Medical Reports最新文献

{"title":"Takotsubo Syndrome induced by sclerotherapy: A case report","authors":"Rui Carlos Detsch Junior ,&nbsp;Joel Avancini Rocha Filho ,&nbsp;Lucas Dionysio ,&nbsp;Walter Campos Junior ,&nbsp;Ana Beatriz Boffa ,&nbsp;Gabriela Araujo Attie ,&nbsp;Pedro Puech-Leão ,&nbsp;Nelson de Luccia ,&nbsp;Maria José Carvalho Carmona","doi":"10.1016/j.hmedic.2025.100297","DOIUrl":"10.1016/j.hmedic.2025.100297","url":null,"abstract":"<div><div>Takotsubo Syndrome (TS), also known as stress cardiomyopathy, is an acute, reversible left ventricular dysfunction often triggered by emotional or physical stressors. Although most cases are associated with emotional distress, TS has also been reported following medical procedures. We present the case of a 40-year-old female who developed TS immediately after undergoing sclerotherapy with Polidocanol for pelvic varices. Shortly after the injection, she experienced acute chest pain, dyspnea, tachycardia, and hypertension. Electrocardiography showed T-wave inversion, and echocardiography revealed a severely reduced left ventricular ejection fraction (23 %) with apical ballooning. Coronary angiography ruled out obstructive coronary disease, consistent with a diagnosis of Polidocanol-induced Takotsubo Syndrome. The patient required inotropic support in the Intensive Care Unit and an intra-aortic balloon pump, with cardiac recovery within seven days. Although rare, TS should be considered in patients experiencing acute cardiovascular symptoms after sclerotherapy. The pathophysiological mechanisms remain unclear but may involve endothelial irritation, systemic inflammation, and autonomic dysregulation. This specific case is unique due to the patient’s age, the severity of the cardiac dysfunction and the time of symptom onset. Awareness of this complication is crucial for early recognition and appropriate management, particularly in high-risk patients undergoing minimally invasive vascular procedures in an ambulatory care unit.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100297"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic lymphocytic leukemia and Priapism: An Unusual association","authors":"Jahnavi Ethakota,&nbsp;Sakshi Bai,&nbsp;Danesh Kumar,&nbsp;Bipneet Singh,&nbsp;Palak Grover,&nbsp;Devin Malik","doi":"10.1016/j.hmedic.2025.100295","DOIUrl":"10.1016/j.hmedic.2025.100295","url":null,"abstract":"<div><h3>Introduction</h3><div>Priapism is a prolonged penile erection, unrelated to sexual arousal. It can lead to permanent tissue damage if not promptly managed. While it is more commonly associated with hematologic disorders such as sickle cell disease and hypercoagulable states, priapism in chronic lymphocytic leukemia (CLL) is exceptionally rare. There are few published case reports regarding CLL presenting with priapism as initial manifestation of the disease.</div></div><div><h3>Case presentation</h3><div>This is a case of a 67-year-old male with CLL on monitoring, presented to the ED with priapism and further evaluation revealed a WBC count of 186.9 k correlating to his CLL diagnosis. The priapism was initially thought to be secondary to trazodone and was subsequently discontinued. The patient presented again in 2 weeks with priapism despite discontinuing trazodone with an elevated WBC count of 246.6 k, uptrending WBC count. The priapism was considered to be secondary to CLL, further imaging revealed extensive lymphadenopathy in the chest and upper abdomen (largest lymph node 2.7 cm).</div></div><div><h3>Treatment</h3><div>He was started on Obinutuzumab and responded well with a decrease in WBC count to 6.65 k after just one dose of Obinutuzumab. The priapism was resolved successfully without recurrence. The patient is currently being treated with Obinutuzumab and Venetoclax.</div></div><div><h3>Conclusion</h3><div>Priapism can be a sign of progression as seen in the above case or as an initial manifestation of CLL. It happens due to leukostasis, where high leukocyte counts cause blood stasis in the penile vasculature. Hyperviscosity and leukemic cell infiltration of penile tissue may further contribute to blood flow obstruction, leading to priapism. This case emphasizes the need to consider hematologic malignancies, such as CLL, as potential causes of priapism in patients with high WBC counts. Immediate intervention is essential to prevent permanent penile damage.