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Bone marrow edema syndrome of the foot misdiagnosed as infection: Case report 足部骨髓水肿综合征误诊为感染1例

Medical Reports Pub Date : 2025-06-12 DOI: 10.1016/j.hmedic.2025.100286

Lauren Shute , Elly Trepman , Derek Bueddefeld , Gerhard Bock , John M. Embil

{"title":"Bone marrow edema syndrome of the foot misdiagnosed as infection: Case report","authors":"Lauren Shute , Elly Trepman , Derek Bueddefeld , Gerhard Bock , John M. Embil","doi":"10.1016/j.hmedic.2025.100286","DOIUrl":"10.1016/j.hmedic.2025.100286","url":null,"abstract":"<div><div>Bone marrow edema syndrome is a rare, self-limited clinical entity of unknown etiology and may be misdiagnosed as an infection. A 62-year-old man developed left foot pain with no prior trauma. Within 2 weeks, he was unable to walk because of increased pain. At 5 weeks, he developed left foot swelling. Radiographs showed midfoot osteopenia. He was treated for presumed gout and infection with nonsteroidal anti-inflammatory drugs, vancomycin, and ceftriaxone but had no improvement. Magnetic resonance imaging showed bone marrow edema and indistinct cortices. Single-photon emission computed tomography–computed tomography and bone scintigraphy showed intense osseous uptake, patchy demineralization, and erosive changes at the left midfoot. The diagnosis of bone marrow edema syndrome was made, based on review of imaging findings and persistent symptoms despite previous treatment. After treatment with analgesics and off-loading devices, he had complete resolution of pain and improvement of midfoot osteopenia by 5 months after symptom onset. In summary, bone marrow edema syndrome in the foot is rare, and awareness of this syndrome is necessary to avoid diagnostic error and unnecessary treatment. If magnetic resonance imaging is not available, single-photon emission computed tomography–computed tomography may be a useful adjunct toward the diagnosis.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100286"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extranodal non-Hodgkin lymphoma mimicking an endodontic periapical lesion: Case report and literature review 结外非霍奇金淋巴瘤模拟根管尖周病变：病例报告和文献复习

Medical Reports Pub Date : 2025-06-09 DOI: 10.1016/j.hmedic.2025.100285

El Yacoubi Oumayma, Znati Kaoutar, Taleb Bouchra

{"title":"Extranodal non-Hodgkin lymphoma mimicking an endodontic periapical lesion: Case report and literature review","authors":"El Yacoubi Oumayma, Znati Kaoutar, Taleb Bouchra","doi":"10.1016/j.hmedic.2025.100285","DOIUrl":"10.1016/j.hmedic.2025.100285","url":null,"abstract":"<div><h3>Introduction and objective</h3><div>Endodontic periapical lesions are the most commonly observed radiolucencies in this region. Nonetheless, studies highlight that between 0.65 % and 4.22 % of periapical conditions may have non-endodontic origins, including cystic formations and benign or malignant tumors.</div><div>Intraosseous non-Hodgkin lymphoma (NHL) is a rare entity with nonspecific clinical and radiographic features, often causing misdiagnosis, particularly when it occurs near the apex of teeth with necrotic pulp or prior endodontic treatment.</div><div>The objective of this paper is first to present a clinical case of non-Hodgkin lymphoma in a periapical location, followed by a comprehensive review of the literature focusing on the clinical, radiological, and histopathological features of this entity to improve diagnostic accuracy and guide practitioners in their therapeutic decisions.</div></div><div><h3>Observation</h3><div>This report details a new case of non-Hodgkin lymphoma (NHL) diagnosed in a 37-year-old man who exhibited a right maxillary swelling that progressively developed over 8 months. Complementary examinations, including radiographic and histological analyses, confirmed a diagnosis of diffuse B-cell NHL. Furthermore, a literature review was conducted using databases such as PubMed, Web of Science, and Scopus to analyze previously reported cases of NHL in periapical locations.</div></div><div><h3>Conclusion</h3><div>Non-Hodgkin lymphomas (NHL) are a group of disorders involving malignant monoclonal proliferation of lymphoid cells, occurring in extranodal sites in approximately 40 % of cases, particularly in the gastrointestinal tract.</div><div>Intraosseous lymphomas in the head and neck region are rare, and their radiolucency in maxillary locations can mimic other benign pathologies, leading to delayed diagnosis in unaware practitioners.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100285"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Holmes tremor following thalamic hemorrhagic stroke 丘脑出血性中风后的福尔摩斯震颤

