Medical Reports最新文献_第4页

Reduced seizure frequency with oral creatine supplementation: A case report 口服肌酸补充剂降低癫痫发作频率：1例报告

Medical Reports Pub Date : 2025-12-01 Epub Date: 2025-09-04 DOI: 10.1016/j.hmedic.2025.100358

Mia van der Kop , Anna Mia Ekström , Eman Al-Raddadi

引用次数: 0

Atypical adult-onset Henoch-Schönlein purpura in a female patient from Bangladesh: Post-streptococcal vasculitis without IgA deposition – A case report 孟加拉国女性患者的非典型成人发病Henoch-Schönlein紫癜：链球菌感染后血管炎无IgA沉积- 1例报告

Medical Reports Pub Date : 2025-12-01 Epub Date: 2025-09-02 DOI: 10.1016/j.hmedic.2025.100359

Zahin Shahriar, Sakib Abrar , Soumik Roy, Shaimul Reza, Fabiha Rahman, Tushar Kanti Bhadra

引用次数: 0

Postoperative Guillain-Barré syndrome following multiple procedures: A case report 术后多次手术后格林-巴勒综合征：1例报告

Medical Reports Pub Date : 2025-12-01 Epub Date: 2025-09-17 DOI: 10.1016/j.hmedic.2025.100372

Palak R. Patel, Craig Carcuffe, Benjamin Abramoff

引用次数: 0

A-not-full-blown Weil’s disease: An atypical cause of leptospirosis-induced acute hepatitis 未完全成熟的魏氏病：钩端螺旋体引起的急性肝炎的一种非典型病因

Medical Reports Pub Date : 2025-12-01 Epub Date: 2025-09-22 DOI: 10.1016/j.hmedic.2025.100375

Amir Omar , Rayane Salameh , Tracy Zouein , Tala Charafeddine , Karam Karam , Noha Al Hachem

{"title":"A-not-full-blown Weil’s disease: An atypical cause of leptospirosis-induced acute hepatitis","authors":"Amir Omar , Rayane Salameh , Tracy Zouein , Tala Charafeddine , Karam Karam , Noha Al Hachem","doi":"10.1016/j.hmedic.2025.100375","DOIUrl":"10.1016/j.hmedic.2025.100375","url":null,"abstract":"<div><div>Leptospirosis is a worldwide zoonotic disease caused by pathogenic Leptospira species. It usually manifests as an acute bacterial febrile septicemia like illness that affects both humans and animals. Human infection may occur via mucosal surfaces, abraded skin, or inhalation of aerosolized contaminated water. Liver involvement is a frequent finding in leptospirosis that ranges from mild dysfunction to severe icteric illness with renal failure. We herein present a case of acute hepatitis and febrile jaundice induced by Leptospirosis. The patient had cardiac involvement but no pulmonary or renal involvement, further adding ambiguity to the diagnosis. The diagnosis of leptospirosis in this case was particularly challenging due to its atypical presentation. The unusual constellation of findings underscores the importance of considering leptospirosis in the differential diagnosis of febrile jaundice, even in the absence of classical risk factors. The initiation of potentially life-saving antibiotic treatment requires a high index of clinical suspicion.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"14 ","pages":"Article 100375"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastrointestinal rectal stromal tumor with hepatic metastases: A case report 胃肠道直肠间质瘤合并肝转移1例

Medical Reports Pub Date : 2025-12-01 Epub Date: 2025-09-06 DOI: 10.1016/j.hmedic.2025.100364

Rabti Souphia , Mejri Khouloud , Ben Hassine Basma , Kthiri Seif , Ben Marzouk Saoussen , Farjaoui Wael , Khalifa Mohamed Bechir

