Nano TransMed最新文献

{"title":"Establishment and application of a brain cell line derived from Plectropomus leopardus","authors":"Zhiru Liu ,&nbsp;Qiaoli Yang ,&nbsp;Minjie Kang ,&nbsp;Caoying Wei ,&nbsp;Tao Li ,&nbsp;Yongcan Zhou ,&nbsp;Zhenjie Cao ,&nbsp;Yun Sun","doi":"10.1016/j.ntm.2024.100038","DOIUrl":"10.1016/j.ntm.2024.100038","url":null,"abstract":"<div><p><em>Plectropomus leopardus</em> is an economically valuable marine farmed fish. However, diseases have seriously restricted the healthy development of its breeding industry. Cell line is an important <em>in vitro</em> research system in the fields of disease control, environmental toxicology, nanotechnology, and so on. However, the application of marine fish cell lines is far from the expected level, and many species have not yet been reported to establish cell lines. In our study, we developed a brain cell line derived from P. leopardus, designated as PLB, and investigated its susceptibility to bacterial agents and heavy metal exposure. The findings indicated that PLB cell lines grew fastest in L-15 medium supplemented with 20 % fetal bovine serum (FBS) at 26 °C. The established cell line was identified by 18 S rRNA gene sequencing as being derived from <em>P. leopardus</em>. Chromosome analysis revealed that the PLB cell line had a chromosome count of 48. The transfection efficiency of PLB cells was about 27 % by liposome transfection method, indicating that PLB cell lines offer utility for conducting functional investigations of exogenous genes. In addition, the bacterial sensitivity analysis results indicated that PLB cells exhibited susceptibility to both <em>Vibrio harveyi</em> and <em>Edwardsiella tarda</em>, furthermore, PLB cells displayed heightened sensitivity towards <em>V. harveyi</em> in comparison to <em>E. tarda</em>. The outcomes from the heavy metal toxicity experiments demonstrated significant toxicity of three heavy metals (Hg²⁺, Cu²⁺ and Cd²⁺) towards PLB cells, with Hg²⁺ exhibiting the highest degree of toxicity among them. Moreover, there was a dose-dependent relationship between cell survival rate of PLB and heavy metal concentration. In summary, PLB cell lines represent a promising tool for conducting in vitro analyses of foreign gene functionality, bacterial susceptibility, and heavy metal toxicity. It helps ensure the safety of aquatic breeding environments and also supports genetic enhancements in fish fry, promoting the development of traits such as increased growth and disease resistance, which are vital for aquaculture progress.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100038"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000098/pdfft?md5=d0b67bbd1e3d1577cec6d01dbd754da7&pid=1-s2.0-S2790676024000098-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141400598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-triggerennd piezocatalytic conductive Guar gum/PEDOT: PSS/BTO composite hydrogels for bacterial-infected skin wound healing","authors":"Shuyan Zhang ,&nbsp;Danna Chen ,&nbsp;Zhipeng Gu ,&nbsp;Hongrong Luo ,&nbsp;Xianchun Chen ,&nbsp;Qiang Fu","doi":"10.1016/j.ntm.2024.100035","DOIUrl":"https://doi.org/10.1016/j.ntm.2024.100035","url":null,"abstract":"<div><p>Open skin wounds are susceptible to infections by multidrug-resistant bacteria, which can lead to delayed wound healing or worsening of symptoms. Therefore, there is an urgent need to develop a comprehensive strategy that addresses bacterial infections while simultaneously promoting wound healing for optimal clinical outcomes. In this study, we aimed to combine the benefits of antibacterial piezoelectric catalysis action and controlled electrical stimulation to promote skin tissue repair. Initially, piezoelectric catalytic BaTiO₃(BTO) nanoparticles were coated with polydopamine (PDA) to improve the interface compatibility between inorganic and organic phase. Subsequently, a novel conductive composite hydrogel termed PPGSCH was synthesized by doping PDA@BTO into poly (3, 4-ethylenedioxythiophene) -poly (styrene sulfonate) (PEDOT: PSS) hydrogel. Traditional dye degradation experiments and EPR tests found that PDA@BTO nanoparticles exhibited superior piezoelectric catalytic efficiency compared with the pristine BTO. Rheological tests and electrical conductivity tests demonstrated better electrical adaptability and mechanical stability of PPGSCH. Remarkably, under the synergism of piezoelectricity and electric polarization induced by ultrasound (US), the antibacterial rate of PPGSCH exceeded 90% <em>in vitro</em>. Furthermore, when subjected to 0.5 W/cm² US irradiation, it can generate moderate levels of reactive oxygen (ROS) and micro current, promoting the proliferation and migration of mouse fibroblasts. Animal experiments on infected skin wounds in mice showed that PPGSCH could reduce inflammation, accelerate angiogenesis, and ultimately expedite the infected wound healing. This work opens up new possibilities for enhancing the repair of infected skin wounds.