Liu , Beibei Sun , Chaoran Ji , Ting Li , Leyi Huang , Kesong Peng , Zhe Tang , Longguang Tang","doi":"10.26599/NTM.2023.9130018","DOIUrl":"10.26599/NTM.2023.9130018","url":null,"abstract":"<div><p>Lung cancer has the highest incidence and mortality rate worldwide. Immunotherapy is a universal treatment for lung cancer, but its overall treatment remains a challenge. Tumor immunoediting is a process in which the immune system restricts or promotes tumor development through elimination, equilibrium, and escape to change tumor immunogenicity and obtain an immunosuppressive mechanism to promote disease progression. An increasing number of immunotherapy drugs, including monoclonal antibody-targeting drugs and chimeric antigen (Ag) receptor-modified T cells (CAR-T cells), have been used in clinical therapy. Additionally, cancer vaccine development and new clustered regularly spaced short palindromes (CRISPR)- based combination therapies against cancer open up new avenues for immunotherapy. However, these immunotherapies cause autoimmune induction and non-specific inflammation, with many limitations. The development and study of nanoparticle systems have shown the possibility of localization, pharmacokinetic programming, and immunomodulator co-delivery. Rapid advances in nanotechnology over the past decade have provided a strategic impetus for cancer immunotherapy improvements. Nanotechnology advancements in various aspects, such as virus-like size, high surface-volume ratio, and surface modifications to precisely target specific cell types, can be investigated through cancer vaccine and immunomodulator delivery system development. This review presents the current immunotherapy approaches for lung cancer and emphasizes the current process and prospects of the fusion of cancer immunotherapy, nanotechnology, bioengineering, and drug delivery.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 1","pages":"Article e9130018"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000365/pdfft?md5=8374d8ea41c4186fb6f6e705a07c7f87&pid=1-s2.0-S2790676023000365-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81422882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TransMedPub Date : 2023-03-01DOI: 10.26599/NTM.2023.9130015
Xiaohua Chen , Yao Deng , Qian Shen , Rong Zhang , Yong Qi , Jingjing Chen , Zequn Lu , Lin Miao , Jinya Ding , Rong Zhong
{"title":"Associations of clinical features and dynamic immune response with the duration of viral RNA shedding in patients with COVID-19","authors":"Xiaohua Chen , Yao Deng , Qian Shen , Rong Zhang , Yong Qi , Jingjing Chen , Zequn Lu , Lin Miao , Jinya Ding , Rong Zhong","doi":"10.26599/NTM.2023.9130015","DOIUrl":"10.26599/NTM.2023.9130015","url":null,"abstract":"<div><p>Background: Clinical features and the dynamic changes of the immune response in coronavirus disease-2019 (COVID-19) patients play essential roles in the disease courses. We hypothesized that clinical features and longitudinal dynamic immune response of COVID-19 patients might be associated with viral shedding duration. Methods: In this retrospective study, we documented 413 adult patients with laboratory-confirmed COVID-19 from Wuhan Huoshenshan Hospital. Demographic, clinical, and laboratory data were extracted from electronic medical records. Risk factors associated with viral shedding duration were examined using odds ratios (ORs) and 95% confidence intervals (CIs) in the multivariable logistic regression models. Results: The median duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral shedding was 48 days (interquartile range, 40-58 days) among all patients. Fever symptom (OR, 2.23; 95% CI, 1.46-3.44), delayed admission after symptom onset (OR, 15.33; 95% CI, 9.14-26.65), CD8<sup>+</sup> T cells (OR, 1.93; 95% CI, 1.10-3.44) were associated with prolonged viral shedding. In contrast, shorter viral shedding was associated with CD4<sup>+</sup> T cells (OR, 0.38; 95% CI, 0.16-0.88), the ratios of CD4<sup>+</sup> T cells to CD8<sup>+</sup> T cells (OR, 0.79; 95% CI, 0.63-0.98). Longitudinal dynamic analyses demonstrate that sustained monocyte level was associated with shorter viral shedding (OR, 0.41; 95% CI, 0.22-0.76). More importantly, the associations of CD4<sup>+</sup> T cells, CD8<sup>+</sup> T cells, the ratio of CD4<sup>+</sup> T cells to CD8<sup>+</sup> T cells, and sustained monocyte level were confined to male patients. Conclusions: Higher CD4<sup>+</sup> T cells, sustained monocyte level, and lower CD8<sup>+</sup> T cells might shorten the disease course. The male-specific associations supported the contribution of sex-dependent immune responses to the disease courses.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 1","pages":"Article e9130015"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S279067602300033X/pdfft?md5=23dd88b3657c5ab1ac16b66991eba300&pid=1-s2.0-S279067602300033X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82688165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TransMedPub Date : 2022-12-01DOI: 10.26599/NTM.2022.9130009
Qingchun Mu , Yuhao Xue , Yuting Lu , Yufei Zhang , Qian Cheng , Jinlong Wan , Peng Liu , Jingjing Liu , Yikun Qu , Chunming Huang , Longguang Tang
