Medical Reports最新文献_第10页

From shattered to restored: Overcoming challenges in management of fractured tooth 从破碎到修复：克服牙齿断裂管理中的挑战

Medical Reports Pub Date : 2024-08-15 DOI: 10.1016/j.hmedic.2024.100107

Aakash Gupta , Ramandeep Singh , Yeshwanth Perambudhuru

{"title":"From shattered to restored: Overcoming challenges in management of fractured tooth","authors":"Aakash Gupta , Ramandeep Singh , Yeshwanth Perambudhuru","doi":"10.1016/j.hmedic.2024.100107","DOIUrl":"10.1016/j.hmedic.2024.100107","url":null,"abstract":"<div><p>Dental trauma is a complicated field since it encompasses a large variety of injury forms, each of which calls for unique considerations. Traumatic dental injuries (TDIs), which account for 5 % of all injuries, are common in children and young adults. In the primary dentition, luxation injuries are the most common type of TDI, while crown fractures are more frequently recorded for permanent teeth. Most commonly affected permanent teeth are maxillary anteriors. Individuals with severe dental injuries frequently walk into the operatory without making an appointment. Complicated crown fracture should be treated as an emergency as each fraction of delay in management will affect the overall prognosis. Out of 8 billion people around the globe, it is evaluated that one-fourth of the world population faces at least single dental trauma related to a fracture of the crown of an anterior tooth before 18 years of age; the most frequent causes of these injuries are drop downs, fights, collision injuries in sports and auto accidents. This case report will throw some light in conservative management of complicated crown fracture with fractured fragment reattachment using intra radicular splint.</p></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"7 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S294991862400072X/pdfft?md5=dbbe4ead67ed6721f227b78ccac87a11&pid=1-s2.0-S294991862400072X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment-induced mania in a patient with narcolepsy with cataplexy case report 嗜睡症伴惊厥患者治疗诱发的躁狂症病例报告

Medical Reports Pub Date : 2024-08-01 DOI: 10.1016/j.hmedic.2024.100101

Roberto Galea, Elsa Cassar, Anthony Zahra

引用次数: 0

Rare compound mutation of EGFR L858R and E709A identified in both solid tumor and liquid biopsy of a lung adenocarcinoma patient 在一名肺腺癌患者的实体瘤和液体活检中发现表皮生长因子受体 L858R 和 E709A 的罕见复合突变

Medical Reports Pub Date : 2024-08-01 DOI: 10.1016/j.hmedic.2024.100100

Prerana Jha , Vaishakhi Trivedi , Minit Shah , Irene A. George , Pooja Mahesh Kulkarni , Neha Sharma , Venkataramanan Ramachandran , Vanita Noronha , Kumar Prabhash , Prashant Kumar

{"title":"Rare compound mutation of EGFR L858R and E709A identified in both solid tumor and liquid biopsy of a lung adenocarcinoma patient","authors":"Prerana Jha , Vaishakhi Trivedi , Minit Shah , Irene A. George , Pooja Mahesh Kulkarni , Neha Sharma , Venkataramanan Ramachandran , Vanita Noronha , Kumar Prabhash , Prashant Kumar","doi":"10.1016/j.hmedic.2024.100100","DOIUrl":"10.1016/j.hmedic.2024.100100","url":null,"abstract":"<div><p>Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer. Among NSCLC, lung adenocarcinoma is majorly characterized by driver activating mutations in the <em>EGFR</em> (Epidermal growth factor receptor) gene, covering exons-18, 19, and 21. The most frequently observed mutations are the classical mutations Exon–19 E746_A750 deletion, and Exon - 21 L858R, <em>EGFR</em> exon-18 G719X than the rare variants of these genes. Besides classical mutations and other rare mutations, compound mutations are not very profound. Here, in this present case report, we identified the rare occurrence of EGFR E709A and L858R in tissue and liquid biopsy sample of the patient. The identified compound mutation had been validated in FFPE (formalin fixed paraffin embedded) tissue sample by Sanger sequencing. In addition, the concordance of the rare variants in tumor tissue as well as liquid biospy strongly suggests the clinical utility of liquid biopsy. The patient had been treated with single agent gefitinib which showed mixed response and later treatment had been upgraded to pemetrexed + carboplatin + gefitinib. The sensitivity and specificity of NGS technology provide an opportunity to identify uncommon variants, which opens up a wider avenue for targeted therapeutics.</p></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"6 ","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949918624000652/pdfft?md5=041f96f9f21e32cc3d4f0178b5eba685&pid=1-s2.0-S2949918624000652-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141847670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Encephalitis & hemophagocytic lymphohistiocytosis secondary to dengue hemorrhagic fever: A case report 登革出血热继发脑炎和嗜血细胞淋巴组织细胞增多症：病例报告