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100295"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventriculoperitoneal shunt malfunction in a complex parturient: a case report","authors":"Nicole Y. Xu,&nbsp;Christine Y. Shen,&nbsp;Allen Wang,&nbsp;Michelle Yanik,&nbsp;Erin I. Martin,&nbsp;Lawrence Weinstein","doi":"10.1016/j.hmedic.2025.100296","DOIUrl":"10.1016/j.hmedic.2025.100296","url":null,"abstract":"<div><div>A ventriculoperitoneal (VP) shunt is an effective procedure used to treat congenital hydrocephalus and has significantly improved the survivability of these patients to reach a reproductive age. However, as people with VP shunts become pregnant, they face a substantial risk related to shunt failure. The literature reports that up to 50 % of parturients with a VP shunt will experience some form of shunt related complication during their pregnancy. However, there are few published case reports documenting the clinical sequelae of parturients who ultimately experience these complications. The added physiological changes associated with pregnancy can further challenge the management of these parturients. Parturients with a VP shunt require a multidisciplinary team and close monitoring to detect any potential neurological changes and shunt malfunction. The use of a multidisciplinary team is essential to ensure the safety of both the mother and the fetus. Here, we present a case of a complex parturient with a VP shunt complicated by shunt malfunction along with a literature review of the incidence of shunt malfunction, severity of symptoms, possible treatment options, and the importance of a collaborative, multidisciplinary approach to optimize maternal and fetal outcomes.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100296"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the heart: hidden lymphoma-induced HLH driving cardiogenic shock","authors":"Elizabeth R. Rimsky ,&nbsp;Kai Wang ,&nbsp;Agarwal Alaukika ,&nbsp;Mokhtar Asmaa ,&nbsp;Amor Martin ,&nbsp;Marcel Odaimi","doi":"10.1016/j.hmedic.2025.100294","DOIUrl":"10.1016/j.hmedic.2025.100294","url":null,"abstract":"<div><h3>Background</h3><div>Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening hyperinflammatory condition triggered by factors like genetic abnormalities, malignancies, and infections. It leads to uncontrolled macrophage activity and cytokine release, causing tissue damage and multi-organ failure. Prompt recognition and diagnosis are essential due to its nonspecific presentation and high mortality.</div></div><div><h3>Case</h3><div>A 76-year-old male with known atrial fibrillation, presented with progressive fatigue. The patient was being treated with steroids and methotrexate (MTX) for a recent episode of sudden onset blurry vision while further evaluation of suspected temporal arteritis was being pursued. Upon admission, the patient developed cardiogenic shock, respiratory failure, and mental status changes, requiring intensive care. Lab findings showed thrombocytopenia, elevated ferritin, high triglycerides, and pancytopenia, fulfilling 5 of the 8 HLH diagnostic criteria. A bone marrow biopsy confirmed B-cell non-Hodgkin’s lymphoma, leading to a diagnosis of lymphoma-induced HLH. The patient was treated with etoposide and later transitioned to R-CHOP chemotherapy, leading to significant clinical improvement and stabilization of HLH markers.</div></div><div><h3>Discussion:</h3><div>This case illustrates the diagnostic complexity of HLH. Early suspicion, diagnosis, and treatment are crucial to improving outcomes in patients with multi-organ dysfunction and nonspecific systemic symptoms.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100294"},"PeriodicalIF":0.0,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ménétrier's disease presenting with melena and severe anemia in the absence of hypoalbuminemia: A case report","authors":"Bipneet Singh ,&nbsp;Jahnavi Ethakota ,&nbsp;Palak Grover ,&nbsp;Gurleen Kaur ,&nbsp;Sruthi Ramanan","doi":"10.1016/j.hmedic.2025.100290","DOIUrl":"10.1016/j.hmedic.2025.100290","url":null,"abstract":"<div><h3>Introduction</h3><div>Ménétrier's disease (MD), an uncommon protein-losing gastropathy characterized by hypertrophic gastric folds, primarily affects individuals in their 30–60s.