{"title":"Gastrointestinal rectal stromal tumor with hepatic metastases: A case report","authors":"Rabti Souphia , Mejri Khouloud , Ben Hassine Basma , Kthiri Seif , Ben Marzouk Saoussen , Farjaoui Wael , Khalifa Mohamed Bechir","doi":"10.1016/j.hmedic.2025.100364","DOIUrl":"10.1016/j.hmedic.2025.100364","url":null,"abstract":"<div><h3>Introduction</h3><div>Gastrointestinal stromal tumors (GISTs) are rare tumors, accounting for approximately 1 % of digestive cancers. Among them, rectal GISTs are unusual (< 5 % of GISTs). Their metastatic form, particularly with liver involvement, is even rarer and poses diagnostic and therapeutic challenges.</div></div><div><h3>Case report</h3><div>A 73-year-old ASA II patient presented with rectal discharge and mild abdominal discomfort. Colonoscopy revealed a 5.2 × 4.7 cm lesion in the lower rectum, 3 cm from the anal margin. Histological and immunohistochemical analysis confirmed a high-risk spindle cell GIST (mitotic index: 8/50 HPF). Extension workup showed five liver metastases (segments VI–VIII), the largest measuring 3.8 cm. According to AJCC 2017 staging, the patient was classified as Stage IV. After multidisciplinary team discussion including oncologists, surgeons, and radiologists, imatinib therapy (400 mg daily) was initiated. Six-month follow-up showed a 30 % reduction in both primary tumor and metastatic lesions, with continued imatinib therapy and no surgical intervention to date.</div></div><div><h3>Discussion</h3><div>Metastatic rectal GIST with liver involvement requires a specific therapeutic approach. Imatinib is the reference treatment, enabling disease stabilization in approximately 80 % of cases. Close monitoring is essential, and surgery may be considered for responsive cases. Multidisciplinary management optimizes outcomes, with rectal GIST management differing from other GI locations due to anatomical challenges.</div></div><div><h3>Conclusion</h3><div>Rectal GIST metastatic to the liver is a complex pathology requiring an individualized strategy. Treatment with imatinib, combined with regular assessment, improves tumor control and prognosis, with some patients achieving long-term disease control exceeding 5 years.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"14 ","pages":"Article 100364"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive analysis of aberrant immunophenotypes in T-ALL T-ALL异常免疫表型的综合分析

Medical Reports Pub Date : 2025-12-01 Epub Date: 2025-08-21 DOI: 10.1016/j.hmedic.2025.100347

Chintamani Pathak, Neha Aggarwal, Smriti Sharan, Siddhartha Sankar Samanta

{"title":"A comprehensive analysis of aberrant immunophenotypes in T-ALL","authors":"Chintamani Pathak, Neha Aggarwal, Smriti Sharan, Siddhartha Sankar Samanta","doi":"10.1016/j.hmedic.2025.100347","DOIUrl":"10.1016/j.hmedic.2025.100347","url":null,"abstract":"<div><div>T cell Acute Lymphoblastic Leukemia (T-ALL) is an aggressive hematologic malignancy characterized by the clonal proliferation of immature T lymphocytes. It accounts for approximately 15 % of childhood ALL cases. Aberrant expression of immunophenotype markers is not uncommon in Acute leukemia, especially T-ALL. Aberrant phenotype in T ALL previously are CD10, CD19,CD79a, CD13, CD33, CD117, CD15 and CD11b. In this case series, we describe clinicopathological profile of 7 T ALL cases with aberrant immunophenotype. All cases diagnosed as T ALL on flow cytometry over a period of 2.5 years were included in this study with emphasis on cases expressing aberrant immunophenotype.Among 29 diagnosed cases T ALL, 8 cases exhibited expression of aberrant markers CD10 (6 cases, paediatric), CD33 (1 case, paediatric),CD117 (1 case, paediatric)co expression of CD10 and CD33 (1 case, paediatric), co expression of CD10, CD79a and CD13 (1 case, adult). The detection of aberrant immunophenotypic markers in T-ALL poses considerable diagnostic challenges. The study underscores the importance of comprehensive diagnostic workup including flowcytometry in managing atypical presentations of T-ALL. It highlights the diagnostic complexity of common & uncommon aberrant immunophenotypes in T-ALL, emphasizing the need for detailed molecular and immunophenotypic profiling to guide treatment planning.In our study, CD10 was found to be the most common aberrant immunophenotype as reported previously. The only adult patient with aberrant immunophenotype had coexpression of 3 CD markers and 1 paediatric case coexpressed 2 CD markers which is rare. None of our cases showed aberrant expression of CD19, CD15 and CD11b.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"14 ","pages":"Article 100347"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herpes zoster ophthalmicus with concurrent HSV/VZV meningitis 眼带状疱疹并发HSV/VZV脑膜炎