Medical Reports Pub Date : 2024-08-01 DOI: 10.1016/j.hmedic.2024.100103

S.D.R. Rajapaksha , S.R.M.D. Ranabahu , W.M.Y.L Wijekoon , M. Caldera , P. Rubasinghe , S.G.T. Rathnasekara , C.N. Sarathchandra , SH Siribaddana

引用次数: 0

A case report of right foot eumycetoma caused by Corynespora cassiicola in Sudan with review of literature 苏丹一例由 Corynespora cassiicola 引起的右足umycetoma 病例报告及文献综述。

Medical Reports Pub Date : 2024-08-01 DOI: 10.1016/j.hmedic.2024.100098

Najwa A. Mhmoud

{"title":"A case report of right foot eumycetoma caused by Corynespora cassiicola in Sudan with review of literature","authors":"Najwa A. Mhmoud","doi":"10.1016/j.hmedic.2024.100098","DOIUrl":"10.1016/j.hmedic.2024.100098","url":null,"abstract":"<div><p><em>Corynespora</em> includes plant pathogenic species with a worldwide distribution and a wide host range, particularly cereals and grass.</p><p>We describe a case of black grains eumycetoma of the right foot of 33 years old Sudanese male caused by <em>Corynespora cassiicola</em> after 55 years from the first case reported by Mahgoub ES in 1969. The fungus was successfully identified based on the cultural and molecular techniques as a <em>Corynespora cassiicola</em>. The clinical strain showed low MIC to itraconazole (0.12 µg/ml). Therefore our patient received 200 mg itraconazole BID and folic acid 5 mg once per day. A good clinical response to medical treatment was seen as the sinuses started to heal and the lesions decreased in size. There was no recurrence at the time of the one-year follow up.</p><p>In conclusion, updated taxonomy is essential to identify the new causative agents to the species level and is fundamental to elucidate the eumycetoma associated with this unusual fungus and to determine the appropriate therapy.</p></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"6 ","pages":"Article 100098"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949918624000639/pdfft?md5=ae83eead9458b61419df09b2182b80f7&pid=1-s2.0-S2949918624000639-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141847961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing unpredictable challenge of a liver injury in ornidazole use: A case report 处理使用奥硝唑过程中不可预测的肝损伤挑战：病例报告

Medical Reports Pub Date : 2024-08-01 DOI: 10.1016/j.hmedic.2024.100097

Ali Can Memiş , Sena Yazıcı Alcan , Sultan Gözde Temiz , Feyza Başar , Kadem Arslan

引用次数: 0

Bortezomib-induced hepatotoxicity in a patient with multiple myeloma: A case report "多发性骨髓瘤患者的硼替佐米肝毒性：病例报告"

Medical Reports Pub Date : 2024-08-01 DOI: 10.1016/j.hmedic.2024.100099

Karam Karam , Houssein Chebbo , Sarah Saleh , Emanuel Youssef Dib , Elias Fiani , Maroun Sadek

引用次数: 0

Unusual presentation of sarcoidosis of the breast mimicking metastatic breast cancer analyzed with digital breast tomosynthesis vacuum assisted biopsy (DBT-VAB): A rare case report 通过数字乳腺断层扫描真空辅助活检（DBT-VAB）分析模仿转移性乳腺癌的乳腺肉样瘤病的不寻常表现：罕见病例报告。

Medical Reports Pub Date : 2024-08-01 DOI: 10.1016/j.hmedic.2024.100104

Valentina Picariello , Giorgia Rossi , Clarissa Alfieri , Flavio Pironi , Luca Saragoni , Dolores Santini

引用次数: 0

Challenges in diagnosing leukocyte adhesion deficiency in Syria: A case report 诊断叙利亚白细胞粘附缺陷症的挑战：病例报告