</div></div><div><h3>Case</h3><div>We present a case of MD in a 69-year-old female with atypical symptoms of melena, fatigue, and lightheadedness. Admission revealed severe anemia with a hemoglobin of 5.1 g/dL (Females: 12.0–15.5 g/dL). Esophagogastroduodenoscopy (EGD) demonstrated markedly hypertrophied gastric folds with mucoid secretions, elevated serum gastrin levels of 339 pg/mL (0–180 pg/mL). Pathology confirmed MD, revealing characteristic mucosal changes without significant inflammation or H. pylori.</div></div><div><h3>Discussion</h3><div>Menetrier's disease is a rare disorder with a low incidence, affecting less than 1 in 100,000 people. The disease is characterized by thickened gastric mucosa, with Middle-aged men having a higher prevalence. The disease is diagnosed with foveolar hyperplasia, and no antibiotic therapy is offered. The trigger for the disease is unclear, but studies have linked it to subclinical viral infections and genetic links. The disease is caused by an increase in the signaling of the epidermal growth factor receptor (EGFR), leading to increased mucus production and decreased acid production. The patient presents with melena, edema, vomiting, anorexia, diarrhea, and rarely gastric intussusception. The patient is initially treated conservatively with PPI and a high-protein diet, with plans to try Cetuximab if hypoalbuminemia and melena persist.</div></div><div><h3>Conclusion</h3><div>Diagnosing rare diseases like Menetrier's disease requires thorough examination and treatment. Treatment and surveillance guidelines are often influenced by gastroenterologists, and providers must stay updated on pathophysiology and current treatments. Complications, such as protein loss, should be managed with protein supplements, and patients should be monitored for potential malignancy.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100290"},"PeriodicalIF":0.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic hypereosinophilic syndrome presenting with eosinophilic pleural and pericardial effusions: A case report","authors":"Abdul Qadir ,&nbsp;Mamunul Islam ,&nbsp;Riyadh Ali Mohammed Hammamy ,&nbsp;Mohammed Kays Issa Alattiya ,&nbsp;Hafsah Iqbal","doi":"10.1016/j.hmedic.2025.100293","DOIUrl":"10.1016/j.hmedic.2025.100293","url":null,"abstract":"<div><div>Hypereosinophilic syndrome (HES) is a rare disorder characterized by persistent eosinophilia and multi-organ involvement, often mimicking common conditions. We report a 36-year-old male with fever, cough, and pleuritic chest pain, initially diagnosed with community-acquired pneumonia. His condition deteriorated despite antibiotic therapy, leading to further evaluation revealing marked peripheral eosinophilia (3.79 × 10⁹/L) and eosinophilic pleural effusions. Extensive workup excluded secondary causes, leading to a diagnosis of idiopathic HES. The patient responded rapidly to corticosteroid therapy, with clinical and radiological improvement. This case highlights the importance of considering HES in patients with unexplained eosinophilic effusions and the role of early corticosteroid intervention in management.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100293"},"PeriodicalIF":0.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entrapment of the lateral rectus muscle with associated oculocardiac reflex in pediatric facial trauma: A case report","authors":"Jesse Simpson,&nbsp;Timothy W. Neal,&nbsp;Isherpreet Shergill,&nbsp;Patrick Wong","doi":"10.1016/j.hmedic.2025.100292","DOIUrl":"10.1016/j.hmedic.2025.100292","url":null,"abstract":"<div><div>Extraocular muscle entrapment is a well-studied occurrence that can occur with fractures involving the orbit. While orbital fractures are more common in adults, muscle entrapment is more common when these fractures occur in pediatric patients. The lateral orbital wall is the strongest surface of the orbit as it is the only surface that lacks an adjacent sinus. In the pediatric population, fractures of the lateral orbital wall are rare, and entrapment of the lateral rectus muscle is even more so. To the authors' knowledge, this is the second reported case of lateral rectus muscle entrapment in a pediatric patient and the first with associated oculocardiac reflex.