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100035"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000062/pdfft?md5=a8c081dc8edfd3a2752373135fd0bd26&pid=1-s2.0-S2790676024000062-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140651040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphology and temporal interactions of silica particles influence the chemotherapeutic cancer cell death","authors":"Astha Sharma ,&nbsp;Jiachen Yan ,&nbsp;Prakrit Siwakoti ,&nbsp;Ayad Saeed ,&nbsp;Vipul Agarwal ,&nbsp;Zhi Ping Xu ,&nbsp;Ran Wang ,&nbsp;Tushar Kumeria","doi":"10.1016/j.ntm.2024.100053","DOIUrl":"10.1016/j.ntm.2024.100053","url":null,"abstract":"<div><div>Encapsulation of drugs into nanocarriers is proven to be highly promising approach in reducing drug toxicity and enhancing therapeutic efficacy. However, controlling the loading efficiency and capacity, and release of therapeutics at specific disease site has remained a key challenge, particularly for toxic chemotherapeutic drugs. This work explored the effect of treatment with empty silica nanoparticles (SNPs) and a chemotherapeutic drug either together (i.e. co-treatment) or in tandem (i.e. temporally spaced) on the cell ablation ability of the drug. The study also investigated whether the efficacy of the drug in response to these treatments was dependent on the morphology of particles. SNPs of four different morphologies (solid: SSNPs, dendritic: DSNPs, mesoporous: MSNPs, and rod: RSNP) were used, while cisplatin (CisPt) served as model chemotherapeutic. The efficacy of CisPt as a function of SNPs morphology and temporal treatment strategy was tested in HeLa cells. The results indicated that the morphology of particles as well as treatment strategy (i.e. co-incubation and post treatment) had an impact on not only the cell viability but also the cell death pathways, as evidenced by varying IC50 values and the flow cytometry analysis. Interestingly, co-treatment of SNPs with CisPt resulted in an across-the-board lower IC50 value compared to when the cells were first treated with SNPs for 24 h followed by CisPt treatment and even when CisPt was loaded into the particles for most of the SNPs.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100053"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan nanoparticle delivery systems: An effective approach to enhancing efficacy and safety of anticancer drugs","authors":"Anil Kumar Grewal,&nbsp;Raj Kumar Salar","doi":"10.1016/j.ntm.2024.100040","DOIUrl":"https://doi.org/10.1016/j.ntm.2024.100040","url":null,"abstract":"<div><p>Currently, cancer is the leading cause of death globally. In the absence of specific treatment and early diagnosis, procedures like surgery, chemotherapy, and radiation therapy are often used to manage the disease. However, these approaches often fail to control cancer due to inefficacy, nonspecific distribution, and side effects of the drugs. Anticancer drugs are essential in reducing cancer cell growth and helping damage those cells. Anticancer drugs often cause severe side effects and have limited bioavailability due to their nonspecific distribution throughout the body. Therefore, the development of intelligent drug release systems is essential. Nanoparticle delivery systems are promising strategies to improve therapeutic efficacy and safety, overcoming challenges. Among these systems, a natural polysaccharide called chitosan, a derivative of chitin, has gained considerable attention as a biocompatible, biodegradable, and mucoadhesive material for creating nanoparticles. Chitosan nanoparticles provide several advantages, including improved stability, cellular uptake, solubility of anticancer drugs, modulation of release kinetics, and biodistribution. Additionally, chitosan nanoparticles can be modified on their surface with ligands or stimuli-responsive moieties to achieve targeted delivery to specific cancer cells or tissues. This review explores recent advances in chitosan-based nanoparticle drug delivery, efficacy, and their applications in cancer therapy.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100040"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000116/pdfft?md5=0baa56eb81fcc0719501f737fb598489&pid=1-s2.0-S2790676024000116-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141480964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding previously published articles","authors":"","doi":"10.1016/j.ntm.2024.100031","DOIUrl":"https://doi.org/10.1016/j.ntm.2024.100031","url":null,"abstract":"","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100031"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000025/pdfft?md5=4d11dd3b39030a65f878107ccb938dd7&pid=1-s2.0-S2790676024000025-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139907351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Barbara Krystyna Pierscionek","doi":"10.1016/j.ntm.2024.100039","DOIUrl":"10.1016/j.ntm.2024.100039","url":null,"abstract":"","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"3 ","pages":"Article 100039"},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676024000104/pdfft?md5=a8c489fa3ac9097533a960326bb54298&pid=1-s2.0-S2790676024000104-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141955698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic nanocarriers harnessing microbial metabolites usher the path for brain disease therapy","authors":"Ying Gong ,&nbsp;Zhijun Liu ,&nbsp;Piaopiao Zhou ,&nbsp;Jiahong Li ,&nbsp;Yang-Bao Miao","doi":"10.1016/j.ntm.2023.100020","DOIUrl":"10.1016/j.ntm.2023.100020","url":null,"abstract":"<div><p>The