{"title":"Advances in the therapy of cerebral ischemia-reperfusion injury with natural product-based nanoparticles","authors":"Qingchun Mu , Yuhao Xue , Yuting Lu , Yufei Zhang , Qian Cheng , Jinlong Wan , Peng Liu , Jingjing Liu , Yikun Qu , Chunming Huang , Longguang Tang","doi":"10.26599/NTM.2022.9130009","DOIUrl":"10.26599/NTM.2022.9130009","url":null,"abstract":"<div><div>Stroke is a serious acute cerebrovascular disease attributable to disruptions in the blood supply to the brain tissue as a result of vascular obstruction or sudden rupture of blood vessels in the brain, which further result in hypoxia of the brain and reduction of necessary nutrients, apoptosis of neurons, and damage to brain tissue. The majority of stroke patients are ischemic stroke. The main clinical treatments for ischemic stroke include medical thrombolysis in the early stage of onset and surgical thrombectomy or stent implantation in the late stage of onset, all of which have their own indications, advantages, and disadvantages, and show limited clinical application. For cerebral ischemia-reperfusion injury with an extremely poor prognosis, there is currently no effective prevention and treatment method in the clinic. Therefore, timely and effective treatment is needed to treat cerebral ischemia-reperfusion injury. An increasing number of studies have shown that natural products have a good curative effect on cerebral ischemia-reperfusion injury. However, due to their low solubility, low bioavailability, and short half-life, many natural products cannot optimally exert their curative effects on cerebral ischemia-reperfusion injury. Natural products-based nanoparticles modified with specific ligands have attracted much attention because of their high-efficiency permeation through the blood–brain barrier, targeted delivery abilities, and the protection of the active components from degradation. Therefore, this review focused on the prevention and treatment of cerebral ischemia-reperfusion injury in the natural product-based nanoparticles.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"1 2","pages":"Article e9130009"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88792106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TransMedPub Date : 2022-12-01DOI: 10.26599/NTM.2022.9130011
Qianqian Ni , Xiaoyuan Chen
{"title":"Current challenges and potential directions towards nanotechnology in medicine and transformation","authors":"Qianqian Ni , Xiaoyuan Chen","doi":"10.26599/NTM.2022.9130011","DOIUrl":"10.26599/NTM.2022.9130011","url":null,"abstract":"","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"1 2","pages":"Article e9130011"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88040318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TransMedPub Date : 2022-12-01DOI: 10.26599/NTM.2022.9130010
Xiaoming Hu , Caijun Zhu , Fengwei Sun , Jin Yang , Zejing Chen , Haiyong Ao , Cao Cui , Zhen Yang , Wei Huang
{"title":"Insights into the organic semiconducting photosensitizers for hypoxia-tolerant type I photodynamic therapy","authors":"Xiaoming Hu , Caijun Zhu , Fengwei Sun , Jin Yang , Zejing Chen , Haiyong Ao , Cao Cui , Zhen Yang , Wei Huang","doi":"10.26599/NTM.2022.9130010","DOIUrl":"10.26599/NTM.2022.9130010","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) is a promising approach to treat cancer and microbial infections due to its minimal invasiveness, high spatiotemporal selectivity, tissue specificity, and low toxicity. Depending on the reactive oxygen species generation mechanisms, PDT can be classified as type I and type II. To date, most reported photosensitizers are based on the type II PDT mechanism, which produces toxic singlet oxygen and requires an abundant and continuous supply of oxygen molecules. Unfortunately, in typical solid tumor microenvironments, vascular abnormalities and rapid metabolisms lead to oxygen deficiency, severely compromising type II PDT's effectiveness. To address this issue, type I PDT with less oxygen consumption has been developed as an effective way to overcome the limitations of traditional type II PDT. In this contribution, we focus on the recent advances in type I organic semiconducting photosensitizers (OSPs), including organic semiconducting small molecules, conjugated polymers, and covalent organic frameworks for advanced hypoxia-tolerant PDT. The conceptual framework and general properties of these OSPs are firstly introduced, followed by introducing OSPs with different chemical structures for type I PDT. Finally, the overall conclusion, insightful perspective, and future direction of the efforts of OSPs for advanced biological applications are outlined.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"1 2","pages":"Article e9130010"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82478182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano TransMedPub Date : 2022-12-01DOI: 10.26599/NTM.2022.9130007
Shuili Jing , Heng Zhou , Chen Zou , David P.C. Chen , Qingsong Ye , Yilong Ai , Yan He
{"title":"Application of telomere biology and telomerase in mesenchymal stem cells","authors":"Shuili Jing , Heng Zhou , Chen Zou , David P.C. Chen , Qingsong Ye , Yilong Ai , Yan He","doi":"10.26599/NTM.2022.9130007","DOIUrl":"10.26599/NTM.2022.9130007","url":null,"abstract":"<div><div>With the increasing understanding of mesenchymal stem cells (MSCs), their potential in tissue engineering and regenerative medicine has attracted more attention. However, some important problems need to be solved before clinical application, such as low amplification efficiency, inconsistent cell product quality, and unsatisfactory survival rate at the receptor site. Telomeres act as a clock, and they shorten when cells divide. The main mechanism for reversing telomere length is telomerase. Furthermore, telomerase is involved in antioxidation, antiapoptosis, immunological modulation, and other noncanonical processes in addition to proliferation-related tasks. Therefore, it is necessary to understand the telomere biology and telomerase of MSCs to improve their proliferation, performance stability, and antiscavenging ability. This review summarizes the progress of telomerase biological function and mechanism in MSCs, and discusses the current situation and deficiency of telomerase-related application in MSCs.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"1 2","pages":"Article e9130007"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77737534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}