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100292"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catch me if you can- Hereditary hemorrhagic telangiectasia presenting as gastrointestinal bleed!","authors":"Bipneet Singh ,&nbsp;Jahnavi Ethakota ,&nbsp;Palak Grover ,&nbsp;Gurleen Kaur","doi":"10.1016/j.hmedic.2025.100289","DOIUrl":"10.1016/j.hmedic.2025.100289","url":null,"abstract":"<div><h3>Background</h3><div>Hereditary hemorrhagic telangiectasia (HHT) is a rare, autosomal dominant genetic disorder. It produces abnormal vasculature throughout the body, contributing to varying bleeding manifestations. Similarly, gastrointestinal involvement can result from arteriovenous malformations (AVM), which can spontaneously bleed, presenting as iron deficiency anemia.</div></div><div><h3>Aim/objective</h3><div>Recognizing patterns that can indicate HHT, using appropriate diagnostic criteria, and learning guideline-directed management.</div></div><div><h3>Case</h3><div>A 61-year-old female presenting with treatment-resistant iron deficiency anemia was evaluated with endoscopy, which revealed a duodenal AVM. The patient underwent a CT scan for lung cancer screening, revealing multiple bilateral pulmonary AVMs. This led to a suspicion of HHT. A push enteroscopy was pursued, revealing 40 bleeding AVMs.</div></div><div><h3>Discussion</h3><div>HHT can present with cerebral, pulmonary, gastrointestinal, and hepatic involvement with fatal complications. Diagnostic criteria and genetic testing can be utilized for the diagnosis, and further screening helps reduce mortality. Even in cases of late presentation, patients should be referred to and established with appropriate sub-specialists to monitor complications. Recognizing HHT as a potential cause of otherwise unexplained gastrointestinal bleeding is crucial for prompt diagnosis and timely intervention to prevent serious complications.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100289"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anal canal squamous cell carcinoma metastasizing to the thigh – A “carcinoma en cuirasse”-like rare presentation","authors":"Sadanand M. Karandikar ,&nbsp;Himanshi Joon ,&nbsp;Shailesh Puntambekar","doi":"10.1016/j.hmedic.2025.100288","DOIUrl":"10.1016/j.hmedic.2025.100288","url":null,"abstract":"<div><div>Anal canal squamous cell carcinoma (SCC) rarely metastasizes to the skin. We report an unusual case of anal SCC with metastasis to the thigh, presenting as an indurated plaque with “carcinoma en cuirasse”- like features. Cutaneous metastases from gastrointestinal malignancies occur in less than 4 % of cases and a diffuse plaque-like presentation is generally associated with breast or lung carcinoma. The case highlights a rare manifestation of anal cancer indicating widespread disease dissemination and poor prognosis.</div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100288"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ertapenem-induced delirium in a patient with preserved renal function: A case report and review","authors":"Sneha Kumar ,&nbsp;Harmanjeet Singh ,&nbsp;Aiden Bowers ,&nbsp;Selcuk Akturan ,&nbsp;Abhineet Kumar","doi":"10.1016/j.hmedic.2025.100287","DOIUrl":"10.1016/j.hmedic.2025.100287","url":null,"abstract":"<div><div>Ertapenem induced Encephalopathy (EIE) is a well documented but uncommon side effect of ertapenem mostly reported in patients with renal impairment leading to prolonged recovery periods of upto 2 weeks. The goal of this case report is to report a patient with no renal impairment who developed ertapenem-induced encephalopathy and had rapid recovery after stopping ertapenem. The case highlights the need for clinicians to consider ertapenem induced neurotoxicty in patients with preserved renal function<span><span>[1]</span></span>, <span><span>[2]</span></span>. Given the strong clinical evidence indicating ertapenem as the likely cause, we applied the Naranjo Scale to assess the probability of an adverse drug reaction. Our patient received a Naranjo Scale score of 7, indicating a probable adverse drug reaction, with a logical temporal sequence supporting this conclusion.<span><span>[3]</span></span>, <span><span>[4]</span></span></div></div>","PeriodicalId":100908,"journal":{"name":"Medical Reports","volume":"13 ","pages":"Article 100287"},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}