gastrointestinal system, often regarded as the 'second brain of humanity,' maintains a profound connection with the cerebral realm. Unlocking the intricate metabolic pathways of gut microorganisms is paramount in the treatment of cerebral ailments. This review primarily focuses on biomimetic precision nanocarriers, harnessing metabolites derived from the gut microbiota, to target brain disorders. Elaborating on the constituents, it illuminates the unique interplay between metabolites originating from the gut microbiota and the cerebral domain. Moreover, the review underscores the symbiotic relationship between nanocarriers fashioned from gut microbiota-derived metabolites and the augmentation of cerebral well-being. Offering a comprehensive outlook, this review sheds light on recent applications, challenges, and future prospects of nanocarriers rooted in metabolites derived from the gut microbiota across a spectrum of disease treatments. It presents an expansive perspective on the attributes of nanocarriers engineered from gut microbiota-derived metabolites, facilitating a deeper understanding of the intricate nexus between these metabolites and cerebral disorders.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 4","pages":"Article 100020"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000547/pdfft?md5=bb9b971517a72b43286dc639cd67e272&pid=1-s2.0-S2790676023000547-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138609031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in modifying the efficacy of immunotherapies through the thermal effects of nanomaterials","authors":"Lan Lei ,&nbsp;Pengyuan Liu ,&nbsp;Wu Jing ,&nbsp;Zhibing Wu","doi":"10.1016/j.ntm.2023.100022","DOIUrl":"10.1016/j.ntm.2023.100022","url":null,"abstract":"<div><p>Tumor immunotherapy represents an intricate approach to combat tumors by modifying the immune microenvironment within the body. Nevertheless, the limited success rate and potential induction of systemic toxic reactions associated with immunotherapy introduce uncertainty regarding its therapeutic effectiveness. Nanoparticles (NPs) exhibit multifaceted applications as therapeutic and diagnostic tools, enabling precise delivery of various immunotherapeutic agents and monitoring of tissue cellular responses. These capabilities facilitate the dynamic assessment of factors influencing immune activity, thereby optimizing future treatment strategies. The utilization of multimodal anti-tumor therapies has paved the way for the induction of potent immune responses, while simultaneously minimizing adverse effects and facilitating the monitoring of immune activities.This review aims to provide an overview of this emerging field and highlight new technologies for next-generation immunotherapy. The current therapeutic approaches are introduced, and the mechanism of action of nanomaterials in combination with thermotherapy to stimulate systemic immune responses is explored. Furthermore, recent advancements in synergistic immunotherapy involving photothermal therapy (PPT) and magnetic hyperthermia therapy (MHT) for tumor treatment are highlighted, summarized, and extensively discussed.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 4","pages":"Article 100022"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000560/pdfft?md5=6f62f481cf06abdac273cd756f7bc6ed&pid=1-s2.0-S2790676023000560-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138613992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperbolic shear polaritons and their potential applications","authors":"Guangyi Jia","doi":"10.1016/j.ntm.2023.100019","DOIUrl":"https://doi.org/10.1016/j.ntm.2023.100019","url":null,"abstract":"<div><p>Hyperbolic shear polaritons recently emerge with widespread attention as a new form of polariton modes with broken symmetry due to shear lattices. Herein, the generation mechanism of hyperbolic shear polaritons is discussed in detail. The exotic anisotropic nanophotonic properties of hyperbolic shear polaritons as well as their potential applications (e.g., ultra-sensitive biomedical sensor, enhancing the near-field thermal radiation and the photonic spin Hall effect) are reviewed. Some existing issues and potential interesting directions for hyperbolic shear polaritons are outlined. This work could inspire more interest in anisotropic two-dimensional crystals and spur the quick generation of new photonic devices based on hyperbolic polaritons.</p></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 4","pages":"Article 100019"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000535/pdfft?md5=72b0c004cc646417d0a05941edd5a40c&pid=1-s2.0-S2790676023000535-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138739337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology: Paving the way for advanced healthcare and beyond","authors":"Chang Lei","doi":"10.1016/j.ntm.2023.100023","DOIUrl":"https://doi.org/10.1016/j.ntm.2023.100023","url":null,"abstract":"","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"2 4","pages":"Article 100023"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2790676023000572/pdfft?md5=a7135976adee78320efa25f6a7780124&pid=1-s2.0-S2790676023000572-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138739324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}