Medical Reports Pub Date : 2025-12-01 Epub Date: 2025-09-12 DOI: 10.1016/j.hmedic.2025.100369

Daria Hoang , Farzana Hoque

引用次数: 0

Empyema caused by Parvimonas micra: A case report 微小细小单胞菌致脓胸1例

Medical Reports Pub Date : 2025-12-01 Epub Date: 2025-08-26 DOI: 10.1016/j.hmedic.2025.100354

Yali Qiu , Xiwei Zhang , Ying Feng , Lifei Wang

引用次数: 0

Severe multiarticular gouty tophi 严重多关节痛风痛风

Medical Reports Pub Date : 2025-12-01 Epub Date: 2025-11-19 DOI: 10.1016/j.hmedic.2025.100390

Krislyn Cardoza , Farzana Hoque

引用次数: 0

Appendiceal mucinous adenocarcinoma presenting as cecal intussusception: A rare case report 以盲肠肠套叠表现的阑尾粘液腺癌一例罕见报告

Medical Reports Pub Date : 2025-12-01 Epub Date: 2025-11-20 DOI: 10.1016/j.hmedic.2025.100400

Lamia Azizi , Philippe Attieh , Noura Chamchoum , Elie Chamchoum , George Ghaleb , Mehsen Azizi , Karam Karam

{"title":"Appendiceal mucinous adenocarcinoma presenting as cecal intussusception: A rare case report","authors":"Lamia Azizi , Philippe Attieh , Noura Chamchoum , Elie Chamchoum , George Ghaleb , Mehsen Azizi , Karam Karam","doi":"10.1016/j.hmedic.2025.100400","DOIUrl":"10.1016/j.hmedic.2025.100400","url":null,"abstract":"<div><h3>Background</h3><div>Appendiceal mucinous adenocarcinoma (MACA) is an uncommon malignancy, representing less than 0.5 % of gastrointestinal cancers. Clinical presentation is often nonspecific, which can delay diagnosis. Intussusception as an initial manifestation is exceptionally rare in adults.</div></div><div><h3>Case Presentation</h3><div>We report the case of a 63-year-old man with no significant medical history who presented with acute abdominal pain, vomiting, and diarrhea. Examination revealed a periumbilical mass, and inflammatory markers were elevated. Contrast-enhanced CT demonstrated a large cecal intussusception extending to the transverse colon with a few right iliac fossa lymph nodes. The patient underwent laparotomy with partial cecectomy, which revealed indurated cecal tissue. Histopathology confirmed mucinous adenocarcinoma of the appendix measuring 3.5 cm, low-grade, invading the subserosa/mesoappendix (pT3), with negative margins and no nodal metastasis (0/12). The final stage was pT3N0M0 (AJCC stage IIA). Given the absence of nodal involvement, adjuvant chemotherapy was not administered, and the patient was managed with structured surveillance including periodic imaging and tumor marker assessment.</div></div><div><h3>Conclusion</h3><div>This case illustrates a rare presentation of MACA as the lead point for cecal intussusception in an adult. It underscores the importance of considering appendiceal tumors in the differential diagnosis of bowel obstruction and highlights the role of prompt surgical resection for diagnosis and management.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"14 ","pages":"Article 100400"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145578915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0