Medical Reports Pub Date : 2024-07-30 DOI: 10.1016/j.hmedic.2024.100105

Leen Sumakie , Mohamad Amir Balloura , Mohammad AL Smadi , Rama Alsaqqa , Rami Sabouni , Groob Alkhayer

{"title":"Challenges in diagnosing leukocyte adhesion deficiency in Syria: A case report","authors":"Leen Sumakie , Mohamad Amir Balloura , Mohammad AL Smadi , Rama Alsaqqa , Rami Sabouni , Groob Alkhayer","doi":"10.1016/j.hmedic.2024.100105","DOIUrl":"10.1016/j.hmedic.2024.100105","url":null,"abstract":"<div><h3>Introduction</h3><p>Leukocyte adhesion deficiency (LAD) is a rare autosomal recessive disorder characterized by improper primary immune response due to absent or decreased adhesion molecules, leading to impaired neutrophil migration into surrounding tissues. LAD is divided into four subtypes: LAD-I, LAD-II, LAD-III, and LAD-IV, based on the underlying mutations. Clinical presentation typically includes recurrent infections and neutrophilia, and it is confirmed through flow cytometry and genetic testing. However, these diagnostic methods may not be available during wartime. Here, we present a case of LAD in a Syrian infant.</p></div><div><h3>Case presentation</h3><p>A 2-month-old infant born to consanguineous parents presented with recurrent skin lesions in the groin and axillary region, accompanied by fever, night sweats, anorexia, and milky vomits twice a day. Clinical examination revealed a 3×4 cm umbilical hernia, multiple ulcerated skin lesions with a base of yellow necrotic tissue in the groin, and a 2.5 cm ulcer in the axilla. The laboratory tests confirm the presence of neutrophilia (WBC: 64.07 ×10<sup>9</sup>/L; Neutrophils: 79 %), raising suspicion for LAD. However, confirmation through flow cytometry and genetic testing was not possible due to unavailability. Antibiotics were administered, but the patient was discharged against medical advice.</p></div><div><h3>Conclusion</h3><p>The scarcity of documented LAD cases from Syria, coupled with the lack of resources to confirm the diagnoses of LAD using flow cytometry, highlights the need for a structured approach to such cases based on clinical presentation and available laboratory findings. This approach is crucial for ensuring timely diagnosis and appropriate management, especially in resource-constrained settings affected by conflict.</p></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"7 ","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949918624000706/pdfft?md5=c1135c1539e279d2599a0d0e9edb9839&pid=1-s2.0-S2949918624000706-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141953867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of concentrated growth factor on soft and hard tissues around dental implants a case report 浓缩生长因子对植牙周围软组织和硬组织的疗效病例报告

Medical Reports Pub Date : 2024-07-14 DOI: 10.1016/j.hmedic.2024.100096

Sitamahalakshmi K , Sai Krishna Bingi , Bhuvanesh Yanamala , Oshin Mary

{"title":"Efficacy of concentrated growth factor on soft and hard tissues around dental implants a case report","authors":"Sitamahalakshmi K , Sai Krishna Bingi , Bhuvanesh Yanamala , Oshin Mary","doi":"10.1016/j.hmedic.2024.100096","DOIUrl":"10.1016/j.hmedic.2024.100096","url":null,"abstract":"<div><p>Dental implants are long-term successful when the osteointegration is maintained with little yearly loss of crestal bone. The current study assesses the crestal bone loss surrounding Osseo integrated implants by adding a concentrated growth factor as an extra factor to maintain the crestal bone levels. The research comprised single patient with a single edentulous location. Along with the implant, concentrated growth factor is inserted. Three and nine months after the implant was implanted, assessments of soft tissue characteristics such as the sulcus bleeding index and plaque index were conducted. Hard tissue metrics, such as volume and bone density, were measured using cone-beam computed tomography both nine months after implant implantation and immediately following implant placement. baseline and nine-month markers were compared, several hard and soft tissue parameters indicated a significant change at nine months. By elevating the density and volume of bone surrounding dental implants, concentrated growth factor can be used as a breakthrough in customized medicine to promote quicker healing and osseous regeneration.</p></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"6 ","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949918624000615/pdfft?md5=5c98953b7a3764d03d2931fc9c120e0a&pid=1-s2.0-S2949918624000615-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141710583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0