Medical Reports Pub Date : 2025-06-09 DOI: 10.1016/j.hmedic.2025.100284

Abhishek Dixit

{"title":"Holmes tremor following thalamic hemorrhagic stroke","authors":"Abhishek Dixit","doi":"10.1016/j.hmedic.2025.100284","DOIUrl":"10.1016/j.hmedic.2025.100284","url":null,"abstract":"<div><h3>Background</h3><div>Holmes tremor (HT) is a rare movement disorder characterized by low-frequency (<4.5 Hz) tremors affecting the upper limbs, exacerbated by posture and voluntary movements. It typically arises from lesions to the brainstem, cerebellum, or thalamus, with stroke being a common etiology. The tremor usually emerges weeks to months after the initial insult due to aberrant neural pathway reorganization.</div></div><div><h3>Case presentation</h3><div>A 67-year-old man with hypertension presented with Right-sided numbness and dysarthria from a left thalamic hemorrhagic stroke with intraventricular extension. Ten days post-discharge, he developed a low-frequency (3–4 Hz) left arm tremor with rest, postural, and kinetic components. Neurological examination revealed mild dysmetria without bradykinesia or rigidity. Treatment with trihexyphenidyl and gabapentin provided minimal benefit, while levodopa 100mg three times daily yielded substantial improvement in limb control. The delayed onset, tremor characteristics, and localization to the thalamus supported the diagnosis of Holmes tremor.</div></div><div><h3>Discussion</h3><div>This case highlights the complex pathophysiology of HT involving disruption of cerebello-thalamo-cortical and dentato-rubro-olivary pathways. The rarity of HT (2–4 % of all tremor cases) and its variable response to pharmacotherapy underscore the need for multidisciplinary management. Current literature supports levodopa as a primary treatment option, with response rates exceeding 50 % in some studies. This patient's positive response to levodopa further confirms dopaminergic pathway involvement in the pathophysiology. For refractory cases, deep brain stimulation (DBS) targeting the ventral intermediate nucleus of the thalamus can be considered, with recent evidence suggesting superior tremor suppression compared to pharmacotherapy alone. This case emphasizes the importance of recognizing HT and its manifestations for proper diagnosis and management.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100284"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physo’s back: A case report and brief review of the safety of physostigmine in the management of antimuscarinic delirium Physo 's back：一个案例报告和简要回顾的毒豆碱治疗抗毒碱谵妄的安全性

Medical Reports Pub Date : 2025-06-07 DOI: 10.1016/j.hmedic.2025.100282

William Bleifuss , Elizabeth DeYoung , Benjamin Willenbring , Sean Boley , Brad Hernandez

引用次数: 0

Very early secondary acute myeloid leukemia in an adolescent patient with Ewing sarcoma of the sacrum: A case report and review of the literature 青少年骶骨尤因肉瘤患者的早期继发性急性髓性白血病：一例报告和文献复习

Medical Reports Pub Date : 2025-06-06 DOI: 10.1016/j.hmedic.2025.100283

Blanca Tomás Soldevilla , José Manuel Marco Sánchez , Cristina Beléndez Bieler , Carolina Agra Pujol , Javier Orcajo Rincón , Ángel Miguel Lancharro Zapata , Elena Cela de Julián , María Cristina Mata Fernández

引用次数: 0

Severe byssinosis with Cor pulmonale and pulmonary arterial hypertension-textile industry: A case report 纺织工业重度肺心病合并肺动脉高压1例

Medical Reports Pub Date : 2025-06-06 DOI: 10.1016/j.hmedic.2025.100280

A. Hemalatha , Gooty Shanaz , J.M. Bhavana , Mohammed Azhar Hussain , B.N. Raghavendra Prasad

{"title":"Severe byssinosis with Cor pulmonale and pulmonary arterial hypertension-textile industry: A case report","authors":"A. Hemalatha , Gooty Shanaz , J.M. Bhavana , Mohammed Azhar Hussain , B.N. Raghavendra Prasad","doi":"10.1016/j.hmedic.2025.100280","DOIUrl":"10.1016/j.hmedic.2025.100280","url":null,"abstract":"<div><div>Byssinosis is an occupational respiratory disease caused by prolonged exposure to cotton dust. It is a significant health concern in the textile industry, particularly in developing countries, and may lead to severe complications if undiagnosed and untreated. We report the case of a 47-year-old Indian male textile worker with advanced Byssinosis, presenting with progressive breathlessness, wheezing, and a two-year history of Cor-Pulmonale and Pulmonary Arterial Hypertension. Clinical findings included clubbing, bilateral pedal edema, and oxygen desaturation (75 %). Treatment involved oxygen therapy, bronchodilators, corticosteroids, and supportive care, with significant symptomatic improvement. This case discusses the severe consequences of chronic Byssinosis due to prolonged occupational exposure. It emphasizes the importance of early detection and preventive strategies, such as personal protective equipment and workplace safety regulations, to mitigate disease progression. Effective management of Byssinosis requires a multifaceted approach to occupational health. Strong preventive measures, early and accurate diagnosis, and evidence-based treatments are essential, particularly in the textile industry.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100280"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastric siderosis in the setting of oral iron intake- A Case report and literature review 口服铁摄入环境下的胃黄铁矿病- 1例报告并文献复习

Medical Reports Pub Date : 2025-06-06 DOI: 10.1016/j.hmedic.2025.100268

Bipneet Singh , Muhammad Zarrar Khan , Palak Patel Rodriguez , Beena Ahsan , Jason Schairer

引用次数: 0

Adolescent HSP: A case report from a South Indian tertiary hospital 青少年热休克：南印度某三级医院一例报告

Medical Reports Pub Date : 2025-06-06 DOI: 10.1016/j.hmedic.2025.100281

S. Maragatham , Christinal Thomas , Duraisami Dhamodharan

引用次数: 0

A case of cutaneous tuberculosis with two distinct types of lesions 皮肤结核伴两种不同类型病变的病例

Medical Reports Pub Date : 2025-06-06 DOI: 10.1016/j.hmedic.2025.100275

Seher Bostancı , Kübra Gündüz , Gizem Nur Öztürk , Bilge Ayça Kırmızı , Aylin Okçu Heper